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Conserved domains on  [gi|568952917|ref|XP_006508684|]
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tetraspanin-32 isoform X3 [Mus musculus]

Protein Classification

PHEMX_like_LEL domain-containing protein( domain architecture ID 10123560)

PHEMX_like_LEL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 94-203 7.27e-41

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


:

Pssm-ID: 239406  Cd Length: 87  Bit Score: 134.58  E-value: 7.27e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952917  94 VEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREdclqsirnvlwthysia 173
Cdd:cd03153    7 VEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRE----------------- 69

                         90       100       110
                 ....*....|....*....|....*....|
gi 568952917 174 siltctslaltvYAMMLCAFLWFAIHSYHG 203
Cdd:cd03153   70 ------------VAMLLCLFLWFAILSGHG 87
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 94-203 7.27e-41

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 134.58  E-value: 7.27e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952917  94 VEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREdclqsirnvlwthysia 173
Cdd:cd03153    7 VEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRE----------------- 69

                         90       100       110
                 ....*....|....*....|....*....|
gi 568952917 174 siltctslaltvYAMMLCAFLWFAIHSYHG 203
Cdd:cd03153   70 ------------VAMLLCLFLWFAILSGHG 87
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 94-203 7.27e-41

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 134.58  E-value: 7.27e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952917  94 VEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREdclqsirnvlwthysia 173
Cdd:cd03153    7 VEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRE----------------- 69

                         90       100       110
                 ....*....|....*....|....*....|
gi 568952917 174 siltctslaltvYAMMLCAFLWFAIHSYHG 203
Cdd:cd03153   70 ------------VAMLLCLFLWFAILSGHG 87
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 102-166 4.62e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 38.17  E-value: 4.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568952917 102 YDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMC-QGREAMREDCLQSIRNVL 166
Cdd:cd03151   15 YDSAYQDAVTDTRSKGTAVLKTFHSTLDCCGKGNLTALLSLLSTDLCpKKLLLDTKDCHQEIDDLF 80
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 96-170 9.87e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 34.40  E-value: 9.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952917  96 DAVLDTYDFVYDQAMKSPSSNWW--QELAVIQDTFLCCGKKSPFGLLVSTGAIM---CQGREAM------REDCLQSIRN 164
Cdd:cd03127    5 DQLESLVSDTLNDAWDEYYVDDDfqEAMDALQSTFECCGVNGPTDYLDLRLLVPsscCKGTDGNcglnlyTEGCLEKLVD 84


                 ....*.
gi 568952917 165 VLWTHY 170
Cdd:cd03127   85 FLRSNL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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