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Conserved domains on  [gi|569001218|ref|XP_006524789|]
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triggering receptor expressed on myeloid cells 1 isoform X2 [Mus musculus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10542315)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets, similar to Homo sapiens T-cell antigen CD7 and voltage-gated sodium channel beta3 subunit Ig Domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 1-89 9.68e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.01  E-value: 9.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001218    1 MKYANSQKAWQRLPDGKEPlTLVVTQRPFTRPSEVHMGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRCVIYhpPNDPVVL 80
Cdd:pfam07686  24 MSEASTSVYWYRQPPGKGP-TFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYTCAVI--PSGEGVF 100


                  ....*....
gi 569001218   81 FHPVRLVVT 89
Cdd:pfam07686 101 GKGTRLTVL 109
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 1-89 9.68e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.01  E-value: 9.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001218    1 MKYANSQKAWQRLPDGKEPlTLVVTQRPFTRPSEVHMGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRCVIYhpPNDPVVL 80
Cdd:pfam07686  24 MSEASTSVYWYRQPPGKGP-TFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYTCAVI--PSGEGVF 100


                  ....*....
gi 569001218   81 FHPVRLVVT 89
Cdd:pfam07686 101 GKGTRLTVL 109
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 1-87 2.46e-10

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 54.71  E-value: 2.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001218   1 MKYANSQKAWQRLPDGKepLTLVVTQRPFTRPsevhmGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRCVIYHPPndPVVL 80
Cdd:cd05716   23 PKYASSRKYWCKWGSEG--CQTLVSSEGVVPG-----GRISLTDDPDNGVFTVTLNQLRKEDAGWYWCGVGDDG--DRGL 93


                 ....*..
gi 569001218  81 FHPVRLV 87
Cdd:cd05716   94 TVQVKLV 100
IGv smart00406
Immunoglobulin V-Type;
10-68 6.36e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.98  E-value: 6.36e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569001218    10 WQRLPDGKePLTLVVTQRPFTR---PSEVhMGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRC 68
Cdd:smart00406  20 WVRQPPGK-GLEWLGYIGSNGSsyyQESY-KGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 1-89 9.68e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.01  E-value: 9.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001218    1 MKYANSQKAWQRLPDGKEPlTLVVTQRPFTRPSEVHMGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRCVIYhpPNDPVVL 80
Cdd:pfam07686  24 MSEASTSVYWYRQPPGKGP-TFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYTCAVI--PSGEGVF 100


                  ....*....
gi 569001218   81 FHPVRLVVT 89
Cdd:pfam07686 101 GKGTRLTVL 109
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 1-87 2.46e-10

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 54.71  E-value: 2.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001218   1 MKYANSQKAWQRLPDGKepLTLVVTQRPFTRPsevhmGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRCVIYHPPndPVVL 80
Cdd:cd05716   23 PKYASSRKYWCKWGSEG--CQTLVSSEGVVPG-----GRISLTDDPDNGVFTVTLNQLRKEDAGWYWCGVGDDG--DRGL 93


                 ....*..
gi 569001218  81 FHPVRLV 87
Cdd:cd05716   94 TVQVKLV 100
IGv smart00406
Immunoglobulin V-Type;
10-68 6.36e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.98  E-value: 6.36e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569001218    10 WQRLPDGKePLTLVVTQRPFTR---PSEVhMGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRC 68
Cdd:smart00406  20 WVRQPPGK-GLEWLGYIGSNGSsyyQESY-KGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 38-88 7.33e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 34.40  E-value: 7.33e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 569001218    38 GKFTLKHDPSEAMLQvqMTDLQVTDSGLYRCVIYhppNDPVVLFHPVRLVV 88
Cdd:smart00410  40 GRFSVSRSGSTSTLT--ISNVTPEDSGTYTCAAT---NSSGSASSGTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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