NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568994608|ref|XP_006521848|]
View 

eukaryotic initiation factor 4A-II isoform X2 [Mus musculus]

Protein Classification

DEAD/DEAH box helicase family protein( domain architecture ID 1000205)

DEAD/DEAH box helicase family protein such as a DEAD/DEAH box-containing ATP-dependent helicase, which catalyzes the unwinding of DNA or RNA

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 18-312 3.20e-163

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member PTZ00424:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 401  Bit Score: 460.06  E-value: 3.20e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAeAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:PTZ00424 108 LAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKA-GVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRG 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLT 177
Cdd:PTZ00424 187 FKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWKFDTLCDLYETLT 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 178 ITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPT 257
Cdd:PTZ00424 267 ITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPA 346

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568994608 258 NRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI 312
Cdd:PTZ00424 347 SPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEEMPMEVADYL 401
 
Name Accession Description Interval E-value
PTZ00424 PTZ00424
helicase 45; Provisional
 18-312 3.20e-163

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 460.06  E-value: 3.20e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAeAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:PTZ00424 108 LAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKA-GVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRG 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLT 177
Cdd:PTZ00424 187 FKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWKFDTLCDLYETLT 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 178 ITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPT 257
Cdd:PTZ00424 267 ITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPA 346

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568994608 258 NRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI 312
Cdd:PTZ00424 347 SPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEEMPMEVADYL 401
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
18-306 8.56e-101

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 302.07  E-value: 8.56e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:COG0513   83 LALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALK-RGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDMG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEwKLDTLCDLYETLT 177
Cdd:COG0513  162 FIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRD-KLELLRRLLRDED 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 178 ITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPT 257
Cdd:COG0513  241 PERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPE 320

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568994608 258 NRENYIHRIgrggrfgrkgVAINFVTEEDKRILRDIETFYNTTVEEMPM 306
Cdd:COG0513  321 DPEDYVHRIgrtgragaegTAISLVTPDERRLLRAIEKLIGQKIEEEEL 369
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 18-141 1.55e-83

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 250.44  E-value: 1.55e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAeAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:cd18046   79 LAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQA-GPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRG 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRIL 141
Cdd:cd18046  158 FKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRIL 201
DEXDc smart00487
DEAD-like helicases superfamily;
17-155 1.64e-31

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 116.82  E-value: 1.64e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608    17 SLVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSR 96
Cdd:smart00487  65 ELAEQWAEELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDG 144

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568994608    97 GFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVkkEELTLEGIKQF 155
Cdd:smart00487 145 GFGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDV--GFTPLEPIEQF 201
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 164-267 4.34e-29

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 107.30  E-value: 4.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  164 WKLDTLCDLYETLTITQAVIFLNTRRKVD--WLTEKmhaRDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARG 241
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTKKTLEaeLLLEK---EGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERG 77

                          90       100
                  ....*....|....*....|....*.
gi 568994608  242 IDVQQVSLVINYDLPTNRENYIHRIG 267
Cdd:pfam00271  78 LDLPDVDLVINYDLPWNPASYIQRIG 103
 
Name Accession Description Interval E-value
PTZ00424 PTZ00424
helicase 45; Provisional
 18-312 3.20e-163

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 460.06  E-value: 3.20e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAeAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:PTZ00424 108 LAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKA-GVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRG 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLT 177
Cdd:PTZ00424 187 FKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWKFDTLCDLYETLT 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 178 ITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPT 257
Cdd:PTZ00424 267 ITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPA 346

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568994608 258 NRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI 312
Cdd:PTZ00424 347 SPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEEMPMEVADYL 401
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
18-306 8.56e-101

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 302.07  E-value: 8.56e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:COG0513   83 LALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALK-RGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDMG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEwKLDTLCDLYETLT 177
Cdd:COG0513  162 FIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRD-KLELLRRLLRDED 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 178 ITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPT 257
Cdd:COG0513  241 PERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPE 320

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568994608 258 NRENYIHRIgrggrfgrkgVAINFVTEEDKRILRDIETFYNTTVEEMPM 306
Cdd:COG0513  321 DPEDYVHRIgrtgragaegTAISLVTPDERRLLRAIEKLIGQKIEEEEL 369
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 18-141 1.55e-83

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 250.44  E-value: 1.55e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAeAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:cd18046   79 LAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQA-GPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRG 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRIL 141
Cdd:cd18046  158 FKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRIL 201
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 18-141 1.10e-73

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 225.28  E-value: 1.10e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:cd17939   77 LAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQ-YGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRG 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRIL 141
Cdd:cd17939  156 FKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRIL 199
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 42-302 1.49e-58

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 194.63  E-value: 1.49e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  42 GGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSAT 121
Cdd:PRK11776 109 GGVPMGPQIDSLE-HGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSAT 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 122 MPTDVLEVTKKFMRDPIRILVKKEElTLEGIKQFYINVEREEwKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHAR 201
Cdd:PRK11776 188 YPEGIAAISQRFQRDPVEVKVESTH-DLPAIEQRFYEVSPDE-RLPALQRLLLHHQPESCVVFCNTKKECQEVADALNAQ 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 202 DFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINF 281
Cdd:PRK11776 266 GFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSL 345

                        250       260
                 ....*....|....*....|.
gi 568994608 282 VTEEDKRILRDIETFYNTTVE 302
Cdd:PRK11776 346 VAPEEMQRANAIEDYLGRKLN 366
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 18-141 1.12e-52

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 171.50  E-value: 1.12e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:cd18045   79 LAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLD-YGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKG 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRIL 141
Cdd:cd18045  158 FKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRIL 201
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 56-312 3.37e-47

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 167.72  E-value: 3.37e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  56 EAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMR 135
Cdd:PRK11634 124 QGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMK 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 136 DPIRILVKKEELTLEGIKQFYINVEREEwKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQK 215
Cdd:PRK11634 204 EPQEVRIQSSVTTRPDISQSYWTVWGMR-KNEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQA 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 216 ERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIET 295
Cdd:PRK11634 283 LREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIER 362

                        250
                 ....*....|....*..
gi 568994608 296 FYNTTVEEMPMNVADLI 312
Cdd:PRK11634 363 TMKLTIPEVELPNAELL 379
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 152-267 1.10e-45

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 151.12  E-value: 1.10e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 152 IKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRV 231
Cdd:cd18787    1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568994608 232 LITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIG 267
Cdd:cd18787   81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIG 116
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 18-140 2.99e-45

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 152.21  E-value: 2.99e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:cd00268   74 LAMQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALK-KGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMG 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd00268  153 FEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 18-305 7.35e-40

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 145.44  E-value: 7.35e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:PRK01297 174 LVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMG 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  98 FKDQIYEIFQKL--NTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQ-FYINVEREEWKLdtLCDLYE 174
Cdd:PRK01297 254 FIPQVRQIIRQTprKEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQhVYAVAGSDKYKL--LYNLVT 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 175 TLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYD 254
Cdd:PRK01297 332 QNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFT 411

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568994608 255 LPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVE-EMP 305
Cdd:PRK01297 412 LPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGRKIScEMP 463
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 41-293 9.72e-39

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 143.00  E-value: 9.72e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  41 IGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSiQVVLLSA 120
Cdd:PLN00206 231 VGGDAMPQQLYRIQ-QGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALSQP-QVLLFSA 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 121 TMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDtlcdLYETLTITQ-----AVIFLNTRRKVDWLT 195
Cdd:PLN00206 309 TVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQK----LFDILKSKQhfkppAVVFVSSRLGADLLA 384

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 196 EKMH-ARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGR 274
Cdd:PLN00206 385 NAITvVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGE 464

                        250
                 ....*....|....*....
gi 568994608 275 KGVAINFVTEEDKRILRDI 293
Cdd:PLN00206 465 KGTAIVFVNEEDRNLFPEL 483
PTZ00110 PTZ00110
helicase; Provisional
 38-293 9.04e-38

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 140.68  E-value: 9.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  38 HACI-GGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVV 116
Cdd:PTZ00110 234 NTVAyGGVPKRGQIYALR-RGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTL 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 117 LLSATMPTDVLEVTKKFMRD-PIRILVKKEELTL-EGIKQfYINVEREEWKLDTLCDLYETLTI--TQAVIFLNTRRKVD 192
Cdd:PTZ00110 313 MWSATWPKEVQSLARDLCKEePVHVNVGSLDLTAcHNIKQ-EVFVVEEHEKRGKLKMLLQRIMRdgDKILIFVETKKGAD 391

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 193 WLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRF 272
Cdd:PTZ00110 392 FLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRA 471

                        250       260
                 ....*....|....*....|.
gi 568994608 273 GRKGVAINFVTEEDKRILRDI 293
Cdd:PTZ00110 472 GAKGASYTFLTPDKYRLARDL 492
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 42-294 6.19e-37

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 137.25  E-value: 6.19e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  42 GGTNVRNEMQKLQAeAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSAT 121
Cdd:PRK10590 111 GGVSINPQMMKLRG-GVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGFIHDIRRVLAKLPAKRQNLLFSAT 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 122 MPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEwKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHAR 201
Cdd:PRK10590 190 FSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKR-KRELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKD 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 202 DFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINF 281
Cdd:PRK10590 269 GIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSL 348

                        250
                 ....*....|...
gi 568994608 282 VTEEDKRILRDIE 294
Cdd:PRK10590 349 VCVDEHKLLRDIE 361
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 60-294 3.11e-35

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 131.99  E-value: 3.11e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  60 IVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTD-VLEVTKKFMRDPI 138
Cdd:PRK11192 126 IVVATPGRLLQYIKEENFDCRAVETLILDEADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPV 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 139 RILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERD 218
Cdd:PRK11192 206 EVEAEPSRRERKKIHQWYYRADDLEHKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRN 285

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568994608 219 VIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIE 294
Cdd:PRK11192 286 EAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIE 361
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
 18-296 1.59e-34

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 132.00  E-value: 1.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNR-RYLSPKWIKMFVLDEADEMLSR 96
Cdd:PRK04537  96 LAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQ-QGVDVIIATPGRLIDYVKQhKVVSLHACEICVLDEADRMFDL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  97 GFKDQIYEIFQKL--NTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQfYINVEREEWKLDTLCDLYE 174
Cdd:PRK04537 175 GFIKDIRFLLRRMpeRGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQ-RIYFPADEEKQTLLLGLLS 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 175 TLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYD 254
Cdd:PRK04537 254 RSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYD 333

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568994608 255 LPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETF 296
Cdd:PRK04537 334 LPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAY 375
DEXDc smart00487
DEAD-like helicases superfamily;
17-155 1.64e-31

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 116.82  E-value: 1.64e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608    17 SLVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSR 96
Cdd:smart00487  65 ELAEQWAEELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDG 144

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568994608    97 GFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVkkEELTLEGIKQF 155
Cdd:smart00487 145 GFGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDV--GFTPLEPIEQF 201
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 42-296 4.03e-29

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 115.07  E-value: 4.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  42 GGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIF-------QKLNtsiq 114
Cdd:PRK04837 119 GGDGYDKQLKVLE-SGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMFDLGFIKDIRWLFrrmppanQRLN---- 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 115 vVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQ--FYINVEReewKLDTLCDLYETLTITQAVIFLNTRRKV- 191
Cdd:PRK04837 194 -MLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEelFYPSNEE---KMRLLQTLIEEEWPDRAIIFANTKHRCe 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 192 ---DWLTEKMHardfTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGR 268
Cdd:PRK04837 270 eiwGHLAADGH----RVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGR 345

                        250       260
                 ....*....|....*....|....*...
gi 568994608 269 GGRFGRKGVAINFVTEEDKRILRDIETF 296
Cdd:PRK04837 346 TGRAGASGHSISLACEEYALNLPAIETY 373
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 164-267 4.34e-29

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 107.30  E-value: 4.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  164 WKLDTLCDLYETLTITQAVIFLNTRRKVD--WLTEKmhaRDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARG 241
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTKKTLEaeLLLEK---EGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERG 77

                          90       100
                  ....*....|....*....|....*.
gi 568994608  242 IDVQQVSLVINYDLPTNRENYIHRIG 267
Cdd:pfam00271  78 LDLPDVDLVINYDLPWNPASYIQRIG 103
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 18-140 2.14e-28

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 108.43  E-value: 2.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEmQKLQAeapHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEML-SR 96
Cdd:cd17963   76 LARQIGEVVEKMGKFTGVKVALAVPGNDVPRG-KKITA---QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLdTQ 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568994608  97 GFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17963  152 GHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 17-129 5.97e-28

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 106.17  E-value: 5.97e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608   17 SLVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAeaPHIVVGTPGRVFDML-NRRYLSPkwIKMFVLDEADEMLS 95
Cdd:pfam00270  56 ELAEQIYEELKKLGKGLGLKVASLLGGDSRKEQLEKLKG--PDILVGTPGRLLDLLqERKLLKN--LKLLVLDEAHRLLD 131

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568994608   96 RGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEV 129
Cdd:pfam00270 132 MGFGPDLEEILRRLPKKRQILLLSATLPRNLEDL 165
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 18-140 7.38e-28

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 106.58  E-value: 7.38e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYM-GATCHACIGGTNVRNEMQKLQAeaPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSR 96
Cdd:cd17943   70 IAVQIHDVFKKIGKKLeGLKCEVFIGGTPVKEDKKKLKG--CHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEG 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568994608  97 GFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17943  148 SFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 18-140 7.40e-27

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 104.30  E-value: 7.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:cd17940   79 LALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLY-QTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQD 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17940  158 FQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 18-142 2.35e-25

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 100.50  E-value: 2.35e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACI-GGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEML-S 95
Cdd:cd17950   82 LAFQISNEYERFSKYMPNVKTAVFfGGVPIKKDIEVLKNKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLeQ 161

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568994608  96 RGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILV 142
Cdd:cd17950  162 LDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
HELICc smart00490
helicase superfamily c-terminal domain;
192-266 3.07e-23

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 91.12  E-value: 3.07e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568994608   192 DWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI 266
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRI 75
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 34-135 8.67e-23

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 93.80  E-value: 8.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  34 GATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNrrylSPKWIKMF------VLDEADEMLSRGFKDQIYEIFQ 107
Cdd:cd17964   97 KLRVQSAVGGTSRRAELNRLRRGRPDILVATPGRLIDHLE----NPGVAKAFtdldylVLDEADRLLDMGFRPDLEQILR 172

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568994608 108 KLNTS----IQVVLLSATMPTDVLEVTKKFMR 135
Cdd:cd17964  173 HLPEKnadpRQTLLFSATVPDEVQQIARLTLK 204
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 18-140 2.02e-22

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 92.32  E-value: 2.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAeAPHIVVGTPGRVFDML-NRRYLSPKWIKMFVLDEADEMLSR 96
Cdd:cd17947   73 LAMQCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRA-RPDIVIATPGRLIDHLrNSPSFDLDSIEILVLDEADRMLEE 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568994608  97 GFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17947  152 GFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 18-137 5.79e-21

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 88.82  E-value: 5.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEaPHIVVGTPGRVFDMLNRRYLSPKW---IKMFVLDEADEML 94
Cdd:cd17955   79 LAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKR-PHIVVATPGRLADHLRSSDDTTKVlsrVKFLVLDEADRLL 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568994608  95 SRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDP 137
Cdd:cd17955  158 TGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKP 200
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 18-140 9.33e-21

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 88.59  E-value: 9.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEApHIVVGTPGRVFDML---NRRYLSPKWIKMFVLDEADEML 94
Cdd:cd17953   97 LALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGA-EIVVCTPGRMIDILtanNGRVTNLRRVTYVVLDEADRMF 175

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 568994608  95 SRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17953  176 DMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 12-140 3.11e-20

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 86.45  E-value: 3.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  12 SKELLSLVLKIQKVILalgdymgatchacIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEAD 91
Cdd:cd17962   78 AKELMKGLPPMKTALL-------------VGGLPLPPQLYRLQ-QGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEAD 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568994608  92 EMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17962  144 TMLKMGFQQQVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 18-140 4.40e-20

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 86.20  E-value: 4.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLqAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:cd17959   83 LALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEAL-ASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLFEMG 161

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17959  162 FAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 27-140 6.54e-20

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 85.85  E-value: 6.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  27 LALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIF 106
Cdd:cd17951   93 LQEGGYPQLRCLLCIGGMSVKEQLEVIR-KGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMGFEEDIRTIF 171

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568994608 107 QKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17951  172 SYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 18-140 1.67e-19

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 84.68  E-value: 1.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLqAEAPHIVVGTPGRVFDML-NRRYLSPKWIKMFVLDEADEMLSR 96
Cdd:cd17954   80 LAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIAL-AKKPHVIVATPGRLVDHLeNTKGFSLKSLKFLVMDEADRLLNM 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568994608  97 GFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17954  159 DFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 13-142 3.25e-19

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 83.79  E-value: 3.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  13 KELLSlvlKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADE 92
Cdd:cd17957   70 RELAS---QIYRELLKLSKGTGLRIVLLSKSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADK 146

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568994608  93 MLSRGFKDQIYEIFQKL-NTSIQVVLLSATMPTDVLEVTKKFMRDPIRILV 142
Cdd:cd17957  147 LFEPGFREQTDEILAACtNPNLQRSLFSATIPSEVEELARSVMKDPIRIIV 197
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 40-136 8.02e-19

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 83.31  E-value: 8.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  40 CIGGTNVRNEMQKLQAEApHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLN----TSIQV 115
Cdd:cd17967  112 VYGGADVVHQQLQLLRGC-DILVATPGRLVDFIERGRISLSSIKFLVLDEADRMLDMGFEPQIRKIVEHPDmppkGERQT 190

                         90       100
                 ....*....|....*....|.
gi 568994608 116 VLLSATMPTDVLEVTKKFMRD 136
Cdd:cd17967  191 LMFSATFPREIQRLAADFLKN 211
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 18-140 9.36e-19

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 82.62  E-value: 9.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGA--TCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRY--LSPKWIKMFVLDEADEM 93
Cdd:cd17960   75 LATQIYEVLQSFLEHHLPklKCQLLIGGTNVEEDVKKFKRNGPNILVGTPGRLEELLSRKAdkVKVKSLEVLVLDEADRL 154

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568994608  94 LSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17960  155 LDLGFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 40-140 1.10e-18

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 82.51  E-value: 1.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  40 CIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLS 119
Cdd:cd17958   96 CVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIRKILLDIRPDRQTIMTS 175

                         90       100
                 ....*....|....*....|.
gi 568994608 120 ATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17958  176 ATWPDGVRRLAQSYLKDPMIV 196
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 18-140 6.13e-18

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 80.11  E-value: 6.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:cd17966   75 LAQQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLR-RGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMG 153

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568994608  98 FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17966  154 FEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 12-138 8.44e-18

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 79.94  E-value: 8.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  12 SKELlslVLKIQKVILALGDYmgatCHACIGGTNVRNEM-----QKLQAEAPHIVVGTPGRVFDMLNRRYLSPK-WIKMF 85
Cdd:cd17961   77 TREL---AQQVSKVLEQLTAY----CRKDVRVVNLSASSsdsvqRALLAEKPDIVVSTPARLLSHLESGSLLLLsTLKYL 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568994608  86 VLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPI 138
Cdd:cd17961  150 VIDEADLVLSYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 18-140 5.64e-17

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 78.13  E-value: 5.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRG 97
Cdd:cd17945   78 LAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLR-NGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMG 156

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994608  98 FKDQIYEIFQKLNTSI--------------------QVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17945  157 FEPQVTKILDAMPVSNkkpdteeaeklaasgkhryrQTMMFTATMPPAVEKIAKGYLRRPVVV 219
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 39-135 9.73e-17

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 78.47  E-value: 9.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  39 ACIGGTNVRNEMQKLQAEApHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLN----TSIQ 114
Cdd:cd18052  153 VVYGGVSVGHQIRQIEKGC-HILVATPGRLLDFIGRGKISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPGmpskEDRQ 231

                         90       100
                 ....*....|....*....|.
gi 568994608 115 VVLLSATMPTDVLEVTKKFMR 135
Cdd:cd18052  232 TLMFSATFPEEIQRLAAEFLK 252
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 40-137 1.65e-16

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 76.59  E-value: 1.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  40 CIGGTNVRNEMQKLQAEApHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKL------NTSI 113
Cdd:cd17938   97 LIGGVKAREQLKRLESGV-DIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGNLETINRIYNRIpkitsdGKRL 175

                         90       100
                 ....*....|....*....|....*
gi 568994608 114 QVVLLSATM-PTDVLEVTKKFMRDP 137
Cdd:cd17938  176 QVIVCSATLhSFEVKKLADKIMHFP 200
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 30-140 1.86e-16

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 76.30  E-value: 1.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  30 GDYMGATCHACIGGTNvRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKL 109
Cdd:cd17952   87 GKAYNLRVVAVYGGGS-KWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVRSIVGHV 165

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568994608 110 NTSIQVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17952  166 RPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 42-138 6.51e-16

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 75.85  E-value: 6.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  42 GGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNT----SIQVVL 117
Cdd:cd18051  141 GGADIGQQMRDLE-RGCHLLVATPGRLVDMLERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTMpptgERQTLM 219

                         90       100
                 ....*....|....*....|.
gi 568994608 118 LSATMPTDVLEVTKKFMRDPI 138
Cdd:cd18051  220 FSATFPKEIQMLARDFLDNYI 240
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 18-140 9.27e-15

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 71.62  E-value: 9.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPhIVVGTPGRVFDML-NRRYLSPKWIKMFVLDEADEMLSR 96
Cdd:cd17942   74 LALQIYGVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVN-ILVATPGRLLDHLqNTKGFLYKNLQCLIIDEADRILEI 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568994608  97 GFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTK-KFMRDPIRI 140
Cdd:cd17942  153 GFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARiSLKKKPLYV 197
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 18-142 2.78e-14

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 70.01  E-value: 2.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEapHIVVGTPGRVFDMLNRR-YLSPKWIKMFVLDEADEMLSR 96
Cdd:cd17941   74 LAMQIFEVLRKVGKYHSFSAGLIIGGKDVKEEKERINRM--NILVCTPGRLLQHMDETpGFDTSNLQMLVLDEADRILDM 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 568994608  97 GFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILV 142
Cdd:cd17941  152 GFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 59-148 1.62e-12

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 65.81  E-value: 1.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  59 HIVVGTPGRVFD-MLNRRYLSPKWIKMFVLDEADEMLS-RGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRD 136
Cdd:cd18048  138 QIVIGTPGTVLDwCFKLRLIDVTNISVFVLDEADVMINvQGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPD 217

                         90
                 ....*....|..
gi 568994608 137 PIRILVKKEELT 148
Cdd:cd18048  218 PNIIKLKKEELT 229
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 41-140 6.80e-12

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 63.76  E-value: 6.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  41 IGGTNVRNEMQKLQAEAPhIVVGTPGRVFDML-NRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSI------ 113
Cdd:cd17949  101 IGGEKRKSEKARLRKGVN-ILIATPGRLLDHLkNTQSFDVSNLRWLVLDEADRLLDMGFEKDITKILELLDDKRskagge 179

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568994608 114 -------QVVLLSATMPTDVLEVTKKFMRDPIRI 140
Cdd:cd17949  180 kskpsrrQTVLVSATLTDGVKRLAGLSLKDPVYI 213
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 60-140 1.65e-11

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 63.10  E-value: 1.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  60 IVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIR 139
Cdd:cd18049  150 ICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIH 229


                 .
gi 568994608 140 I 140
Cdd:cd18049  230 I 230
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 39-135 1.71e-11

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 62.56  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  39 ACI-GGTNVRNEMQKLQaEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIF-----QKLNTS 112
Cdd:cd17944   94 ACFyGGTPYQQQIFAIR-NGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEILsvsykKDSEDN 172

                         90       100
                 ....*....|....*....|...
gi 568994608 113 IQVVLLSATMPTDVLEVTKKFMR 135
Cdd:cd17944  173 PQTLLFSATCPDWVYNVAKKYMK 195
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 60-140 3.70e-11

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 62.34  E-value: 3.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  60 IVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIR 139
Cdd:cd18050  188 ICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQ 267


                 .
gi 568994608 140 I 140
Cdd:cd18050  268 I 268
SF2_C_dicer cd18802
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ...
 166-263 8.21e-11

C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350189 [Multi-domain]  Cd Length: 142  Bit Score: 59.14  E-value: 8.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 166 LDTLCDLYETLTITQAVIFLNTRRKV----DWLTEKMHARDF-----------TVSALHGDMDQKERDVIMREFRSGSSR 230
Cdd:cd18802   13 IEILREYFPKTPDFRGIIFVERRATAvvlsRLLKEHPSTLAFircgfligrgnSSQRKRSLMTQRKQKETLDKFRDGELN 92

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568994608 231 VLITTDLLARGIDVQQVSLVINYDLPTNRENYI 263
Cdd:cd18802   93 LLIATSVLEEGIDVPACNLVIRFDLPKTLRSYI 125
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
 18-137 2.83e-10

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 58.96  E-value: 2.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGD-YMGATCHACIGGtnvrNEMQKLQAEAPHIVVGTPGRVFD-MLNRRYLSPKWIKMFVLDEADEML- 94
Cdd:cd18047   83 LALQTGKVIEQMGKfYPELKLAYAVRG----NKLERGQKISEQIVIGTPGTVLDwCSKLKFIDPKKIKVFVLDEADVMIa 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568994608  95 SRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDP 137
Cdd:cd18047  159 TQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 40-132 3.95e-10

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 58.92  E-value: 3.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  40 CIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQK----------- 108
Cdd:cd17948   98 VITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEKLSHFLRRfplasrrsent 177

                         90       100
                 ....*....|....*....|....*.
gi 568994608 109 --LNTSIQVVLLSATMPTDVLEVTKK 132
Cdd:cd17948  178 dgLDPGTQLVLVSATMPSGVGEVLSK 203
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 165-258 4.28e-09

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 54.02  E-value: 4.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 165 KLDTLCDLYETLTITQ--AVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSS--RVLITTDLLAR 240
Cdd:cd18793   12 KLEALLELLEELREPGekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDirVFLLSTKAGGV 91

                         90
                 ....*....|....*...
gi 568994608 241 GIDVQQVSLVINYDLPTN 258
Cdd:cd18793   92 GLNLTAANRVILYDPWWN 109
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
162-251 6.01e-09

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 56.96  E-value: 6.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 162 EEWKLDTLCDLYETLT-ITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLAR 240
Cdd:COG1061  288 AERKDKILRELLREHPdDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNE 367

                         90
                 ....*....|.
gi 568994608 241 GIDVQQVSLVI 251
Cdd:COG1061  368 GVDVPRLDVAI 378
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 18-122 1.10e-08

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 54.55  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEmQKLQAEAPHIVVGTPGRVFDMLNRR--YL-SPKWIKMFVLDEADEML 94
Cdd:cd17946   80 LAVQVKDHLKAIAKYTNIKIASIVGGLAVQKQ-ERLLKKRPEIVVATPGRLWELIQEGneHLaNLKSLRFLVLDEADRML 158

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568994608  95 SRG-FKD--QIYEIFQK----LNTSIQVVLLSATM 122
Cdd:cd17946  159 EKGhFAEleKILELLNKdragKKRKRQTFVFSATL 193
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 181-261 3.88e-08

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 54.46  E-value: 3.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 181 AVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSS--RVLITTDLLARGIDVQQVSLVINYDLPTN 258
Cdd:COG0553  552 VLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEapVFLISLKAGGEGLNLTAADHVIHYDLWWN 631


                 ....*
gi 568994608 259 --REN 261
Cdd:COG0553  632 paVEE 636
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 17-121 9.82e-08

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 50.48  E-value: 9.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  17 SLVLKIQKVILALGDyMGATCHACIGGTNVrNEMQKLQAEAPHIVVGTPGRVFDMLNR--RYLSPKWiKMFVLDEADEML 94
Cdd:cd00046   41 ALALQTAERLRELFG-PGIRVAVLVGGSSA-EEREKNKLGDADIIIATPDMLLNLLLRedRLFLKDL-KLIIVDEAHALL 117

                         90       100
                 ....*....|....*....|....*....
gi 568994608  95 SRGFKDQIYE--IFQKLNTSIQVVLLSAT 121
Cdd:cd00046  118 IDSRGALILDlaVRKAGLKNAQVILLSAT 146
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 182-262 2.31e-07

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 52.02  E-value: 2.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 182 VIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNREN 261
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319


                 .
gi 568994608 262 Y 262
Cdd:PRK11057 320 Y 320
Cas3 COG1203
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ...
 47-235 3.62e-07

CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 440816 [Multi-domain]  Cd Length: 535  Bit Score: 51.24  E-value: 3.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  47 RNEMQKLQAEaphIVVGTPGRVFDML--NRRYLSPKWIKM----FVLDEAD----EMLsRGFKDQIYEIfQKLNTSiqVV 116
Cdd:COG1203  231 KLLKELWDAP---VVVTTIDQLFESLfsNRKGQERRLHNLansvIILDEVQayppYML-ALLLRLLEWL-KNLGGS--VI 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 117 LLSATMPTDVlevtKKFMRDPIRILVKKEELTLEGIKQFY---INVEREEWKLDTLCDLYETL--TITQAVIFLNTRRKV 191
Cdd:COG1203  304 LMTATLPPLL----REELLEAYELIPDEPEELPEYFRAFVrkrVELKEGPLSDEELAELILEAlhKGKSVLVIVNTVKDA 379

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568994608 192 DWLTEKMHARDFTVSA--LHGDMDQKER----DVIMREFRSGSSRVLITT 235
Cdd:COG1203  380 QELYEALKEKLPDEEVylLHSRFCPADRseieKEIKERLERGKPCILVST 429
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 18-126 3.83e-06

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 47.24  E-value: 3.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  18 LVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQA-------EAPHIVVGTPGRVFDMLNR-RYLSPKWIKMFVLDE 89
Cdd:cd17956   80 LVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVdtsgrylSRVDILVATPGRLVDHLNStPGFTLKHLRFLVIDE 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568994608  90 ADEMLSRGF--------------KDQIYEIFQKLNTSI------QVVLLSATMPTDV 126
Cdd:cd17956  160 ADRLLNQSFqdwletvmkalgrpTAPDLGSFGDANLLErsvrplQKLLFSATLTRDP 216
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
182-266 1.04e-05

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 46.67  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 182 VIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNREN 261
Cdd:COG0514  234 IVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEA 313


                 ....*
gi 568994608 262 YIHRI 266
Cdd:COG0514  314 YYQEI 318
SF2_C_UvrB cd18790
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ...
 171-254 1.04e-05

C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350177 [Multi-domain]  Cd Length: 171  Bit Score: 44.93  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 171 DLYETLtitQAVIFLNTRRKVDWLTEKMhARDFT---------VSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARG 241
Cdd:cd18790   15 DLLGEI---RKRVARGERVLVTTLTKRM-AEDLTeylqelgvkVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREG 90

                         90
                 ....*....|...
gi 568994608 242 IDVQQVSLVINYD 254
Cdd:cd18790   91 LDLPEVSLVAILD 103
SF2_C_RecG cd18811
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ...
 194-254 1.33e-05

C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350198 [Multi-domain]  Cd Length: 159  Bit Score: 44.64  E-value: 1.33e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568994608 194 LTEKMHArDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYD 254
Cdd:cd18811   54 LKERFRP-ELNVGLLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNATVMVIED 113
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
60-242 1.85e-05

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 46.04  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  60 IVVGTPGRvFDMLNRRylSPKWIK---MFVLDEA----DEmlSRGFkdqIYEI----FQKLNTSIQVVLLSATM--PTDV 126
Cdd:COG1204  116 ILVATPEK-LDSLLRN--GPSWLRdvdLVVVDEAhlidDE--SRGP---TLEVllarLRRLNPEAQIVALSATIgnAEEI 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 127 LE-VTKKFMRDPIRIlVKKEELTLEGIKQFYINVEREEwkLDTLCDL-YETLTI-TQAVIFLNTRRKVDWLTEKMHAR-- 201
Cdd:COG1204  188 AEwLDAELVKSDWRP-VPLNEGVLYDGVLRFDDGSRRS--KDPTLALaLDLLEEgGQVLVFVSSRRDAESLAKKLADElk 264

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568994608 202 ---------------------------DFTVSAL--------HGDMDQKERDVIMREFRSGSSRVLITTDLLARGI 242
Cdd:COG1204  265 rrltpeereeleelaeellevseethtNEKLADClekgvafhHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGV 340
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
 183-256 2.24e-05

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 43.79  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 183 IFLNTRRKVDWLTEKMHAR------DFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLP 256
Cdd:cd18796   43 VFTNTRSQAERLAQRLRELcpdrvpPDFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIGSP 122
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
180-255 3.69e-05

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 45.11  E-value: 3.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 180 QAVIFLNTRRKVDWLTEKMHARDFTV------SALHGD--MDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVI 251
Cdd:COG1111  355 RIIVFTQYRDTAEMIVEFLSEPGIKAgrfvgqASKEGDkgLTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVI 434


                 ....
gi 568994608 252 NYDL 255
Cdd:COG1111  435 FYEP 438
SF2_C_Ski2 cd18795
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ...
 180-242 6.30e-05

C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350182 [Multi-domain]  Cd Length: 154  Bit Score: 42.54  E-value: 6.30e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568994608 180 QAVIFLNTRRKvdwlTEKMhARDFT-VSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGI 242
Cdd:cd18795   45 PVLVFCSSRKE----CEKT-AKDLAgIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGV 103
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
 181-266 1.38e-04

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 41.04  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 181 AVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRE 260
Cdd:cd18794   33 GIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSME 112


                 ....*.
gi 568994608 261 NYIHRI 266
Cdd:cd18794  113 SYYQES 118
Cas3_I cd09639
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ...
 113-244 1.60e-04

CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I


Pssm-ID: 187770 [Multi-domain]  Cd Length: 353  Bit Score: 42.80  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608 113 IQVVLLSATMPtdvlEVTKKFMRDpIRILVKKEELTLEGIKQFYINVEREEWKLD--TLCDLYETL-TITQAVIFLNTRR 189
Cdd:cd09639  155 VPILLMSATLP----KFLKEYAEK-IGYVEENEPLDLKPNERAPFIKIESDKVGEisSLERLLEFIkKGGSVAIIVNTVD 229

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994608 190 KV----DWLTEKMHarDFTVSALHGDMDQKER----DVIMREFRSGSSRVLITTDLLARGIDV 244
Cdd:cd09639  230 RAqefyQQLKEKGP--EEEIMLIHSRFTEKDRakkeAELLLEFKKSEKFVIVATQVIEASLDI 290
RecG COG1200
RecG-like helicase [Replication, recombination and repair];
196-235 3.07e-04

RecG-like helicase [Replication, recombination and repair];


Pssm-ID: 440813 [Multi-domain]  Cd Length: 684  Bit Score: 42.34  E-value: 3.07e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568994608 196 EKMHAR------DFTVSALHGDMDQKERDVIMREFRSGSSRVLITT 235
Cdd:COG1200  491 EETYEElreafpGLRVGLLHGRMKPAEKDAVMAAFKAGEIDVLVAT 536
PRK05298 PRK05298
excinuclease ABC subunit UvrB;
194-250 3.26e-04

excinuclease ABC subunit UvrB;


Pssm-ID: 235395 [Multi-domain]  Cd Length: 652  Bit Score: 42.34  E-value: 3.26e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568994608 194 LTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLV 250
Cdd:PRK05298 462 LTDYLKELGIKVRYLHSDIDTLERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLV 518
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
 60-140 9.37e-04

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 40.05  E-value: 9.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994608  60 IVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIR 139
Cdd:cd17965  164 ILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRKLFPDVVR 243


                 .
gi 568994608 140 I 140
Cdd:cd17965  244 I 244
SF2_C_FANCM_Hef cd18801
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ...
 212-254 1.13e-03

C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350188 [Multi-domain]  Cd Length: 143  Bit Score: 38.49  E-value: 1.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568994608 212 MDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYD 254
Cdd:cd18801   74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYD 116
SF2_C_RecG_TRCF cd18792
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ...
 197-254 1.21e-03

C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350179 [Multi-domain]  Cd Length: 160  Bit Score: 38.79  E-value: 1.21e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568994608 197 KMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYD 254
Cdd:cd18792   55 KELVPEARVALLHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIED 112
PRK10917 PRK10917
ATP-dependent DNA helicase RecG; Provisional
 202-244 1.68e-03

ATP-dependent DNA helicase RecG; Provisional


Pssm-ID: 236794 [Multi-domain]  Cd Length: 681  Bit Score: 40.13  E-value: 1.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568994608 202 DFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDV 244
Cdd:PRK10917 505 ELRVGLLHGRMKPAEKDAVMAAFKAGEIDILVATTVIEVGVDV 547
UvrB COG0556
Excinuclease UvrABC helicase subunit UvrB [Replication, recombination and repair];
194-250 9.42e-03

Excinuclease UvrABC helicase subunit UvrB [Replication, recombination and repair];


Pssm-ID: 440322 [Multi-domain]  Cd Length: 657  Bit Score: 37.68  E-value: 9.42e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568994608 194 LTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLV 250
Cdd:COG0556  459 LTDYLKELGIKVRYLHSDIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLV 515
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH