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Conserved domains on  [gi|569008762|ref|XP_006527692|]
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mediator of RNA polymerase II transcription subunit 14 isoform X1 [Mus musculus]

Protein Classification

mediator of RNA polymerase II transcription subunit 14( domain architecture ID 10554477)

mediator of RNA polymerase II transcription subunit 14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Gene Ontology:  GO:0003712|GO:0016592
PubMed:  29209056

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 57-244 2.25e-72

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


:

Pssm-ID: 462543  Cd Length: 192  Bit Score: 239.71  E-value: 2.25e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762    57 LSTLIEFLLHRAYSELMVLTDLLP--RKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAIL 134
Cdd:pfam08638    4 LSLLVDRLVQRSYNELSELIETLPntSESDVEKKRRLLDFAQRTRQQFIKLLVLVKWSRKAEDVSKLIDLLAFLRQQNMA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762   135 FVDTADRLASLARDaLVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDkIIPPDPITKIEKQATLHQLNQILRHRLVTTD- 213
Cdd:pfam08638   84 FEDAADALKNMKRS-LVNARLPNPDLPTALEVLSTGRYPRLPTLIYD-IIPPPPLTPKEILKTLRDLNTLLSIRLNLHEk 161

                          170       180       190
                   ....*....|....*....|....*....|.
gi 569008762   214 LPPQLANLTVANGRVKFRVEGEFEATLTVMG 244
Cdd:pfam08638  162 IPPQFRNYTIADGRVTFTVPGEFEVDLTIAG 192
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1019-1158 3.09e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 3.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762  1019 GTSGAYPLTSPPTSYHSTVNQSPSMMHT--QSPGTLDPS---SPYTMVSPsgragnwpgspqVSGPSPATRLPGMSPANP 1093
Cdd:pfam03154  202 SAPSVPPQGSPATSQPPNQTQSTAAPHTliQQTPTLHPQrlpSPHPPLQP------------MTQPPPPSQVSPQPLPQP 269

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762  1094 SLHSPVPDVSHSPRAGTSSqtMPTNMPP-PRKLPQRSWAASIP----TILTHSALNILLLPSPTPGLVPG 1158
Cdd:pfam03154  270 SLHGQMPPMPHSLQTGPSH--MQHPVPPqPFPLTPQSSQSQVPpgpsPAAPGQSQQRIHTPPSQSQLQSQ 337
 
Name Accession Description Interval E-value
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 57-244 2.25e-72

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


Pssm-ID: 462543  Cd Length: 192  Bit Score: 239.71  E-value: 2.25e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762    57 LSTLIEFLLHRAYSELMVLTDLLP--RKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAIL 134
Cdd:pfam08638    4 LSLLVDRLVQRSYNELSELIETLPntSESDVEKKRRLLDFAQRTRQQFIKLLVLVKWSRKAEDVSKLIDLLAFLRQQNMA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762   135 FVDTADRLASLARDaLVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDkIIPPDPITKIEKQATLHQLNQILRHRLVTTD- 213
Cdd:pfam08638   84 FEDAADALKNMKRS-LVNARLPNPDLPTALEVLSTGRYPRLPTLIYD-IIPPPPLTPKEILKTLRDLNTLLSIRLNLHEk 161

                          170       180       190
                   ....*....|....*....|....*....|.
gi 569008762   214 LPPQLANLTVANGRVKFRVEGEFEATLTVMG 244
Cdd:pfam08638  162 IPPQFRNYTIADGRVTFTVPGEFEVDLTIAG 192
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1019-1158 3.09e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 3.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762  1019 GTSGAYPLTSPPTSYHSTVNQSPSMMHT--QSPGTLDPS---SPYTMVSPsgragnwpgspqVSGPSPATRLPGMSPANP 1093
Cdd:pfam03154  202 SAPSVPPQGSPATSQPPNQTQSTAAPHTliQQTPTLHPQrlpSPHPPLQP------------MTQPPPPSQVSPQPLPQP 269

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762  1094 SLHSPVPDVSHSPRAGTSSqtMPTNMPP-PRKLPQRSWAASIP----TILTHSALNILLLPSPTPGLVPG 1158
Cdd:pfam03154  270 SLHGQMPPMPHSLQTGPSH--MQHPVPPqPFPLTPQSSQSQVPpgpsPAAPGQSQQRIHTPPSQSQLQSQ 337
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 961-1160 1.48e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762  961 PAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPtsyhstvnqs 1040
Cdd:PHA03307    3 NAPDLYDLIEAAAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPP---------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762 1041 PSMMHTQSPGTLDPSSPYTMVSPSGRAGNWPGSP-QVSGPSPATRLPGMSPANPsLHSPVPDVSHSPRAGTSSQTMPTNM 1119
Cdd:PHA03307   73 PGPGTEAPANESRSTPTWSLSTLAPASPAREGSPtPPGPSSPDPPPPTPPPASP-PPSPAPDLSEMLRPVGSPGPPPAAS 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 569008762 1120 PPPRKLPQRSWAASIPTILtHSALNILLLPSPTPGLVPGLA 1160
Cdd:PHA03307  152 PPAAGASPAAVASDAASSR-QAALPLSSPEETARAPSSPPA 191
 
Name Accession Description Interval E-value
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 57-244 2.25e-72

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


Pssm-ID: 462543  Cd Length: 192  Bit Score: 239.71  E-value: 2.25e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762    57 LSTLIEFLLHRAYSELMVLTDLLP--RKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAIL 134
Cdd:pfam08638    4 LSLLVDRLVQRSYNELSELIETLPntSESDVEKKRRLLDFAQRTRQQFIKLLVLVKWSRKAEDVSKLIDLLAFLRQQNMA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762   135 FVDTADRLASLARDaLVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDkIIPPDPITKIEKQATLHQLNQILRHRLVTTD- 213
Cdd:pfam08638   84 FEDAADALKNMKRS-LVNARLPNPDLPTALEVLSTGRYPRLPTLIYD-IIPPPPLTPKEILKTLRDLNTLLSIRLNLHEk 161

                          170       180       190
                   ....*....|....*....|....*....|.
gi 569008762   214 LPPQLANLTVANGRVKFRVEGEFEATLTVMG 244
Cdd:pfam08638  162 IPPQFRNYTIADGRVTFTVPGEFEVDLTIAG 192
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1019-1158 3.09e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 3.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762  1019 GTSGAYPLTSPPTSYHSTVNQSPSMMHT--QSPGTLDPS---SPYTMVSPsgragnwpgspqVSGPSPATRLPGMSPANP 1093
Cdd:pfam03154  202 SAPSVPPQGSPATSQPPNQTQSTAAPHTliQQTPTLHPQrlpSPHPPLQP------------MTQPPPPSQVSPQPLPQP 269

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762  1094 SLHSPVPDVSHSPRAGTSSqtMPTNMPP-PRKLPQRSWAASIP----TILTHSALNILLLPSPTPGLVPG 1158
Cdd:pfam03154  270 SLHGQMPPMPHSLQTGPSH--MQHPVPPqPFPLTPQSSQSQVPpgpsPAAPGQSQQRIHTPPSQSQLQSQ 337
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 961-1160 1.48e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762  961 PAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPtsyhstvnqs 1040
Cdd:PHA03307    3 NAPDLYDLIEAAAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPP---------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762 1041 PSMMHTQSPGTLDPSSPYTMVSPSGRAGNWPGSP-QVSGPSPATRLPGMSPANPsLHSPVPDVSHSPRAGTSSQTMPTNM 1119
Cdd:PHA03307   73 PGPGTEAPANESRSTPTWSLSTLAPASPAREGSPtPPGPSSPDPPPPTPPPASP-PPSPAPDLSEMLRPVGSPGPPPAAS 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 569008762 1120 PPPRKLPQRSWAASIPTILtHSALNILLLPSPTPGLVPGLA 1160
Cdd:PHA03307  152 PPAAGASPAAVASDAASSR-QAALPLSSPEETARAPSSPPA 191
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1018-1150 2.15e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 2.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008762  1018 PGTSGAYPLTSPPTSYHSTVN---QSPS-MMHTQSPG----TLDPSSPYTMVSPSGRAGNWPgSPQVSGPSPATRLPGMS 1089
Cdd:pfam05109  497 NGTESKAPDMTSPTSAVTTPTpnaTSPTpAVTTPTPNatspTLGKTSPTSAVTTPTPNATSP-TPAVTTPTPNATIPTLG 575

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569008762  1090 PANPS--LHSPVPDVSH------SPRAGTSSQTM-PTNMPPPRKLPQRSWAASIPT----ILTHSALNILLLPS 1150
Cdd:pfam05109  576 KTSPTsaVTTPTPNATSptvgetSPQANTTNHTLgGTSSTPVVTSPPKNATSAVTTgqhnITSSSTSSMSLRPS 649
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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