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Conserved domains on  [gi|568949253|ref|XP_006507227|]
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uncharacterized protein LOC101604 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 1000026)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
132-292 5.65e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949253 132 PHQCPDCGKSFTQRSTLVAHMYT--HTGE--KPFHCP--DCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLI 205
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949253 206 AHLRVHT-------GEKPYCCAD--CGRCFSQSSGLREHqRVVHSGVTP--FTCTHCGRAFARAAYLQCHMRTHTGEKPY 274
Cdd:COG5048  369 NEPPQSLqqykdlkNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 568949253 275 SCPDCGRcFRQSSDMAAH 292
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
PRK05580 super family cl42512
primosome assembly protein PriA; Validated
 79-141 2.18e-03

primosome assembly protein PriA; Validated


The actual alignment was detected with superfamily member PRK05580:

Pssm-ID: 455857 [Multi-domain]  Cd Length: 679  Bit Score: 40.14  E-value: 2.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568949253  79 CHVCGKSFahqsklvehlythtgekpfQCPDCDkyfgraSSLSMHRAIHR------GER---PHQCPDCGKS 141
Cdd:PRK05580 384 CRDCGWVA-------------------ECPHCD------ASLTLHRFQRRlrchhcGYQepiPKACPECGST 430
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-292 5.65e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949253 132 PHQCPDCGKSFTQRSTLVAHMYT--HTGE--KPFHCP--DCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLI 205
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949253 206 AHLRVHT-------GEKPYCCAD--CGRCFSQSSGLREHqRVVHSGVTP--FTCTHCGRAFARAAYLQCHMRTHTGEKPY 274
Cdd:COG5048  369 NEPPQSLqqykdlkNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 568949253 275 SCPDCGRcFRQSSDMAAH 292
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
PRK05580 PRK05580
primosome assembly protein PriA; Validated
 79-141 2.18e-03

primosome assembly protein PriA; Validated


Pssm-ID: 235514 [Multi-domain]  Cd Length: 679  Bit Score: 40.14  E-value: 2.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568949253  79 CHVCGKSFahqsklvehlythtgekpfQCPDCDkyfgraSSLSMHRAIHR------GER---PHQCPDCGKS 141
Cdd:PRK05580 384 CRDCGWVA-------------------ECPHCD------ASLTLHRFQRRlrchhcGYQepiPKACPECGST 430
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-285 2.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.54e-03
                          10        20
                  ....*....|....*....|..
gi 568949253  264 HMRTHTGEKPYSCPDCGRCFRQ 285
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
67-141 3.63e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.63e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568949253  67 HNPILKADQRHGCHVCGKSFAHQSKLVEHLYTHTGEKPFQCPD--CDKYFGRASSLSMHRAIHRGERPHQCPDCGKS 141
Cdd:COG5048   24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
119-144 4.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 568949253  119 SLSMHRAIHRGERPHQCPDCGKSFTQ 144
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-292 5.65e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949253 132 PHQCPDCGKSFTQRSTLVAHMYT--HTGE--KPFHCP--DCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLI 205
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949253 206 AHLRVHT-------GEKPYCCAD--CGRCFSQSSGLREHqRVVHSGVTP--FTCTHCGRAFARAAYLQCHMRTHTGEKPY 274
Cdd:COG5048  369 NEPPQSLqqykdlkNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 568949253 275 SCPDCGRcFRQSSDMAAH 292
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-251 9.57e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 9.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949253 103 KPFQCPDCDKYFGRASSLSMHR--AIHRGE--RPHQCP--DCGKSFTQRSTLVAHMYTHTGEKPFHCPDCN-------KS 169
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949253 170 FSRPSSLSSHRAIHRGERPHCCSD--CGRAFTHRSGLIAHLRVHTGEKPYCC--ADCGRCFSQSSGLREHQRVVHSGVTP 245
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*.
gi 568949253 246 FTCTHC 251
Cdd:COG5048  448 LCSILK 453
PRK05580 PRK05580
primosome assembly protein PriA; Validated
 79-141 2.18e-03

primosome assembly protein PriA; Validated


Pssm-ID: 235514 [Multi-domain]  Cd Length: 679  Bit Score: 40.14  E-value: 2.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568949253  79 CHVCGKSFahqsklvehlythtgekpfQCPDCDkyfgraSSLSMHRAIHR------GER---PHQCPDCGKS 141
Cdd:PRK05580 384 CRDCGWVA-------------------ECPHCD------ASLTLHRFQRRlrchhcGYQepiPKACPECGST 430
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-285 2.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.54e-03
                          10        20
                  ....*....|....*....|..
gi 568949253  264 HMRTHTGEKPYSCPDCGRCFRQ 285
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
67-141 3.63e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.63e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568949253  67 HNPILKADQRHGCHVCGKSFAHQSKLVEHLYTHTGEKPFQCPD--CDKYFGRASSLSMHRAIHRGERPHQCPDCGKS 141
Cdd:COG5048   24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
119-144 4.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 568949253  119 SLSMHRAIHRGERPHQCPDCGKSFTQ 144
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
92-114 4.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.23e-03
                          10        20
                  ....*....|....*....|...
gi 568949253   92 LVEHLYTHTGEKPFQCPDCDKYF 114
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 133-155 5.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 5.83e-03
                          10        20
                  ....*....|....*....|...
gi 568949253  133 HQCPDCGKSFTQRSTLVAHMYTH 155
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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