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Conserved domains on  [gi|568995553|ref|XP_006522298|]
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vesicle-trafficking protein SEC22a isoform X2 [Mus musculus]

Protein Classification

longin domain-containing protein( domain architecture ID 13000475)

longin domain-containing protein such as synaptobrevin family proteins, Arabidopsis thaliana phytolongin and mammalian vesicle-trafficking protein SEC2, which are involved in membrane-trafficking and vesicle transport, respectively

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Longin cd14824
longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including ...
 21-142 1.12e-32

longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


:

Pssm-ID: 341428  Cd Length: 122  Bit Score: 117.36  E-value: 1.12e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995553  21 LSASVIRVRDGLPLSASTDYEQ-STGMQECRKYFKMLSRKLAQFPDRCTLKTGRYNINFISSLGVSYMMLCSENYPNVLA 99
Cdd:cd14824    1 LYALIARGSDGLILAEYTDLSSfSSVKENFKFVAKTILERTPPSGQRQSVEEGDYVFHYLVEDGLCYLCITDKEYPKRVA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568995553 100 FSFLDELQKEFITTYNMMKTnTAVRPYCFIEFDNFIQRTKQRY 142
Cdd:cd14824   81 FAFLEEVLDEFLSKYGSSAW-TAARPYLFSEFDPELKKLMKKY 122
 
Name Accession Description Interval E-value
Longin cd14824
longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including ...
 21-142 1.12e-32

longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 341428  Cd Length: 122  Bit Score: 117.36  E-value: 1.12e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995553  21 LSASVIRVRDGLPLSASTDYEQ-STGMQECRKYFKMLSRKLAQFPDRCTLKTGRYNINFISSLGVSYMMLCSENYPNVLA 99
Cdd:cd14824    1 LYALIARGSDGLILAEYTDLSSfSSVKENFKFVAKTILERTPPSGQRQSVEEGDYVFHYLVEDGLCYLCITDKEYPKRVA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568995553 100 FSFLDELQKEFITTYNMMKTnTAVRPYCFIEFDNFIQRTKQRY 142
Cdd:cd14824   81 FAFLEEVLDEFLSKYGSSAW-TAARPYLFSEFDPELKKLMKKY 122
Longin pfam13774
Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for ...
 54-133 1.34e-21

Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 463978  Cd Length: 81  Bit Score: 86.82  E-value: 1.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995553   54 KMLSRKLAQFPDRCTLKTGRYNINFISSLGVSYMMLCSENYPNVLAFSFLDELQKEFITTYNMMkTNTAVRPYCFI-EFD 132
Cdd:pfam13774   2 KTILEKIPQNPQRQTYEGDNYTFHYLIEDGLTYLVIADKSYPRRLAFAFLEEIKDEFLSTYGPW-TASALRPYAFNkEFD 80


                  .
gi 568995553  133 N 133
Cdd:pfam13774  81 T 81
SNC1 COG5143
Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion];
20-162 1.52e-06

Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion];


Pssm-ID: 227472 [Multi-domain]  Cd Length: 190  Bit Score: 47.81  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995553  20 ILSASVIRVrDGLPLSASTD-YEQSTGMQECRKYFKMLSRKLA-QFPDRCTLKTGRYNIN-FISSLGVSYMMLCSENYPN 96
Cdd:COG5143    1 IASISLFRV-KGEPLRTLSDaESLSSFSFFHRSKVKEVLRFLSkTSASRASIESGDYFFHyLKMSSGIVYVPISDKEYPN 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568995553  97 VLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQRtkqRYNNPRSLSTKINLSDMQMEIK 162
Cdd:COG5143   80 KLAYGYLNSIATEFLKSSALEQLIDDTVGIMRVNIDKVIEK---GYRDPSIQDKLDQLQQELEETK 142
 
Name Accession Description Interval E-value
Longin cd14824
longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including ...
 21-142 1.12e-32

longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 341428  Cd Length: 122  Bit Score: 117.36  E-value: 1.12e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995553  21 LSASVIRVRDGLPLSASTDYEQ-STGMQECRKYFKMLSRKLAQFPDRCTLKTGRYNINFISSLGVSYMMLCSENYPNVLA 99
Cdd:cd14824    1 LYALIARGSDGLILAEYTDLSSfSSVKENFKFVAKTILERTPPSGQRQSVEEGDYVFHYLVEDGLCYLCITDKEYPKRVA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568995553 100 FSFLDELQKEFITTYNMMKTnTAVRPYCFIEFDNFIQRTKQRY 142
Cdd:cd14824   81 FAFLEEVLDEFLSKYGSSAW-TAARPYLFSEFDPELKKLMKKY 122
Longin pfam13774
Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for ...
 54-133 1.34e-21

Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 463978  Cd Length: 81  Bit Score: 86.82  E-value: 1.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995553   54 KMLSRKLAQFPDRCTLKTGRYNINFISSLGVSYMMLCSENYPNVLAFSFLDELQKEFITTYNMMkTNTAVRPYCFI-EFD 132
Cdd:pfam13774   2 KTILEKIPQNPQRQTYEGDNYTFHYLIEDGLTYLVIADKSYPRRLAFAFLEEIKDEFLSTYGPW-TASALRPYAFNkEFD 80


                  .
gi 568995553  133 N 133
Cdd:pfam13774  81 T 81
longin-like cd14818
Longin-like domains; Longin-like domains are small protein domains present in a variety of ...
 23-138 6.99e-13

Longin-like domains; Longin-like domains are small protein domains present in a variety of proteins and members of protein complexes involved in or required for different steps during the transport of proteins from the ribosome to the ER to the plasma membrane, via the Golgi apparatus. Examples are mu and sigma subunits of the heterotetrameric adaptor protein (AP) complex, zeta and delta subunits of the heterotetrameric F-COPI complex, a subgroup of R-SNARE proteins, a subfamily of the transport protein particle (TRAPP), and the signal recognition particle receptor subunit alpha (SR-alpha).


Pssm-ID: 341426  Cd Length: 117  Bit Score: 64.47  E-value: 6.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995553  23 ASVIRVRDGLPLSASTDYEQSTGMQECRKYFKMLSRKL-AQFPDRCTLKTGRYNINFISSLGVSYMMLCSENYPNVLAFS 101
Cdd:cd14818    2 QLAVFDPQGQVLAASNWLGKKPSVKFSLIQIKSFFSKLiTSGFDFLTLTIGSYTFHYYLNKGLYFVVITDEQELRQELFQ 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568995553 102 FLDELQKEFITTYnMMKTNTAVRPYCFIEFDNFIQRT 138
Cdd:cd14818   82 TLNLLLKEFNSLH-GSEVITKNIEDDLEEFESYLDIK 117
SNC1 COG5143
Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion];
20-162 1.52e-06

Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion];


Pssm-ID: 227472 [Multi-domain]  Cd Length: 190  Bit Score: 47.81  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995553  20 ILSASVIRVrDGLPLSASTD-YEQSTGMQECRKYFKMLSRKLA-QFPDRCTLKTGRYNIN-FISSLGVSYMMLCSENYPN 96
Cdd:COG5143    1 IASISLFRV-KGEPLRTLSDaESLSSFSFFHRSKVKEVLRFLSkTSASRASIESGDYFFHyLKMSSGIVYVPISDKEYPN 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568995553  97 VLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQRtkqRYNNPRSLSTKINLSDMQMEIK 162
Cdd:COG5143   80 KLAYGYLNSIATEFLKSSALEQLIDDTVGIMRVNIDKVIEK---GYRDPSIQDKLDQLQQELEETK 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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