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Conserved domains on  [gi|568959923|ref|XP_006510600|]
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spliceosome-associated protein CWC15 homolog isoform X1 [Mus musculus]

Protein Classification

spliceosome-associated CWC15 family protein( domain architecture ID 12059005)

spliceosome-associated CWC15 family protein is important for spliceosomal activation and cell viability; it forms a heterodimer with CTNNBL1 which is required to maintain normal levels of the Prp19 complex and to facilitate the interaction of CWC15 with CDC5L

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cwf_Cwc_15 pfam04889
Cwf15/Cwc15 cell cycle control protein; This family represents Cwf15/Cwc15 (from ...
 1-228 2.63e-73

Cwf15/Cwc15 cell cycle control protein; This family represents Cwf15/Cwc15 (from Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively) and their homologs. The function of these proteins is unknown, but they form part of the spliceosome and are thus thought to be involved in mRNA splicing.


:

Pssm-ID: 428176 [Multi-domain]  Cd Length: 244  Bit Score: 222.52  E-value: 2.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959923    1 MTTAARPTFEPARGGRgkgegDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDF-----------RRELEERERA 69
Cdd:pfam04889   1 MTTAHRPTWDPARGKE-----ALRGPSRQYSSRDLPAHTKLKFRQPGQGTEAELEKRDLraeleeaeaahFAKKRGGAGL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959923   70 AARDKNRDRPTREHTTSSSVSKKPRLDQIP-AANLDADDPLTDEEDEDFEEESDDDD------------TAALLAELEKI 136
Cdd:pfam04889  76 LAPEDPAIGAAEGDEDDEEEAKRRRLEILEeTREIDADDDDDDDSDDDEDSESDDDDdsdsdddddedeTAELLRELEKI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959923  137 KKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTgpSQPQANFKVKRRWDDDVVFKNCAKGIDDQKKdKRFVNDTLR 216
Cdd:pfam04889 156 KRERAEEKAREERERAAEEEEQREEEIATGNPLLNLE--SGQSGDFTVKRRWDDDVVFKNQARGEEDKGK-KRFVNDLLR 232

                         250
                  ....*....|..
gi 568959923  217 SEFHKKFMEKYI 228
Cdd:pfam04889 233 SDFHKKFMNKYI 244
 
Name Accession Description Interval E-value
Cwf_Cwc_15 pfam04889
Cwf15/Cwc15 cell cycle control protein; This family represents Cwf15/Cwc15 (from ...
 1-228 2.63e-73

Cwf15/Cwc15 cell cycle control protein; This family represents Cwf15/Cwc15 (from Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively) and their homologs. The function of these proteins is unknown, but they form part of the spliceosome and are thus thought to be involved in mRNA splicing.


Pssm-ID: 428176 [Multi-domain]  Cd Length: 244  Bit Score: 222.52  E-value: 2.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959923    1 MTTAARPTFEPARGGRgkgegDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDF-----------RRELEERERA 69
Cdd:pfam04889   1 MTTAHRPTWDPARGKE-----ALRGPSRQYSSRDLPAHTKLKFRQPGQGTEAELEKRDLraeleeaeaahFAKKRGGAGL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959923   70 AARDKNRDRPTREHTTSSSVSKKPRLDQIP-AANLDADDPLTDEEDEDFEEESDDDD------------TAALLAELEKI 136
Cdd:pfam04889  76 LAPEDPAIGAAEGDEDDEEEAKRRRLEILEeTREIDADDDDDDDSDDDEDSESDDDDdsdsdddddedeTAELLRELEKI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959923  137 KKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTgpSQPQANFKVKRRWDDDVVFKNCAKGIDDQKKdKRFVNDTLR 216
Cdd:pfam04889 156 KRERAEEKAREERERAAEEEEQREEEIATGNPLLNLE--SGQSGDFTVKRRWDDDVVFKNQARGEEDKGK-KRFVNDLLR 232

                         250
                  ....*....|..
gi 568959923  217 SEFHKKFMEKYI 228
Cdd:pfam04889 233 SDFHKKFMNKYI 244
 
Name Accession Description Interval E-value
Cwf_Cwc_15 pfam04889
Cwf15/Cwc15 cell cycle control protein; This family represents Cwf15/Cwc15 (from ...
 1-228 2.63e-73

Cwf15/Cwc15 cell cycle control protein; This family represents Cwf15/Cwc15 (from Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively) and their homologs. The function of these proteins is unknown, but they form part of the spliceosome and are thus thought to be involved in mRNA splicing.


Pssm-ID: 428176 [Multi-domain]  Cd Length: 244  Bit Score: 222.52  E-value: 2.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959923    1 MTTAARPTFEPARGGRgkgegDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDF-----------RRELEERERA 69
Cdd:pfam04889   1 MTTAHRPTWDPARGKE-----ALRGPSRQYSSRDLPAHTKLKFRQPGQGTEAELEKRDLraeleeaeaahFAKKRGGAGL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959923   70 AARDKNRDRPTREHTTSSSVSKKPRLDQIP-AANLDADDPLTDEEDEDFEEESDDDD------------TAALLAELEKI 136
Cdd:pfam04889  76 LAPEDPAIGAAEGDEDDEEEAKRRRLEILEeTREIDADDDDDDDSDDDEDSESDDDDdsdsdddddedeTAELLRELEKI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959923  137 KKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTgpSQPQANFKVKRRWDDDVVFKNCAKGIDDQKKdKRFVNDTLR 216
Cdd:pfam04889 156 KRERAEEKAREERERAAEEEEQREEEIATGNPLLNLE--SGQSGDFTVKRRWDDDVVFKNQARGEEDKGK-KRFVNDLLR 232

                         250
                  ....*....|..
gi 568959923  217 SEFHKKFMEKYI 228
Cdd:pfam04889 233 SDFHKKFMNKYI 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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