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Conserved domains on  [gi|568949460|ref|XP_006507326|]
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ecto-ADP-ribosyltransferase 5 isoform X6 [Mus musculus]

Protein Classification

ADP-ribosyltransferase family protein( domain architecture ID 1014)

ADP-ribosyltransferase family protein similar to mono (ADP-ribosyl) transferases, which exist in vertebrates and transfer ADP-ribose to arginine

CATH:  3.90.176.10
Gene Ontology:  GO:0016779

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VIP2 super family cl00173
VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative ...
 29-119 4.56e-44

VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of biological pathways distinct from classical A-B toxins. A novel family of insecticidal ADP-ribosyltransferses were isolated from Bacillus cereus during vegetative growth, where VIP1 likely targets insect cells and VIP2 ribosylates actin. VIP2 shares significant sequence similarity with enzymatic components of other binary toxins, Clostridium botulinum C2 toxin, C. perfringens iota toxin, C. piroforme toxin, C. piroforme toxin and C. difficile toxin.


The actual alignment was detected with superfamily member pfam01129:

Pssm-ID: 469640  Cd Length: 222  Bit Score: 143.36  E-value: 4.56e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949460   29 LSLVPDTFDDAYVGCSEEMEEKAGLLLKEEMARHALLRESWEAAQEAWAHRRHKLTLPPGFKAQHGVAIMVYTNSSnTLY 108
Cdd:pfam01129   1 LDMAPNAFDDQYLGCVDRMEAKAPLLLKEEFAMNQALAVSWEQAKKRWQERKALLSLPMGFKDDHGIALLAYTSSS-PLY 79

                          90
                  ....*....|.
gi 568949460  109 WELNQAVRTGG 119
Cdd:pfam01129  80 RLFNEAVREAG 90
 
Name Accession Description Interval E-value
ART pfam01129
NAD:arginine ADP-ribosyltransferase;
29-119 4.56e-44

NAD:arginine ADP-ribosyltransferase;


Pssm-ID: 279473  Cd Length: 222  Bit Score: 143.36  E-value: 4.56e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949460   29 LSLVPDTFDDAYVGCSEEMEEKAGLLLKEEMARHALLRESWEAAQEAWAHRRHKLTLPPGFKAQHGVAIMVYTNSSnTLY 108
Cdd:pfam01129   1 LDMAPNAFDDQYLGCVDRMEAKAPLLLKEEFAMNQALAVSWEQAKKRWQERKALLSLPMGFKDDHGIALLAYTSSS-PLY 79

                          90
                  ....*....|.
gi 568949460  109 WELNQAVRTGG 119
Cdd:pfam01129  80 RLFNEAVREAG 90
 
Name Accession Description Interval E-value
ART pfam01129
NAD:arginine ADP-ribosyltransferase;
29-119 4.56e-44

NAD:arginine ADP-ribosyltransferase;


Pssm-ID: 279473  Cd Length: 222  Bit Score: 143.36  E-value: 4.56e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949460   29 LSLVPDTFDDAYVGCSEEMEEKAGLLLKEEMARHALLRESWEAAQEAWAHRRHKLTLPPGFKAQHGVAIMVYTNSSnTLY 108
Cdd:pfam01129   1 LDMAPNAFDDQYLGCVDRMEAKAPLLLKEEFAMNQALAVSWEQAKKRWQERKALLSLPMGFKDDHGIALLAYTSSS-PLY 79

                          90
                  ....*....|.
gi 568949460  109 WELNQAVRTGG 119
Cdd:pfam01129  80 RLFNEAVREAG 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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