NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|569000249|ref|XP_006524318|]
View 

zinc finger protein 563 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-350 9.49e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 189 KPYKCHQCGKAFSSSSKVRRHERT--HTGE--KPYICNH--CGKAFPSRGSLRRHDRIHSGEKPFVCKY--CGKAFTGQS 260
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 261 SLPRHERIH-----SGEKPYVCKY--CGKCFISSSTCRVHERTHTGEKLYVCN--LCNKAVTTRTSLRNHERIHSGEKPY 331
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 569000249 332 VCEQCGKGFISSGTFRIHE 350
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-470 1.49e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 357 KPYRCKECGKAFTIQSSLQRHERIHTREKPYDC--KECGKAFSGYSSLRRHERIHSGERPYAC-KQCGKAFPALGDCQRH 433
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 569000249 434 EQIHTGEKPYICKQCGKAFTRCGSLRIHE--KTHARENS 470
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLlsISNLRNNP 150
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-350 9.49e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 189 KPYKCHQCGKAFSSSSKVRRHERT--HTGE--KPYICNH--CGKAFPSRGSLRRHDRIHSGEKPFVCKY--CGKAFTGQS 260
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 261 SLPRHERIH-----SGEKPYVCKY--CGKCFISSSTCRVHERTHTGEKLYVCN--LCNKAVTTRTSLRNHERIHSGEKPY 331
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 569000249 332 VCEQCGKGFISSGTFRIHE 350
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-470 1.49e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 357 KPYRCKECGKAFTIQSSLQRHERIHTREKPYDC--KECGKAFSGYSSLRRHERIHSGERPYAC-KQCGKAFPALGDCQRH 433
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 569000249 434 EQIHTGEKPYICKQCGKAFTRCGSLRIHE--KTHARENS 470
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLlsISNLRNNP 150
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-424 4.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.96e-04
                          10        20
                  ....*....|....*....|....
gi 569000249  401 SLRRHERIHSGERPYACKQCGKAF 424
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-257 5.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.21e-04
                          10        20
                  ....*....|....*....|....*
gi 569000249  233 SLRRHDRIHSGEKPFVCKYCGKAFT 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 218-265 6.41e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 6.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 569000249 218 PYICNHCGKAFPSRGSLRRHdrIHSGEKPFVCKYCGKAFTGQSSLPRH 265
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-350 9.49e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 189 KPYKCHQCGKAFSSSSKVRRHERT--HTGE--KPYICNH--CGKAFPSRGSLRRHDRIHSGEKPFVCKY--CGKAFTGQS 260
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 261 SLPRHERIH-----SGEKPYVCKY--CGKCFISSSTCRVHERTHTGEKLYVCN--LCNKAVTTRTSLRNHERIHSGEKPY 331
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 569000249 332 VCEQCGKGFISSGTFRIHE 350
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-435 2.83e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 160 DSLYKFRECGKTFMYPECYLKHGNTHtIEKPYKCHQCGKAFSSSSKVRRHERT-HTGEKPYICNHCGKAFPSRGS-LRRH 237
Cdd:COG5048  197 PSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLsSSDSSSSASESPRSSLPTASSqSSSP 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 238 DRIHSGE-----KPFVCKYCGKAFTGQSSLPRHER--IHSGE--KPYVCKY--CGKCFISSSTCRVHERTHTGEKLYVCN 306
Cdd:COG5048  276 NESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 307 LCNkavttrtslRNHERIHSGEKPyvceqcgkgfiSSGTFRIHERIHTgEKPYRC--KECGKAFTIQSSLQRHERIHTRE 384
Cdd:COG5048  356 LLN---------SSSKFSPLLNNE-----------PPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSF 414

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 569000249 385 KPYDCK--ECGKAFSGYSSLRRHERIHSGERPYACKQCGKAFPALGDCQRHEQ 435
Cdd:COG5048  415 RPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-468 6.33e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 6.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 189 KPYKCHQCGKAFSSSSKVRRHERTHTGEKPYICNH--CGKAFPSRGSLRRHDRIHSGEKPFVCKYCG------------- 253
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 254 -------KAFTGQSSLPRHERIHSGEKPYV---------CKYCGKCFISSSTC----------------------RVHER 295
Cdd:COG5048  112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLsisnlrnnpLPGNNSSSVNTPQSnslhpplpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 296 THTGeklYVCNLCNKAVTTRTSLRNHERIHSGEKPYVCEQCGK-GFISSGTFRIHERIHTGEK--PYRCKECGKAFTIQS 372
Cdd:COG5048  192 VSTS---IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 373 SLQRHERIHT-------REKPYDCKECGKAFSGYSSLRRHER--IHSGE--RPYAC--KQCGKAFPALGDCQRHEQIHTG 439
Cdd:COG5048  269 SSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                        330       340
                 ....*....|....*....|....*....
gi 569000249 440 EKPYICKqcgkaFTRCGSLRIHEKTHARE 468
Cdd:COG5048  349 ISPAKEK-----LLNSSSKFSPLLNNEPP 372
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 179-270 1.24e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 179 LKHGNTHTI-----------EKPYKCH--QCGKAFSSSSKVRRHeRTHtgekpyicNHCGKAFPSRGSLRRHDRIHSGEK 245
Cdd:COG5189  327 LAHGGERNIdtpsrmlkvkdGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDK 397

                         90       100
                 ....*....|....*....|....*
gi 569000249 246 PFVCKYCGKAFTGQSSLPRHeRIHS 270
Cdd:COG5189  398 PYRCEVCDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-470 1.49e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 357 KPYRCKECGKAFTIQSSLQRHERIHTREKPYDC--KECGKAFSGYSSLRRHERIHSGERPYAC-KQCGKAFPALGDCQRH 433
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 569000249 434 EQIHTGEKPYICKQCGKAFTRCGSLRIHE--KTHARENS 470
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLlsISNLRNNP 150
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-424 4.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.96e-04
                          10        20
                  ....*....|....*....|....
gi 569000249  401 SLRRHERIHSGERPYACKQCGKAF 424
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-257 5.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.21e-04
                          10        20
                  ....*....|....*....|....*
gi 569000249  233 SLRRHDRIHSGEKPFVCKYCGKAFT 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-397 6.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.40e-04
                          10        20
                  ....*....|....*....|....*
gi 569000249  373 SLQRHERIHTREKPYDCKECGKAFS 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
301-450 7.26e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 301 KLYVCNLCNKAVTTRTSLRNHER--IHSGE--KPYVC--EQCGKGFISSGTFRIHERIHTGEKPYRCK--ECGKAFTI-- 370
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000249 371 ---QSSLQRHERIHTREKPYDC--KECGKAFSGYSSLRRHERIHSGERPYACK--QCGKAFPALGDCQRHEQIHTGEKPY 443
Cdd:COG5048  368 nnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*..
gi 569000249 444 ICKQCGK 450
Cdd:COG5048  448 LCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
346-369 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....
gi 569000249  346 FRIHERIHTGEKPYRCKECGKAFT 369
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
317-342 2.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 569000249  317 SLRNHERIHSGEKPYVCEQCGKGFIS 342
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-286 3.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.43e-03
                          10        20
                  ....*....|....*....|...
gi 569000249  264 RHERIHSGEKPYVCKYCGKCFIS 286
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 218-265 6.41e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 6.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 569000249 218 PYICNHCGKAFPSRGSLRRHdrIHSGEKPFVCKYCGKAFTGQSSLPRH 265
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-228 9.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.91e-03
                          10        20
                  ....*....|....*....|..
gi 569000249  207 RRHERTHTGEKPYICNHCGKAF 228
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH