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Conserved domains on  [gi|568963127|ref|XP_006511874|]
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transcriptional regulator QRICH1 isoform X1 [Mus musculus]

Protein Classification

CARD and DUF3504 domain-containing protein( domain architecture ID 10109286)

CARD and DUF3504 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 600-760 6.40e-83

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


:

Pssm-ID: 463430  Cd Length: 162  Bit Score: 261.05  E-value: 6.40e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568963127  600 LPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKspsNPKDKSTSIRYLKALGI-- 677
Cdd:pfam12012   1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKP---NPREKSTYLRYYEPPDQve 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568963127  678 HQTGQKVTDD--MYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML 755
Cdd:pfam12012  78 TGGRKKRDEGvnKVVEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRNTLESML 157


                  ....*
gi 568963127  756 TRILV 760
Cdd:pfam12012 158 TRILL 162
CARD cd01671
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase ...
 6-45 3.54e-03

Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


:

Pssm-ID: 260018 [Multi-domain]  Cd Length: 79  Bit Score: 37.11  E-value: 3.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568963127   6 ENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEF 45
Cdd:cd01671   24 KGVLTEEDKEEILSEKTRQDKARKLLDILPRRGPKAFEVF 63
 
Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 600-760 6.40e-83

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 261.05  E-value: 6.40e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568963127  600 LPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKspsNPKDKSTSIRYLKALGI-- 677
Cdd:pfam12012   1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKP---NPREKSTYLRYYEPPDQve 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568963127  678 HQTGQKVTDD--MYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML 755
Cdd:pfam12012  78 TGGRKKRDEGvnKVVEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRNTLESML 157


                  ....*
gi 568963127  756 TRILV 760
Cdd:pfam12012 158 TRILL 162
CARD cd01671
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase ...
 6-45 3.54e-03

Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260018 [Multi-domain]  Cd Length: 79  Bit Score: 37.11  E-value: 3.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568963127   6 ENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEF 45
Cdd:cd01671   24 KGVLTEEDKEEILSEKTRQDKARKLLDILPRRGPKAFEVF 63
 
Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 600-760 6.40e-83

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 261.05  E-value: 6.40e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568963127  600 LPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKspsNPKDKSTSIRYLKALGI-- 677
Cdd:pfam12012   1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKP---NPREKSTYLRYYEPPDQve 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568963127  678 HQTGQKVTDD--MYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML 755
Cdd:pfam12012  78 TGGRKKRDEGvnKVVEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRNTLESML 157


                  ....*
gi 568963127  756 TRILV 760
Cdd:pfam12012 158 TRILL 162
CARD cd01671
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase ...
 6-45 3.54e-03

Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260018 [Multi-domain]  Cd Length: 79  Bit Score: 37.11  E-value: 3.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568963127   6 ENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEF 45
Cdd:cd01671   24 KGVLTEEDKEEILSEKTRQDKARKLLDILPRRGPKAFEVF 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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