NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568952915|ref|XP_006508683|]
View 

tetraspanin-32 isoform X2 [Mus musculus]

Protein Classification

Tetraspanin and PHEMX_like_LEL domain-containing protein( domain architecture ID 13626493)

Tetraspanin and PHEMX_like_LEL domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 128-210 1.26e-45

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


:

Pssm-ID: 239406  Cd Length: 87  Bit Score: 147.29  E-value: 1.26e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952915 128 QVEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREvYAMMLCAFLWFAIHS 207
Cdd:cd03153    6 QVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRE-VAMLLCLFLWFAILS 84


                 ...
gi 568952915 208 YHG 210
Cdd:cd03153   85 GHG 87
Tetraspanin super family cl28961
Tetraspanin family;
11-167 3.26e-04

Tetraspanin family;


The actual alignment was detected with superfamily member pfam00335:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 40.38  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952915   11 KCQILITNFLVLLLGLSMATMVVVIHFGDHFTVIGHASLERnpyetlryWAFYVGISLAGLLSLGAALSTIATVREAHGL 90
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASA--------YIPILLIVLGAVIFLVGFLGCCGALKENRCL 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568952915   91 MAAGFLCFALSFCILVQVAFWRFYNPTQGIASYDALVQveDAVLDTYDFVYDQAMKSPSSnwwqeLAVIQDTFLCCG 167
Cdd:pfam00335  74 LLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLK--KSLEDGYRDWLDLYSCLNSA-----LDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 128-210 1.26e-45

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 147.29  E-value: 1.26e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952915 128 QVEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREvYAMMLCAFLWFAIHS 207
Cdd:cd03153    6 QVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRE-VAMLLCLFLWFAILS 84


                 ...
gi 568952915 208 YHG 210
Cdd:cd03153   85 GHG 87
Tetraspanin pfam00335
Tetraspanin family;
11-167 3.26e-04

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 40.38  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952915   11 KCQILITNFLVLLLGLSMATMVVVIHFGDHFTVIGHASLERnpyetlryWAFYVGISLAGLLSLGAALSTIATVREAHGL 90
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASA--------YIPILLIVLGAVIFLVGFLGCCGALKENRCL 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568952915   91 MAAGFLCFALSFCILVQVAFWRFYNPTQGIASYDALVQveDAVLDTYDFVYDQAMKSPSSnwwqeLAVIQDTFLCCG 167
Cdd:pfam00335  74 LLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLK--KSLEDGYRDWLDLYSCLNSA-----LDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 128-210 1.26e-45

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 147.29  E-value: 1.26e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952915 128 QVEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREvYAMMLCAFLWFAIHS 207
Cdd:cd03153    6 QVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRE-VAMLLCLFLWFAILS 84


                 ...
gi 568952915 208 YHG 210
Cdd:cd03153   85 GHG 87
Tetraspanin pfam00335
Tetraspanin family;
11-167 3.26e-04

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 40.38  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952915   11 KCQILITNFLVLLLGLSMATMVVVIHFGDHFTVIGHASLERnpyetlryWAFYVGISLAGLLSLGAALSTIATVREAHGL 90
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASA--------YIPILLIVLGAVIFLVGFLGCCGALKENRCL 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568952915   91 MAAGFLCFALSFCILVQVAFWRFYNPTQGIASYDALVQveDAVLDTYDFVYDQAMKSPSSnwwqeLAVIQDTFLCCG 167
Cdd:pfam00335  74 LLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLK--KSLEDGYRDWLDLYSCLNSA-----LDSLQSEFGCCG 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH