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Conserved domains on  [gi|568922736|ref|XP_006501516|]
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insulin receptor-related protein isoform X3 [Mus musculus]

Protein Classification

FU and Recep_L_domain domain-containing protein( domain architecture ID 12013543)

protein containing domains FU, Recep_L_domain, and FN3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Furin-like pfam00757
Furin-like cysteine rich region;
173-326 5.60e-56

Furin-like cysteine rich region;


:

Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 189.18  E-value: 5.60e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736  173 GEECADVCPGVLgaagEPCSrttfSGRTDYRCWTSSHCQKVCPCPRGMACTAGGDCCHSECLGGCSQPeDPRACVACRHL 252
Cdd:pfam00757   1 NRECGDVCPGTM----EKCH----SCCNNGYCWGPGHCQKVCPEQCKKRCTKPGECCHEQCLGGCTGP-NDSDCLACRHF 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922736  253 YFQGVCLRACPPGTYQYeSWRCVTAELCAhlREVPGLATTFGIYEGSCLAQCPPGFTRNGS-SIFCHKCEGLCPK 326
Cdd:pfam00757  72 NDEGTCVDQCPPGTYQF-GWRCVTFKECP--KSHLPGYNPLVIHNGECVRECPSGYTEVENnSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 346-461 5.07e-32

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 120.42  E-value: 5.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736  346 GCTHVEGNLILNLRQGYNlEPELQRNLGLVETITGFLKIKHSfALVTLGFFKNLKLIRGDSMVDGNYTLYVLDNQNLQQL 425
Cdd:pfam01030   1 NCTVIYGNLEITLIDENN-DSELLSFLSNVEEITGYLLIANT-NLVSLSFLPNLRIIRGRNLFDDNYALYILDNPNLTEL 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568922736  426 GSWVTAGLTIpvGKIYFAFNPRLCLEHIYQLEEVTG 461
Cdd:pfam01030  79 GLPSLKEITS--GGVYIHNNPKLCYTETEILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 47-158 4.71e-30

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 114.64  E-value: 4.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736   47 NCSVVEGHLQILLMFAAtGEDFRGLSFPRLTQVTDYLLLFRVygLESLRDLFPNLTVIRGTRLFLG-YALIIFEMPHLRD 125
Cdd:pfam01030   1 NCTVIYGNLEITLIDEN-NDSELLSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFDDnYALYILDNPNLTE 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568922736  126 VGLPSLGAVLRGAVRVEKNQELCHLST-IDWGLL 158
Cdd:pfam01030  78 LGLPSLKEITSGGVYIHNNPKLCYTETeILWKLL 111
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 819-858 5.42e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 5.42e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568922736 819 PGKVAWKAAGKSSVTLHWLEPPDPNGLILKYEIKYRRLGE 858
Cdd:cd00063    4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 605-649 1.04e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 1.04e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568922736 605 PTVPQDVISTSNSSSHLLVRWKPPVQRNGNITYYLVLWQRLAEDG 649
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 494-600 1.34e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736 494 TEEDRILLRWERyEPLEARDLLSFIVYYKEspfqnatehvgpdaCGTQSWnlldVELPLSRTQEPGVTLAPLKPWTQYAV 573
Cdd:cd00063   12 VTSTSVTLSWTP-PEDDGGPITGYVVEYRE--------------KGSGDW----KEVEVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|....*..
gi 568922736 574 FVRAITlttaedSPHQGAQSPIVYLRT 600
Cdd:cd00063   73 RVRAVN------GGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
Furin-like pfam00757
Furin-like cysteine rich region;
173-326 5.60e-56

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 189.18  E-value: 5.60e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736  173 GEECADVCPGVLgaagEPCSrttfSGRTDYRCWTSSHCQKVCPCPRGMACTAGGDCCHSECLGGCSQPeDPRACVACRHL 252
Cdd:pfam00757   1 NRECGDVCPGTM----EKCH----SCCNNGYCWGPGHCQKVCPEQCKKRCTKPGECCHEQCLGGCTGP-NDSDCLACRHF 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922736  253 YFQGVCLRACPPGTYQYeSWRCVTAELCAhlREVPGLATTFGIYEGSCLAQCPPGFTRNGS-SIFCHKCEGLCPK 326
Cdd:pfam00757  72 NDEGTCVDQCPPGTYQF-GWRCVTFKECP--KSHLPGYNPLVIHNGECVRECPSGYTEVENnSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 346-461 5.07e-32

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 120.42  E-value: 5.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736  346 GCTHVEGNLILNLRQGYNlEPELQRNLGLVETITGFLKIKHSfALVTLGFFKNLKLIRGDSMVDGNYTLYVLDNQNLQQL 425
Cdd:pfam01030   1 NCTVIYGNLEITLIDENN-DSELLSFLSNVEEITGYLLIANT-NLVSLSFLPNLRIIRGRNLFDDNYALYILDNPNLTEL 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568922736  426 GSWVTAGLTIpvGKIYFAFNPRLCLEHIYQLEEVTG 461
Cdd:pfam01030  79 GLPSLKEITS--GGVYIHNNPKLCYTETEILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 47-158 4.71e-30

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 114.64  E-value: 4.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736   47 NCSVVEGHLQILLMFAAtGEDFRGLSFPRLTQVTDYLLLFRVygLESLRDLFPNLTVIRGTRLFLG-YALIIFEMPHLRD 125
Cdd:pfam01030   1 NCTVIYGNLEITLIDEN-NDSELLSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFDDnYALYILDNPNLTE 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568922736  126 VGLPSLGAVLRGAVRVEKNQELCHLST-IDWGLL 158
Cdd:pfam01030  78 LGLPSLKEITSGGVYIHNNPKLCYTETeILWKLL 111
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 228-275 1.14e-07

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 49.05  E-value: 1.14e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568922736 228 CCHSECLGgCSQPeDPRACVACRHLYF--QGVCLRACPPGTYQY-ESWRCV 275
Cdd:cd00064    1 PCHPSCAT-CTGP-GPDQCTSCRHGFYldGGTCVSECPEGTYADtEGGVCL 49
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 819-858 5.42e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 5.42e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568922736 819 PGKVAWKAAGKSSVTLHWLEPPDPNGLILKYEIKYRRLGE 858
Cdd:cd00063    4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS 43
FU smart00261
Furin-like repeats;
228-267 9.22e-06

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 43.27  E-value: 9.22e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568922736   228 CCHSECLGgCSQPeDPRACVACRHLYF--QGVCLRACPPGTY 267
Cdd:smart00261   6 PCHPECAT-CTGP-GPDDCTSCKHGFFldGGKCVSECPPGTY 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 605-649 1.04e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 1.04e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568922736 605 PTVPQDVISTSNSSSHLLVRWKPPVQRNGNITYYLVLWQRLAEDG 649
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD 45
fn3 pfam00041
Fibronectin type III domain;
608-643 4.55e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.79  E-value: 4.55e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568922736  608 PQDVISTSNSSSHLLVRWKPPVQRNGNITYYLVLWQ 643
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR 38
fn3 pfam00041
Fibronectin type III domain;
819-861 1.33e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.25  E-value: 1.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 568922736  819 PGKVAWKAAGKSSVTLHWLEPPDPNGLILKYEIKYRRLGEVRP 861
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEP 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 494-600 1.34e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736 494 TEEDRILLRWERyEPLEARDLLSFIVYYKEspfqnatehvgpdaCGTQSWnlldVELPLSRTQEPGVTLAPLKPWTQYAV 573
Cdd:cd00063   12 VTSTSVTLSWTP-PEDDGGPITGYVVEYRE--------------KGSGDW----KEVEVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|....*..
gi 568922736 574 FVRAITlttaedSPHQGAQSPIVYLRT 600
Cdd:cd00063   73 RVRAVN------GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 817-858 1.84e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568922736   817 GIPGKVAWKAAGKSSVTLHWLEPPDPNGL--ILKYEIKYRRLGE 858
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGS 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
497-640 1.96e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.91  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736 497 DRILLRWEryePLEARDLLSFIVYYKESPFQNATEhvgpdacgtqswnlldvelpLSRTQEPGVTLAPLKPWTQYAVFVR 576
Cdd:COG3401  247 GSVTLSWD---PVTESDATGYRVYRSNSGDGPFTK--------------------VATVTTTSYTDTGLTNGTTYYYRVT 303

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568922736 577 AITLTTAEdsphqGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPVqrNGNITYYLV 640
Cdd:COG3401  304 AVDAAGNE-----SAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASS--DADVTGYNV 360
 
Name Accession Description Interval E-value
Furin-like pfam00757
Furin-like cysteine rich region;
173-326 5.60e-56

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 189.18  E-value: 5.60e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736  173 GEECADVCPGVLgaagEPCSrttfSGRTDYRCWTSSHCQKVCPCPRGMACTAGGDCCHSECLGGCSQPeDPRACVACRHL 252
Cdd:pfam00757   1 NRECGDVCPGTM----EKCH----SCCNNGYCWGPGHCQKVCPEQCKKRCTKPGECCHEQCLGGCTGP-NDSDCLACRHF 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922736  253 YFQGVCLRACPPGTYQYeSWRCVTAELCAhlREVPGLATTFGIYEGSCLAQCPPGFTRNGS-SIFCHKCEGLCPK 326
Cdd:pfam00757  72 NDEGTCVDQCPPGTYQF-GWRCVTFKECP--KSHLPGYNPLVIHNGECVRECPSGYTEVENnSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 346-461 5.07e-32

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 120.42  E-value: 5.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736  346 GCTHVEGNLILNLRQGYNlEPELQRNLGLVETITGFLKIKHSfALVTLGFFKNLKLIRGDSMVDGNYTLYVLDNQNLQQL 425
Cdd:pfam01030   1 NCTVIYGNLEITLIDENN-DSELLSFLSNVEEITGYLLIANT-NLVSLSFLPNLRIIRGRNLFDDNYALYILDNPNLTEL 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568922736  426 GSWVTAGLTIpvGKIYFAFNPRLCLEHIYQLEEVTG 461
Cdd:pfam01030  79 GLPSLKEITS--GGVYIHNNPKLCYTETEILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 47-158 4.71e-30

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 114.64  E-value: 4.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736   47 NCSVVEGHLQILLMFAAtGEDFRGLSFPRLTQVTDYLLLFRVygLESLRDLFPNLTVIRGTRLFLG-YALIIFEMPHLRD 125
Cdd:pfam01030   1 NCTVIYGNLEITLIDEN-NDSELLSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFDDnYALYILDNPNLTE 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568922736  126 VGLPSLGAVLRGAVRVEKNQELCHLST-IDWGLL 158
Cdd:pfam01030  78 LGLPSLKEITSGGVYIHNNPKLCYTETeILWKLL 111
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 228-275 1.14e-07

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 49.05  E-value: 1.14e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568922736 228 CCHSECLGgCSQPeDPRACVACRHLYF--QGVCLRACPPGTYQY-ESWRCV 275
Cdd:cd00064    1 PCHPSCAT-CTGP-GPDQCTSCRHGFYldGGTCVSECPEGTYADtEGGVCL 49
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 819-858 5.42e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 5.42e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568922736 819 PGKVAWKAAGKSSVTLHWLEPPDPNGLILKYEIKYRRLGE 858
Cdd:cd00063    4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS 43
FU smart00261
Furin-like repeats;
228-267 9.22e-06

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 43.27  E-value: 9.22e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568922736   228 CCHSECLGgCSQPeDPRACVACRHLYF--QGVCLRACPPGTY 267
Cdd:smart00261   6 PCHPECAT-CTGP-GPDDCTSCKHGFFldGGKCVSECPPGTY 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 605-649 1.04e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 1.04e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568922736 605 PTVPQDVISTSNSSSHLLVRWKPPVQRNGNITYYLVLWQRLAEDG 649
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD 45
fn3 pfam00041
Fibronectin type III domain;
608-643 4.55e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.79  E-value: 4.55e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568922736  608 PQDVISTSNSSSHLLVRWKPPVQRNGNITYYLVLWQ 643
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR 38
fn3 pfam00041
Fibronectin type III domain;
819-861 1.33e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.25  E-value: 1.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 568922736  819 PGKVAWKAAGKSSVTLHWLEPPDPNGLILKYEIKYRRLGEVRP 861
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEP 45
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 234-317 8.48e-04

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 39.72  E-value: 8.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736  234 LGGCSQPEDPRACVACRHLYF----------QGVCLRACPPGTY--------------QYESWRCVTAELCAHLREvpgl 289
Cdd:pfam15913   1 CSGCVLCSEENGCLTCQPRLFlllerngirqYGVCLHSCPPGYFgirgqevnrctkckAENCESCFSKDFCTKCKE---- 76

                          90       100
                  ....*....|....*....|....*...
gi 568922736  290 atTFGIYEGSCLAQCPPGFTRNGSSIFC 317
Cdd:pfam15913  77 --GFYLHKGKCLDTCPEGTAAQNSTMEC 102
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 494-600 1.34e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736 494 TEEDRILLRWERyEPLEARDLLSFIVYYKEspfqnatehvgpdaCGTQSWnlldVELPLSRTQEPGVTLAPLKPWTQYAV 573
Cdd:cd00063   12 VTSTSVTLSWTP-PEDDGGPITGYVVEYRE--------------KGSGDW----KEVEVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|....*..
gi 568922736 574 FVRAITlttaedSPHQGAQSPIVYLRT 600
Cdd:cd00063   73 RVRAVN------GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 817-858 1.84e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568922736   817 GIPGKVAWKAAGKSSVTLHWLEPPDPNGL--ILKYEIKYRRLGE 858
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGS 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
497-640 1.96e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.91  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922736 497 DRILLRWEryePLEARDLLSFIVYYKESPFQNATEhvgpdacgtqswnlldvelpLSRTQEPGVTLAPLKPWTQYAVFVR 576
Cdd:COG3401  247 GSVTLSWD---PVTESDATGYRVYRSNSGDGPFTK--------------------VATVTTTSYTDTGLTNGTTYYYRVT 303

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568922736 577 AITLTTAEdsphqGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPVqrNGNITYYLV 640
Cdd:COG3401  304 AVDAAGNE-----SAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASS--DADVTGYNV 360
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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