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Conserved domains on  [gi|569007239|ref|XP_006527135|]
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uncharacterized protein KIAA2026 homolog isoform X4 [Mus musculus]

Protein Classification

Bromodomain and Herpes_BLLF1 domain-containing protein( domain architecture ID 12937963)

Bromodomain and Herpes_BLLF1 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
137-193 7.64e-12

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


:

Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 63.55  E-value: 7.64e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007239  137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKL 193
Cdd:cd04369    43 MDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPIYKDAKKLEKLFEKLL 99
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
1472-1828 4.78e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.37  E-value: 4.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1472 TFSGIGASVPLSSLSVASSPASAGTRPPVLVSGNDTSSRIMPVLSNRLCPSNLGNTVAIS-TVKTGHLASSVLISTTQ-- 1548
Cdd:pfam05109  406 TRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGpTVSTADVTSPTPAGTTSga 485
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1549 ----PTVSPK-----CLTPALQIPVT-VALPTPVTTSPKIINTVPQsatiPGATRPvSLSKRQSQTSLQFQSPGTTTivP 1618
Cdd:pfam05109  486 spvtPSPSPRdngteSKAPDMTSPTSaVTTPTPNATSPTPAVTTPT----PNATSP-TLGKTSPTSAVTTPTPNATS--P 558
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1619 TNANTNKPPAELSPSAspGKIVNISNVTSMPNQHMSPSLVKST----LGNNSIAGGSAIHTC-SPPSNITSLAGAPfsep 1693
Cdd:pfam05109  559 TPAVTTPTPNATIPTL--GKTSPTSAVTTPTPNATSPTVGETSpqanTTNHTLGGTSSTPVVtSPPKNATSAVTTG---- 632
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1694 ciQQKIVINTSTPLAPGTQIMmngARFIVPPQGLGAGSHV-LLISTNPKYGPPLVlnsgqsiLATPVDNPVQKIiqtSNS 1772
Cdd:pfam05109  633 --QHNITSSSTSSMSLRPSSI---SETLSPSTSDNSTSHMpLLTSAHPTGGENIT-------QVTPASTSTHHV---STS 697
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 569007239  1773 SLSGQPLKPSVRNSPKTVNSLGSPSSLSAVHTPPhiintPAKVCVPPAPPAALTSV 1828
Cdd:pfam05109  698 SPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTP-----PKNATSPQAPSGQKTAV 748
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
951-1206 1.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.37  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239   951 VEKEIAAPQQKGP-----EHCSPGPQTSASCSlvsVPVTSVSTQLPNTVLSKTSTPSSNVSARSQPLSPVASVSNALTSP 1025
Cdd:pfam05109  454 VPTNLTAPASTGPtvstaDVTSPTPAGTTSGA---SPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTP 530
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1026 VKTSQSEAGKVKSTASSTTLPQPH-TSPTisstvqpllPATTlneSTDPGSSIPCFSQQT----VDSSEAKQELKTVCIR 1100
Cdd:pfam05109  531 TPNATSPTLGKTSPTSAVTTPTPNaTSPT---------PAVT---TPTPNATIPTLGKTSptsaVTTPTPNATSPTVGET 598
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1101 DSQSILVRTRGGNTGVVKVQTNPEQNSPNSLSsssvftfTPQFQaflVPKSTSCSASSQVAGVTTTSSlPSFSQASTS-V 1179
Cdd:pfam05109  599 SPQANTTNHTLGGTSSTPVVTSPPKNATSAVT-------TGQHN---ITSSSTSSMSLRPSSISETLS-PSTSDNSTShM 667
                          250       260
                   ....*....|....*....|....*..
gi 569007239  1180 SISCGFHPPMGKNLKSTQGQTLSSGYV 1206
Cdd:pfam05109  668 PLLTSAHPTGGENITQVTPASTSTHHV 694
PRK03918 super family cl35229
DNA double-strand break repair ATPase Rad50;
601-799 2.22e-03

DNA double-strand break repair ATPase Rad50;


The actual alignment was detected with superfamily member PRK03918:

Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.13  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  601 LDELRELITKIENELKDLENSRKKSGKWYHRRQAVKELHSTlirllnellpwEPKLMKAfqrNRSRLKKDYDDFRRqpdh 680
Cdd:PRK03918  468 LKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKEL-----------EEKLKKY---NLEELEKKAEEYEK---- 529
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  681 gqfTRELWATDECE-GNPEREAPKAEVSKSVDAA--EPLDTLEKEQEGSDDmKLSEIGFPMARS---------KLLKKEL 748
Cdd:PRK03918  530 ---LKEKLIKLKGEiKSLKKELEKLEELKKKLAEleKKLDELEEELAELLK-ELEELGFESVEEleerlkelePFYNEYL 605
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569007239  749 PSKDIVKTLPKTLKRQSKQSSYLDDSTKELSpRKKAKLSTNETSVENLEVN 799
Cdd:PRK03918  606 ELKDAEKELEREEKELKKLEEELDKAFEELA-ETEKRLEELRKELEELEKK 655
 
Name Accession Description Interval E-value
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
137-193 7.64e-12

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 63.55  E-value: 7.64e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007239  137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKL 193
Cdd:cd04369    43 MDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPIYKDAKKLEKLFEKLL 99
BROMO smart00297
bromo domain;
137-196 3.06e-09

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 56.13  E-value: 3.06e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239    137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKLALL 196
Cdd:smart00297   48 MDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDSEVYKDAKKLEKFFEKKLREL 107
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
137-193 1.30e-06

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 52.89  E-value: 1.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007239  137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKL 193
Cdd:COG5076   189 MDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKLI 245
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
137-184 1.54e-05

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 45.00  E-value: 1.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 569007239   137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQK 184
Cdd:pfam00439   37 MDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAEK 84
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
1472-1828 4.78e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.37  E-value: 4.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1472 TFSGIGASVPLSSLSVASSPASAGTRPPVLVSGNDTSSRIMPVLSNRLCPSNLGNTVAIS-TVKTGHLASSVLISTTQ-- 1548
Cdd:pfam05109  406 TRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGpTVSTADVTSPTPAGTTSga 485
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1549 ----PTVSPK-----CLTPALQIPVT-VALPTPVTTSPKIINTVPQsatiPGATRPvSLSKRQSQTSLQFQSPGTTTivP 1618
Cdd:pfam05109  486 spvtPSPSPRdngteSKAPDMTSPTSaVTTPTPNATSPTPAVTTPT----PNATSP-TLGKTSPTSAVTTPTPNATS--P 558
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1619 TNANTNKPPAELSPSAspGKIVNISNVTSMPNQHMSPSLVKST----LGNNSIAGGSAIHTC-SPPSNITSLAGAPfsep 1693
Cdd:pfam05109  559 TPAVTTPTPNATIPTL--GKTSPTSAVTTPTPNATSPTVGETSpqanTTNHTLGGTSSTPVVtSPPKNATSAVTTG---- 632
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1694 ciQQKIVINTSTPLAPGTQIMmngARFIVPPQGLGAGSHV-LLISTNPKYGPPLVlnsgqsiLATPVDNPVQKIiqtSNS 1772
Cdd:pfam05109  633 --QHNITSSSTSSMSLRPSSI---SETLSPSTSDNSTSHMpLLTSAHPTGGENIT-------QVTPASTSTHHV---STS 697
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 569007239  1773 SLSGQPLKPSVRNSPKTVNSLGSPSSLSAVHTPPhiintPAKVCVPPAPPAALTSV 1828
Cdd:pfam05109  698 SPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTP-----PKNATSPQAPSGQKTAV 748
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
1527-1632 1.84e-03

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 42.31  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239 1527 TVAISTVKTGHLASSVLISTTQPTVSpkcltpalQIPVTVALPTPVTTSPKIINTVPQSAtiPGATRPVSLSKRQSQTSL 1606
Cdd:PRK13042    5 TIAKTSLALGLLTTGVITTTTQAANA--------TTPSSTKVEAPQSTPPSTKVEAPQSK--PNATTPPSTKVEAPQQTP 74
                          90       100
                  ....*....|....*....|....*..
gi 569007239 1607 QFQSPGTTTI-VPTNANTNKPPAELSP 1632
Cdd:PRK13042   75 NATTPSSTKVeTPQSPTTKQVPTEINP 101
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
951-1206 1.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.37  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239   951 VEKEIAAPQQKGP-----EHCSPGPQTSASCSlvsVPVTSVSTQLPNTVLSKTSTPSSNVSARSQPLSPVASVSNALTSP 1025
Cdd:pfam05109  454 VPTNLTAPASTGPtvstaDVTSPTPAGTTSGA---SPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTP 530
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1026 VKTSQSEAGKVKSTASSTTLPQPH-TSPTisstvqpllPATTlneSTDPGSSIPCFSQQT----VDSSEAKQELKTVCIR 1100
Cdd:pfam05109  531 TPNATSPTLGKTSPTSAVTTPTPNaTSPT---------PAVT---TPTPNATIPTLGKTSptsaVTTPTPNATSPTVGET 598
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1101 DSQSILVRTRGGNTGVVKVQTNPEQNSPNSLSsssvftfTPQFQaflVPKSTSCSASSQVAGVTTTSSlPSFSQASTS-V 1179
Cdd:pfam05109  599 SPQANTTNHTLGGTSSTPVVTSPPKNATSAVT-------TGQHN---ITSSSTSSMSLRPSSISETLS-PSTSDNSTShM 667
                          250       260
                   ....*....|....*....|....*..
gi 569007239  1180 SISCGFHPPMGKNLKSTQGQTLSSGYV 1206
Cdd:pfam05109  668 PLLTSAHPTGGENITQVTPASTSTHHV 694
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
601-799 2.22e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.13  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  601 LDELRELITKIENELKDLENSRKKSGKWYHRRQAVKELHSTlirllnellpwEPKLMKAfqrNRSRLKKDYDDFRRqpdh 680
Cdd:PRK03918  468 LKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKEL-----------EEKLKKY---NLEELEKKAEEYEK---- 529
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  681 gqfTRELWATDECE-GNPEREAPKAEVSKSVDAA--EPLDTLEKEQEGSDDmKLSEIGFPMARS---------KLLKKEL 748
Cdd:PRK03918  530 ---LKEKLIKLKGEiKSLKKELEKLEELKKKLAEleKKLDELEEELAELLK-ELEELGFESVEEleerlkelePFYNEYL 605
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569007239  749 PSKDIVKTLPKTLKRQSKQSSYLDDSTKELSpRKKAKLSTNETSVENLEVN 799
Cdd:PRK03918  606 ELKDAEKELEREEKELKKLEEELDKAFEELA-ETEKRLEELRKELEELEKK 655
 
Name Accession Description Interval E-value
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
137-193 7.64e-12

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 63.55  E-value: 7.64e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007239  137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKL 193
Cdd:cd04369    43 MDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPIYKDAKKLEKLFEKLL 99
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
83-192 1.91e-09

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 56.52  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239   83 YRILGEFLQEKHRGLTAPFLQPLGGVAAGEEEVAEGRrsggrgsrvppQQPsqgMCLLKMEEKFSSGQYRGITEFVADFR 162
Cdd:cd05498     6 SGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDII-----------KHP---MDLSTIKKKLDNREYADAQEFAADVR 71
                          90       100       110
                  ....*....|....*....|....*....|
gi 569007239  163 LMLETCYRLHGVDHWISKQGQKLEMLLEQK 192
Cdd:cd05498    72 LMFSNCYKYNPPDHPVHAMARKLQDVFEDR 101
BROMO smart00297
bromo domain;
137-196 3.06e-09

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 56.13  E-value: 3.06e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239    137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKLALL 196
Cdd:smart00297   48 MDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
78-193 3.68e-09

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 55.75  E-value: 3.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239   78 ELQQGYRILGEFLQEKHRGLTAPFLQPLGGVAAGeeevaegrrsggrgsrVPP-----QQPsqgMCLLKMEEKFSSGQYR 152
Cdd:cd05499     1 ELKFCEEVLKELMKPKHSAYNWPFLDPVDPVALN----------------IPNyfsiiKKP---MDLGTISKKLQNGQYQ 61
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 569007239  153 GITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKL 193
Cdd:cd05499    62 SAKEFERDVRLIFKNCYTFNPEGTDVYMMGHQLEEVFNDKW 102
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
137-193 6.30e-08

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 52.32  E-value: 6.30e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007239  137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKL 193
Cdd:cd05500    47 MDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMGKRLQAAFEKHL 103
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
137-193 1.30e-06

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 52.89  E-value: 1.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007239  137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKL 193
Cdd:COG5076   189 MDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKLI 245
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
137-193 7.29e-06

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 46.39  E-value: 7.29e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007239  137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKL 193
Cdd:cd05509    42 MDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYYKCANKLEKFFWKKL 98
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
141-196 1.21e-05

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 46.13  E-value: 1.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569007239  141 KMEEKfSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMLLEQKLALL 196
Cdd:cd05502    52 KLQPK-SPQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFFEEQLKEI 106
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
137-184 1.54e-05

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 45.00  E-value: 1.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 569007239   137 MCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVDHWISKQGQK 184
Cdd:pfam00439   37 MDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAEK 84
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
1472-1828 4.78e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.37  E-value: 4.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1472 TFSGIGASVPLSSLSVASSPASAGTRPPVLVSGNDTSSRIMPVLSNRLCPSNLGNTVAIS-TVKTGHLASSVLISTTQ-- 1548
Cdd:pfam05109  406 TRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGpTVSTADVTSPTPAGTTSga 485
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1549 ----PTVSPK-----CLTPALQIPVT-VALPTPVTTSPKIINTVPQsatiPGATRPvSLSKRQSQTSLQFQSPGTTTivP 1618
Cdd:pfam05109  486 spvtPSPSPRdngteSKAPDMTSPTSaVTTPTPNATSPTPAVTTPT----PNATSP-TLGKTSPTSAVTTPTPNATS--P 558
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1619 TNANTNKPPAELSPSAspGKIVNISNVTSMPNQHMSPSLVKST----LGNNSIAGGSAIHTC-SPPSNITSLAGAPfsep 1693
Cdd:pfam05109  559 TPAVTTPTPNATIPTL--GKTSPTSAVTTPTPNATSPTVGETSpqanTTNHTLGGTSSTPVVtSPPKNATSAVTTG---- 632
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1694 ciQQKIVINTSTPLAPGTQIMmngARFIVPPQGLGAGSHV-LLISTNPKYGPPLVlnsgqsiLATPVDNPVQKIiqtSNS 1772
Cdd:pfam05109  633 --QHNITSSSTSSMSLRPSSI---SETLSPSTSDNSTSHMpLLTSAHPTGGENIT-------QVTPASTSTHHV---STS 697
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 569007239  1773 SLSGQPLKPSVRNSPKTVNSLGSPSSLSAVHTPPhiintPAKVCVPPAPPAALTSV 1828
Cdd:pfam05109  698 SPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTP-----PKNATSPQAPSGQKTAV 748
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
1443-1712 1.14e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.14  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1443 SPNSNSAPASSNIVNHSLPAASESARTANTfSGIGASVPLSSLSVAS------SPASAGTRPPVLVSGNDTSSRIMPVlS 1516
Cdd:pfam05109  441 APNTTTGLPSSTHVPTNLTAPASTGPTVST-ADVTSPTPAGTTSGASpvtpspSPRDNGTESKAPDMTSPTSAVTTPT-P 518
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1517 NRLCPSNLGNTVAISTVKTGHLASSVLISTTQPTVSPKCLTPALQIPV---------------TVALPTPVTTSPKIINT 1581
Cdd:pfam05109  519 NATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTpnatiptlgktsptsAVTTPTPNATSPTVGET 598
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1582 VPQSATIP-----GATRPVSLSKRQSQTSL------QFQSPGTT-----------TIVPTNANTNKPPAELSPSASPGKI 1639
Cdd:pfam05109  599 SPQANTTNhtlggTSSTPVVTSPPKNATSAvttgqhNITSSSTSsmslrpssiseTLSPSTSDNSTSHMPLLTSAHPTGG 678
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007239  1640 VNISNVT--SMPNQHMSPSLVKSTLGNNSIAGGSA-IHTCSPPSNITSLAGAPFSepciqqkiviNTSTPLAPGTQ 1712
Cdd:pfam05109  679 ENITQVTpaSTSTHHVSTSSPAPRPGTTSQASGPGnSSTSTKPGEVNVTKGTPPK----------NATSPQAPSGQ 744
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
1440-1662 1.74e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.02  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1440 SPISPNSNSAPASSNIVNHSLPAASESARTANTFSGIGASVPLSSLSVASSPASAGTRPPVLVSGNDTSSRIMPVLSNRL 1519
Cdd:pfam17823  122 SPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASS 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1520 CPSNLGNTVAISTVKTGHLASSVLISTTQ-PTVSP---------KCLTPALQIPVTVALPTPVTTSPKIINTVPQSATI- 1588
Cdd:pfam17823  202 APATLTPARGISTAATATGHPAAGTALAAvGNSSPaagtvtaavGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLs 281
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569007239  1589 PGATRPVSLSKRQSQTSLQFQSPGTTTIVptnaNTNKPPAELSPSASPGKivniSNVTSMPNQHMSPSLVKSTL 1662
Cdd:pfam17823  282 PAKHMPSDTMARNPAAPMGAQAQGPIIQV----STDQPVHNTAGEPTPSP----SNTTLEPNTPKSVASTNLAV 347
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
1527-1632 1.84e-03

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 42.31  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239 1527 TVAISTVKTGHLASSVLISTTQPTVSpkcltpalQIPVTVALPTPVTTSPKIINTVPQSAtiPGATRPVSLSKRQSQTSL 1606
Cdd:PRK13042    5 TIAKTSLALGLLTTGVITTTTQAANA--------TTPSSTKVEAPQSTPPSTKVEAPQSK--PNATTPPSTKVEAPQQTP 74
                          90       100
                  ....*....|....*....|....*..
gi 569007239 1607 QFQSPGTTTI-VPTNANTNKPPAELSP 1632
Cdd:PRK13042   75 NATTPSSTKVeTPQSPTTKQVPTEINP 101
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
951-1206 1.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.37  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239   951 VEKEIAAPQQKGP-----EHCSPGPQTSASCSlvsVPVTSVSTQLPNTVLSKTSTPSSNVSARSQPLSPVASVSNALTSP 1025
Cdd:pfam05109  454 VPTNLTAPASTGPtvstaDVTSPTPAGTTSGA---SPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTP 530
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1026 VKTSQSEAGKVKSTASSTTLPQPH-TSPTisstvqpllPATTlneSTDPGSSIPCFSQQT----VDSSEAKQELKTVCIR 1100
Cdd:pfam05109  531 TPNATSPTLGKTSPTSAVTTPTPNaTSPT---------PAVT---TPTPNATIPTLGKTSptsaVTTPTPNATSPTVGET 598
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  1101 DSQSILVRTRGGNTGVVKVQTNPEQNSPNSLSsssvftfTPQFQaflVPKSTSCSASSQVAGVTTTSSlPSFSQASTS-V 1179
Cdd:pfam05109  599 SPQANTTNHTLGGTSSTPVVTSPPKNATSAVT-------TGQHN---ITSSSTSSMSLRPSSISETLS-PSTSDNSTShM 667
                          250       260
                   ....*....|....*....|....*..
gi 569007239  1180 SISCGFHPPMGKNLKSTQGQTLSSGYV 1206
Cdd:pfam05109  668 PLLTSAHPTGGENITQVTPASTSTHHV 694
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
601-799 2.22e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.13  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  601 LDELRELITKIENELKDLENSRKKSGKWYHRRQAVKELHSTlirllnellpwEPKLMKAfqrNRSRLKKDYDDFRRqpdh 680
Cdd:PRK03918  468 LKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKEL-----------EEKLKKY---NLEELEKKAEEYEK---- 529
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007239  681 gqfTRELWATDECE-GNPEREAPKAEVSKSVDAA--EPLDTLEKEQEGSDDmKLSEIGFPMARS---------KLLKKEL 748
Cdd:PRK03918  530 ---LKEKLIKLKGEiKSLKKELEKLEELKKKLAEleKKLDELEEELAELLK-ELEELGFESVEEleerlkelePFYNEYL 605
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569007239  749 PSKDIVKTLPKTLKRQSKQSSYLDDSTKELSpRKKAKLSTNETSVENLEVN 799
Cdd:PRK03918  606 ELKDAEKELEREEKELKKLEEELDKAFEELA-ETEKRLEELRKELEELEKK 655
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
134-175 7.31e-03

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 37.76  E-value: 7.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 569007239  134 SQGMCLLKMEEKFSSGQYRGITEFVADFRLMLETCYRLHGVD 175
Cdd:cd05512    39 KQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKD 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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