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Conserved domains on  [gi|568968831|ref|XP_006514318|]
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glycosyltransferase 8 domain-containing protein 2 isoform X1 [Mus musculus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 71-338 6.98e-66

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06429:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 257  Bit Score: 208.78  E-value: 6.98e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  71 INSIYSNTD-ANLVFYVVGLRSTLPRIRKWIEHSKLREINFKIVEFNPTVLKGKIRPDS---------------SRPELL 134
Cdd:cd06429   18 NSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmqleseadtsnlkqRKPEYI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 135 QPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdihrlvglqntymgyldyrkk 214
Cdd:cd06429   98 SLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------------------------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 215 tikdlgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPMLIVFHGKYSTINPLWHIRH 294
Cdd:cd06429  149 ------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGLIVFYGLTSPLDPSWHVRG 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568968831 295 LGWNPDARysEHFLQEAKLLHWNGRHKPWDFPSVHN--DLWESWFV 338
Cdd:cd06429  214 LGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPSykELWEKYLS 257
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 71-338 6.98e-66

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 208.78  E-value: 6.98e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  71 INSIYSNTD-ANLVFYVVGLRSTLPRIRKWIEHSKLREINFKIVEFNPTVLKGKIRPDS---------------SRPELL 134
Cdd:cd06429   18 NSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmqleseadtsnlkqRKPEYI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 135 QPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdihrlvglqntymgyldyrkk 214
Cdd:cd06429   98 SLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------------------------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 215 tikdlgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPMLIVFHGKYSTINPLWHIRH 294
Cdd:cd06429  149 ------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGLIVFYGLTSPLDPSWHVRG 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568968831 295 LGWNPDARysEHFLQEAKLLHWNGRHKPWDFPSVHN--DLWESWFV 338
Cdd:cd06429  214 LGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPSykELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 71-323 2.72e-40

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 142.46  E-value: 2.72e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831   71 INSIYSNT-DANLVFYVVGLRSTLPRIRKWIEHSKLREINFKIVEFNPTVLKGKIRPDSSRPELLQPLNFVRFYLPLLVH 149
Cdd:pfam01501  18 IKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPKYWSLLNYLRLYLPDLFP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  150 QHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDcdlpsaqdihrlvglqnTYMGYLDYRKKTIKDLGISPSTCSFN 229
Cdd:pfam01501  98 KLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNFSEPIILENFGPPACYFN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  230 PGVIVANMTEWKHQRITKQLEKWMqkNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEHFLQ 309
Cdd:pfam01501 160 AGMLLFDLDAWRKENITERYIKWL--NLNENRTLWKLG---DQDPLNIVFYGKVKPLDPRWNVLGLGYYNKKKSLNEITE 234

                         250
                  ....*....|....
gi 568968831  310 EAKLLHWNGRHKPW 323
Cdd:pfam01501 235 NAAVIHYNGPTKPW 248
PLN02659 PLN02659
Probable galacturonosyltransferase
 103-336 3.00e-25

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 106.27  E-value: 3.00e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 103 SKLREINFKIVEFN---PTVLKGKIRPDSsrPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGH 179
Cdd:PLN02659 295 SQFRGGSSAIVANNtekPHVIAAKLQALS--PKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GK 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 180 AAAFSDDCdlpSAQDihRLVgLQNTYMGYLDYRKKTIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEE 259
Cdd:PLN02659 372 VNGAVETC---RGED--KFV-MSKKLKSYLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKS 444

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 260 NLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW---DFPSVHnDLWESW 336
Cdd:PLN02659 445 DLSLWQLG---TLPPGLIAFHGHVHVIDPFWHMLGLGYQENTSLAD--AESAGVVHFNGRAKPWldiAFPQLR-PLWAKY 518
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 73-333 2.15e-22

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 95.43  E-value: 2.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  73 SIYS----NTDANLVFYVVGLRSTLPRIRKWIEHSKLREINFKIVEFNPTVLKgKIRPDSSRPellqPLNFVRFYLP-LL 147
Cdd:COG1442   23 SIASllenNPDRPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVDDELLK-DLPVSKHIS----KATYYRLLIPeLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 148 VHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSaqdihrlvglqntymgyldYRKKTIKDLGISPSTCS 227
Cdd:COG1442   98 PDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG-------------------SQKKRAKRLGLPDDDGY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 228 FNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssslgggvatsP----MLIVFHGKYSTINPLW-----HIRHLGWN 298
Cdd:COG1442  158 FNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGGKVKFLPPRYnyqysLYYELKDK 226

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568968831 299 PDARYSEHFLQEAKLLHWNGRHKPWDFPSVHN--DLW 333
Cdd:COG1442  227 SNKKELLEARKNPVIIHYTGPTKPWHKWCTHPyaDLY 263
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 71-338 6.98e-66

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 208.78  E-value: 6.98e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  71 INSIYSNTD-ANLVFYVVGLRSTLPRIRKWIEHSKLREINFKIVEFNPTVLKGKIRPDS---------------SRPELL 134
Cdd:cd06429   18 NSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmqleseadtsnlkqRKPEYI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 135 QPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdihrlvglqntymgyldyrkk 214
Cdd:cd06429   98 SLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------------------------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 215 tikdlgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPMLIVFHGKYSTINPLWHIRH 294
Cdd:cd06429  149 ------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGLIVFYGLTSPLDPSWHVRG 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568968831 295 LGWNPDARysEHFLQEAKLLHWNGRHKPWDFPSVHN--DLWESWFV 338
Cdd:cd06429  214 LGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPSykELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 71-323 2.72e-40

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 142.46  E-value: 2.72e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831   71 INSIYSNT-DANLVFYVVGLRSTLPRIRKWIEHSKLREINFKIVEFNPTVLKGKIRPDSSRPELLQPLNFVRFYLPLLVH 149
Cdd:pfam01501  18 IKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPKYWSLLNYLRLYLPDLFP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  150 QHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDcdlpsaqdihrlvglqnTYMGYLDYRKKTIKDLGISPSTCSFN 229
Cdd:pfam01501  98 KLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNFSEPIILENFGPPACYFN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  230 PGVIVANMTEWKHQRITKQLEKWMqkNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEHFLQ 309
Cdd:pfam01501 160 AGMLLFDLDAWRKENITERYIKWL--NLNENRTLWKLG---DQDPLNIVFYGKVKPLDPRWNVLGLGYYNKKKSLNEITE 234

                         250
                  ....*....|....
gi 568968831  310 EAKLLHWNGRHKPW 323
Cdd:pfam01501 235 NAAVIHYNGPTKPW 248
Glyco_transf_8 cd00505
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ...
 72-324 1.96e-33

Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.


Pssm-ID: 132996 [Multi-domain]  Cd Length: 246  Bit Score: 124.09  E-value: 1.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  72 NSIYSNTDANLVFYVVGLRsTLPRIRKWIEHskLREINFKIVEFNPTVLKGKIRPDS-SRPELlqPLNFVRFYLPLLVHQ 150
Cdd:cd00505   21 KSVLRHRTKPLRFHVLTNP-LSDTFKAALDN--LRKLYNFNYELIPVDILDSVDSEHlKRPIK--IVTLTKLHLPNLVPD 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 151 HEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDlpsaqdihrlvglqnTYMGYLDYRKKTIKDLgispsTCSFNP 230
Cdd:cd00505   96 YDKILYVDADILVLTDIDELWDTPLGGQELAAAPDPGD---------------RREGKYYRQKRSHLAG-----PDYFNS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 231 GVIVANMTEW-KHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHgkystINPLWHIRHLGWNPDARYSEHFLQ 309
Cdd:cd00505  156 GVFVVNLSKErRNQLLKVALEKWLQSLSSLSGGDQDLLNTFFKQVPFIVKS-----LPCIWNVRLTGCYRSLNCFKAFVK 230

                        250
                 ....*....|....*
gi 568968831 310 EAKLLHWNGRHKPWD 324
Cdd:cd00505  231 NAKVIHFNGPTKPWN 245
PLN02659 PLN02659
Probable galacturonosyltransferase
 103-336 3.00e-25

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 106.27  E-value: 3.00e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 103 SKLREINFKIVEFN---PTVLKGKIRPDSsrPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGH 179
Cdd:PLN02659 295 SQFRGGSSAIVANNtekPHVIAAKLQALS--PKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GK 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 180 AAAFSDDCdlpSAQDihRLVgLQNTYMGYLDYRKKTIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEE 259
Cdd:PLN02659 372 VNGAVETC---RGED--KFV-MSKKLKSYLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKS 444

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 260 NLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW---DFPSVHnDLWESW 336
Cdd:PLN02659 445 DLSLWQLG---TLPPGLIAFHGHVHVIDPFWHMLGLGYQENTSLAD--AESAGVVHFNGRAKPWldiAFPQLR-PLWAKY 518
PLN02742 PLN02742
Probable galacturonosyltransferase
 71-323 1.56e-22

Probable galacturonosyltransferase


Pssm-ID: 215395 [Multi-domain]  Cd Length: 534  Bit Score: 98.31  E-value: 1.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  71 INSIYSNTDA--NLVFYVVGLRSTLPRIRKWIEHSKLR----EINfKIVEF---NPT---VLK----------------- 121
Cdd:PLN02742 244 VNSTVSNAKHpdQLVFHLVTDEVNYGAMQAWFAMNDFKgvtvEVQ-KIEEFswlNASyvpVLKqlqdsdtqsyyfsgsqd 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 122 -GKIRPDSSRPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsAQDIHRlvg 200
Cdd:PLN02742 323 dGKTEIKFRNPKYLSMLNHLRFYIPEIYPALEKVVFLDDDVVVQKDLTPLFSIDLH-GNVNGAVETC----LETFHR--- 394

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 201 lqntYMGYLDYRKKTIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFH 280
Cdd:PLN02742 395 ----YHKYLNFSHPLISS-HFDPDACGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVDRTLW--KLG---TLPPGLLTFY 464

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568968831 281 GKYSTINPLWHIRHLGWNPDArySEHFLQEAKLLHWNGRHKPW 323
Cdd:PLN02742 465 GLTEPLDRRWHVLGLGYDTNI--DPRLIESAAVLHFNGNMKPW 505
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 73-333 2.15e-22

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 95.43  E-value: 2.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  73 SIYS----NTDANLVFYVVGLRSTLPRIRKWIEHSKLREINFKIVEFNPTVLKgKIRPDSSRPellqPLNFVRFYLP-LL 147
Cdd:COG1442   23 SIASllenNPDRPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVDDELLK-DLPVSKHIS----KATYYRLLIPeLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 148 VHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSaqdihrlvglqntymgyldYRKKTIKDLGISPSTCS 227
Cdd:COG1442   98 PDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG-------------------SQKKRAKRLGLPDDDGY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 228 FNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssslgggvatsP----MLIVFHGKYSTINPLW-----HIRHLGWN 298
Cdd:COG1442  158 FNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGGKVKFLPPRYnyqysLYYELKDK 226

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568968831 299 PDARYSEHFLQEAKLLHWNGRHKPWDFPSVHN--DLW 333
Cdd:COG1442  227 SNKKELLEARKNPVIIHYTGPTKPWHKWCTHPyaDLY 263
PLN02870 PLN02870
Probable galacturonosyltransferase
 114-323 3.21e-21

Probable galacturonosyltransferase


Pssm-ID: 215468 [Multi-domain]  Cd Length: 533  Bit Score: 94.62  E-value: 3.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 114 EFNPTVLKGKIRPDSsrPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpSAQ 193
Cdd:PLN02870 308 ETTPRTFASKLQARS--PKYISLLNHLRIYLPELFPNLDKVVFLDDDVVIQRDLSPLWDIDLG-GKVNGAVETC---RGE 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 194 DIHRlvgLQNTYMGYLDYRKKTIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATS 273
Cdd:PLN02870 382 DEWV---MSKRFRNYFNFSHPLIAK-NLDPEECAWAYGMNIFDLRAWRKTNIRETYHSWLKENLKSNLTMWKLG---TLP 454

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568968831 274 PMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 323
Cdd:PLN02870 455 PALIAFKGHVHPIDPSWHMLGLGYQSKTNIES--VKKAAVIHYNGQSKPW 502
PLN02523 PLN02523
galacturonosyltransferase
 91-323 5.56e-20

galacturonosyltransferase


Pssm-ID: 215286 [Multi-domain]  Cd Length: 559  Bit Score: 91.09  E-value: 5.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  91 STLPRIRKwIEHSKLREINFKIVEFNPTvlKGKIRPDSSRPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQEL 170
Cdd:PLN02523 320 SYVPVLRQ-LESANLQKFYFENKLENAT--KDSSNMKFRNPKYLSMLNHLRFYLPEMYPKLHRILFLDDDVVVQKDLTGL 396

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 171 YDTTLAlGHAAAFSDDCdlpsAQDIHRlvglqntYMGYLDYRKKTIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLE 250
Cdd:PLN02523 397 WKIDMD-GKVNGAVETC----FGSFHR-------YAQYLNFSHPLIKE-KFNPKACAWAYGMNIFDLDAWRREKCTEQYH 463

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568968831 251 KWMQKNVEENLYssSLGggvATSPMLIVFhgkYSTINPL---WHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 323
Cdd:PLN02523 464 YWQNLNENRTLW--KLG---TLPPGLITF---YSTTKPLdksWHVLGLGYNPSISMDE--IRNAAVIHFNGNMKPW 529
PLN02829 PLN02829
Probable galacturonosyltransferase
 131-323 3.46e-19

Probable galacturonosyltransferase


Pssm-ID: 215443 [Multi-domain]  Cd Length: 639  Bit Score: 88.75  E-value: 3.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 131 PELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsAQDIHRlvglqntYMGYLD 210
Cdd:PLN02829 437 PKYLSILNHLRFYLPEIFPKLNKVLFLDDDIVVQKDLTGLWSIDLK-GNVNGAVETC----GESFHR-------FDRYLN 504

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 211 YRKKTIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLW 290
Cdd:PLN02829 505 FSNPLISK-NFDPHACGWAYGMNVFDLDEWKRQNITEVYHSWQKLNHDRQLW--KLG---TLPPGLITFWKRTYPLDRSW 578

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568968831 291 HIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 323
Cdd:PLN02829 579 HVLGLGYNPNVNQRD--IERAAVIHYNGNMKPW 609
PLN02910 PLN02910
polygalacturonate 4-alpha-galacturonosyltransferase
 89-323 6.45e-19

polygalacturonate 4-alpha-galacturonosyltransferase


Pssm-ID: 215493 [Multi-domain]  Cd Length: 657  Bit Score: 88.08  E-value: 6.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  89 LRSTLPRIRKWIEHSKLREINFKiVEFNPTVLKGKIRPDSSRPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQ 168
Cdd:PLN02910 414 LNSSYCSVLRQLESARIKEYYFK-ANHPSSLSAGADNLKYRNPKYLSMLNHLRFYLPEVYPKLEKILFLDDDIVVQKDLT 492

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 169 ELYDTTLAlGHAAAFSDDCDlpsaQDIHRlvglqntYMGYLDYRKKTIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQ 248
Cdd:PLN02910 493 PLWSIDMQ-GMVNGAVETCK----ESFHR-------FDKYLNFSNPKISE-NFDPNACGWAFGMNMFDLKEWRKRNITGI 559

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568968831 249 LEKWMQKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 323
Cdd:PLN02910 560 YHYWQDLNEDRTLW--KLG---SLPPGLITFYNLTYPLDRSWHVLGLGYDPALNQTE--IENAAVVHYNGNYKPW 627
GT8_A4GalT_like cd04194
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ...
 139-325 9.89e-19

A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.


Pssm-ID: 133037 [Multi-domain]  Cd Length: 248  Bit Score: 84.19  E-value: 9.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 139 FVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsaqdihrlvglqntymgYLDYRKKTIKD 218
Cdd:cd04194   84 YYRLLIPDLLPDYDKVLYLDADIIVLGDLSELFDIDLG-DNLLAAVRDP--------------------FIEQEKKRKRR 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 219 LGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssslgggvatsP----MLIVFHGKYSTINPLW--HI 292
Cdd:cd04194  143 LGGYDDGSYFNSGVLLINLKKWREENITEKLLELIKEYGGRLIY-----------PdqdiLNAVLKDKILYLPPRYnfQT 211

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 568968831 293 RHLGWNPDARYSEHFLQEA----KLLHWNGRHKPWDF 325
Cdd:cd04194  212 GFYYLLKKKSKEEQELEEArknpVIIHYTGSDKPWNK 248
PLN02867 PLN02867
Probable galacturonosyltransferase
 131-333 1.10e-18

Probable galacturonosyltransferase


Pssm-ID: 178458 [Multi-domain]  Cd Length: 535  Bit Score: 86.88  E-value: 1.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 131 PELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSD----DCDLPSAQdihrlvglqntYM 206
Cdd:PLN02867 325 PSCLSLLNHLRIYIPELFPDLNKIVFLDDDVVVQHDLSSLWELDLNGKVVGAVVDswcgDNCCPGRK-----------YK 393

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 207 GYLDYRKKTIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATSPMLIVFHGKYSTI 286
Cdd:PLN02867 394 DYLNFSHPLISS-NLDQERCAWLYGMNVFDLKAWRRTNITEAYHKWLKLSLNSGLQLWQPG---ALPPALLAFKGHVHPI 469

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568968831 287 NPLWHIRHLGWNPdARYSEHFLQEAKLLHWNGRHKPW---DFPSVHNdLW 333
Cdd:PLN02867 470 DPSWHVAGLGSRP-PEVPREILESAAVLHFSGPAKPWleiGFPEVRS-LW 517
PLN02718 PLN02718
Probable galacturonosyltransferase
 71-323 5.82e-15

Probable galacturonosyltransferase


Pssm-ID: 178320 [Multi-domain]  Cd Length: 603  Bit Score: 75.70  E-value: 5.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831  71 INSIYSNTD--ANLVFYVVGLRSTLPRIRKW----------IEHSKLREINFKIVEFNPTVLKgkirPDSSRPELLQPLN 138
Cdd:PLN02718 330 VNSTISSSKepEKIVFHVVTDSLNYPAISMWfllnppgkatIQILNIDDMNVLPADYNSLLMK----QNSHDPRYISALN 405

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 139 FVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDC--DLPSAQDIHRLVGLQNTYMGyldyrKKti 216
Cdd:PLN02718 406 HARFYLPDIFPGLNKIVLFDHDVVVQRDLSRLWSLDMK-GKVVGAVETCleGEPSFRSMDTFINFSDPWVA-----KK-- 477

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 217 kdlgISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSS-SLGGGVATspmlivFHGKYSTINPLWHIRHL 295
Cdd:PLN02718 478 ----FDPKACTWAFGMNLFDLEEWRRQKLTSVYHKYLQLGVKRPLWKAgSLPIGWLT------FYNQTVALDKRWHVLGL 547

                        250       260
                 ....*....|....*....|....*...
gi 568968831 296 GWNPDARYSEhfLQEAKLLHWNGRHKPW 323
Cdd:PLN02718 548 GHESGVGASD--IEQAAVIHYDGVMKPW 573
PLN02769 PLN02769
Probable galacturonosyltransferase
 142-323 5.40e-09

Probable galacturonosyltransferase


Pssm-ID: 215412 [Multi-domain]  Cd Length: 629  Bit Score: 57.40  E-value: 5.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 142 FYLPLLVHQHEKVIYLDDDVIVQGDIQELYDttLALGH----AAAFsddCDLpsaqdihRLVGLQNtYMGyldyrkKTIK 217
Cdd:PLN02769 443 FLLPEIFKKLKKVVVLDDDVVVQRDLSFLWN--LDMGGkvngAVQF---CGV-------RLGQLKN-YLG------DTNF 503

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 218 DlgisPSTCSFNPGVIVANMTEWKHQRITK---QLEKWMQKNVEENLyssslgGGVATSPMLIVFHgkySTINPL---WH 291
Cdd:PLN02769 504 D----TNSCAWMSGLNVIDLDKWRELDVTEtylKLLQKFSKDGEESL------RAAALPASLLTFQ---DLIYPLddrWV 570

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568968831 292 IRHLGWnpDARYSEHFLQEAKLLHWNGRHKPW 323
Cdd:PLN02769 571 LSGLGH--DYGIDEQAIKKAAVLHYNGNMKPW 600
PRK15171 PRK15171
lipopolysaccharide 3-alpha-galactosyltransferase;
148-248 5.77e-06

lipopolysaccharide 3-alpha-galactosyltransferase;


Pssm-ID: 185093 [Multi-domain]  Cd Length: 334  Bit Score: 47.44  E-value: 5.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968831 148 VHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLPSAQDihRLVGLQNTYM--GYldyrkktikdlgispst 225
Cdd:PRK15171 118 IDKTDKVLYLDADIACKGSIKELIDLDFAENEIAAVVAEGDAEWWSK--RAQSLQTPGLasGY----------------- 178

                         90       100
                 ....*....|....*....|...
gi 568968831 226 csFNPGVIVANMTEWKHQRITKQ 248
Cdd:PRK15171 179 --FNSGFLLINIPAWAQENISAK 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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