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Conserved domains on  [gi|568921699|ref|XP_006501017|]
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cyclin-A1 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 132-270 7.83e-83

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20560:

Pssm-ID: 477360  Cd Length: 163  Bit Score: 250.14  E-value: 7.83e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 132 LLDFNTVSPMLVDPTTHAQSEEATDFGSDVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVG 211
Cdd:cd20560    1 LLDLSSASPMLVDTSLQSQSEDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 212 EEYKLRTETLYLAVNFLDR------------------------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVL 267
Cdd:cd20560   81 EEYKLQTETLYLAVNYLDRflscmsvlrgklqlvgtaaillasKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160


                 ...
gi 568921699 268 AFD 270
Cdd:cd20560  161 AFD 163
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 274-396 9.05e-80

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410266  Cd Length: 123  Bit Score: 240.87  E-value: 9.05e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVP 353
Cdd:cd20563    1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDPFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568921699 354 CLSELHKACLSIPHRPQQAIREKYKASKYLHVSLMEPPVVLPL 396
Cdd:cd20563   81 CLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
Cyclin_N2 pfam16500
Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found ...
 90-144 6.73e-05

Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found upstream of the family Cyclin_N, pfam00134. This region controls the stability of the region by recruiting the APC/C. This region includes the ABBA motif.


:

Pssm-ID: 465146  Cd Length: 72  Bit Score: 40.87  E-value: 6.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568921699   90 GFDIYMDDPEQGDRDTCSGKEgiifEDVYEVDTSMLKSDLHF---------LLDFNTVSPMLVD 144
Cdd:pfam16500  11 AFTIHVDEPEQEERPSEPVSK----ETEEESEELALNPAVTLerqplaeldLLDLSTDSPMLVD 70
 
Name Accession Description Interval E-value
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 132-270 7.83e-83

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 250.14  E-value: 7.83e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 132 LLDFNTVSPMLVDPTTHAQSEEATDFGSDVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVG 211
Cdd:cd20560    1 LLDLSSASPMLVDTSLQSQSEDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 212 EEYKLRTETLYLAVNFLDR------------------------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVL 267
Cdd:cd20560   81 EEYKLQTETLYLAVNYLDRflscmsvlrgklqlvgtaaillasKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160


                 ...
gi 568921699 268 AFD 270
Cdd:cd20560  161 AFD 163
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 274-396 9.05e-80

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 240.87  E-value: 9.05e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVP 353
Cdd:cd20563    1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDPFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568921699 354 CLSELHKACLSIPHRPQQAIREKYKASKYLHVSLMEPPVVLPL 396
Cdd:cd20563   81 CLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 170-272 4.43e-46

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 154.60  E-value: 4.43e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699  170 EIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------- 230
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRflskksvpknklqlvgvtc 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 568921699  231 -----KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFDLT 272
Cdd:pfam00134  81 lfiaaKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
134-386 8.30e-43

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 154.93  E-value: 8.30e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 134 DFNTVSPMLVDPT---THAQSEEA-----------TDFGSDVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGM 199
Cdd:COG5024  133 DENSLSPYELDENqlaLDEKQAESkresqswqdldATDQEDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEWSM 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 200 RAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------KYEEIYPPDVDEFVYITDDTYTKRQ 255
Cdd:COG5024  213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRflssrvvslekyqlvgisalfiasKYEEVNCPSIKDLVYATDGAFTRDD 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 256 LLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEaDPFLKYLPSLVAAAAYCLANYIVNRHF 335
Cdd:COG5024  293 IIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVD-YKFIQISPSWCAAAAMYLSRKILSQNQ 371

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568921699 336 WPETLAAFTG-YSLNEIVPCLSELHKaCLSIPHRPQQAIREKYKASKYLHVS 386
Cdd:COG5024  372 WDRTLIHYSGnYTNPDLKPLNESNKE-NLQNPSVHHDAIFPKYPSPTFGKAS 422
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 274-391 1.16e-39

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 137.37  E-value: 1.16e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699  274 PTTNQFLLQYLRRQGV--CIRTENLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEI 351
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYD-FLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568921699  352 VPCLSELHKACLSIPHRPQQAIREKYKASKYLHVSLMEPP 391
Cdd:pfam02984  80 KPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 278-360 1.26e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 74.17  E-value: 1.26e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699   278 QFLLQYLRRQGVCIRTENLAKYVAELSLLEaDPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGY-SLNEIVPCLS 356
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSD-YKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYfTEEEILRMER 79


                   ....
gi 568921699   357 ELHK 360
Cdd:smart00385  80 LLLE 83
Cyclin_N2 pfam16500
Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found ...
 90-144 6.73e-05

Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found upstream of the family Cyclin_N, pfam00134. This region controls the stability of the region by recruiting the APC/C. This region includes the ABBA motif.


Pssm-ID: 465146  Cd Length: 72  Bit Score: 40.87  E-value: 6.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568921699   90 GFDIYMDDPEQGDRDTCSGKEgiifEDVYEVDTSMLKSDLHF---------LLDFNTVSPMLVD 144
Cdd:pfam16500  11 AFTIHVDEPEQEERPSEPVSK----ETEEESEELALNPAVTLerqplaeldLLDLSTDSPMLVD 70
 
Name Accession Description Interval E-value
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 132-270 7.83e-83

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 250.14  E-value: 7.83e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 132 LLDFNTVSPMLVDPTTHAQSEEATDFGSDVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVG 211
Cdd:cd20560    1 LLDLSSASPMLVDTSLQSQSEDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 212 EEYKLRTETLYLAVNFLDR------------------------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVL 267
Cdd:cd20560   81 EEYKLQTETLYLAVNYLDRflscmsvlrgklqlvgtaaillasKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160


                 ...
gi 568921699 268 AFD 270
Cdd:cd20560  161 AFD 163
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 274-396 9.05e-80

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 240.87  E-value: 9.05e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVP 353
Cdd:cd20563    1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDPFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568921699 354 CLSELHKACLSIPHRPQQAIREKYKASKYLHVSLMEPPVVLPL 396
Cdd:cd20563   81 CLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 166-269 2.26e-67

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 209.41  E-value: 2.26e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 166 EYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR--------------- 230
Cdd:cd20504    1 EYADDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRflsqmsvlrsklqlv 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568921699 231 ---------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAF 269
Cdd:cd20504   81 gtacmfiaaKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 164-270 1.54e-60

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 192.20  E-value: 1.54e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 164 VTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------- 230
Cdd:cd20561    1 VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRflssmsvlrgklq 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568921699 231 -----------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFD 270
Cdd:cd20561   81 lvgtaamllasKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 274-382 1.71e-54

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 175.56  E-value: 1.71e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVP 353
Cdd:cd20505    1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADPYLKYLPSVIAAAAVCLANHTLGNEVWPQKLARSTGYSLEDLLP 80

                         90       100
                 ....*....|....*....|....*....
gi 568921699 354 CLSELHKACLSIPHRPQQAIREKYKASKY 382
Cdd:cd20505   81 CLRDLHRTFLNAPSSPQQAIREKYKSSKY 109
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 164-269 5.82e-48

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 159.23  E-value: 5.82e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 164 VTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------- 230
Cdd:cd20507    1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRylskkqvprkklq 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568921699 231 -----------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAF 269
Cdd:cd20507   81 lvgvtalliasKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 170-272 4.43e-46

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 154.60  E-value: 4.43e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699  170 EIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------- 230
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRflskksvpknklqlvgvtc 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 568921699  231 -----KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFDLT 272
Cdd:pfam00134  81 lfiaaKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 274-382 5.36e-44

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 148.43  E-value: 5.36e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVP 353
Cdd:cd20564    1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLESLKP 80

                         90       100
                 ....*....|....*....|....*....
gi 568921699 354 CLSELHKACLSIPHRPQQAIREKYKASKY 382
Cdd:cd20564   81 CLMDLHQTYLKAPQHAQQSIREKYKNSKY 109
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
134-386 8.30e-43

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 154.93  E-value: 8.30e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 134 DFNTVSPMLVDPT---THAQSEEA-----------TDFGSDVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGM 199
Cdd:COG5024  133 DENSLSPYELDENqlaLDEKQAESkresqswqdldATDQEDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEWSM 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 200 RAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------KYEEIYPPDVDEFVYITDDTYTKRQ 255
Cdd:COG5024  213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRflssrvvslekyqlvgisalfiasKYEEVNCPSIKDLVYATDGAFTRDD 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 256 LLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEaDPFLKYLPSLVAAAAYCLANYIVNRHF 335
Cdd:COG5024  293 IIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVD-YKFIQISPSWCAAAAMYLSRKILSQNQ 371

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568921699 336 WPETLAAFTG-YSLNEIVPCLSELHKaCLSIPHRPQQAIREKYKASKYLHVS 386
Cdd:COG5024  372 WDRTLIHYSGnYTNPDLKPLNESNKE-NLQNPSVHHDAIFPKYPSPTFGKAS 422
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 167-270 1.66e-40

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 140.24  E-value: 1.66e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 167 YAEEIHRYLREAEVRHRPKAHYMRK-QPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR--------------- 230
Cdd:cd20562    8 YATDIYLNLRVAELKRRPLPDYMEKiQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRflsgnyvnrqrlqll 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568921699 231 ---------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFD 270
Cdd:cd20562   88 gvscmliasKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 274-391 1.16e-39

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 137.37  E-value: 1.16e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699  274 PTTNQFLLQYLRRQGV--CIRTENLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEI 351
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYD-FLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568921699  352 VPCLSELHKACLSIPHRPQQAIREKYKASKYLHVSLMEPP 391
Cdd:pfam02984  80 KPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 158-269 1.15e-38

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 135.93  E-value: 1.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 158 GSDVIN---VTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR---- 230
Cdd:cd20567    9 EVDKNNplaAVEYVEDIYSFYRKVEPESCVPPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRflsv 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568921699 231 --------------------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAF 269
Cdd:cd20567   89 kqvprkelqlvgvtamliasKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 160-270 9.81e-38

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 133.15  E-value: 9.81e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 160 DVINVTEYAEEIHRYLREAEVRHRPKAhYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR--------- 230
Cdd:cd20508    9 DPFQVSEYAKDIFDYMKEREEKFVVPD-YLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLylskkvvkk 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568921699 231 ---------------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFD 270
Cdd:cd20508   88 eklqllgatailiasKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 274-382 1.10e-36

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 129.29  E-value: 1.10e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQYLRRQGVC---IRTENLAKYVAELSLLEaDPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNE 350
Cdd:cd20506    1 PTIKTFLRRFLRAAQASvpdLKLEFLANYLAELSLLD-YEFLKYLPSLIAASAVFLARHTLNPHPWNPTLEHYTGYKAAD 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568921699 351 IVPCLSELHKACLSIPHRPQQAIREKYKASKY 382
Cdd:cd20506   80 LKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 160-269 1.91e-34

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 124.33  E-value: 1.91e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 160 DVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR--------- 230
Cdd:cd20568    1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRflskrvvsl 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568921699 231 ---------------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAF 269
Cdd:cd20568   81 nklqlvgisalfiasKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 169-267 3.50e-30

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 112.79  E-value: 3.50e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 169 EEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------ 230
Cdd:cd20519    6 EEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRylstqtnvpktqlqligi 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568921699 231 -------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVL 267
Cdd:cd20519   86 tclfiaaKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKAL 129
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 165-269 2.89e-28

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 107.64  E-value: 2.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 165 TEYAEEIHRYLREAEVRHRPKAHYMRKQpDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR-------------- 230
Cdd:cd20566    6 SDYVKDIYQYLRQLEVQQSIRPHYLDGK-EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRflqvqpvsrkklql 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568921699 231 ----------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAF 269
Cdd:cd20566   85 vgvtalllasKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 165-269 1.43e-27

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 105.73  E-value: 1.43e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 165 TEYAEEIHRYLREAEVRHRPKAHYMRKQpDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR-------------- 230
Cdd:cd20565    2 SEYVKDIYAYLRQLEEEQAVRPKYLEGQ-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRflqnnpvpkkmlql 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568921699 231 ----------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAF 269
Cdd:cd20565   81 vgvtamfiasKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 200-271 6.43e-22

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 89.30  E-value: 6.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 200 RAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------KYEEIYPPDVDEFVYITDDTYTKRQ 255
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRylsrqkislsllqllgitclfiacKFEERFPPEVATLCYLTDDSYSKKQ 80

                         90
                 ....*....|....*.
gi 568921699 256 LLRMEHLLLKVLAFDL 271
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 274-360 6.72e-21

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 86.21  E-value: 6.72e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRHFW-PETLAAFTGYSLNEIV 352
Cdd:cd20537    1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYE-FLKYRPSLIAAAALYLARKILGEPPPsPQLLQLVTGYSENDLQ 79


                 ....*...
gi 568921699 353 PCLSELHK 360
Cdd:cd20537   80 ECAKELLE 87
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 187-267 1.54e-20

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 86.86  E-value: 1.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 187 HYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR-------------------------KYEEIYPPDVD 241
Cdd:cd20579   30 NFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRfmatqenvvktrlqligisslfiaaKLEEIYPPKLH 109

                         90       100
                 ....*....|....*....|....*.
gi 568921699 242 EFVYITDDTYTKRQLLRMEHLLLKVL 267
Cdd:cd20579  110 QFAYVTDGACTEDEILSMELIIMKAL 135
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 281-387 2.29e-20

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 85.74  E-value: 2.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 281 LQYLRR----QGVCIRTENLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPCLS 356
Cdd:cd20512    3 MNFLRRiskaDDYDIQTRTLAKYLLEITILDHR-FLGYPPSLLAAAAMYLARKMLGRGDWNDNLVHYSGYTESQLIPCAD 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568921699 357 ELHKaCLSIPHRPQQAIREKYKASKYLHVSL 387
Cdd:cd20512   82 IMLE-YLVKPIKHHDAFFKKYSSKKFLKASI 111
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 179-267 3.69e-20

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 85.67  E-value: 3.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 179 EVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR-------------------------KYE 233
Cdd:cd20580   22 ESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRfmltqkninksmlqligitslfiasKLE 101

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568921699 234 EIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVL 267
Cdd:cd20580  102 EIYPPKLHEFAYVTDGACSEDDILDMELIILKAL 135
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 281-385 4.43e-20

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 84.59  E-value: 4.43e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 281 LQYLRR----QGVCIRTENLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPCLS 356
Cdd:cd20509    4 LHFLRRfskaGGADAQKHTLAKYLMELTLLDYD-MVHYKPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPIVQ 82

                         90       100
                 ....*....|....*....|....*....
gi 568921699 357 ELHKACLSIPHRPQQAIREKYKASKYLHV 385
Cdd:cd20509   83 KMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 199-267 1.33e-18

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 80.06  E-value: 1.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 199 MRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------KYEEIYPPDVDEFVYITDDTYTKR 254
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRflattpvardcfqllgvtslliacKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 568921699 255 QLLRMEHLLLKVL 267
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 278-360 1.26e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 74.17  E-value: 1.26e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699   278 QFLLQYLRRQGVCIRTENLAKYVAELSLLEaDPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGY-SLNEIVPCLS 356
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSD-YKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYfTEEEILRMER 79


                   ....
gi 568921699   357 ELHK 360
Cdd:smart00385  80 LLLE 83
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 274-390 1.15e-15

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 72.72  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRH-FWPETLAAFTGYSLNEIV 352
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYE-MLKYSPSMLAASAVYTARCTLNKTpEWTSTLEFHTGYSESQLM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568921699 353 PC---LSELHKAClsiPHRPQQAIREKYKASKYLHVSLMEP 390
Cdd:cd20511   80 ECarlMVRLHSKA---GTGKLTAVYKKYSSSKFGAVALLPP 117
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 283-387 1.53e-15

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 72.32  E-value: 1.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 283 YLRRQGVCIR----TENLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPCLSEL 358
Cdd:cd20510    6 FLRRYAKCARasmeTLTLARYILELSLMEYQ-FVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPLVRKL 84

                         90       100
                 ....*....|....*....|....*....
gi 568921699 359 HKACLSIPHRPQQAIREKYKASKYLHVSL 387
Cdd:cd20510   85 NAMLTKPPNKKLKTVRSKYSHKVFFEVAK 113
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 295-391 8.52e-15

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 69.96  E-value: 8.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 295 NLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRHF-WPETLAAFTGYSLNEIVPCLSELHKACLSIP----HR- 368
Cdd:cd20522    1 CLASYICELSLLHTE-LGRYSPAVIAASCLLLARVLLNQALpWPSQLEEFTGFSLEDLLSCVLHLHKKCFHEDspkdYRn 79

                         90       100
                 ....*....|....*....|....
gi 568921699 369 -PQQAIREKYKASKYLHVSLMEPP 391
Cdd:cd20522   80 vSLTAVKQRYEDERFLSISKIKVM 103
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 281-386 2.08e-11

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 60.67  E-value: 2.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 281 LQYLRRQG----VCIRTENLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPCLS 356
Cdd:cd20569    4 LHFLRRASkigeVDVEQHTLAKYLMELTMVDYD-MVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPVMQ 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568921699 357 ELHKACLSIPH--RPQQAIREKYKASKYLHVS 386
Cdd:cd20569   83 HMAKNVVKVNQglTKHMTVKNKYASSKQMKIS 114
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 175-270 1.03e-10

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 59.62  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 175 LREAEVRHRPKAHYMRK-QPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR----------------------- 230
Cdd:cd20515   30 LLSLEERYLPSASYFKCvQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRflslvpirksqlqllgavclfla 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568921699 231 -KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFD 270
Cdd:cd20515  110 sKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 281-388 2.53e-10

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 57.58  E-value: 2.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 281 LQYLRRQG----VCIRTENLAKYVAELSLLEADpFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPCLS 356
Cdd:cd20570    4 LHFLRRASkagsADVEKHTLAKYLMELTLIDYD-MVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYTGYTEDDLKPIMQ 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568921699 357 ELHKACLSIPHRPQQ--AIREKYKASKYLHVSLM 388
Cdd:cd20570   83 HMAKNVVKVNEGLTKhvAVKNKYASSKLMKISTI 116
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 175-270 1.49e-09

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 56.15  E-value: 1.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 175 LREAEVRHRPKAHYMR-KQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR----------------------- 230
Cdd:cd20575   30 LLRLEERYVPRVSYFQcVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRylscvptrkaqlqllgavcmlla 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568921699 231 -KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFD 270
Cdd:cd20575  110 sKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 297-358 2.61e-09

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 54.29  E-value: 2.61e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568921699 297 AKYVAELSLLEaDPFLKYLPSLVAAAAYCLAnyivnRH------FWPETLAAFTGYSLNEIVPCLSEL 358
Cdd:cd20529   40 ADFFLDLSLQD-YAFLNYKPSLLAAACIAAA-----RKalglspTWPEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 177-270 1.35e-07

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 50.75  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 177 EAEVRHRPKAHYMR-KQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------K 231
Cdd:cd20573   31 KAEETCLPSVSYFKcVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRflsveptkksrlqllgatcmflasK 110

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568921699 232 YEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFD 270
Cdd:cd20573  111 MKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 274-358 2.19e-07

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 48.50  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQY-----LRRQGVCI----RTENLAKYVAELSLleAD-PFLKYLPSLVAAAAYCLANYIVNRHfwPETLAAF 343
Cdd:cd20722    1 PTLQFFLEHFsslrlENRELSCAeearKARALARYLAELSL--ADyAFNQYPPSLLAICSLELADRMLQHR--SPITERL 76

                         90
                 ....*....|....*
gi 568921699 344 TGYSLNEIVPCLSEL 358
Cdd:cd20722   77 SGYPQSALEDCVGKL 91
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 274-359 3.17e-07

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 48.28  E-value: 3.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 274 PTTNQFLLQYLRR------QGVCIRT-ENLAKYVAELSLLEaDPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGY 346
Cdd:cd20721    1 PTILTFLRMYIERlslesgAAHASRPlERLAMFLAEISLLH-YSFLQFRPSTVAAACLVLAEIMHNRPAAWAAEALSAEL 79

                         90       100
                 ....*....|....*....|
gi 568921699 347 -------SLNEIVPCLSELH 359
Cdd:cd20721   80 aavlvhtRAPEVLRCVQALH 99
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 167-270 9.62e-07

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 48.06  E-value: 9.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 167 YAEEIHRYLREAEVRHRPKAHYMR-KQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR--------------- 230
Cdd:cd20574   22 YDDRVLQNLLTIEERYLPQCSYFKcVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRflavvptrkchlqll 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568921699 231 ---------KYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFD 270
Cdd:cd20574  102 gavcmflasKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 199-259 1.29e-06

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 46.16  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 199 MRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------KYEEIYPPDVDEFVYITDDTYTKR 254
Cdd:cd20521    3 MRYILVDWLVEVATMKDFSSLTLHVAVSCVDRylmvrkvprsklqllgiacmviatRFLGKDILTIREAAWLTDNTYKYE 82


                 ....*
gi 568921699 255 QLLRM 259
Cdd:cd20521   83 DVVRM 87
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 198-269 3.05e-06

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 45.29  E-value: 3.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 198 GMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------KYEEIyppdvDEFV--------Y 245
Cdd:cd20528    5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRfmdrydisedqlhlvaltclllaaKFEEL-----DDNIpkisdlnrY 79

                         90       100
                 ....*....|....*....|....
gi 568921699 246 ITDDTYTKRQLLRMEHLLLKVLAF 269
Cdd:cd20528   80 LCNSVYSKQEYLQMELLILEFFQW 103
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 278-354 1.91e-05

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 42.78  E-value: 1.91e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568921699 278 QFLLQYLRRQGVCIRTENLAKYVAELsLLEADPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPC 354
Cdd:cd00043    4 DFIRRLCSKLGLPEEVLELAIELLDR-FLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSGVSEKELRKA 79
Cyclin_N2 pfam16500
Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found ...
 90-144 6.73e-05

Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found upstream of the family Cyclin_N, pfam00134. This region controls the stability of the region by recruiting the APC/C. This region includes the ABBA motif.


Pssm-ID: 465146  Cd Length: 72  Bit Score: 40.87  E-value: 6.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568921699   90 GFDIYMDDPEQGDRDTCSGKEgiifEDVYEVDTSMLKSDLHF---------LLDFNTVSPMLVD 144
Cdd:pfam16500  11 AFTIHVDEPEQEERPSEPVSK----ETEEESEELALNPAVTLerqplaeldLLDLSTDSPMLVD 70
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 203-270 1.92e-04

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 40.06  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 203 LVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------KYEEIYP--PDVDEFVYITDDTYTKRQL 256
Cdd:cd20559    2 LLDFLFELHVELRLSPQTFFLSVNLIDRycskrivlkkhyqlvgctclwiasKFWESKArvPLLSELSKMCCNSYGEELF 81

                         90
                 ....*....|....
gi 568921699 257 LRMEHLLLKVLAFD 270
Cdd:cd20559   82 IQMEMHILNTLNWD 95
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 200-267 4.64e-04

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 39.22  E-value: 4.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 200 RAILVDWLVEVGEEYKLRTETLYLAVNFLDR---------------------------KYEEI-YPPDVDEFVYITDDTY 251
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRflssydlpkdkpwmlqllavaclslaaKMEETdVPLLVDLQVEEPKYVF 81

                         90
                 ....*....|....*.
gi 568921699 252 TKRQLLRMEHLLLKVL 267
Cdd:cd20543   82 EAKTIQRMELLVLSTL 97
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 195-269 6.55e-03

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 36.00  E-value: 6.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 195 ITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------KYEEIYPPDVDEFVYITDDT 250
Cdd:cd20517    1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRlllkkqgtketlqktgaaclliasKIRTVKPITVSKLTYLSCDC 80

                         90
                 ....*....|....*....
gi 568921699 251 YTKRQLLRMEHLLLKVLAF 269
Cdd:cd20517   81 FTNLELINQEKDILEALKW 99
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 203-260 7.81e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 35.08  E-value: 7.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921699 203 LVDWLVEVGEEYKLRTETLYLAVNFLDR------------------------KYEEIyPPDVDEFVYITDdtYTKRQLLR 258
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRflskglllgrspeliaaaclylacKLEEL-PRTLKEIAKVSG--VSEKELRK 78


                 ..
gi 568921699 259 ME 260
Cdd:cd00043   79 AE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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