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Conserved domains on  [gi|569007197|ref|XP_006527124|]
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solute carrier family 22. member 29 isoform X3 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-308 2.35e-82

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17374:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 341  Bit Score: 253.37  E-value: 2.35e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   1 MSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSesarwli 80
Cdd:cd17374  100 FAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  81 linkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrKRICVLSFIRLFFTVSIIGLA 160
Cdd:cd17374  173 -----------------------------------------------------------KRTLILSFVWFANSFSYYGLS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 161 VHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLC 240
Cdd:cd17374  194 LDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAA 273

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007197 241 VGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17374  274 FTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 1-308 2.35e-82

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 253.37  E-value: 2.35e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   1 MSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSesarwli 80
Cdd:cd17374  100 FAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  81 linkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrKRICVLSFIRLFFTVSIIGLA 160
Cdd:cd17374  173 -----------------------------------------------------------KRTLILSFVWFANSFSYYGLS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 161 VHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLC 240
Cdd:cd17374  194 LDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAA 273

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007197 241 VGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17374  274 FTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 6-317 2.31e-53

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 182.91  E-value: 2.31e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197    6 ISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKP 85
Cdd:TIGR00898 197 IWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRI 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   86 QKGLKELRKVAHMNGMKnsgdLTMEIVRTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVSIIGLAVHLQH 165
Cdd:TIGR00898 277 EEALKILQRIAKINGKK----LPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGN 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  166 LSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLCVGVSH 245
Cdd:TIGR00898 353 LGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVY 432

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007197  246 LHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLPETKNQPLPD 317
Cdd:TIGR00898 433 LYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
144-308 3.08e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.49  E-value: 3.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 144 VLSFIRLFFTVSIIGLAVHL-------QHLS-SNIILLQFLISALAILVSVIGPFVLNHIGRR--ITYLVLMSLRGIFIM 213
Cdd:COG2271  184 LLALAYFLVYFALYGFLTWLptylvevRGLSlAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALL 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 214 IAVFVPQemQTLRIIMATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFM--LVATYYANLPWI 291
Cdd:COG2271  264 LLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFL 341

                        170
                 ....*....|....*..
gi 569007197 292 FYGGFSIFNAFTVFLLP 308
Cdd:COG2271  342 LLAALALLAALLALLLL 358
Sugar_tr pfam00083
Sugar (and other) transporter;
25-315 1.71e-07

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 52.66  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   25 MMAVLSSCAPNIGFMILAGLAFLFRI------WHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVahm 98
Cdd:pfam00083 138 ALGSLYQLAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKL--- 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   99 ngmKNSGDLTMEIV--RTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFT--VSIIGLAVHLQHLS--SNIIL 172
Cdd:pfam00083 215 ---RGVPDVDRELDeiKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTgiNAIFYYSTTIFENLglSDSFL 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  173 LQFLISALAILVSVIGPFVLNHIGRRITYLVlmslrGIFIMIAVFVPQEMQTLRIIMATLAGG---ISSLCV-------- 241
Cdd:pfam00083 292 VTIIVGVVNFVFTFIAIFLVDRFGRRPLLLL-----GAAGMAICFVILGIVALLGVSKSDWAGivaIVFIALfiaffamg 366

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007197  242 --GVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIF--YGGFSI-FNAFTVFLLPETKNQPL 315
Cdd:pfam00083 367 wgPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFfiFAGLLVlFIIFVFFFVPETKGRTL 445
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 1-308 2.35e-82

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 253.37  E-value: 2.35e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   1 MSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSesarwli 80
Cdd:cd17374  100 FAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  81 linkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrKRICVLSFIRLFFTVSIIGLA 160
Cdd:cd17374  173 -----------------------------------------------------------KRTLILSFVWFANSFSYYGLS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 161 VHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLC 240
Cdd:cd17374  194 LDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAA 273

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007197 241 VGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17374  274 FTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 6-317 2.31e-53

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 182.91  E-value: 2.31e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197    6 ISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKP 85
Cdd:TIGR00898 197 IWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRI 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   86 QKGLKELRKVAHMNGMKnsgdLTMEIVRTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVSIIGLAVHLQH 165
Cdd:TIGR00898 277 EEALKILQRIAKINGKK----LPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGN 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  166 LSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLCVGVSH 245
Cdd:TIGR00898 353 LGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVY 432

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007197  246 LHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLPETKNQPLPD 317
Cdd:TIGR00898 433 LYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 1-308 5.53e-29

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 114.05  E-value: 5.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   1 MSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLsesarwli 80
Cdd:cd17446   98 MALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFLYSWWF-------- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  81 linkpqkglkelrkvAHMNgmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrkriCVLSFIRLFFTVSIIGLA 160
Cdd:cd17446  170 ---------------PRIT-------------------------------------------FCLSLVWFSTSFAYYGLA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 161 VHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLC 240
Cdd:cd17446  192 MDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQDLQTVRTALAVFGKGCLAAS 271

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007197 241 VGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17446  272 FNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILSGIAACFLP 339
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 1-308 1.76e-28

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 112.67  E-value: 1.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   1 MSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSesarwli 80
Cdd:cd17317   90 VTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP------- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  81 linkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrKRICVLSFIRLFFTVSIIGLA 160
Cdd:cd17317  163 -----------------------------------------------------------RRTIIVGLIWFVTSLVYYGLS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 161 VHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLC 240
Cdd:cd17317  184 LNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAA 263

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007197 241 VGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17317  264 FSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 6-308 9.99e-24

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 99.80  E-value: 9.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   6 ISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSesarwlilinkp 85
Cdd:cd17447  105 FSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITWWWVP------------ 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  86 qkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrkRICVLSFIrLFFTVSII--GLAVHL 163
Cdd:cd17447  173 -------------------------------------------------------KISLCTGI-VWFGVAFTyyGISFNI 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 164 QHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLCVGV 243
Cdd:cd17447  197 SGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEFTVVRTVIAVLGKGFSEAAFTT 276

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007197 244 SHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17447  277 VFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVILLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 150-308 2.67e-11

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 64.02  E-value: 2.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 150 LFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIM 229
Cdd:cd17376  184 MAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATAL 263

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007197 230 ATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17376  264 VMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLTVLIGILTLFLP 342
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 26-312 6.58e-11

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 63.05  E-value: 6.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  26 MAVLSSCAPNIGFMI--LAGLAFLF---RIWHHLQLTMSAPIFFFLILTRWLSESARWLIL----INKPQKGLKELRKVa 96
Cdd:cd17357  142 LGSLTQIGVTLGILLgqVFGLPSVLgteTLWPYLLFFPGIPALLQLAALPFFPESPKFLLIskgdEEEAEKSLKFLRGI- 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  97 hmngmknSGDLTMEIVRTSMKAELEAAKTKPSLRDLFHTSILRKR---ICVLSFIRLF--------FTVSIIGLAVHLQH 165
Cdd:cd17357  221 -------EDDVDQELEEIKKESEQMGDQKQVSLMQLLRDPSLRLPlllVLVVSASQQFsginaiffYSTFIFENAGFSPQ 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 166 LSsniILLQFLISALAILVSVIGPFVLNHIGRR---ITYLVLMSLRGIFIMIAVFVPQEMQTLRII--------MATLAG 234
Cdd:cd17357  294 LA---EWANLGIGIVNVLSTIVGPFLIEKVGRRpllLISLSVCAVALLLMSVFLFLSEQNSWMSYGcivaiflfIFFFAI 370

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 235 GISSLCVgvshLHTNELLPTTLRATALGVIGFFGNSGLFLS----PLFMLVATYYANLpwIFYGGFSIFNAFTVFLLPET 310
Cdd:cd17357  371 GLGPIPW----FIGAELFPQAPRSAAQSLGSSVNWTSNFIVgmafPPLQSIGGGFVFI--IFAIPCALFLLYLYRYLPET 444


                 ..
gi 569007197 311 KN 312
Cdd:cd17357  445 KG 446
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 142-308 2.45e-09

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 57.75  E-value: 2.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 142 ICVLSFIRLFFTVSII---------GLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFI 212
Cdd:cd17378  166 ILVYLFARRLLAVMVIgfgigmvyyGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASC 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 213 MIAVFVPQEMQT-LRIIMAtlAGGISSLCVG--VSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLP 289
Cdd:cd17378  246 LLCFVLSIGGTTsLQIALE--LVGFFGAAGAfnLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALS 323

                        170
                 ....*....|....*....
gi 569007197 290 WIFYGGFSIFNAFTVFLLP 308
Cdd:cd17378  324 FGVFGVAILLLGLFALGLP 342
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 10-308 2.93e-09

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 57.75  E-value: 2.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  10 SHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILtrwlsesaRWLIlinkPQkgl 89
Cdd:cd17379  107 GYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLLY--------YWFI----PK--- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  90 kelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfHTSILrkricvlsfIRLFFTVSII--GLAVHLQHLS 167
Cdd:cd17379  172 --------------------------------------------HTFIL---------MYAWFTSAVVyqGLIMRLGITG 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 168 SNIiLLQFLISALAILVS-VIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLCVGVSHL 246
Cdd:cd17379  199 GNL-YLDFFISALVELPAaFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPDLHWLKTTIACVGRLGITMAFEIVCL 277

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569007197 247 HTNELLPTTLRATALGVIGFFGNSGLFLSPlFML--VATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17379  278 VNTELYPTFLRNLGVSVCSSLCDIGGIIAP-FLLyrLAEIWLELPLIVFGVLALVAGGLVLLLP 340
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 166-308 3.25e-09

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 57.45  E-value: 3.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 166 LSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIMATLAGGISSLCVGVSH 245
Cdd:cd17375  199 LGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVLSMTGKFAIAIAFGLIY 278

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007197 246 LHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17375  279 LYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSGILTLMLP 341
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 137-304 3.47e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 57.61  E-value: 3.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 137 ILRKRICVLSFIRLFFTVSIIGLAV--------HLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLR 208
Cdd:cd17316  174 LLRRRTLLLILLWFFISFGYYGLTTflptylqtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 209 GIFIMIAVFVPQEMQTLRIIMATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSP--LFMLVATYYA 286
Cdd:cd17316  254 GILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPplIALLLASTGG 333

                        170
                 ....*....|....*...
gi 569007197 287 NLPWIFYGGFSIFNAFTV 304
Cdd:cd17316  334 TGVPALILALLAIVALIV 351
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
144-308 3.08e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.49  E-value: 3.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 144 VLSFIRLFFTVSIIGLAVHL-------QHLS-SNIILLQFLISALAILVSVIGPFVLNHIGRR--ITYLVLMSLRGIFIM 213
Cdd:COG2271  184 LLALAYFLVYFALYGFLTWLptylvevRGLSlAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALL 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 214 IAVFVPQemQTLRIIMATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFM--LVATYYANLPWI 291
Cdd:COG2271  264 LLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFL 341

                        170
                 ....*....|....*..
gi 569007197 292 FYGGFSIFNAFTVFLLP 308
Cdd:COG2271  342 LLAALALLAALLALLLL 358
Sugar_tr pfam00083
Sugar (and other) transporter;
25-315 1.71e-07

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 52.66  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   25 MMAVLSSCAPNIGFMILAGLAFLFRI------WHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVahm 98
Cdd:pfam00083 138 ALGSLYQLAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKL--- 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   99 ngmKNSGDLTMEIV--RTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFT--VSIIGLAVHLQHLS--SNIIL 172
Cdd:pfam00083 215 ---RGVPDVDRELDeiKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTgiNAIFYYSTTIFENLglSDSFL 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  173 LQFLISALAILVSVIGPFVLNHIGRRITYLVlmslrGIFIMIAVFVPQEMQTLRIIMATLAGG---ISSLCV-------- 241
Cdd:pfam00083 292 VTIIVGVVNFVFTFIAIFLVDRFGRRPLLLL-----GAAGMAICFVILGIVALLGVSKSDWAGivaIVFIALfiaffamg 366

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007197  242 --GVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIF--YGGFSI-FNAFTVFLLPETKNQPL 315
Cdd:pfam00083 367 wgPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFfiFAGLLVlFIIFVFFFVPETKGRTL 445
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
118-311 5.55e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.65  E-value: 5.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 118 AELEAAKTKPSLRDLFHTsILRKRICVLSFIRLFFTVSIIGLAVHLQHLSSNII--------LLQFLISALAILVSVIGP 189
Cdd:COG2223  184 PAGAAAAAKASLRDQLEA-LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFglsaatagLLAALFALLGALGRPLGG 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 190 FVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLrIIMATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGN 269
Cdd:COG2223  263 WLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF-LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGG 341

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 569007197 270 SGLFLSPLFM---LVATYYANLPWIFYGGFSIFNAFTVFLLPETK 311
Cdd:COG2223  342 LGGFLGPLLFgalLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 35-315 1.32e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 49.88  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  35 NIGFMILAGLAFLFRiWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKvahMNGmKNSGDLTMEIVRT 114
Cdd:cd17358  140 NIGILLGYVLGSFLP-WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQF---LRG-KDADISKEAAEIQ 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 115 SMKAELEAAKTKPSLRDLFHTSILRK-RICVL---------SFIRLFFTVSIIGLAVHLqhLSSNIILLqfLISALAILV 184
Cdd:cd17358  215 EELAELEKEAKESSFSDLFQRKYLKPlVIGLGlmlfqqlsgINAVIFYASSIFDEAGSG--LDPNTATI--IIGVVQVVG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 185 SVIGPFVLNHIGRRItyLVLMSLRGIFI-MIAVFVPQEMQTLRIIMAT--------LAGGISSLCVGVSHLH---TNELL 252
Cdd:cd17358  291 TLVATLLVDRLGRRP--LLLVSAIGMGIgLLALGLYFYLQEHGALLSSvswlplvgLVIYIISFSIGLGPLPwviMSEIF 368

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007197 253 PTTLRATALGVIGFFGNSGLFLSPLFM--LVATYYANLPWIFYGGFSIFN-AFTVFLLPETKNQPL 315
Cdd:cd17358  369 PAKIKGLAGSLVTLVNWLFAFIVTKTFpfLTLAWGASGTFWIFAGICGLAlVFVLLFVPETKGKSL 434
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 172-307 3.20e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 45.25  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 172 LLQFLISALAILVSVIGPFV---LNHIGRRITYLVLMSLRGIFIMIAVFVPQEMqtLRIIMATLAGGISSLCVGVSHLHT 248
Cdd:cd17319  219 LLAAIPFLAGAIGMILGGRLsdrLLRGARRLVIIIGLLLAAVGLLLAYLTTSPV--VAVILLSLAGFGIGAASPVFWSLP 296

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007197 249 NELLPTTLRATALGVIGFFGNSGLFLSPL---FMLVATYYANLPWIFYGGFSIFNAFTVFLL 307
Cdd:cd17319  297 ADLLPGEAAATAGGLINSGGNLGGFVAPLligYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 13-277 1.08e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.88  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   13 LMLEWTSPKFLAMMAVLSSCAPNIGfMILAGLAFLFRI----WHHLQLTMS-APIFFFLILTRWLSESARWLILiNKPQK 87
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIG-AAVGGFLAGWLIpvfgWRSLFYVGGiAPLLLLLLLMRFLPESIDFLVS-KRPET 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197   88 GLKELRKVAHMNGMKNSGDLTMEIVRTSMKAELEAAKTKPSLrdLFHTSILRKRICVLSFIRLFFTVSIIGLAVHLQHLS 167
Cdd:TIGR00895 207 VRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKT--ARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSL 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  168 SNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMsLRGIFImIAVFVPQEMQTLRIIMATLAGGISSLCVGVSHLH 247
Cdd:TIGR00895 285 SLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLL-LGAVFA-VLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYAL 362

                         250       260       270
                  ....*....|....*....|....*....|
gi 569007197  248 TNELLPTTLRATALGVIGFFGNSGLFLSPL 277
Cdd:TIGR00895 363 MALFYPTAIRATGVGWAIGIGRLGAIIGPI 392
MFS_1 pfam07690
Major Facilitator Superfamily;
142-341 1.13e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.56  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  142 ICVLSFIRLFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQ- 220
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSl 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  221 -EMQTLRIIMATLAGGISSLCVGVshlhTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFY--GGFS 297
Cdd:pfam07690  86 wLLLVLRVLQGLGAGALFPAALAL----IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLilAILS 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 569007197  298 IFNAFTVFLLPETKNQPLPDSTHDVGNDWKESRKGKREDPIIKV 341
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWL 205
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 151-307 3.15e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.03  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 151 FFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLN-HIGRRITYLVLMSLRGIFIMIAVFVPQemQTLRIIM 229
Cdd:cd06174  222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPS--LLLLLLL 299

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007197 230 ATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLL 307
Cdd:cd06174  300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
121-271 9.34e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.73  E-value: 9.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 121 EAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVSIIGLAVHLQ---HLSSNIILLQFLISALA-ILVSVIGPFVLNHIG 196
Cdd:COG2814  192 ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQevlGLSASAAGLLLALFGLGgVLGALLAGRLADRFG 271

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007197 197 RRITYLVLMSLRGIFIMIAVFVPQemQTLRIIMATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSG 271
Cdd:COG2814  272 RRRLLLIGLLLLALGLLLLALAGS--LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 111-307 9.62e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 9.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 111 IVRTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVSIIGL-------AVHLQHLSSNIILLQFLISALA-I 182
Cdd:cd17325  170 LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALepflplyAAELGGLSPAQIGLLFGAQGLAsA 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 183 LVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQemQTLRIIMATLAGGISSLCVGVSHLHTNELLPTTLRATALG 262
Cdd:cd17325  250 LSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG 327

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 569007197 263 VIGFFGNSGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLL 307
Cdd:cd17325  328 LFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 142-315 1.14e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.18  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 142 ICVLSFIRLFFTVSIIGLAVHL--QHLSSNIILLQFLISA----LAILVSVIGPFVlNHIGRRITYLVLMSLRGIFIMIA 215
Cdd:COG0477   18 ALALGTFLEGLDFTIVNVALPSiaADLGASSAQLGWIVSAyllgRAIGLLLFGRLG-DRYGRKRVLLIGLLLFGLASLLC 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 216 VFVP--QEMQTLRIIMATLAGGISSLCVGVshlhTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFY 293
Cdd:COG0477   97 GLAPspELLIAARALQGIGAGGLMPGALAL----IAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172

                        170       180
                 ....*....|....*....|....
gi 569007197 294 GG--FSIFNAFTVFLLPETKNQPL 315
Cdd:COG0477  173 INapLGLLALVLRLRLPESRGLLL 196
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
151-311 1.18e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 151 FFTVSIIGLAVHL--QHLSSNIILLQFLISALAILVSVIGPF---VLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQ-- 223
Cdd:COG2814   23 GLGIGIVLPALPLiaADLGASPAQAGLVVTAYLLGAALGAPLagrLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLll 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 224 TLRIIMATLAGGISSLCVGVshlhTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFY--GGFSIFNA 301
Cdd:COG2814  103 AARFLQGLGAGALFPAALAL----IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLvnAVLALLAL 178

                        170
                 ....*....|.
gi 569007197 302 F-TVFLLPETK 311
Cdd:COG2814  179 LlLLRLLPESR 189
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 140-308 2.19e-03

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 39.37  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 140 KRICVLSFirlfftVSIIGLAVH---------LQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGI 210
Cdd:cd17445  174 KNLLILGF------TTFIAHAIShcyqsfsddVRGTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGI 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 211 FIMIAVFVPQEMQTLRIIMATLAGGISSLCVG-VSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLP 289
Cdd:cd17445  248 ASLILLGLMDYLNDAAIKTFSILGLFSSQAAAsLSILFAAEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLH 327

                        170
                 ....*....|....*....
gi 569007197 290 WIFYGGFSIFNAFTVFLLP 308
Cdd:cd17445  328 HVVLASLALLAILSIMLLP 346
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 196-308 2.19e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 39.38  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 196 GRRITYLVLMSLRGIFIMIAVFVPQEMQT--LRIIMAT---LAGGIS-SLCVGVSHLHTNELLPTTLRATALGVIGFFGN 269
Cdd:cd17377  235 GRRRTLAGFLFLGGIACLLVMFVPEKKDSgvFAVVNSTslsLLGKLTiSAAFNIVYIYTSELYPTVVRNAGLGVCSMFSR 314

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 569007197 270 SGLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLP 308
Cdd:cd17377  315 VGGIIAPFIPSLKSVQWSLPFIVFGASGLSAGLLSLLLP 353
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 176-308 3.37e-03

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 39.02  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 176 LISALA-ILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIaVFVPQEMQTLRIIMATLAgGISSLCVGVSHLHTNELLPT 254
Cdd:cd17442  243 IISTLGeIALNPLNILGINFLGRRLSLVITMGLTAIFFLL-LNICTSSAGLTIFLFMLR-ALVSANFNTVYIYTAEVYPT 320

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 255 TLRATALGVIGFFGNSGLFLSPLFMLVAtyyanLPWIFYGGFSIFN------AFTVFLLP 308
Cdd:cd17442  321 TMRALGMGTSGSLCRIGAMVAPFISQVL-----MSASVLGALCLFSsvcivcAISAFTLP 375
MFS_1 pfam07690
Major Facilitator Superfamily;
142-276 4.35e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.55  E-value: 4.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197  142 ICVLSFIRLFFTVSIIGLAVHLQHLSSNIILLQF-LISALAILVSVIGPFVLNHIGRRITYLVLMSLRGI-FIMIAVFVP 219
Cdd:pfam07690 208 ALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLgLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaALGLLLLSL 287

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007197  220 QEMQTLRIIMATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSP 276
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 147-314 4.44e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.56  E-value: 4.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 147 FIRLFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYL--VLMSLRGIFIMIAVFVPQEMQT 224
Cdd:cd06174   10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLlgLLLFALGALLFAFAPSFWLLLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007197 225 LRIimatLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPW----IFYGGFSIFN 300
Cdd:cd06174   90 GRF----LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWravfLIAAALALLA 165

                        170
                 ....*....|....
gi 569007197 301 AFTVFLLPETKNQP 314
Cdd:cd06174  166 AILLLLVVPDPPES 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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