NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568934676|ref|XP_006504234|]
View 

SLAIN motif-containing protein 2 isoform X1 [Mus musculus]

Protein Classification

SLAIN motif-containing protein( domain architecture ID 12172998)

SLAIN motif-containing protein is a microtubule plus-end tracking protein, similar to human SLAIN2 that binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 1-466 4.88e-143

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


:

Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 416.04  E-value: 4.88e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676    1 MQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQtmsALKRQNLYNNPFNSVSYSNSYSPNasSPYSSGFNSPSSTPVR 80
Cdd:pfam15301  12 SQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQ---ASRWRSLYSSPSSSSSAYSGNAEA--SSYSSGLNSPGYLKST 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676   81 PpivKQLILPGNSGNFKSSSdrnpPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAASTSRR 160
Cdd:pfam15301  87 N---KQLLTCGSSGYLRRHS----ALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  161 SSGSSCN---STRRGTFSDQELDAQSLDDEDDSLQHAVHPALNRFSPSPRNsprpspkqSPRNSPRSRSPARGIEYSRAS 237
Cdd:pfam15301 160 SRRSSSFslhSLRRGTYSDQELDAYSLEDEEEEYCSLPQPRLHRFSPLPHS--------SPRDSPRSRSPSTSQEYSRLS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  238 PQpmisRLQQPRLSLQGHPTDLQtSNVKNEEKLRRSLPNLSRTSSTQ-VDSVKSSRS-DSNFQVPNGGIPRMQPQASAts 315
Cdd:pfam15301 232 AQ----RLRQPRRSLQGPGAELQ-KYAKSEEKLRRSMPNLARRTSLRsLESVRNSRSfESNLQVPNSGLSRLQQSSSS-- 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  316 qrlkslprtslkakqllptsstkrVPSPGKFR-SPAAPSPLALRQPVKAFSNHGSGSGsqettqftqtTSSPGPPVVQNS 394
Cdd:pfam15301 305 ------------------------IPSPSKLRvQSAGQSPLALRQPVKATSYVSSTVA----------GPSKGLPSSQSL 350

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568934676  395 APANPSSninSATLTRPAGT-TAMRSGLPRPSAPSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDSWKDGCY 466
Cdd:pfam15301 351 PSGGSSG---SPLPSRPSGGySGGRSSLPRPASFVGGTSPVPRSKLAQPVRRSLTPPKTYSALRDESWKDGCY 420
 
Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 1-466 4.88e-143

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 416.04  E-value: 4.88e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676    1 MQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQtmsALKRQNLYNNPFNSVSYSNSYSPNasSPYSSGFNSPSSTPVR 80
Cdd:pfam15301  12 SQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQ---ASRWRSLYSSPSSSSSAYSGNAEA--SSYSSGLNSPGYLKST 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676   81 PpivKQLILPGNSGNFKSSSdrnpPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAASTSRR 160
Cdd:pfam15301  87 N---KQLLTCGSSGYLRRHS----ALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  161 SSGSSCN---STRRGTFSDQELDAQSLDDEDDSLQHAVHPALNRFSPSPRNsprpspkqSPRNSPRSRSPARGIEYSRAS 237
Cdd:pfam15301 160 SRRSSSFslhSLRRGTYSDQELDAYSLEDEEEEYCSLPQPRLHRFSPLPHS--------SPRDSPRSRSPSTSQEYSRLS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  238 PQpmisRLQQPRLSLQGHPTDLQtSNVKNEEKLRRSLPNLSRTSSTQ-VDSVKSSRS-DSNFQVPNGGIPRMQPQASAts 315
Cdd:pfam15301 232 AQ----RLRQPRRSLQGPGAELQ-KYAKSEEKLRRSMPNLARRTSLRsLESVRNSRSfESNLQVPNSGLSRLQQSSSS-- 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  316 qrlkslprtslkakqllptsstkrVPSPGKFR-SPAAPSPLALRQPVKAFSNHGSGSGsqettqftqtTSSPGPPVVQNS 394
Cdd:pfam15301 305 ------------------------IPSPSKLRvQSAGQSPLALRQPVKATSYVSSTVA----------GPSKGLPSSQSL 350

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568934676  395 APANPSSninSATLTRPAGT-TAMRSGLPRPSAPSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDSWKDGCY 466
Cdd:pfam15301 351 PSGGSSG---SPLPSRPSGGySGGRSSLPRPASFVGGTSPVPRSKLAQPVRRSLTPPKTYSALRDESWKDGCY 420
PHA03247 PHA03247
large tegument protein UL36; Provisional
 204-460 1.30e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  204 PSPRNSPRPSPKQS---PRNSPRSRSPARGIEYSRASPQPMISRLQQPRLSLQGHPTDLQtsnvkneeklrrslPNLSRT 280
Cdd:PHA03247 2554 PLPPAAPPAAPDRSvppPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP--------------PSPLPP 2619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  281 SSTQVDSVKSSRSDSNFQVPNGGI----PRMQPQASATSQRLKSLPRTSLKAKQLLPTSSTKRvpspgkFRSPAAPSPLA 356
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPptvpPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR------PRRRAARPTVG 2693

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  357 lrqPVKAFSNHGSGSGSQETTQFTQTTSSPGPPVVQNSAPANPSSNINSATLTRPAGTT-----------AMRSGLPRPS 425
Cdd:PHA03247 2694 ---SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtpggparparpPTTAGPPAPA 2770

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 568934676  426 APSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDS 460
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805
 
Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 1-466 4.88e-143

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 416.04  E-value: 4.88e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676    1 MQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQtmsALKRQNLYNNPFNSVSYSNSYSPNasSPYSSGFNSPSSTPVR 80
Cdd:pfam15301  12 SQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQ---ASRWRSLYSSPSSSSSAYSGNAEA--SSYSSGLNSPGYLKST 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676   81 PpivKQLILPGNSGNFKSSSdrnpPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAASTSRR 160
Cdd:pfam15301  87 N---KQLLTCGSSGYLRRHS----ALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  161 SSGSSCN---STRRGTFSDQELDAQSLDDEDDSLQHAVHPALNRFSPSPRNsprpspkqSPRNSPRSRSPARGIEYSRAS 237
Cdd:pfam15301 160 SRRSSSFslhSLRRGTYSDQELDAYSLEDEEEEYCSLPQPRLHRFSPLPHS--------SPRDSPRSRSPSTSQEYSRLS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  238 PQpmisRLQQPRLSLQGHPTDLQtSNVKNEEKLRRSLPNLSRTSSTQ-VDSVKSSRS-DSNFQVPNGGIPRMQPQASAts 315
Cdd:pfam15301 232 AQ----RLRQPRRSLQGPGAELQ-KYAKSEEKLRRSMPNLARRTSLRsLESVRNSRSfESNLQVPNSGLSRLQQSSSS-- 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  316 qrlkslprtslkakqllptsstkrVPSPGKFR-SPAAPSPLALRQPVKAFSNHGSGSGsqettqftqtTSSPGPPVVQNS 394
Cdd:pfam15301 305 ------------------------IPSPSKLRvQSAGQSPLALRQPVKATSYVSSTVA----------GPSKGLPSSQSL 350

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568934676  395 APANPSSninSATLTRPAGT-TAMRSGLPRPSAPSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDSWKDGCY 466
Cdd:pfam15301 351 PSGGSSG---SPLPSRPSGGySGGRSSLPRPASFVGGTSPVPRSKLAQPVRRSLTPPKTYSALRDESWKDGCY 420
PHA03247 PHA03247
large tegument protein UL36; Provisional
 204-460 1.30e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  204 PSPRNSPRPSPKQS---PRNSPRSRSPARGIEYSRASPQPMISRLQQPRLSLQGHPTDLQtsnvkneeklrrslPNLSRT 280
Cdd:PHA03247 2554 PLPPAAPPAAPDRSvppPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP--------------PSPLPP 2619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  281 SSTQVDSVKSSRSDSNFQVPNGGI----PRMQPQASATSQRLKSLPRTSLKAKQLLPTSSTKRvpspgkFRSPAAPSPLA 356
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPptvpPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR------PRRRAARPTVG 2693

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  357 lrqPVKAFSNHGSGSGSQETTQFTQTTSSPGPPVVQNSAPANPSSNINSATLTRPAGTT-----------AMRSGLPRPS 425
Cdd:PHA03247 2694 ---SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtpggparparpPTTAGPPAPA 2770

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 568934676  426 APSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDS 460
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805
PHA03247 PHA03247
large tegument protein UL36; Provisional
 197-450 4.49e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  197 PALNRFSPSPRNSPRPSpkqSPRNSPRSRSPArgieysrASPQPmisrlQQPRLSlqGHPTDlqtsnvkneEKLRRSLPN 276
Cdd:PHA03247 2562 AAPDRSVPPPRPAPRPS---EPAVTSRARRPD-------APPQS-----ARPRAP--VDDRG---------DPRGPAPPS 2615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  277 LSRTSSTQVDSVKSSRSDSNFQVPNGGI----PRMQPQASATSQRLKSLPRTSLKAKQLLPTSSTKRvpspgkFRSPAAP 352
Cdd:PHA03247 2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPptvpPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR------PRRRAAR 2689

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  353 SPLAlrqPVKAFSNHGSGSGSQETTQFTQTTSSPGPPVVQNSAPANPSSNINSATLTRPAG--TTAMRSGLPRPSAPSAG 430
Cdd:PHA03247 2690 PTVG---SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGP 2766

                         250       260
                  ....*....|....*....|
gi 568934676  431 GIPVPRSKLVQPVRRSLPAP 450
Cdd:PHA03247 2767 PAPAPPAAPAAGPPRRLTRP 2786
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 64-295 4.75e-03

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 39.43  E-value: 4.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676   64 SSPYSSGFNSPSSTPVRPPIVKqlilPGNSGNFKSSSDRNPPLSPQSSIDSeLSASELDEDS----IGSNYKLNDVTD-- 137
Cdd:pfam08580 420 SPATLVANKTPGSSPPSSVIMT----PVNKGSKTPSSRRGSSFDFGSSSER-VINSKLRRESklpqIASTLKQTKRPSki 494

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  138 -VQILARMQEESLRQEYAASTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDSLQHaVHPALNRFSPSP-----RNSPR 211
Cdd:pfam08580 495 pRASPNHSGFLSTPSNTATSETPTPALRPPSRPQPPPPGNRPRWNASTNTNDLDVGH-NFKPLTLTTPSPtpsrsSRSSS 573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934676  212 PSPKQSPRNSPRSRSPARG------IEYSRASPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSSTQV 285
Cdd:pfam08580 574 TLPPVSPLSRDKSRSPAPTcrsvsrASRRRASRKPTRIGSPNSRTSLLDEPPYPKLTLSKGLPRTPRNRQSYAGTSPSRS 653

                         250
                  ....*....|
gi 568934676  286 DSVKSSRSDS 295
Cdd:pfam08580 654 VSVSSGLGPQ 663
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH