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Conserved domains on  [gi|568909081|ref|XP_006529657|]
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contactin-associated protein like 5-2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 56-173 2.83e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 122.85  E-value: 2.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   56 AQLNGrmgTGGWSPENSSAHQWLQLDLGNRVEITAVATQGR--YGSSDWVTSYCLIFSDTGHNWQQYKQGDSIWTFIGNM 133
Cdd:cd00057    29 ARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRkgGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNS 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568909081  134 NANSVVHHKLLHAVRARFVRFVPLEWnpNGKIGMRVEVYG 173
Cdd:cd00057   106 DGSTPVTNDFPPPIVARYIRILPTTW--NGNISLRLELYG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 209-338 7.11e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.43  E-value: 7.11e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   209 FKSMQGDGVLFHGEGQRGDHITLELQNGRLALYLNLDDSKARLSSItpsailGSLLDDQHWHSVLLERVGKQANFTVDRN 288
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSS------GKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568909081   289 TQHFRTN-GDTDALDIDYELSFGGIPVP-SKPGTFLKKNFQGCIENLYYNGV 338
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLlLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 396-522 1.74e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 1.74e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   396 FRTWNEDGLLLSTElSEGSGTLLLILEGGTLRLLIKNVAGHGTESLTGRSLNNGQWHSVNINARRNRVTLTLDNDPASPA 475
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568909081   476 LETPW-LQIYSGYSYYFGGCPDNLTdSQCLNPIKAFQGCMRLIFIDNQ 522
Cdd:pfam02210   80 LPPGEsLLLNLNGPLYLGGLPPLLL-LPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 780-924 2.44e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.49  E-value: 2.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  780 AVSFSTEAaYLHIPTFHAE-FSADISFFFKTTALSGV--FLENLGVKNFLRLEMSSpSEVIFAIDvgNGPMELLVQSPYP 856
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLllYAGSQNGGDFLALELED-GRLVLRYD--LGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568909081  857 LNDNQWHYIQAERNIKETLLHVDNLPkSMRMASEEGHFLLQLNSQLFVGGT--------SSRQKGFLGCIRSLHLN 924
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1032-1160 4.63e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 84.39  E-value: 4.63e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  1032 FMTAQAPTLLLYLNFSSQNFLAILLsRNGSLQIQYRLSKEESHVFTiSTENLANRRVHQVKMSRDGPELSIQMDQQ-LFS 1110
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQtVVS 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568909081  1111 YNFPPEVE-FQTVRSLILGKVtetLGLDPEVAKANTLGFVGCLSSVQYNHI 1160
Cdd:pfam02210   79 SLPPGESLlLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-582 4.46e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 4.46e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568909081   551 CFPNYCEHGGHCTQTWTNFYCNCSnTGYTGAT 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 948-981 5.84e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 5.84e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568909081   948 CNSYgrNCQNGGKCVEKHIGYTCDCTNsPYEGPF 981
Cdd:pfam00008    1 CAPN--PCSNGGTCVDTPGGYTCICPE-GYTGKR 31
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 56-173 2.83e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 122.85  E-value: 2.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   56 AQLNGrmgTGGWSPENSSAHQWLQLDLGNRVEITAVATQGR--YGSSDWVTSYCLIFSDTGHNWQQYKQGDSIWTFIGNM 133
Cdd:cd00057    29 ARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRkgGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNS 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568909081  134 NANSVVHHKLLHAVRARFVRFVPLEWnpNGKIGMRVEVYG 173
Cdd:cd00057   106 DGSTPVTNDFPPPIVARYIRILPTTW--NGNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 58-171 5.11e-30

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 115.62  E-value: 5.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081    58 LNGRMGTGgWSPENSSAHQWLQLDLGNRVEITAVATQGRY-GSSDWVTSYCLIFSDTGHNWQQYKQGdsiwTFIGNMNAN 136
Cdd:pfam00754   18 LDGDPNTA-WSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDE----KIPGNNDNN 92

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 568909081   137 SVVHHKLLHAVRARFVRFVPLEWNPNGKIGMRVEV 171
Cdd:pfam00754   93 TPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 209-338 7.11e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.43  E-value: 7.11e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   209 FKSMQGDGVLFHGEGQRGDHITLELQNGRLALYLNLDDSKARLSSItpsailGSLLDDQHWHSVLLERVGKQANFTVDRN 288
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSS------GKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568909081   289 TQHFRTN-GDTDALDIDYELSFGGIPVP-SKPGTFLKKNFQGCIENLYYNGV 338
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLlLLPALPVRAGFVGCIRDVRVNGE 126
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 56-174 5.48e-27

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 107.60  E-value: 5.48e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081     56 AQLNGRMGtGGWSPENSSAHQWLQLDLGNRVEITAVATQGRYGSSDWVTSYcLIFSDTGHNWQQYKQGDSIwTFIGNMNA 135
Cdd:smart00231   26 ARLNGGSD-GGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPGNSDA 102

                            90       100       110
                    ....*....|....*....|....*....|....*....
gi 568909081    136 NSVVHHKLLHAVRARFVRFVPLEWnpNGKIGMRVEVYGC 174
Cdd:smart00231  103 GTVVLNDFPPPIVARYVRILPTGW--NGNIILRVELLGC 139
LamG smart00282
Laminin G domain;
205-338 4.39e-26

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 104.73  E-value: 4.39e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081    205 ISLKFKSMQGDGVLFH-GEGQRGDHITLELQNGRLALYLNLDDSKARLSSITPSailgslLDDQHWHSVLLERVGKQANF 283
Cdd:smart00282    2 ISFSFRTTSPNGLLLYaGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTP------LNDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568909081    284 TVD-RNTQHFRTNGDTDALDIDYELSFGGIPVPSK-PGTFLKKNFQGCIENLYYNGV 338
Cdd:smart00282   76 SVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKlPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 180-336 6.40e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 6.40e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  180 VADFDGRSSllYRFNQKTMSTLKDVISLKFKSMQGDGVLFH-GEGQRGDHITLELQNGRLALYLNLDDSKARLSSITPsa 258
Cdd:cd00110     1 GVSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  259 ilgslLDDQHWHSVLLERVGKQANFTVDRNTQ-HFRTNGDTDALDIDYELSFGGIPVPSK-PGTFLKKNFQGCIENLYYN 336
Cdd:cd00110    77 -----LNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKsPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 396-522 1.74e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 1.74e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   396 FRTWNEDGLLLSTElSEGSGTLLLILEGGTLRLLIKNVAGHGTESLTGRSLNNGQWHSVNINARRNRVTLTLDNDPASPA 475
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568909081   476 LETPW-LQIYSGYSYYFGGCPDNLTdSQCLNPIKAFQGCMRLIFIDNQ 522
Cdd:pfam02210   80 LPPGEsLLLNLNGPLYLGGLPPLLL-LPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 780-924 2.44e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.49  E-value: 2.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  780 AVSFSTEAaYLHIPTFHAE-FSADISFFFKTTALSGV--FLENLGVKNFLRLEMSSpSEVIFAIDvgNGPMELLVQSPYP 856
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLllYAGSQNGGDFLALELED-GRLVLRYD--LGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568909081  857 LNDNQWHYIQAERNIKETLLHVDNLPkSMRMASEEGHFLLQLNSQLFVGGT--------SSRQKGFLGCIRSLHLN 924
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 807-926 2.67e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 96.33  E-value: 2.67e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   807 FKTTALSGVFLENLGVKN-FLRLEMSSpSEVIFAIDVGNGPMELLVqSPYPLNDNQWHYIQAERNIKETLLHVDNLPKSM 885
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSdFLALELVN-GRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 568909081   886 RMASEEGHFlLQLNSQLFVGG--------TSSRQKGFLGCIRSLHLNGQ 926
Cdd:pfam02210   79 SLPPGESLL-LNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
391-522 2.80e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 96.64  E-value: 2.80e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081    391 SVSFQFRTWNEDGLLLSTELSEGSGTLLLILEGGTLRLLIKNVAGHGTESLTGRSLNNGQWHSVNINARRNRVTLTLDND 470
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 568909081    471 PA----SPALETPWLqiySGYSYYFGGCPDNLTDSQcLNPIKAFQGCMRLIFIDNQ 522
Cdd:smart00282   81 NRvsgeSPGGLTILN---LDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 368-520 6.23e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 96.33  E-value: 6.23e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  368 PITFvnSRSSYLLLPGTP-QIDGLSVSFQFRTWNEDGLLLSTELSEGSGTLLLILEGGTLRLLIKNvaGHGTESLT-GRS 445
Cdd:cd00110     1 GVSF--SGSSYVRLPTLPaPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL--GSGSLVLSsKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568909081  446 LNNGQWHSVNINARRNRVTLTLDNDP---ASPALETPWLQiySGYSYYFGGCPDNLTdSQCLNPIKAFQGCMRLIFID 520
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGERvveSGSPGGSALLN--LDGPLYLGGLPEDLK-SPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
802-926 5.94e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.79  E-value: 5.94e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081    802 DISFFFKTTALSGV--FLENLGVKNFLRLEMSSpSEVIFAIDVGNGPMELLVQsPYPLNDNQWHYIQAERNIKETLLHVD 879
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRD-GRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568909081    880 NLPkSMRMASEEGHFLLQLNSQLFVGGT--------SSRQKGFLGCIRSLHLNGQ 926
Cdd:smart00282   79 GGN-RVSGESPGGLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1032-1160 4.63e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 84.39  E-value: 4.63e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  1032 FMTAQAPTLLLYLNFSSQNFLAILLsRNGSLQIQYRLSKEESHVFTiSTENLANRRVHQVKMSRDGPELSIQMDQQ-LFS 1110
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQtVVS 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568909081  1111 YNFPPEVE-FQTVRSLILGKVtetLGLDPEVAKANTLGFVGCLSSVQYNHI 1160
Cdd:pfam02210   79 SLPPGESLlLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1028-1159 8.14e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 63.90  E-value: 8.14e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   1028 ITLSFMTAQAPTLLLYLNFSSQN-FLAILLsRNGSLQIQYRLSKEESHVfTISTENLANRRVHQVKMSRDGPELSIQMDQ 1106
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGdYLALEL-RDGRLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568909081   1107 QLFSY--NFPPEVEFQTVRSLILGKVTETLGLDPEVakaNTLGFVGCLSSVQYNH 1159
Cdd:smart00282   80 GNRVSgeSPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1019-1158 9.57e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 58.58  E-value: 9.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081 1019 KDTAPSKEAITLSFMTAQAPTLLLYL-NFSSQNFLAILLsRNGSLQIQYRLSKEESHVftISTENLANRRVHQVKMSRDG 1097
Cdd:cd00110    15 LPAPRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALEL-EDGRLVLRYDLGSGSLVL--SSKTPLNDGQWHSVSVERNG 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568909081 1098 PELSIQMDQQLF--SYNFPPEVEFQTVRSLILGKVTETLGLDPEVakaNTLGFVGCLSSVQYN 1158
Cdd:cd00110    92 RSVTLSVDGERVveSGSPGGSALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-582 4.46e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 4.46e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568909081   551 CFPNYCEHGGHCTQTWTNFYCNCSnTGYTGAT 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 542-583 1.77e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568909081  542 IDLCSIkdrcfPNYCEHGGHCTQTWTNFYCNCSNtGYTGATC 583
Cdd:cd00054     2 IDECAS-----GNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 948-981 5.84e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 5.84e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568909081   948 CNSYgrNCQNGGKCVEKHIGYTCDCTNsPYEGPF 981
Cdd:pfam00008    1 CAPN--PCSNGGTCVDTPGGYTCICPE-GYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 948-983 1.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568909081  948 CNSYGrNCQNGGKCVEKHIGYTCDCtNSPYEGPFCK 983
Cdd:cd00054     5 CASGN-PCQNGGTCVNTVGSYRCSC-PPGYTGRNCE 38
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 56-173 2.83e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 122.85  E-value: 2.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   56 AQLNGrmgTGGWSPENSSAHQWLQLDLGNRVEITAVATQGR--YGSSDWVTSYCLIFSDTGHNWQQYKQGDSIWTFIGNM 133
Cdd:cd00057    29 ARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRkgGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNS 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568909081  134 NANSVVHHKLLHAVRARFVRFVPLEWnpNGKIGMRVEVYG 173
Cdd:cd00057   106 DGSTPVTNDFPPPIVARYIRILPTTW--NGNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 58-171 5.11e-30

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 115.62  E-value: 5.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081    58 LNGRMGTGgWSPENSSAHQWLQLDLGNRVEITAVATQGRY-GSSDWVTSYCLIFSDTGHNWQQYKQGdsiwTFIGNMNAN 136
Cdd:pfam00754   18 LDGDPNTA-WSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDE----KIPGNNDNN 92

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 568909081   137 SVVHHKLLHAVRARFVRFVPLEWNPNGKIGMRVEV 171
Cdd:pfam00754   93 TPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 209-338 7.11e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.43  E-value: 7.11e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   209 FKSMQGDGVLFHGEGQRGDHITLELQNGRLALYLNLDDSKARLSSItpsailGSLLDDQHWHSVLLERVGKQANFTVDRN 288
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSS------GKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568909081   289 TQHFRTN-GDTDALDIDYELSFGGIPVP-SKPGTFLKKNFQGCIENLYYNGV 338
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLlLLPALPVRAGFVGCIRDVRVNGE 126
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 56-174 5.48e-27

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 107.60  E-value: 5.48e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081     56 AQLNGRMGtGGWSPENSSAHQWLQLDLGNRVEITAVATQGRYGSSDWVTSYcLIFSDTGHNWQQYKQGDSIwTFIGNMNA 135
Cdd:smart00231   26 ARLNGGSD-GGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPGNSDA 102

                            90       100       110
                    ....*....|....*....|....*....|....*....
gi 568909081    136 NSVVHHKLLHAVRARFVRFVPLEWnpNGKIGMRVEVYGC 174
Cdd:smart00231  103 GTVVLNDFPPPIVARYVRILPTGW--NGNIILRVELLGC 139
LamG smart00282
Laminin G domain;
205-338 4.39e-26

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 104.73  E-value: 4.39e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081    205 ISLKFKSMQGDGVLFH-GEGQRGDHITLELQNGRLALYLNLDDSKARLSSITPSailgslLDDQHWHSVLLERVGKQANF 283
Cdd:smart00282    2 ISFSFRTTSPNGLLLYaGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTP------LNDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568909081    284 TVD-RNTQHFRTNGDTDALDIDYELSFGGIPVPSK-PGTFLKKNFQGCIENLYYNGV 338
Cdd:smart00282   76 SVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKlPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 180-336 6.40e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 6.40e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  180 VADFDGRSSllYRFNQKTMSTLKDVISLKFKSMQGDGVLFH-GEGQRGDHITLELQNGRLALYLNLDDSKARLSSITPsa 258
Cdd:cd00110     1 GVSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  259 ilgslLDDQHWHSVLLERVGKQANFTVDRNTQ-HFRTNGDTDALDIDYELSFGGIPVPSK-PGTFLKKNFQGCIENLYYN 336
Cdd:cd00110    77 -----LNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKsPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 396-522 1.74e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 1.74e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   396 FRTWNEDGLLLSTElSEGSGTLLLILEGGTLRLLIKNVAGHGTESLTGRSLNNGQWHSVNINARRNRVTLTLDNDPASPA 475
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568909081   476 LETPW-LQIYSGYSYYFGGCPDNLTdSQCLNPIKAFQGCMRLIFIDNQ 522
Cdd:pfam02210   80 LPPGEsLLLNLNGPLYLGGLPPLLL-LPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 780-924 2.44e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.49  E-value: 2.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  780 AVSFSTEAaYLHIPTFHAE-FSADISFFFKTTALSGV--FLENLGVKNFLRLEMSSpSEVIFAIDvgNGPMELLVQSPYP 856
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLllYAGSQNGGDFLALELED-GRLVLRYD--LGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568909081  857 LNDNQWHYIQAERNIKETLLHVDNLPkSMRMASEEGHFLLQLNSQLFVGGT--------SSRQKGFLGCIRSLHLN 924
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 807-926 2.67e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 96.33  E-value: 2.67e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   807 FKTTALSGVFLENLGVKN-FLRLEMSSpSEVIFAIDVGNGPMELLVqSPYPLNDNQWHYIQAERNIKETLLHVDNLPKSM 885
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSdFLALELVN-GRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 568909081   886 RMASEEGHFlLQLNSQLFVGG--------TSSRQKGFLGCIRSLHLNGQ 926
Cdd:pfam02210   79 SLPPGESLL-LNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
391-522 2.80e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 96.64  E-value: 2.80e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081    391 SVSFQFRTWNEDGLLLSTELSEGSGTLLLILEGGTLRLLIKNVAGHGTESLTGRSLNNGQWHSVNINARRNRVTLTLDND 470
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 568909081    471 PA----SPALETPWLqiySGYSYYFGGCPDNLTDSQcLNPIKAFQGCMRLIFIDNQ 522
Cdd:smart00282   81 NRvsgeSPGGLTILN---LDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 368-520 6.23e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 96.33  E-value: 6.23e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  368 PITFvnSRSSYLLLPGTP-QIDGLSVSFQFRTWNEDGLLLSTELSEGSGTLLLILEGGTLRLLIKNvaGHGTESLT-GRS 445
Cdd:cd00110     1 GVSF--SGSSYVRLPTLPaPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL--GSGSLVLSsKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568909081  446 LNNGQWHSVNINARRNRVTLTLDNDP---ASPALETPWLQiySGYSYYFGGCPDNLTdSQCLNPIKAFQGCMRLIFID 520
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGERvveSGSPGGSALLN--LDGPLYLGGLPEDLK-SPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
802-926 5.94e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.79  E-value: 5.94e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081    802 DISFFFKTTALSGV--FLENLGVKNFLRLEMSSpSEVIFAIDVGNGPMELLVQsPYPLNDNQWHYIQAERNIKETLLHVD 879
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRD-GRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568909081    880 NLPkSMRMASEEGHFLLQLNSQLFVGGT--------SSRQKGFLGCIRSLHLNGQ 926
Cdd:smart00282   79 GGN-RVSGESPGGLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1032-1160 4.63e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 84.39  E-value: 4.63e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081  1032 FMTAQAPTLLLYLNFSSQNFLAILLsRNGSLQIQYRLSKEESHVFTiSTENLANRRVHQVKMSRDGPELSIQMDQQ-LFS 1110
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQtVVS 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568909081  1111 YNFPPEVE-FQTVRSLILGKVtetLGLDPEVAKANTLGFVGCLSSVQYNHI 1160
Cdd:pfam02210   79 SLPPGESLlLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
209-340 1.01e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 71.96  E-value: 1.01e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   209 FKSMQGDGVLFHGEGQR-GDHITLELQNGRLALYLNLDDSKARLSSitpsailGSLLDDQHWHSVLLERVGKQANFTVDR 287
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALELRDGRLEVSYDLGSGAAVVRS-------GDKLNDGKWHSVELERNGRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568909081   288 NTQHFRTN--GDTDALDIDYELSFGGIPVP--SKPGTFLKKNFQGCIENLYYNGVNI 340
Cdd:pfam00054   74 EARPTGESplGATTDLDVDGPLYVGGLPSLgvKKRRLAISPSFDGCIRDVIVNGKPL 130
Laminin_G_1 pfam00054
Laminin G domain;
807-929 1.45e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 71.58  E-value: 1.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   807 FKTTALSGVFLENLGV--KNFLRLEMSSpSEVIFAIDVGNGPmeLLVQSPYPLNDNQWHYIQAERNIKETLLHVDNLPKS 884
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQteRDFLALELRD-GRLEVSYDLGSGA--AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568909081   885 MRMASEEGHFLLQLNSQLFVGGTSS---------RQKGFLGCIRSLHLNGQKVD 929
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGGLPSlgvkkrrlaISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
396-525 1.27e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 68.88  E-value: 1.27e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   396 FRTWNEDGLLLSTELSEGSGTLLLILEGGTLRLLIKNvaGHGTESLTGRS-LNNGQWHSVNINARRNRVTLTLDNDpASP 474
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDL--GSGAAVVRSGDkLNDGKWHSVELERNGRSGTLSVDGE-ARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568909081   475 ALETPwlqiySGYS--------YYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKD 525
Cdd:pfam00054   78 TGESP-----LGATtdldvdgpLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
1028-1159 8.14e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 63.90  E-value: 8.14e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081   1028 ITLSFMTAQAPTLLLYLNFSSQN-FLAILLsRNGSLQIQYRLSKEESHVfTISTENLANRRVHQVKMSRDGPELSIQMDQ 1106
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGdYLALEL-RDGRLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568909081   1107 QLFSY--NFPPEVEFQTVRSLILGKVTETLGLDPEVakaNTLGFVGCLSSVQYNH 1159
Cdd:smart00282   80 GNRVSgeSPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1019-1158 9.57e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 58.58  E-value: 9.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909081 1019 KDTAPSKEAITLSFMTAQAPTLLLYL-NFSSQNFLAILLsRNGSLQIQYRLSKEESHVftISTENLANRRVHQVKMSRDG 1097
Cdd:cd00110    15 LPAPRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALEL-EDGRLVLRYDLGSGSLVL--SSKTPLNDGQWHSVSVERNG 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568909081 1098 PELSIQMDQQLF--SYNFPPEVEFQTVRSLILGKVTETLGLDPEVakaNTLGFVGCLSSVQYN 1158
Cdd:cd00110    92 RSVTLSVDGERVveSGSPGGSALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-582 4.46e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 4.46e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568909081   551 CFPNYCEHGGHCTQTWTNFYCNCSnTGYTGAT 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 542-583 1.77e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568909081  542 IDLCSIkdrcfPNYCEHGGHCTQTWTNFYCNCSNtGYTGATC 583
Cdd:cd00054     2 IDECAS-----GNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 948-981 5.84e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 5.84e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568909081   948 CNSYgrNCQNGGKCVEKHIGYTCDCTNsPYEGPF 981
Cdd:pfam00008    1 CAPN--PCSNGGTCVDTPGGYTCICPE-GYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 948-983 1.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568909081  948 CNSYGrNCQNGGKCVEKHIGYTCDCtNSPYEGPFCK 983
Cdd:cd00054     5 CASGN-PCQNGGTCVNTVGSYRCSC-PPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 553-583 7.51e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 7.51e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568909081  553 PNYCEHGGHCTQTWTNFYCNCsNTGYTGA-TC 583
Cdd:cd00053     5 SNPCSNGGTCVNTPGSYRCVC-PPGYTGDrSC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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