NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568981960|ref|XP_006516802|]
View 

F-actin-uncapping protein LRRC16A isoform X4 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 790-1081 7.96e-117

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


:

Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 367.95  E-value: 7.96e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960   790 AETLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSSSHRKLA 869
Cdd:pfam16000    1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960   870 NHFSRLNKSLPQREDLEVELVEEKPVKRAILTVEDltEVERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEM-EFDLDK 948
Cdd:pfam16000   81 RHLSQRGRTLLEPESLPDGDRPESSPLGPGKRHEG--EIERLEELETPMATLKSKRKSIHSRKLRPVSVAFSVsELDLDK 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960   949 ALEEVPIHIED----PPFPSVRQEK------RSSGLISELPSeEGRRLEHFTKLRPKRNKKQQPTQAAVCTisILPQDGE 1018
Cdd:pfam16000  159 APEEVPIHVEDassgPPLPSSSPSEpelsasESLDSLSELPT-EGQKLQHLTKGRPKRNKTRAPTRPPGKV--GPAQDGE 235

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568981960  1019 QNGLMGRVDEGVDEFFTKKVTKMDcKRSSSRSSDAHELGEGDEKKKRDSRRSGFLNLIKSRSR 1081
Cdd:pfam16000  236 QNGLSGRVDEGLEDFFSKKVIKLS-TPTSPTSEPSSSSLFPDSPKKRKKRKSGFFNFIKPRSS 297
Carm_PH pfam17888
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ...
 38-119 3.30e-35

Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.


:

Pssm-ID: 436119  Cd Length: 94  Bit Score: 129.32  E-value: 3.30e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960    38 GDRVENKVLVLTSCRAFLLSARIPSKLELTFSYLEIHGVICHKPAQMVVETEKCNMSMKMVSPEDVSEVLAHIGTCLRRI 117
Cdd:pfam17888   13 GDKVEDRILVLTPWRLFLLSAKVPTKVERTFHFLEIRAINSRNPNQVIVETDKSNYSLKLASEEDVDHVVGHILTALKKI 92


                   ..
gi 568981960   118 FP 119
Cdd:pfam17888   93 FP 94
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 260-662 5.09e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  260 IDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAKLPKglkHLNLSKTSLSPKGVNSLcqslsanpltastl 339
Cdd:COG5238    94 WEGAEEVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPR---RINLIQVLKDPLGGNAV-------------- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  340 tHLDLSGNALRGDDLSHMYNFLaQPNTIVHLDLSNTECSLEmvcsallrGCLQCLAVLNLSRSVFShrkgkevppsfkqf 419
Cdd:COG5238   157 -HLLGLAARLGLLAAISMAKAL-QNNSVETVYLGCNQIGDE--------GIEELAEALTQNTTVTT-------------- 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  420 fssslaliqINLSGTKLSPEPLKALLLGLACNHSLKgvSLDLSNCELGhclrSGGAQVLEGCIAEIHNITSLDISDNGL- 498
Cdd:COG5238   213 ---------LWLKRNPIGDEGAEILAEALKGNKSLT--TLDLSNNQIG----DEGVIALAEALKNNTTVETLYLSGNQIg 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  499 ESDLSTLIVWLSKNRSIQHLALgkNFNNMKSKNLTpvldNLVQMIQdEDSPLQSLSLADSKLKAEVTI-IINALGSNTSL 577
Cdd:COG5238   278 AEGAIALAKALQGNTTLTSLDL--SVNRIGDEGAI----ALAEGLQ-GNKTLHTLNLAYNGIGAQGAIaLAKALQENTTL 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  578 TKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKN--YTLRFMPIPMYDAAQAlktnpeKTE 655
Cdd:COG5238   351 HSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNrlHTLILDGNLIGAEAQQ------RLE 424


                  ....*..
gi 568981960  656 EALQKIE 662
Cdd:COG5238   425 QLLERIK 431
PHA02682 super family cl31817
ORF080 virion core protein; Provisional
 1113-1318 2.93e-05

ORF080 virion core protein; Provisional


The actual alignment was detected with superfamily member PHA02682:

Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 47.55  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1113 IKAAEHNGAPDrtEEIktpEPLEEGPAEEAGRaersdsrgspqggrrYVQvmgsgllAEMKAKqerrAACAQKKLGNDVI 1192
Cdd:PHA02682   34 IPAPAAPCPPD--ADV---DPLDKYSVKEAGR---------------YYQ-------SRLKAN----SACMQRPSGQSPL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1193 SQDPSSPV------SCNTERLEGGATVPKLQPGLPEARFGSGTPEKNAKAEPRVDGGCRSRSSSSMPTSPKPllqSPKPS 1266
Cdd:PHA02682   83 APSPACAApapacpACAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLP---TPKPA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568981960 1267 PSARPSIPQKprTASRPEDTPDSPSGPSSPKVAllPPILKKVSSDKERDGQN 1318
Cdd:PHA02682  160 PAAKPIFLHN--QLPPPDYPAASCPTIETAPAA--SPVLEPRIPDKIIDADN 207
 
Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 790-1081 7.96e-117

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 367.95  E-value: 7.96e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960   790 AETLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSSSHRKLA 869
Cdd:pfam16000    1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960   870 NHFSRLNKSLPQREDLEVELVEEKPVKRAILTVEDltEVERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEM-EFDLDK 948
Cdd:pfam16000   81 RHLSQRGRTLLEPESLPDGDRPESSPLGPGKRHEG--EIERLEELETPMATLKSKRKSIHSRKLRPVSVAFSVsELDLDK 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960   949 ALEEVPIHIED----PPFPSVRQEK------RSSGLISELPSeEGRRLEHFTKLRPKRNKKQQPTQAAVCTisILPQDGE 1018
Cdd:pfam16000  159 APEEVPIHVEDassgPPLPSSSPSEpelsasESLDSLSELPT-EGQKLQHLTKGRPKRNKTRAPTRPPGKV--GPAQDGE 235

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568981960  1019 QNGLMGRVDEGVDEFFTKKVTKMDcKRSSSRSSDAHELGEGDEKKKRDSRRSGFLNLIKSRSR 1081
Cdd:pfam16000  236 QNGLSGRVDEGLEDFFSKKVIKLS-TPTSPTSEPSSSSLFPDSPKKRKKRKSGFFNFIKPRSS 297
Carm_PH pfam17888
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ...
 38-119 3.30e-35

Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.


Pssm-ID: 436119  Cd Length: 94  Bit Score: 129.32  E-value: 3.30e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960    38 GDRVENKVLVLTSCRAFLLSARIPSKLELTFSYLEIHGVICHKPAQMVVETEKCNMSMKMVSPEDVSEVLAHIGTCLRRI 117
Cdd:pfam17888   13 GDKVEDRILVLTPWRLFLLSAKVPTKVERTFHFLEIRAINSRNPNQVIVETDKSNYSLKLASEEDVDHVVGHILTALKKI 92


                   ..
gi 568981960   118 FP 119
Cdd:pfam17888   93 FP 94
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 260-662 5.09e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  260 IDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAKLPKglkHLNLSKTSLSPKGVNSLcqslsanpltastl 339
Cdd:COG5238    94 WEGAEEVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPR---RINLIQVLKDPLGGNAV-------------- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  340 tHLDLSGNALRGDDLSHMYNFLaQPNTIVHLDLSNTECSLEmvcsallrGCLQCLAVLNLSRSVFShrkgkevppsfkqf 419
Cdd:COG5238   157 -HLLGLAARLGLLAAISMAKAL-QNNSVETVYLGCNQIGDE--------GIEELAEALTQNTTVTT-------------- 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  420 fssslaliqINLSGTKLSPEPLKALLLGLACNHSLKgvSLDLSNCELGhclrSGGAQVLEGCIAEIHNITSLDISDNGL- 498
Cdd:COG5238   213 ---------LWLKRNPIGDEGAEILAEALKGNKSLT--TLDLSNNQIG----DEGVIALAEALKNNTTVETLYLSGNQIg 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  499 ESDLSTLIVWLSKNRSIQHLALgkNFNNMKSKNLTpvldNLVQMIQdEDSPLQSLSLADSKLKAEVTI-IINALGSNTSL 577
Cdd:COG5238   278 AEGAIALAKALQGNTTLTSLDL--SVNRIGDEGAI----ALAEGLQ-GNKTLHTLNLAYNGIGAQGAIaLAKALQENTTL 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  578 TKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKN--YTLRFMPIPMYDAAQAlktnpeKTE 655
Cdd:COG5238   351 HSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNrlHTLILDGNLIGAEAQQ------RLE 424


                  ....*..
gi 568981960  656 EALQKIE 662
Cdd:COG5238   425 QLLERIK 431
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 229-373 2.38e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 72.77  E-value: 2.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  229 KLSTDVCEQILRVVSRSNRLEELVLENAGLRIDFAQKLAGALAHNPNsgLHTINLAGNSLEDRGVSSLSIQFAKLPKgLK 308
Cdd:cd00116   148 RLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCN--LEVLDLNNNGLTDEGASALAETLASLKS-LE 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568981960  309 HLNLSKTSLSPKGVNSLCqslSANPLTASTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLS 373
Cdd:cd00116   225 VLNLGDNNLTDAGAAALA---SALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLR 286
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 1113-1318 2.93e-05

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 47.55  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1113 IKAAEHNGAPDrtEEIktpEPLEEGPAEEAGRaersdsrgspqggrrYVQvmgsgllAEMKAKqerrAACAQKKLGNDVI 1192
Cdd:PHA02682   34 IPAPAAPCPPD--ADV---DPLDKYSVKEAGR---------------YYQ-------SRLKAN----SACMQRPSGQSPL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1193 SQDPSSPV------SCNTERLEGGATVPKLQPGLPEARFGSGTPEKNAKAEPRVDGGCRSRSSSSMPTSPKPllqSPKPS 1266
Cdd:PHA02682   83 APSPACAApapacpACAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLP---TPKPA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568981960 1267 PSARPSIPQKprTASRPEDTPDSPSGPSSPKVAllPPILKKVSSDKERDGQN 1318
Cdd:PHA02682  160 PAAKPIFLHN--QLPPPDYPAASCPTIETAPAA--SPVLEPRIPDKIIDADN 207
 
Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 790-1081 7.96e-117

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 367.95  E-value: 7.96e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960   790 AETLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSSSHRKLA 869
Cdd:pfam16000    1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960   870 NHFSRLNKSLPQREDLEVELVEEKPVKRAILTVEDltEVERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEM-EFDLDK 948
Cdd:pfam16000   81 RHLSQRGRTLLEPESLPDGDRPESSPLGPGKRHEG--EIERLEELETPMATLKSKRKSIHSRKLRPVSVAFSVsELDLDK 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960   949 ALEEVPIHIED----PPFPSVRQEK------RSSGLISELPSeEGRRLEHFTKLRPKRNKKQQPTQAAVCTisILPQDGE 1018
Cdd:pfam16000  159 APEEVPIHVEDassgPPLPSSSPSEpelsasESLDSLSELPT-EGQKLQHLTKGRPKRNKTRAPTRPPGKV--GPAQDGE 235

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568981960  1019 QNGLMGRVDEGVDEFFTKKVTKMDcKRSSSRSSDAHELGEGDEKKKRDSRRSGFLNLIKSRSR 1081
Cdd:pfam16000  236 QNGLSGRVDEGLEDFFSKKVIKLS-TPTSPTSEPSSSSLFPDSPKKRKKRKSGFFNFIKPRSS 297
Carm_PH pfam17888
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ...
 38-119 3.30e-35

Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.


Pssm-ID: 436119  Cd Length: 94  Bit Score: 129.32  E-value: 3.30e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960    38 GDRVENKVLVLTSCRAFLLSARIPSKLELTFSYLEIHGVICHKPAQMVVETEKCNMSMKMVSPEDVSEVLAHIGTCLRRI 117
Cdd:pfam17888   13 GDKVEDRILVLTPWRLFLLSAKVPTKVERTFHFLEIRAINSRNPNQVIVETDKSNYSLKLASEEDVDHVVGHILTALKKI 92


                   ..
gi 568981960   118 FP 119
Cdd:pfam17888   93 FP 94
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 260-662 5.09e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  260 IDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAKLPKglkHLNLSKTSLSPKGVNSLcqslsanpltastl 339
Cdd:COG5238    94 WEGAEEVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPR---RINLIQVLKDPLGGNAV-------------- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  340 tHLDLSGNALRGDDLSHMYNFLaQPNTIVHLDLSNTECSLEmvcsallrGCLQCLAVLNLSRSVFShrkgkevppsfkqf 419
Cdd:COG5238   157 -HLLGLAARLGLLAAISMAKAL-QNNSVETVYLGCNQIGDE--------GIEELAEALTQNTTVTT-------------- 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  420 fssslaliqINLSGTKLSPEPLKALLLGLACNHSLKgvSLDLSNCELGhclrSGGAQVLEGCIAEIHNITSLDISDNGL- 498
Cdd:COG5238   213 ---------LWLKRNPIGDEGAEILAEALKGNKSLT--TLDLSNNQIG----DEGVIALAEALKNNTTVETLYLSGNQIg 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  499 ESDLSTLIVWLSKNRSIQHLALgkNFNNMKSKNLTpvldNLVQMIQdEDSPLQSLSLADSKLKAEVTI-IINALGSNTSL 577
Cdd:COG5238   278 AEGAIALAKALQGNTTLTSLDL--SVNRIGDEGAI----ALAEGLQ-GNKTLHTLNLAYNGIGAQGAIaLAKALQENTTL 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  578 TKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKN--YTLRFMPIPMYDAAQAlktnpeKTE 655
Cdd:COG5238   351 HSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNrlHTLILDGNLIGAEAQQ------RLE 424


                  ....*..
gi 568981960  656 EALQKIE 662
Cdd:COG5238   425 QLLERIK 431
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 250-628 2.24e-15

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 80.22  E-value: 2.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  250 ELVLENAGLRIDFAQKLAGALAH----NPNSGLHTINLAGNSLEDRGVSSLSIQFAKlPKGLKHLNLSKTSLSPKGVNSL 325
Cdd:COG5238   150 PLGGNAVHLLGLAARLGLLAAISmakaLQNNSVETVYLGCNQIGDEGIEELAEALTQ-NTTVTTLWLKRNPIGDEGAEIL 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  326 CQSLSANPltasTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDlsntecslemvcsallrgclqclavlnlsrsvfs 405
Cdd:COG5238   229 AEALKGNK----SLTTLDLSNNQIGDEGVIALAEALKNNTTVETLY---------------------------------- 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  406 hrkgkevppsfkqffssslaliqinLSGTKLSPEPLKALLLGLACNHSLKgvSLDLSNCELGhclrSGGAQVLEGCIAEI 485
Cdd:COG5238   271 -------------------------LSGNQIGAEGAIALAKALQGNTTLT--SLDLSVNRIG----DEGAIALAEGLQGN 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  486 HNITSLDISDNGLESDLSTLIvwlsknrsIQHLALGKNfnnmksknltpvldnlvqmiqdedspLQSLSLADSKLKAE-V 564
Cdd:COG5238   320 KTLHTLNLAYNGIGAQGAIAL--------AKALQENTT--------------------------LHSLDLSDNQIGDEgA 365

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981960  565 TIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINtKLRTVIWDKNNITAQGFQDIAVAME 628
Cdd:COG5238   366 IALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLLE 428
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 403-665 4.61e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 76.37  E-value: 4.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  403 VFSHRKGKEVPpSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGlacNHSLKGVS---LDLSNCELGHCLRSGGAQVLE 479
Cdd:COG5238   103 VALAETATAVA-TPPPDLRRIMAKTLEDSLILYLALPRRINLIQV---LKDPLGGNavhLLGLAARLGLLAAISMAKALQ 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  480 GCIAEIHNITSLDISDNGLESdlstLIVWLSKNRSIQHLALGKNfnNMKSKNLtpvlDNLVQMIQdEDSPLQSLSLADSK 559
Cdd:COG5238   179 NNSVETVYLGCNQIGDEGIEE----LAEALTQNTTVTTLWLKRN--PIGDEGA----EILAEALK-GNKSLTTLDLSNNQ 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  560 LKAE-VTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPI 638
Cdd:COG5238   248 IGDEgVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNL 327

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 568981960  639 pMYDA---------AQALKTNPekTEEALQKIENYL 665
Cdd:COG5238   328 -AYNGigaqgaialAKALQENT--TLHSLDLSDNQI 360
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 229-373 2.38e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 72.77  E-value: 2.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  229 KLSTDVCEQILRVVSRSNRLEELVLENAGLRIDFAQKLAGALAHNPNsgLHTINLAGNSLEDRGVSSLSIQFAKLPKgLK 308
Cdd:cd00116   148 RLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCN--LEVLDLNNNGLTDEGASALAETLASLKS-LE 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568981960  309 HLNLSKTSLSPKGVNSLCqslSANPLTASTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLS 373
Cdd:cd00116   225 VLNLGDNNLTDAGAAALA---SALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLR 286
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 281-599 3.25e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 72.39  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  281 INLAGNSLEDRGVSSLSiQFAKLPKGLKHLNLS--KTSLSPKGVNSLCQSLSANPLtastLTHLDLSGNALrGDDLSHMY 358
Cdd:cd00116    28 LRLEGNTLGEEAAKALA-SALRPQPSLKELCLSlnETGRIPRGLQSLLQGLTKGCG----LQELDLSDNAL-GPDGCGVL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  359 NFLAQPNTIVHLDLSNteCSLE-----MVCSALLRgcLQC-LAVLNLSRSVFSHRKGKEVppsfKQFFSSSLALIQINLS 432
Cdd:cd00116   102 ESLLRSSSLQELKLNN--NGLGdrglrLLAKGLKD--LPPaLEKLVLGRNRLEGASCEAL----AKALRANRDLKELNLA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  433 GTKLSPEPLKALLLGLACNHSLKgvSLDLSNCelghCLRSGGAQVLEGCIAEIHNITSLDISDNGLesdlstlivwlsKN 512
Cdd:cd00116   174 NNGIGDAGIRALAEGLKANCNLE--VLDLNNN----GLTDEGASALAETLASLKSLEVLNLGDNNL------------TD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  513 RSIQHLALGknfnnMKSKNLTpvldnlvqmiqdedspLQSLSLADSKLKAE-VTIIINALGSNTSLTKVDISGNGMGDMG 591
Cdd:cd00116   236 AGAAALASA-----LLSPNIS----------------LLTLSLSCNDITDDgAKDLAEVLAEKESLLELDLRGNKFGEEG 294


                  ....*...
gi 568981960  592 AKMLAKAL 599
Cdd:cd00116   295 AQLLAESL 302
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 221-400 5.23e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 71.62  E-value: 5.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  221 TKLSSKDLKLSTDVCeQILRVVSRSNRLEELVLENAGLRIDFAQKLAGALAHNPnSGLHTINLAGNSLEDRGVSSLSIQF 300
Cdd:cd00116    84 QELDLSDNALGPDGC-GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLP-PALEKLVLGRNRLEGASCEALAKAL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  301 AKLPKgLKHLNLSKTSLSPKGVNSLCQSLSANPLtastLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLSNTECSLE 380
Cdd:cd00116   162 RANRD-LKELNLANNGIGDAGIRALAEGLKANCN----LEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDA 236

                         170       180
                  ....*....|....*....|...
gi 568981960  381 ---MVCSALLRGcLQCLAVLNLS 400
Cdd:cd00116   237 gaaALASALLSP-NISLLTLSLS 258
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 248-355 7.21e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 68.15  E-value: 7.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  248 LEELVLENAGLRIDFAQKLAGALAHNPNsgLHTINLAGNSLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQ 327
Cdd:cd00116   195 LEVLDLNNNGLTDEGASALAETLASLKS--LEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAE 272

                          90       100       110
                  ....*....|....*....|....*....|
gi 568981960  328 SLSANPltasTLTHLDLSGNAL--RGDDLS 355
Cdd:cd00116   273 VLAEKE----SLLELDLRGNKFgeEGAQLL 298
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
294-663 7.00e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 7.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  294 SSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNalrgddlshmyNFLAQPNTIVHLDLS 373
Cdd:COG4886    53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----------EELSNLTNLESLDLS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  374 NTEcsLEMVCSALLRgcLQCLAVLNLSRSVFShrkgkEVPPSFKQFfsssLALIQINLSGTKLS--PEPLKALllglacn 451
Cdd:COG4886   122 GNQ--LTDLPEELAN--LTNLKELDLSNNQLT-----DLPEPLGNL----TNLKSLDLSNNQLTdlPEELGNL------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  452 HSLKgvSLDLSNCELghclrsggaQVLEGCIAEIHNITSLDISDNglesDLSTLIVWLSKNRSIQHLALGKNfnnmkskN 531
Cdd:COG4886   182 TNLK--ELDLSNNQI---------TDLPEPLGNLTNLEELDLSGN----QLTDLPEPLANLTNLETLDLSNN-------Q 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  532 LT--PVLDNLVQmiqdedspLQSLSLADSKLKAevtiiINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVI 609
Cdd:COG4886   240 LTdlPELGNLTN--------LEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568981960  610 WDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDAAQALKTNPEKTEEALQKIEN 663
Cdd:COG4886   307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 280-624 8.35e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 65.07  E-value: 8.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  280 TINLAGNSLEDRGVSSLsiqFAKLPKgLKHLNLSKTSLSPKGVNSLCQSLSANPltasTLTHLDLSGNALRGDD---LSH 356
Cdd:cd00116     2 QLSLKGELLKTERATEL---LPKLLC-LQVLRLEGNTLGEEAAKALASALRPQP----SLKELCLSLNETGRIPrglQSL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  357 MYNFLAQPNtIVHLDLSNteCSLEMVCSALLRGCLQ--CLAVLNLSRSVFSHRKGKEVPPSFKqffSSSLALIQINLSGT 434
Cdd:cd00116    74 LQGLTKGCG-LQELDLSD--NALGPDGCGVLESLLRssSLQELKLNNNGLGDRGLRLLAKGLK---DLPPALEKLVLGRN 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  435 KLSPEPLKALLLGLACNHSLKgvSLDLSNCELGHclrsGGAQVLEGCIAEIHNITSLDISDNGLE----SDLSTLivwLS 510
Cdd:cd00116   148 RLEGASCEALAKALRANRDLK--ELNLANNGIGD----AGIRALAEGLKANCNLEVLDLNNNGLTdegaSALAET---LA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  511 KNRSIQHLALGKNfnnmkskNLTpvldnlvqmiqdeDSPLQSLSLADSKLkaevtiiinalgsNTSLTKVDISGNGMGDM 590
Cdd:cd00116   219 SLKSLEVLNLGDN-------NLT-------------DAGAAALASALLSP-------------NISLLTLSLSCNDITDD 265

                         330       340       350
                  ....*....|....*....|....*....|....
gi 568981960  591 GAKMLAKALQINTKLRTVIWDKNNITAQGFQDIA 624
Cdd:cd00116   266 GAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 417-634 3.15e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.14  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  417 KQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKgvSLDLSNCELGHCLRsgGAQVLEGCIAEIHNITSLDISDN 496
Cdd:cd00116    16 TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLK--ELCLSLNETGRIPR--GLQSLLQGLTKGCGLQELDLSDN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  497 GLESDLSTLIVWLSKNRSIQHL-----ALGKNFNNMKSKNLTPVldnlvqmiqdeDSPLQSLSLADSKLKAEVTI-IINA 570
Cdd:cd00116    92 ALGPDGCGVLESLLRSSSLQELklnnnGLGDRGLRLLAKGLKDL-----------PPALEKLVLGRNRLEGASCEaLAKA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981960  571 LGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLR 634
Cdd:cd00116   161 LRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLE 224
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 244-352 2.07e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 61.34  E-value: 2.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  244 RSNRLEELVLENAGLRIDFAQKLAGALAHNPNsgLHTINLAGNSLEDRGVSSLsIQFAKLPKGLKHLNLSKTSLSPKGVN 323
Cdd:COG5238   318 GNKTLHTLNLAYNGIGAQGAIALAKALQENTT--LHSLDLSDNQIGDEGAIAL-AKYLEGNTTLRELNLGKNNIGKQGAE 394

                          90       100
                  ....*....|....*....|....*....
gi 568981960  324 SLCQSLSANpltasTLTHLDLSGNALRGD 352
Cdd:COG5238   395 ALIDALQTN-----RLHTLILDGNLIGAE 418
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 217-479 2.53e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 61.34  E-value: 2.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  217 NQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRIDFAQKLAGALAHNPNsgLHTINLAGNSLEDRGVSSL 296
Cdd:COG5238   179 NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS--LTTLDLSNNQIGDEGVIAL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  297 sIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPltasTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLSNte 376
Cdd:COG5238   257 -AEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNT----TLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAY-- 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960  377 CSLEMVCSALLRGCLQC---LAVLNLSrsvfSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNhs 453
Cdd:COG5238   330 NGIGAQGAIALAKALQEnttLHSLDLS----DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-- 403

                         250       260
                  ....*....|....*....|....*.
gi 568981960  454 lKGVSLDLSNCELGHCLRSGGAQVLE 479
Cdd:COG5238   404 -RLHTLILDGNLIGAEAQQRLEQLLE 428
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 1113-1318 2.93e-05

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 47.55  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1113 IKAAEHNGAPDrtEEIktpEPLEEGPAEEAGRaersdsrgspqggrrYVQvmgsgllAEMKAKqerrAACAQKKLGNDVI 1192
Cdd:PHA02682   34 IPAPAAPCPPD--ADV---DPLDKYSVKEAGR---------------YYQ-------SRLKAN----SACMQRPSGQSPL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1193 SQDPSSPV------SCNTERLEGGATVPKLQPGLPEARFGSGTPEKNAKAEPRVDGGCRSRSSSSMPTSPKPllqSPKPS 1266
Cdd:PHA02682   83 APSPACAApapacpACAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLP---TPKPA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568981960 1267 PSARPSIPQKprTASRPEDTPDSPSGPSSPKVAllPPILKKVSSDKERDGQN 1318
Cdd:PHA02682  160 PAAKPIFLHN--QLPPPDYPAASCPTIETAPAA--SPVLEPRIPDKIIDADN 207
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1001-1389 3.37e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1001 QPTQAAVCTISILPQD---GEQNGLMGRVDEGVDEFFTkkVTKMDCKRSssRSSDAHELGEGDEKKKRDSRrsgflnliK 1077
Cdd:PHA03307   19 EFFPRPPATPGDAADDllsGSQGQLVSDSAELAAVTVV--AGAAACDRF--EPPTGPPPGPGTEAPANESR--------S 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1078 SRSRSERPPTVLMTEELSSPKGAMRSPPVDTTRKEIKAA-EHNGAPDRTEEIKTPEPLEEGP------AEEAGRAERSDS 1150
Cdd:PHA03307   87 TPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASpPPSPAPDLSEMLRPVGSPGPPPaasppaAGASPAAVASDA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1151 RGSPQG------GRRYVQVMGSGLlAEMKAKQERRAACAQKKLGNDVISQDPSSPVSCNTERLEGGAtVPKLQPGLPEAR 1224
Cdd:PHA03307  167 ASSRQAalplssPEETARAPSSPP-AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDA-GASSSDSSSSES 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1225 FGSGTPEKNAKAEPRvdggcrsrssSSMPTSPKPLLQSPKPSPSARPSIPQKPRTASRPEDTPDSPSGPSSPKVALLPPI 1304
Cdd:PHA03307  245 SGCGWGPENECPLPR----------PAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRA 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1305 LKKVSSDKErDGQNSSQSSPRSFSQEVVQRGDYFKRHSDHDSGKPSSRGKRSSKlyfaiAEEEANAPGYRKSQPTNASRR 1384
Cdd:PHA03307  315 SSSSSSSRE-SSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRK-----RPRPSRAPSSPAASAGRPTRR 388


                  ....*
gi 568981960 1385 SWGPA 1389
Cdd:PHA03307  389 RARAA 393
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1058-1420 4.44e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.60  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1058 EGDEKKKRDSRRSgflnliKSRSRSERPPTVLMTEELSSPKGAMRSPP--VDTTRKEIKAAEHNGAPDRTEEIKTPE-PL 1134
Cdd:PTZ00449  528 EGEEGEHEDSKES------DEPKEGGKPGETKEGEVGKKPGPAKEHKPskIPTLSKKPEFPKDPKHPKDPEEPKKPKrPR 601

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1135 EegpaeeagrAERSDSRGSPQggRRYVQVMGSGLLAEMKAKQERRAACAQKKlgndVISQDPSSPVSCNTERLEGGATVP 1214
Cdd:PTZ00449  602 S---------AQRPTRPKSPK--LPELLDIPKSPKRPESPKSPKRPPPPQRP----SSPERPEGPKIIKSPKPPKSPKPP 666

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1215 kLQPGLPEARFGS----GTPEKNAKAEPRVDGGCRSRSSSSMPTSPKPLLQSPKPSPSARPSIPQKPRTASRPEDTPDSP 1290
Cdd:PTZ00449  667 -FDPKFKEKFYDDyldaAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPD 745

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981960 1291 SGPSspkvaLLPPILKKV-----SSDKERDG------QNSSQSSPRSFSQEVVQRGDYFKRHSDHDSGK-PS--SRGKRS 1356
Cdd:PTZ00449  746 DIEF-----FTPPEEERTffhetPADTPLPDilaeefKEEDIHAETGEPDEAMKRPDSPSEHEDKPPGDhPSlpKKRHRL 820

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568981960 1357 SKLYFAIAEEEanapgyrksqpTNASRRSWGPAQEYQEQKQRSSGKD-------GHQGSKCS-----DSGEEAEKE 1420
Cdd:PTZ00449  821 DGLALSTTDLE-----------SDAGRIAKDASGKIVKLKRSKSFDDlttveeaEEMGAEARkivvdDDGTEADDE 885
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH