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Conserved domains on  [gi|568914587|ref|XP_006498526|]
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low-density lipoprotein receptor-related protein 1B isoform X5 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3426-3460 2.85e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 2.85e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3426 CGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDEDNC 3460
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1978-2018 7.41e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 7.41e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568914587   1978 VVTNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFR 2018
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1358-1398 2.56e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 2.56e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568914587   1358 EVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGS 1398
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1037-1070 9.15e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 9.15e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 1037 CLDDQFRCSSGRCIPGHWACDGDNDCGDFSDETH 1070
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1084-1119 1.05e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.05e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 1084 CIGNEFQCRpDGNCIPDLWRCDGEKDCEDGSDEKGC 1119
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 668-717 1.07e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.07e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568914587    668 KTLLEGGMSHPRAIVVDPVNGWMYWTDWKEDkiddsvgRIEKAWMDGVNR 717
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-------VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2064-2106 1.42e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.42e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   2064 MIVSVGITWPNGISIDYEENKLYWCDARSDKIERIDLDtGANR 2106
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD-GTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3227-3263 2.44e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 55.33  E-value: 2.44e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  3227 CTVNNGGCSHLCLLGPGkTHTCACPTNFYLAADNRTC 3263
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3503-3537 3.36e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.36e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3503 CSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDEKNC 3537
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3582-3617 4.73e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 4.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3582 CKEDQFQCKNKaYCIPIRWLCDGIYDCVDGSDEETC 3617
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2361-2403 4.85e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 4.85e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568914587  2361 NLMFWTNWNeQHPSIMRATLTGKNAHVVVSTDILTPNGLTIDH 2403
Cdd:pfam00058    1 GRLYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 957-989 5.82e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 5.82e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587    957 TCQADQFSCGNGRCIPTAWLCDREDDCGDQTDE 989
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3712-3746 6.04e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 6.04e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3712 CKKDEFTCSNRNCIPMELQCDSLDDCGDGSDEQGC 3746
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2841-2875 1.27e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.27e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 2841 CNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDETNC 2875
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3267-3298 1.35e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.35e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3267 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE 3298
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 917-950 1.62e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.62e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587  917 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESN 950
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 350-392 1.62e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 1.62e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587    350 TLIESELHNPKAIAADPIAGKLFFTDYGNvPKIERCDLDGMNR 392
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3465-3499 1.90e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 1.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3465 CTLKDFLCSNGDCVSSRFWCDGEFDCADGSDEKNC 3499
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1402-1445 2.11e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 2.11e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568914587   1402 TLIAGAMEHPRAIALDPRYGILFWTDWDAnfPRIESASMSGAGR 1445
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3030-3068 2.13e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 2.13e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568914587   3030 IKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNG 3068
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2039-2080 2.80e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 2.80e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  2039 GFLFWTEWGQVPCIGKARLDGSEKVMIVSVGITWPNGISIDY 2080
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2386-2428 4.54e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 4.54e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   2386 HVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQR 2428
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1313-1537 4.79e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.01  E-value: 4.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1313 LLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGN-----IYWIDSNL 1387
Cdd:COG3391    10 AVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGadgrrLYVANSGS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1388 DQIEV-SKLDGSLRATLIAGAmeHPRAIALDPRYGILFWTDWDANFPRIesasMSGAGRKTIyKDMKTGAWPNGLTVDHF 1466
Cdd:COG3391    90 GRVSViDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV----IDTATGKVV-ATIPVGAGPHGIAVDPD 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568914587 1467 ERRIVWTDARSDAIYS--AFYDGTNMiEIIRGHEYLSHPFAVSLY--GSEVYWTDWRTNTlakANKWTGqNVSVI 1537
Cdd:COG3391   163 GKRLYVANSGSNTVSVivSVIDTATG-KVVATIPVGGGPVGVAVSpdGRRLYVANRGSNT---SNGGSN-TVSVI 232
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3307-3341 6.08e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 6.08e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3307 CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNC 3341
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 622-661 6.98e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 6.98e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568914587    622 ETILKDDLDNVEGIAVDWIGNNLYWTnDGHRKTINVARLE 661
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWT-DWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1207-1243 7.14e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 7.14e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  1207 CSLNNGGCSNHCSVVPGrGIVCSCPEGHQLKKDNRTC 1243
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3544-3578 8.65e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 8.65e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3544 CSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMDC 3578
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1000-1033 1.03e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 1.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 1000 PLTQFICKSGRCISNKWHCDTDDDCGDRSDEVGC 1033
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3117-3156 1.21e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.21e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587   3117 VVIETKISRPMALTIDYVNHRLYWAD--ENHIEFSNMDGSHR 3156
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwgLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2622-2656 1.28e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.28e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 2622 CSTVEFRCADGTCIPRSARCNQNMDCSDASDEKGC 2656
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3346-3381 1.36e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3346 CLAGQFKCtKNKKCIPVNLRCNGQDDCGDEEDEKDC 3381
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3386-3421 1.59e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.59e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3386 CSPDYFQCKTtKHCISKLWVCDEDPDCADASDEANC 3421
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1672-1714 2.47e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 2.47e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   1672 ETVISRDIQSIRGLAVDWVSRNLYWISSEFDetQINVARLDGS 1714
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGT 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 63-95 2.77e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 2.77e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587   63 CDPGEFLCHDHvTCVSQSWLCDGDPDCPDQSDE 95
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2710-2743 2.80e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 2.80e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   2710 TCAADMFSCQGSHaCVPQHWLCDGERDCPDGSDE 2743
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 829-864 2.90e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.55  E-value: 2.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587   829 CRINNGGCGTLCLAIPAGRVCACADNQLLDENGTTC 864
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3624-3656 3.03e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.03e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587 3624 CRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDEA 3656
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 718-760 3.51e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.51e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587    718 QVFVTSKMLWPNGLTLDFHTSTLYWCDAYYDHIEKVFLNGTHR 760
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1131-1162 4.86e-07

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 4.86e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568914587  1131 KFSCRStGRCINNAWVCDGDVDCEDQSDEEDC 1162
Cdd:pfam00057    7 EFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4013-4052 6.08e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 6.08e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568914587   4013 RVLVQKNLQRPTGLTVDHFGERIYWADFELSIIGSVLYDG 4052
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 194-224 1.13e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 1.13e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568914587   194 GICSQTCKNTYGSYACSCVEGYIMQSDNRSC 224
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2794-2827 1.17e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 1.17e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   2794 QCGPEEFRCADGRClVNTLWQCDGDFDCPDSSDE 2827
Cdd:smart00192    1 TCPPGEFQCDNGRC-IPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1766-1797 2.26e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 2.26e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   1766 PVGLSIDYVENKLYWISSGNGTINRCNLDGGN 1797
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1869-1905 2.31e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.85  E-value: 2.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  1869 CQVNNGGCSQLCLPTSEtTRTCMCTVGYYLQKNRMSC 1905
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1944-2169 2.93e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 52.32  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1944 VGIDfhaENDTIYWTDMGLNKISRAKRDQTWKEDVVTNGLGRVE-----GIAVDwIAGNIYWTDHGFNLIEVARLNGSFR 2018
Cdd:cd05819    13 IAVD---SSGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQfnepaGVAVD-SDGNLYVADTGNHRIQKFDPDGNFL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2019 YVIISQG-----LDQPRSIAVHPEkGFLFWTEWGQVpCIGKARLDGSekvMIVSVGITW--------PNGISIDyEENKL 2085
Cdd:cd05819    89 ASFGGSGdgdgeFNGPRGIAVDSS-GNIYVADTGNH-RIQKFDPDGE---FLTTFGSGGsgpgqfngPTGVAVD-SDGNI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2086 YWCDARSDKIERIDLDTGANREVLLSGSNVDLFS----VAVFGA-YIYWSDraHANGSVRRghkndATETVTMRTGLGVN 2160
Cdd:cd05819   163 YVADTGNHRIQVFDPDGNFLTTFGSTGTGPGQFNyptgIAVDSDgNIYVAD--SGNNRVQV-----FDPDGAGFGGNGNF 235


                  ....*....
gi 568914587 2161 LKEIKIFNR 2169
Cdd:cd05819   236 LGSDGQFNR 244
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2583-2617 3.54e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.43  E-value: 3.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 2583 CRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDC 2617
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 394-435 6.10e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 6.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587    394 RIVYSKAEQPSALALDLVNRLVYWVDLYLDYVGVVDYQGKNR 435
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
2918-2952 6.24e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 6.24e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568914587   2918 DIDECSSGFPCSQ--QCINTYGTYKCHCAEGYETQPD 2952
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2178-2213 6.74e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 6.74e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  2178 CAKENGGCQQLCLYRGNSrRTCACAHGY-LAGDGVTC 2213
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGYeLQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2985-3029 6.92e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 6.92e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568914587   2985 YTLLKQGLNNVIALDFDYREEFIYWIDSSRPngsRINRMCLNGSD 3029
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD---VIEVANLDGTN 42
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3989-4030 2.38e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 2.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  3989 GMMYWTVIGDHSHIEEAAMDGTLRRVLVQKNLQRPTGLTVDH 4030
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 314-346 2.66e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 2.66e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587    314 QNVEQMAFDWLTRNIYFVDHVSDRIFVCNFNGS 346
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1649-1689 2.95e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.69  E-value: 2.95e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1649 ERLYWTDIKTQ-TITRAFINGTGLETVISRDIQSIRGLAVDW 1689
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3073-3114 5.71e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.97  E-value: 5.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587   3073 VLVSKRLKFPRDLSLDPRAGNLYWIDcCEYPHIGRVGMDGTN 3114
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTD-WGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 506-547 1.04e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 1.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587   506 CEVDaygmPGGCSHICLLSSSykTRTCRCRTGFNMGSDGRSC 547
Cdd:pfam14670    1 CSVN----NGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3665-3701 1.11e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.19  E-value: 1.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568914587 3665 CPPTRpYRCRNDRiCLQLEKICNGINDCGDNSDEEHC 3701
Cdd:cd00112     1 CPPNE-FRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 599-639 2.53e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.38  E-value: 2.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587   599 NYIYFAD-TTSFLIGRQKIDGTERETILKDDLDNVEGIAVDW 639
Cdd:pfam00058    1 GRLYWTDsSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1736-1773 3.34e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.99  E-value: 3.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1736 GKLYWTDGN---TINMANMDGSNSKILFQ-NQKEPVGLSIDY 1773
Cdd:pfam00058    1 GRLYWTDSSlraSISSADLNGSDRKTLFTdDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2887-2916 4.87e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 4.87e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568914587  2887 GCSQDCQDLPVSYKCKCWPGFQLKDDGKTC 2916
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
3794-3828 5.61e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 5.61e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568914587   3794 DLNECLLFGICSHH--CLNTRGSYKCVCDQNFQEKNN 3828
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYTDGRN 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1167-1202 1.18e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.11  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 1167 CGPPKYPCANDTsvCLQPEKLCNGRKDCPDGSDEGD 1202
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2676-2705 2.57e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.34  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568914587 2676 RCNStSLCVLPSWICDGSNDCGDYSDELKC 2705
Cdd:cd00112     7 RCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2545-2574 2.90e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 2.90e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568914587 2545 SEFECGNGDCVDYVLTCDGIPHCKDKSDEK 2574
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 107-140 3.22e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.00  E-value: 3.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587    107 KCPLNHIAChGSSACVHLSKLCNGVVDCPDGFDE 140
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4200-4234 4.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 4.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568914587 4200 VNHCS--NYCQNGGTCIPsTLGRPTCICALGFTGPNC 4234
Cdd:cd00054     2 IDECAsgNPCQNGGTCVN-TVGSYRCSCPPGYTGRNC 37
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3891-4123 7.45e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 7.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 3891 FNPGGIFYKMIDARekrqaNSGLicPEFKRPRDIAVDwVAGNVYWTD--HSRMHWFSYYTTHWTSL-RYSINVGQLNGpn 3967
Cdd:cd05819    34 FDPDGNFITSFGSF-----GSGD--GQFNEPAGVAVD-SDGNLYVADtgNHRIQKFDPDGNFLASFgGSGDGDGEFNG-- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 3968 ctrlltnmagePYAIAVNPkRGMMYwtvIGDHSH--IEEAAMDGTLRRVLVQKN-----LQRPTGLTVDHFGErIYWADF 4040
Cdd:cd05819   104 -----------PRGIAVDS-SGNIY---VADTGNhrIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVDSDGN-IYVADT 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 4041 E-------------LSIIGSvlydgsspvvSVSSKQGLLHPHRIDVFED-YIYGAGPKNGifRVQKFGHGSVEVLALGVD 4106
Cdd:cd05819   168 GnhriqvfdpdgnfLTTFGS----------TGTGPGQFNYPTGIAVDSDgNIYVADSGNN--RVQVFDPDGAGFGGNGNF 235

                         250
                  ....*....|....*..
gi 568914587 4107 KTKSilvshryKQLNLP 4123
Cdd:cd05819   236 LGSD-------GQFNRP 245
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3426-3460 2.85e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 2.85e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3426 CGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDEDNC 3460
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1978-2018 7.41e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 7.41e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568914587   1978 VVTNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFR 2018
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3425-3457 1.17e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 1.17e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3425 TCGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDE 3457
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1358-1398 2.56e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 2.56e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568914587   1358 EVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGS 1398
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3424-3460 3.76e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 3.76e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  3424 KTCGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDEDNC 3460
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1037-1070 9.15e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 9.15e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 1037 CLDDQFRCSSGRCIPGHWACDGDNDCGDFSDETH 1070
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1084-1119 1.05e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.05e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 1084 CIGNEFQCRpDGNCIPDLWRCDGEKDCEDGSDEKGC 1119
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 668-717 1.07e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.07e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568914587    668 KTLLEGGMSHPRAIVVDPVNGWMYWTDWKEDkiddsvgRIEKAWMDGVNR 717
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-------VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2064-2106 1.42e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.42e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   2064 MIVSVGITWPNGISIDYEENKLYWCDARSDKIERIDLDtGANR 2106
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD-GTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3227-3263 2.44e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 55.33  E-value: 2.44e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  3227 CTVNNGGCSHLCLLGPGkTHTCACPTNFYLAADNRTC 3263
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1037-1068 3.14e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 3.14e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   1037 CLDDQFRCSSGRCIPGHWACDGDNDCGDFSDE 1068
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3503-3537 3.36e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.36e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3503 CSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDEKNC 3537
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3582-3617 4.73e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 4.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3582 CKEDQFQCKNKaYCIPIRWLCDGIYDCVDGSDEETC 3617
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2361-2403 4.85e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 4.85e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568914587  2361 NLMFWTNWNeQHPSIMRATLTGKNAHVVVSTDILTPNGLTIDH 2403
Cdd:pfam00058    1 GRLYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 957-989 5.82e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 5.82e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587    957 TCQADQFSCGNGRCIPTAWLCDREDDCGDQTDE 989
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3712-3746 6.04e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 6.04e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3712 CKKDEFTCSNRNCIPMELQCDSLDDCGDGSDEQGC 3746
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 958-989 6.66e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 6.66e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568914587  958 CQADQFSCGNGRCIPTAWLCDREDDCGDQTDE 989
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2841-2875 1.27e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.27e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 2841 CNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDETNC 2875
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1084-1119 1.28e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.28e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  1084 CIGNEFQCRpDGNCIPDLWRCDGEKDCEDGSDEKGC 1119
Cdd:pfam00057    3 CSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3267-3298 1.35e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.35e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3267 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE 3298
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 917-950 1.62e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.62e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587  917 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESN 950
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 350-392 1.62e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 1.62e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587    350 TLIESELHNPKAIAADPIAGKLFFTDYGNvPKIERCDLDGMNR 392
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1084-1116 1.72e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 1.72e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   1084 CIGNEFQCRpDGNCIPDLWRCDGEKDCEDGSDE 1116
Cdd:smart00192    2 CPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3267-3300 1.82e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 1.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 3267 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPD 3300
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3465-3499 1.90e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 1.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3465 CTLKDFLCSNGDCVSSRFWCDGEFDCADGSDEKNC 3499
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1402-1445 2.11e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 2.11e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568914587   1402 TLIAGAMEHPRAIALDPRYGILFWTDWDAnfPRIESASMSGAGR 1445
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3030-3068 2.13e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 2.13e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568914587   3030 IKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNG 3068
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2039-2080 2.80e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 2.80e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  2039 GFLFWTEWGQVPCIGKARLDGSEKVMIVSVGITWPNGISIDY 2080
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 917-948 2.89e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.89e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587    917 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDE 948
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2386-2428 4.54e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 4.54e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   2386 HVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQR 2428
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1313-1537 4.79e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.01  E-value: 4.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1313 LLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGN-----IYWIDSNL 1387
Cdd:COG3391    10 AVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGadgrrLYVANSGS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1388 DQIEV-SKLDGSLRATLIAGAmeHPRAIALDPRYGILFWTDWDANFPRIesasMSGAGRKTIyKDMKTGAWPNGLTVDHF 1466
Cdd:COG3391    90 GRVSViDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV----IDTATGKVV-ATIPVGAGPHGIAVDPD 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568914587 1467 ERRIVWTDARSDAIYS--AFYDGTNMiEIIRGHEYLSHPFAVSLY--GSEVYWTDWRTNTlakANKWTGqNVSVI 1537
Cdd:COG3391   163 GKRLYVANSGSNTVSVivSVIDTATG-KVVATIPVGGGPVGVAVSpdGRRLYVANRGSNT---SNGGSN-TVSVI 232
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3307-3341 6.08e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 6.08e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3307 CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNC 3341
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3581-3614 6.27e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 6.27e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   3581 ECKEDQFQCKNKaYCIPIRWLCDGIYDCVDGSDE 3614
Cdd:smart00192    1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1037-1068 6.40e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 6.40e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568914587  1037 CLDDQFRCSSGRCIPGHWACDGDNDCGDFSDE 1068
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 622-661 6.98e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 6.98e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568914587    622 ETILKDDLDNVEGIAVDWIGNNLYWTnDGHRKTINVARLE 661
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWT-DWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1207-1243 7.14e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 7.14e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  1207 CSLNNGGCSNHCSVVPGrGIVCSCPEGHQLKKDNRTC 1243
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3710-3746 8.49e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 8.49e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  3710 KPCKKDEFTCSNRNCIPMELQCDSLDDCGDGSDEQGC 3746
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3544-3578 8.65e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 8.65e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3544 CSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMDC 3578
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
956-990 9.10e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 9.10e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568914587   956 RTCQADQFSCGNGRCIPTAWLCDREDDCGDQTDEV 990
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1000-1033 1.03e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 1.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 1000 PLTQFICKSGRCISNKWHCDTDDDCGDRSDEVGC 1033
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3712-3743 1.12e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.12e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3712 CKKDEFTCSNRNCIPMELQCDSLDDCGDGSDE 3743
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3117-3156 1.21e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.21e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587   3117 VVIETKISRPMALTIDYVNHRLYWAD--ENHIEFSNMDGSHR 3156
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwgLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2622-2656 1.28e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.28e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 2622 CSTVEFRCADGTCIPRSARCNQNMDCSDASDEKGC 2656
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3346-3381 1.36e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3346 CLAGQFKCtKNKKCIPVNLRCNGQDDCGDEEDEKDC 3381
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3386-3421 1.59e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.59e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3386 CSPDYFQCKTtKHCISKLWVCDEDPDCADASDEANC 3421
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1939-2109 1.66e-07

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 56.05  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1939 GAAFAVGIDFHAENdTIYWTDMGLNKISRAKRDqTWKEDVVTNGLGRVEGIAVDWiAGNIYWTDHGFNLIEVARLNGSFR 2018
Cdd:COG3386     6 GFRLGEGPVWDPDG-RLYWVDIPGGRIHRYDPD-GGAVEVFAEPSGRPNGLAFDP-DGRLLVADHGRGLVRFDPADGEVT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2019 YVIISQGLDQPRS--IAVHPeKGFLFWTEWGQVPCIGK-ARLDGSEKVMIVSVGITWPNGISIDYEENKLYWCDARSDKI 2095
Cdd:COG3386    83 VLADEYGKPLNRPndGVVDP-DGRLYFTDMGEYLPTGAlYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161

                         170
                  ....*....|....*..
gi 568914587 2096 ERIDLD-TGA--NREVL 2109
Cdd:COG3386   162 YRFDLDaDGTlgNRRVF 178
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
997-1033 1.79e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 1.79e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587   997 TCEPlTQFICKSGRCISNKWHCDTDDDCGDRSDEVGC 1033
Cdd:pfam00057    2 TCSP-NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1672-1714 2.47e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 2.47e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   1672 ETVISRDIQSIRGLAVDWVSRNLYWISSEFDetQINVARLDGS 1714
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGT 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 63-95 2.77e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 2.77e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587   63 CDPGEFLCHDHvTCVSQSWLCDGDPDCPDQSDE 95
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2710-2743 2.80e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 2.80e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   2710 TCAADMFSCQGSHaCVPQHWLCDGERDCPDGSDE 2743
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2841-2872 2.89e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 2.89e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   2841 CNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDE 2872
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 829-864 2.90e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.55  E-value: 2.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587   829 CRINNGGCGTLCLAIPAGRVCACADNQLLDENGTTC 864
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1457-1489 2.95e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 2.95e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   1457 WPNGLTVDHFERRIVWTDARSDAIYSAFYDGTN 1489
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3624-3656 3.03e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.03e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587 3624 CRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDEA 3656
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1378-1418 3.05e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 3.05e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1378 GNIYWIDSNLDQ-IEVSKLDGSLRATLIAGAMEHPRAIALDP 1418
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 718-760 3.51e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.51e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587    718 QVFVTSKMLWPNGLTLDFHTSTLYWCDAYYDHIEKVFLNGTHR 760
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2621-2653 4.03e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 4.03e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   2621 TCSTVEFRCADGTCIPRSARCNQNMDCSDASDE 2653
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3582-3617 4.72e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 4.72e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3582 CKEDQFQCKNKAyCIPIRWLCDGIYDCVDGSDEETC 3617
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1131-1162 4.86e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 4.86e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568914587  1131 KFSCRStGRCINNAWVCDGDVDCEDQSDEEDC 1162
Cdd:pfam00057    7 EFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3544-3578 5.25e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 5.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568914587  3544 CSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMDC 3578
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4013-4052 6.08e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 6.08e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568914587   4013 RVLVQKNLQRPTGLTVDHFGERIYWADFELSIIGSVLYDG 4052
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3386-3421 6.08e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 6.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3386 CSPDYFQCKTTKhCISKLWVCDEDPDCADASDEANC 3421
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2620-2656 6.20e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 6.20e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  2620 STCSTVEFRCADGTCIPRSARCNQNMDCSDASDEKGC 2656
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 63-95 6.51e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 6.51e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587     63 CDPGEFLCHDHvTCVSQSWLCDGDPDCPDQSDE 95
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3501-3537 6.64e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 6.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  3501 TSCSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDEKNC 3537
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3624-3655 7.18e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 7.18e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3624 CRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDE 3655
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2711-2744 7.83e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 7.83e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 2711 CAADMFSCqGSHACVPQHWLCDGERDCPDGSDEL 2744
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1996-2036 8.80e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 8.80e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1996 GNIYWTDHGFNL-IEVARLNGSFRYVIISQGLDQPRSIAVHP 2036
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2019-2061 9.64e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.98  E-value: 9.64e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   2019 YVIISQGLDQPRSIAVHPEKGFLFWTEWGQvPCIGKARLDGSE 2061
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 194-224 1.13e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 1.13e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568914587   194 GICSQTCKNTYGSYACSCVEGYIMQSDNRSC 224
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2794-2827 1.17e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 1.17e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   2794 QCGPEEFRCADGRClVNTLWQCDGDFDCPDSSDE 2827
Cdd:smart00192    1 TCPPGEFQCDNGRC-IPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1128-1162 1.25e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.59  E-value: 1.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 1128 HKTKFSCRStGRCINNAWVCDGDVDCEDQSDEEDC 1162
Cdd:cd00112     2 PPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3503-3534 1.41e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.41e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3503 CSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDE 3534
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3464-3496 1.51e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.51e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3464 TCTLKDFLCSNGDCVSSRFWCDGEFDCADGSDE 3496
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2795-2828 1.87e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 1.87e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 2795 CGPEEFRCADGRClVNTLWQCDGDFDCPDSSDEA 2828
Cdd:cd00112     1 CPPNEFRCANGRC-IPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
917-950 2.09e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568914587   917 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESN 950
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3306-3338 2.26e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 2.26e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3306 KCQPGRFQCGTGLCALPAFICDGENDCGDNSDE 3338
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1766-1797 2.26e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 2.26e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   1766 PVGLSIDYVENKLYWISSGNGTINRCNLDGGN 1797
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2709-2744 2.31e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  2709 VTCAADMFSCQGShACVPQHWLCDGERDCPDGSDEL 2744
Cdd:pfam00057    1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1869-1905 2.31e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.85  E-value: 2.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  1869 CQVNNGGCSQLCLPTSEtTRTCMCTVGYYLQKNRMSC 1905
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3464-3499 2.42e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.42e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3464 TCTLKDFLCSNGDCVSSRFWCDGEFDCADGSDEKNC 3499
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 997-1030 2.52e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 2.52e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587    997 TCEPlTQFICKSGRCISNKWHCDTDDDCGDRSDE 1030
Cdd:smart00192    1 TCPP-GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3306-3341 2.54e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.54e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3306 KCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNC 3341
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1944-2169 2.93e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 52.32  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1944 VGIDfhaENDTIYWTDMGLNKISRAKRDQTWKEDVVTNGLGRVE-----GIAVDwIAGNIYWTDHGFNLIEVARLNGSFR 2018
Cdd:cd05819    13 IAVD---SSGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQfnepaGVAVD-SDGNLYVADTGNHRIQKFDPDGNFL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2019 YVIISQG-----LDQPRSIAVHPEkGFLFWTEWGQVpCIGKARLDGSekvMIVSVGITW--------PNGISIDyEENKL 2085
Cdd:cd05819    89 ASFGGSGdgdgeFNGPRGIAVDSS-GNIYVADTGNH-RIQKFDPDGE---FLTTFGSGGsgpgqfngPTGVAVD-SDGNI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2086 YWCDARSDKIERIDLDTGANREVLLSGSNVDLFS----VAVFGA-YIYWSDraHANGSVRRghkndATETVTMRTGLGVN 2160
Cdd:cd05819   163 YVADTGNHRIQVFDPDGNFLTTFGSTGTGPGQFNyptgIAVDSDgNIYVAD--SGNNRVQV-----FDPDGAGFGGNGNF 235


                  ....*....
gi 568914587 2161 LKEIKIFNR 2169
Cdd:cd05819   236 LGSDGQFNR 244
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3544-3575 3.31e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 3.31e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3544 CSSSEYMCASGGCLSASLKCNGEPDCVDGSDE 3575
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2583-2617 3.54e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.43  E-value: 3.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 2583 CRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDC 2617
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
63-95 3.73e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 3.73e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568914587    63 CDPGEFLCHDHVtCVSQSWLCDGDPDCPDQSDE 95
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3346-3378 4.27e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 4.27e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3346 CLAGQFKCtKNKKCIPVNLRCNGQDDCGDEEDE 3378
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2793-2828 4.28e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 4.28e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  2793 RQCGPEEFRCADGRClVNTLWQCDGDFDCPDSSDEA 2828
Cdd:pfam00057    1 STCSPNEFQCGSGEC-IPRSWVCDGDPDCGDGSDEE 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3386-3418 4.80e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 4.80e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3386 CSPDYFQCKTtKHCISKLWVCDEDPDCADASDE 3418
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 394-435 6.10e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 6.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587    394 RIVYSKAEQPSALALDLVNRLVYWVDLYLDYVGVVDYQGKNR 435
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
2918-2952 6.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 6.24e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568914587   2918 DIDECSSGFPCSQ--QCINTYGTYKCHCAEGYETQPD 2952
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1423-1465 6.38e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 6.38e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568914587  1423 LFWTDWdANFPRIESASMSGAGRKTIYKDmkTGAWPNGLTVDH 1465
Cdd:pfam00058    3 LYWTDS-SLRASISSADLNGSDRKTLFTD--DLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2178-2213 6.74e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 6.74e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  2178 CAKENGGCQQLCLYRGNSrRTCACAHGY-LAGDGVTC 2213
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGYeLQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2985-3029 6.92e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 6.92e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568914587   2985 YTLLKQGLNNVIALDFDYREEFIYWIDSSRPngsRINRMCLNGSD 3029
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD---VIEVANLDGTN 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2918-2948 1.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 1.79e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587 2918 DIDECSSGFPCS--QQCINTYGTYKCHCAEGYE 2948
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1128-1159 1.99e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 1.99e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   1128 HKTKFSCRStGRCINNAWVCDGDVDCEDQSDE 1159
Cdd:smart00192    3 PPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2841-2875 2.29e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 2.29e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568914587  2841 CNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDETNC 2875
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3989-4030 2.38e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 2.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  3989 GMMYWTVIGDHSHIEEAAMDGTLRRVLVQKNLQRPTGLTVDH 4030
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 314-346 2.66e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 2.66e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587    314 QNVEQMAFDWLTRNIYFVDHVSDRIFVCNFNGS 346
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 1949-2106 2.95e-05

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 48.80  E-value: 2.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  1949 HAENDTIYWTDMGLNKISR----AKRDQTWK-EDVVTNGLGRVEGiavDWIAGNiywtDHGFNLIEVARlnGSFRYVIIS 2023
Cdd:pfam08450    8 DEEEGALYWVDILGGRIHRldpaTGKETVWDtPGPVGAIAPRDDG---GLIVAL----KDGVALLDLAT--GELTPLADP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  2024 QGLDQPRSI----AVHPEKGFLFWTEW---GQVPCIGKA-RLDGSEKVMIVSVGITWPNGISIDYEENKLYWCDARSDKI 2095
Cdd:pfam08450   79 EDDDWPLNRfndgKVDPDGRFWFGTMGddeAPGGDPGALyRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKI 158

                          170
                   ....*....|.
gi 568914587  2096 ERIDLDTGANR 2106
Cdd:pfam08450  159 WAYDYDLDGGL 169
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1649-1689 2.95e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.69  E-value: 2.95e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1649 ERLYWTDIKTQ-TITRAFINGTGLETVISRDIQSIRGLAVDW 1689
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 690-734 3.88e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.69  E-value: 3.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568914587   690 MYWTDWKEDkiddsvGRIEKAWMDGVNRQVFVTSKMLWPNGLTLD 734
Cdd:pfam00058    3 LYWTDSSLR------ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3624-3656 4.73e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 4.73e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568914587  3624 CRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDEA 3656
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3073-3114 5.71e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.97  E-value: 5.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587   3073 VLVSKRLKFPRDLSLDPRAGNLYWIDcCEYPHIGRVGMDGTN 3114
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTD-WGLDVIEVANLDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3005-3046 5.98e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.92  E-value: 5.98e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568914587  3005 EFIYWIDSSrpNGSRINRMCLNGSD--IKVVHNTAVPNALAVDW 3046
Cdd:pfam00058    1 GRLYWTDSS--LRASISSADLNGSDrkTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2583-2614 6.40e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 6.40e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   2583 CRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDE 2614
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3265-3300 9.98e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 9.98e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3265 SNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPD 3300
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 506-547 1.04e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 1.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587   506 CEVDaygmPGGCSHICLLSSSykTRTCRCRTGFNMGSDGRSC 547
Cdd:pfam14670    1 CSVN----NGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3665-3701 1.11e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.19  E-value: 1.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568914587 3665 CPPTRpYRCRNDRiCLQLEKICNGINDCGDNSDEEHC 3701
Cdd:cd00112     1 CPPNE-FRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3346-3381 1.15e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 1.15e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3346 CLAGQFKCtKNKKCIPVNLRCNGQDDCGDEEDEKDC 3381
Cdd:pfam00057    3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1977-2144 1.15e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1977 DVVTNGLGRVEGIAVDWIAGN-IYWTDHGFNLIEVARLNgSFRYV-IISQGlDQPRSIAVHPEKGFLFWTEW--GQVpci 2052
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRrLYVANSGSGRVSVIDLA-TGKVVaTIPVG-GGPRGLAVDPDGGRLYVADSgnGRV--- 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2053 gkARLDGS--EKVMIVSVGiTWPNGISIDYEENKLYWCDARSDKI----ERIDLDTGANREVLLSGSNVDLFSVAVFGAY 2126
Cdd:COG3391   135 --SVIDTAtgKVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNTVsvivSVIDTATGKVVATIPVGGGPVGVAVSPDGRR 211

                         170
                  ....*....|....*...
gi 568914587 2127 IYWSDRaHANGSVRRGHK 2144
Cdd:COG3391   212 LYVANR-GSNTSNGGSNT 228
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1635-1670 1.57e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 1.57e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568914587   1635 DIDDVAVIDFDASEERLYWTDIKTQTITRAFINGTG 1670
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 599-639 2.53e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.38  E-value: 2.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587   599 NYIYFAD-TTSFLIGRQKIDGTERETILKDDLDNVEGIAVDW 639
Cdd:pfam00058    1 GRLYWTDsSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2581-2617 2.54e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 2.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  2581 RSCRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDC 2617
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1736-1773 3.34e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.99  E-value: 3.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1736 GKLYWTDGN---TINMANMDGSNSKILFQ-NQKEPVGLSIDY 1773
Cdd:pfam00058    1 GRLYWTDSSlraSISSADLNGSDRKTLFTdDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 580-621 4.64e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 4.64e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587    580 MIPIENLVNPRALDFHAEANYIYFADTTSFLIGRQKIDGTER 621
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2887-2916 4.87e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 4.87e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568914587  2887 GCSQDCQDLPVSYKCKCWPGFQLKDDGKTC 2916
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
3794-3828 5.61e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 5.61e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568914587   3794 DLNECLLFGICSHH--CLNTRGSYKCVCDQNFQEKNN 3828
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYTDGRN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 326-366 1.13e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587   326 RNIYFVDHVSD-RIFVCNFNGSVCVTLIESELHNPKAIAADP 366
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1167-1202 1.18e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.11  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 1167 CGPPKYPCANDTsvCLQPEKLCNGRKDCPDGSDEGD 1202
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEEN 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1167-1200 1.53e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.77  E-value: 1.53e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   1167 CGPPKYPCANdtSVCLQPEKLCNGRKDCPDGSDE 1200
Cdd:smart00192    2 CPPGEFQCDN--GRCIPSSWVCDGVDDCGDGSDE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-225 2.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 2.18e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587    186 DQDECSIYGICSQ--TCKNTYGSYACSCVEGYimqSDNRSCK 225
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2676-2705 2.57e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.34  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568914587 2676 RCNStSLCVLPSWICDGSNDCGDYSDELKC 2705
Cdd:cd00112     7 RCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 186-219 2.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 2.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587  186 DQDECSIYGICS--QTCKNTYGSYACSCVEGYIMQS 219
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2349-2384 2.81e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.81e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568914587   2349 DHPHVLALDECQNLMFWTNWNeqHPSIMRATLTGKN 2384
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2545-2574 2.90e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 2.90e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568914587 2545 SEFECGNGDCVDYVLTCDGIPHCKDKSDEK 2574
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 107-140 3.22e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.00  E-value: 3.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587    107 KCPLNHIAChGSSACVHLSKLCNGVVDCPDGFDE 140
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2928-2953 3.44e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 3.44e-03
                           10        20
                   ....*....|....*....|....*.
gi 568914587  2928 CSQQCINTYGTYKCHCAEGYETQPDN 2953
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDG 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3092-3133 3.50e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 3.50e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  3092 GNLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDY 3133
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4200-4234 4.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 4.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568914587 4200 VNHCS--NYCQNGGTCIPsTLGRPTCICALGFTGPNC 4234
Cdd:cd00054     2 IDECAsgNPCQNGGTCVN-TVGSYRCSCPPGYTGRNC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2545-2573 4.46e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.61  E-value: 4.46e-03
                            10        20
                    ....*....|....*....|....*....
gi 568914587   2545 SEFECGNGDCVDYVLTCDGIPHCKDKSDE 2573
Cdd:smart00192    5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2675-2705 5.51e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.23  E-value: 5.51e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568914587  2675 IRCNSTSlCVLPSWICDGSNDCGDYSDELKC 2705
Cdd:pfam00057    8 FQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3794-3827 5.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 5.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3794 DLNECLLFGICSHH--CLNTRGSYKCVCDQNFQEKN 3827
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3665-3698 5.93e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.23  E-value: 5.93e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   3665 CPPTRpYRCRNdRICLQLEKICNGINDCGDNSDE 3698
Cdd:smart00192    2 CPPGE-FQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 108-140 6.62e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.19  E-value: 6.62e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587  108 CPLNHIAChGSSACVHLSKLCNGVVDCPDGFDE 140
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3891-4123 7.45e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 7.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 3891 FNPGGIFYKMIDARekrqaNSGLicPEFKRPRDIAVDwVAGNVYWTD--HSRMHWFSYYTTHWTSL-RYSINVGQLNGpn 3967
Cdd:cd05819    34 FDPDGNFITSFGSF-----GSGD--GQFNEPAGVAVD-SDGNLYVADtgNHRIQKFDPDGNFLASFgGSGDGDGEFNG-- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 3968 ctrlltnmagePYAIAVNPkRGMMYwtvIGDHSH--IEEAAMDGTLRRVLVQKN-----LQRPTGLTVDHFGErIYWADF 4040
Cdd:cd05819   104 -----------PRGIAVDS-SGNIY---VADTGNhrIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVDSDGN-IYVADT 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 4041 E-------------LSIIGSvlydgsspvvSVSSKQGLLHPHRIDVFED-YIYGAGPKNGifRVQKFGHGSVEVLALGVD 4106
Cdd:cd05819   168 GnhriqvfdpdgnfLTTFGS----------TGTGPGQFNYPTGIAVDSDgNIYVADSGNN--RVQVFDPDGAGFGGNGNF 235

                         250
                  ....*....|....*..
gi 568914587 4107 KTKSilvshryKQLNLP 4123
Cdd:cd05819   236 LGSD-------GQFNRP 245
EGF_CA smart00179
Calcium-binding EGF-like domain;
2877-2917 7.46e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 7.46e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568914587   2877 INECLSKKISGCSQDCQDLPVSYKCKCWPGFQlkdDGKTCV 2917
Cdd:smart00179    2 IDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2671-2702 9.23e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.46  E-value: 9.23e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   2671 STGFIRCNStSLCVLPSWICDGSNDCGDYSDE 2702
Cdd:smart00192    3 PPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3426-3460 2.85e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 2.85e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3426 CGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDEDNC 3460
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1978-2018 7.41e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 7.41e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568914587   1978 VVTNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFR 2018
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3425-3457 1.17e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 1.17e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3425 TCGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDE 3457
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1358-1398 2.56e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 2.56e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568914587   1358 EVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGS 1398
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3424-3460 3.76e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 3.76e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  3424 KTCGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDEDNC 3460
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1037-1070 9.15e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 9.15e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 1037 CLDDQFRCSSGRCIPGHWACDGDNDCGDFSDETH 1070
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1084-1119 1.05e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.05e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 1084 CIGNEFQCRpDGNCIPDLWRCDGEKDCEDGSDEKGC 1119
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 668-717 1.07e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.07e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568914587    668 KTLLEGGMSHPRAIVVDPVNGWMYWTDWKEDkiddsvgRIEKAWMDGVNR 717
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-------VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2064-2106 1.42e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.42e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   2064 MIVSVGITWPNGISIDYEENKLYWCDARSDKIERIDLDtGANR 2106
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD-GTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3227-3263 2.44e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 55.33  E-value: 2.44e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  3227 CTVNNGGCSHLCLLGPGkTHTCACPTNFYLAADNRTC 3263
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1037-1068 3.14e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 3.14e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   1037 CLDDQFRCSSGRCIPGHWACDGDNDCGDFSDE 1068
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3503-3537 3.36e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.36e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3503 CSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDEKNC 3537
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3582-3617 4.73e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 4.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3582 CKEDQFQCKNKaYCIPIRWLCDGIYDCVDGSDEETC 3617
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2361-2403 4.85e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 4.85e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568914587  2361 NLMFWTNWNeQHPSIMRATLTGKNAHVVVSTDILTPNGLTIDH 2403
Cdd:pfam00058    1 GRLYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 957-989 5.82e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 5.82e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587    957 TCQADQFSCGNGRCIPTAWLCDREDDCGDQTDE 989
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3712-3746 6.04e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 6.04e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3712 CKKDEFTCSNRNCIPMELQCDSLDDCGDGSDEQGC 3746
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 958-989 6.66e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 6.66e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568914587  958 CQADQFSCGNGRCIPTAWLCDREDDCGDQTDE 989
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2841-2875 1.27e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.27e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 2841 CNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDETNC 2875
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1084-1119 1.28e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.28e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  1084 CIGNEFQCRpDGNCIPDLWRCDGEKDCEDGSDEKGC 1119
Cdd:pfam00057    3 CSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3267-3298 1.35e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.35e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3267 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE 3298
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 917-950 1.62e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.62e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587  917 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESN 950
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 350-392 1.62e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 1.62e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587    350 TLIESELHNPKAIAADPIAGKLFFTDYGNvPKIERCDLDGMNR 392
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1084-1116 1.72e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 1.72e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   1084 CIGNEFQCRpDGNCIPDLWRCDGEKDCEDGSDE 1116
Cdd:smart00192    2 CPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3267-3300 1.82e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 1.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 3267 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPD 3300
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3465-3499 1.90e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 1.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3465 CTLKDFLCSNGDCVSSRFWCDGEFDCADGSDEKNC 3499
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1402-1445 2.11e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 2.11e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568914587   1402 TLIAGAMEHPRAIALDPRYGILFWTDWDAnfPRIESASMSGAGR 1445
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3030-3068 2.13e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 2.13e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568914587   3030 IKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNG 3068
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2039-2080 2.80e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 2.80e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  2039 GFLFWTEWGQVPCIGKARLDGSEKVMIVSVGITWPNGISIDY 2080
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 917-948 2.89e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.89e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587    917 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDE 948
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2386-2428 4.54e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 4.54e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   2386 HVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQR 2428
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1313-1537 4.79e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.01  E-value: 4.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1313 LLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGN-----IYWIDSNL 1387
Cdd:COG3391    10 AVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGadgrrLYVANSGS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1388 DQIEV-SKLDGSLRATLIAGAmeHPRAIALDPRYGILFWTDWDANFPRIesasMSGAGRKTIyKDMKTGAWPNGLTVDHF 1466
Cdd:COG3391    90 GRVSViDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV----IDTATGKVV-ATIPVGAGPHGIAVDPD 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568914587 1467 ERRIVWTDARSDAIYS--AFYDGTNMiEIIRGHEYLSHPFAVSLY--GSEVYWTDWRTNTlakANKWTGqNVSVI 1537
Cdd:COG3391   163 GKRLYVANSGSNTVSVivSVIDTATG-KVVATIPVGGGPVGVAVSpdGRRLYVANRGSNT---SNGGSN-TVSVI 232
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3307-3341 6.08e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 6.08e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3307 CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNC 3341
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3581-3614 6.27e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 6.27e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   3581 ECKEDQFQCKNKaYCIPIRWLCDGIYDCVDGSDE 3614
Cdd:smart00192    1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1037-1068 6.40e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 6.40e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568914587  1037 CLDDQFRCSSGRCIPGHWACDGDNDCGDFSDE 1068
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 622-661 6.98e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 6.98e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568914587    622 ETILKDDLDNVEGIAVDWIGNNLYWTnDGHRKTINVARLE 661
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWT-DWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1207-1243 7.14e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 7.14e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  1207 CSLNNGGCSNHCSVVPGrGIVCSCPEGHQLKKDNRTC 1243
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3710-3746 8.49e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 8.49e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  3710 KPCKKDEFTCSNRNCIPMELQCDSLDDCGDGSDEQGC 3746
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3544-3578 8.65e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 8.65e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 3544 CSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMDC 3578
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
956-990 9.10e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 9.10e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568914587   956 RTCQADQFSCGNGRCIPTAWLCDREDDCGDQTDEV 990
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1000-1033 1.03e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 1.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 1000 PLTQFICKSGRCISNKWHCDTDDDCGDRSDEVGC 1033
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3712-3743 1.12e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.12e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3712 CKKDEFTCSNRNCIPMELQCDSLDDCGDGSDE 3743
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3117-3156 1.21e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.21e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587   3117 VVIETKISRPMALTIDYVNHRLYWAD--ENHIEFSNMDGSHR 3156
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwgLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2622-2656 1.28e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.28e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 2622 CSTVEFRCADGTCIPRSARCNQNMDCSDASDEKGC 2656
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3346-3381 1.36e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3346 CLAGQFKCtKNKKCIPVNLRCNGQDDCGDEEDEKDC 3381
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3386-3421 1.59e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.59e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3386 CSPDYFQCKTtKHCISKLWVCDEDPDCADASDEANC 3421
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1939-2109 1.66e-07

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 56.05  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1939 GAAFAVGIDFHAENdTIYWTDMGLNKISRAKRDqTWKEDVVTNGLGRVEGIAVDWiAGNIYWTDHGFNLIEVARLNGSFR 2018
Cdd:COG3386     6 GFRLGEGPVWDPDG-RLYWVDIPGGRIHRYDPD-GGAVEVFAEPSGRPNGLAFDP-DGRLLVADHGRGLVRFDPADGEVT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2019 YVIISQGLDQPRS--IAVHPeKGFLFWTEWGQVPCIGK-ARLDGSEKVMIVSVGITWPNGISIDYEENKLYWCDARSDKI 2095
Cdd:COG3386    83 VLADEYGKPLNRPndGVVDP-DGRLYFTDMGEYLPTGAlYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161

                         170
                  ....*....|....*..
gi 568914587 2096 ERIDLD-TGA--NREVL 2109
Cdd:COG3386   162 YRFDLDaDGTlgNRRVF 178
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
997-1033 1.79e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 1.79e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587   997 TCEPlTQFICKSGRCISNKWHCDTDDDCGDRSDEVGC 1033
Cdd:pfam00057    2 TCSP-NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1672-1714 2.47e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 2.47e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   1672 ETVISRDIQSIRGLAVDWVSRNLYWISSEFDetQINVARLDGS 1714
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGT 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 63-95 2.77e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 2.77e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587   63 CDPGEFLCHDHvTCVSQSWLCDGDPDCPDQSDE 95
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2710-2743 2.80e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 2.80e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   2710 TCAADMFSCQGSHaCVPQHWLCDGERDCPDGSDE 2743
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2841-2872 2.89e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 2.89e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   2841 CNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDE 2872
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 829-864 2.90e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.55  E-value: 2.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587   829 CRINNGGCGTLCLAIPAGRVCACADNQLLDENGTTC 864
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1457-1489 2.95e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 2.95e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   1457 WPNGLTVDHFERRIVWTDARSDAIYSAFYDGTN 1489
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3624-3656 3.03e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.03e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587 3624 CRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDEA 3656
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1378-1418 3.05e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 3.05e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1378 GNIYWIDSNLDQ-IEVSKLDGSLRATLIAGAMEHPRAIALDP 1418
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 718-760 3.51e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.51e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587    718 QVFVTSKMLWPNGLTLDFHTSTLYWCDAYYDHIEKVFLNGTHR 760
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2621-2653 4.03e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 4.03e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   2621 TCSTVEFRCADGTCIPRSARCNQNMDCSDASDE 2653
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3582-3617 4.72e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 4.72e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3582 CKEDQFQCKNKAyCIPIRWLCDGIYDCVDGSDEETC 3617
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1925-2141 4.84e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 54.64  E-value: 4.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1925 LEPRDKVDALMPISGAAFAVGIDFhAENDTIYWTDMGLNKISRA-KRDQTWKEDVVTNGLGRVEGIAVDwIAGNIYWTDH 2003
Cdd:COG4257    43 LDPATGEFTEYPLGGGSGPHGIAV-DPDGNLWFTDNGNNRIGRIdPKTGEITTFALPGGGSNPHGIAFD-PDGNLWFTDQ 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2004 GFNLIevARLN---GSFRYVIISQGLDQPRSIAVHPeKGFLFWTEWGqVPCIGkaRLD---GSEKVMIVSVGITWPNGIS 2077
Cdd:COG4257   121 GGNRI--GRLDpatGEVTEFPLPTGGAGPYGIAVDP-DGNLWVTDFG-ANAIG--RIDpdtGTLTEYALPTPGAGPRGLA 194

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568914587 2078 IDyEENKLYWCDARSDKIERIDLDTGANREVLLSGSNVDLFSVAVFGA-YIYWSDraHANGSVRR 2141
Cdd:COG4257   195 VD-PDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGARPYGVAVDGDgRVWFAE--SGANRIVR 256
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1131-1162 4.86e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 4.86e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568914587  1131 KFSCRStGRCINNAWVCDGDVDCEDQSDEEDC 1162
Cdd:pfam00057    7 EFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3544-3578 5.25e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 5.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568914587  3544 CSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMDC 3578
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4013-4052 6.08e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 6.08e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568914587   4013 RVLVQKNLQRPTGLTVDHFGERIYWADFELSIIGSVLYDG 4052
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3386-3421 6.08e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 6.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3386 CSPDYFQCKTTKhCISKLWVCDEDPDCADASDEANC 3421
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2620-2656 6.20e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 6.20e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  2620 STCSTVEFRCADGTCIPRSARCNQNMDCSDASDEKGC 2656
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 63-95 6.51e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 6.51e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587     63 CDPGEFLCHDHvTCVSQSWLCDGDPDCPDQSDE 95
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3501-3537 6.64e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 6.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  3501 TSCSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDEKNC 3537
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3624-3655 7.18e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 7.18e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3624 CRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDE 3655
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2711-2744 7.83e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 7.83e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 2711 CAADMFSCqGSHACVPQHWLCDGERDCPDGSDEL 2744
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1996-2036 8.80e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 8.80e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1996 GNIYWTDHGFNL-IEVARLNGSFRYVIISQGLDQPRSIAVHP 2036
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2019-2061 9.64e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.98  E-value: 9.64e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568914587   2019 YVIISQGLDQPRSIAVHPEKGFLFWTEWGQvPCIGKARLDGSE 2061
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 194-224 1.13e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 1.13e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568914587   194 GICSQTCKNTYGSYACSCVEGYIMQSDNRSC 224
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2794-2827 1.17e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 1.17e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   2794 QCGPEEFRCADGRClVNTLWQCDGDFDCPDSSDE 2827
Cdd:smart00192    1 TCPPGEFQCDNGRC-IPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1128-1162 1.25e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.59  E-value: 1.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 1128 HKTKFSCRStGRCINNAWVCDGDVDCEDQSDEEDC 1162
Cdd:cd00112     2 PPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3503-3534 1.41e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.41e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3503 CSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDE 3534
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3464-3496 1.51e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.51e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3464 TCTLKDFLCSNGDCVSSRFWCDGEFDCADGSDE 3496
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2795-2828 1.87e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 1.87e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568914587 2795 CGPEEFRCADGRClVNTLWQCDGDFDCPDSSDEA 2828
Cdd:cd00112     1 CPPNEFRCANGRC-IPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
917-950 2.09e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568914587   917 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESN 950
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3306-3338 2.26e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 2.26e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3306 KCQPGRFQCGTGLCALPAFICDGENDCGDNSDE 3338
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1766-1797 2.26e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 2.26e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   1766 PVGLSIDYVENKLYWISSGNGTINRCNLDGGN 1797
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2709-2744 2.31e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  2709 VTCAADMFSCQGShACVPQHWLCDGERDCPDGSDEL 2744
Cdd:pfam00057    1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1869-1905 2.31e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.85  E-value: 2.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  1869 CQVNNGGCSQLCLPTSEtTRTCMCTVGYYLQKNRMSC 1905
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3464-3499 2.42e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.42e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3464 TCTLKDFLCSNGDCVSSRFWCDGEFDCADGSDEKNC 3499
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 997-1030 2.52e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 2.52e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587    997 TCEPlTQFICKSGRCISNKWHCDTDDDCGDRSDE 1030
Cdd:smart00192    1 TCPP-GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3306-3341 2.54e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.54e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3306 KCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNC 3341
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1944-2169 2.93e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 52.32  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1944 VGIDfhaENDTIYWTDMGLNKISRAKRDQTWKEDVVTNGLGRVE-----GIAVDwIAGNIYWTDHGFNLIEVARLNGSFR 2018
Cdd:cd05819    13 IAVD---SSGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQfnepaGVAVD-SDGNLYVADTGNHRIQKFDPDGNFL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2019 YVIISQG-----LDQPRSIAVHPEkGFLFWTEWGQVpCIGKARLDGSekvMIVSVGITW--------PNGISIDyEENKL 2085
Cdd:cd05819    89 ASFGGSGdgdgeFNGPRGIAVDSS-GNIYVADTGNH-RIQKFDPDGE---FLTTFGSGGsgpgqfngPTGVAVD-SDGNI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2086 YWCDARSDKIERIDLDTGANREVLLSGSNVDLFS----VAVFGA-YIYWSDraHANGSVRRghkndATETVTMRTGLGVN 2160
Cdd:cd05819   163 YVADTGNHRIQVFDPDGNFLTTFGSTGTGPGQFNyptgIAVDSDgNIYVAD--SGNNRVQV-----FDPDGAGFGGNGNF 235


                  ....*....
gi 568914587 2161 LKEIKIFNR 2169
Cdd:cd05819   236 LGSDGQFNR 244
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3544-3575 3.31e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 3.31e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   3544 CSSSEYMCASGGCLSASLKCNGEPDCVDGSDE 3575
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2583-2617 3.54e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.43  E-value: 3.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568914587 2583 CRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDC 2617
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
63-95 3.73e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 3.73e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568914587    63 CDPGEFLCHDHVtCVSQSWLCDGDPDCPDQSDE 95
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3346-3378 4.27e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 4.27e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3346 CLAGQFKCtKNKKCIPVNLRCNGQDDCGDEEDE 3378
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2793-2828 4.28e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 4.28e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  2793 RQCGPEEFRCADGRClVNTLWQCDGDFDCPDSSDEA 2828
Cdd:pfam00057    1 STCSPNEFQCGSGEC-IPRSWVCDGDPDCGDGSDEE 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
641-791 4.51e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.23  E-value: 4.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  641 GNNLYWTNDGHRKtinVARLEKASQSRKTLLEGGmSHPRAIVVDPVNGWMYWTDWKED---KIDDSVGRIEKAWMDGVnr 717
Cdd:COG3391    79 GRRLYVANSGSGR---VSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGrvsVIDTATGKVVATIPVGA-- 152

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568914587  718 qvfvtskmlWPNGLTLDFHTSTLYWCDAYYDHIEKVF--LNGTHRKVVYSGKELNHPFGL--SHHGNYVFWTDYMNGS 791
Cdd:COG3391   153 ---------GPHGIAVDPDGKRLYVANSGSNTVSVIVsvIDTATGKVVATIPVGGGPVGVavSPDGRRLYVANRGSNT 221
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3386-3418 4.80e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 4.80e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587   3386 CSPDYFQCKTtKHCISKLWVCDEDPDCADASDE 3418
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1950-2101 4.84e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 51.51  E-value: 4.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1950 AENDTIYWTDMGLNKISRAKRD-----QTWKEDVVTNGLGRVEGIAVDwIAGNIYWTDHGFNLIEVARLNGSFRYVIISQ 2024
Cdd:cd14956    21 DADDNVYVADARNGRIQVFDKDgtflrRFGTTGDGPGQFGRPRGLAVD-KDGWLYVADYWGDRIQVFTLTGELQTIGGSS 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2025 G-----LDQPRSIAVHPeKGFLFWTEWGQVPcIGKARLDGSekvMIVSVGIT--------WPNGISIDyEENKLYWCDAR 2091
Cdd:cd14956   100 GsgpgqFNAPRGVAVDA-DGNLYVADFGNQR-IQKFDPDGS---FLRQWGGTgiepgsfnYPRGVAVD-PDGTLYVADTY 173

                         170
                  ....*....|
gi 568914587 2092 SDKIERIDLD 2101
Cdd:cd14956   174 NDRIQVFDND 183
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 394-435 6.10e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 6.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587    394 RIVYSKAEQPSALALDLVNRLVYWVDLYLDYVGVVDYQGKNR 435
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
2918-2952 6.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 6.24e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568914587   2918 DIDECSSGFPCSQ--QCINTYGTYKCHCAEGYETQPD 2952
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1423-1465 6.38e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 6.38e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568914587  1423 LFWTDWdANFPRIESASMSGAGRKTIYKDmkTGAWPNGLTVDH 1465
Cdd:pfam00058    3 LYWTDS-SLRASISSADLNGSDRKTLFTD--DLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2178-2213 6.74e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 6.74e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  2178 CAKENGGCQQLCLYRGNSrRTCACAHGY-LAGDGVTC 2213
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGYeLQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2985-3029 6.92e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 6.92e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568914587   2985 YTLLKQGLNNVIALDFDYREEFIYWIDSSRPngsRINRMCLNGSD 3029
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD---VIEVANLDGTN 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2918-2948 1.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 1.79e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587 2918 DIDECSSGFPCS--QQCINTYGTYKCHCAEGYE 2948
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1128-1159 1.99e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 1.99e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   1128 HKTKFSCRStGRCINNAWVCDGDVDCEDQSDE 1159
Cdd:smart00192    3 PPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2841-2875 2.29e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 2.29e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568914587  2841 CNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDETNC 2875
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3989-4030 2.38e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 2.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  3989 GMMYWTVIGDHSHIEEAAMDGTLRRVLVQKNLQRPTGLTVDH 4030
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 314-346 2.66e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 2.66e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568914587    314 QNVEQMAFDWLTRNIYFVDHVSDRIFVCNFNGS 346
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 1949-2106 2.95e-05

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 48.80  E-value: 2.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  1949 HAENDTIYWTDMGLNKISR----AKRDQTWK-EDVVTNGLGRVEGiavDWIAGNiywtDHGFNLIEVARlnGSFRYVIIS 2023
Cdd:pfam08450    8 DEEEGALYWVDILGGRIHRldpaTGKETVWDtPGPVGAIAPRDDG---GLIVAL----KDGVALLDLAT--GELTPLADP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  2024 QGLDQPRSI----AVHPEKGFLFWTEW---GQVPCIGKA-RLDGSEKVMIVSVGITWPNGISIDYEENKLYWCDARSDKI 2095
Cdd:pfam08450   79 EDDDWPLNRfndgKVDPDGRFWFGTMGddeAPGGDPGALyRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKI 158

                          170
                   ....*....|.
gi 568914587  2096 ERIDLDTGANR 2106
Cdd:pfam08450  159 WAYDYDLDGGL 169
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1649-1689 2.95e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.69  E-value: 2.95e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1649 ERLYWTDIKTQ-TITRAFINGTGLETVISRDIQSIRGLAVDW 1689
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 690-734 3.88e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.69  E-value: 3.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568914587   690 MYWTDWKEDkiddsvGRIEKAWMDGVNRQVFVTSKMLWPNGLTLD 734
Cdd:pfam00058    3 LYWTDSSLR------ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3624-3656 4.73e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 4.73e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568914587  3624 CRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDEA 3656
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3073-3114 5.71e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.97  E-value: 5.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587   3073 VLVSKRLKFPRDLSLDPRAGNLYWIDcCEYPHIGRVGMDGTN 3114
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTD-WGLDVIEVANLDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3005-3046 5.98e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.92  E-value: 5.98e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568914587  3005 EFIYWIDSSrpNGSRINRMCLNGSD--IKVVHNTAVPNALAVDW 3046
Cdd:pfam00058    1 GRLYWTDSS--LRASISSADLNGSDrkTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2583-2614 6.40e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 6.40e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   2583 CRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDE 2614
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3265-3300 9.98e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 9.98e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3265 SNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPD 3300
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 506-547 1.04e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 1.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587   506 CEVDaygmPGGCSHICLLSSSykTRTCRCRTGFNMGSDGRSC 547
Cdd:pfam14670    1 CSVN----NGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3665-3701 1.11e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.19  E-value: 1.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568914587 3665 CPPTRpYRCRNDRiCLQLEKICNGINDCGDNSDEEHC 3701
Cdd:cd00112     1 CPPNE-FRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3346-3381 1.15e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 1.15e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568914587  3346 CLAGQFKCtKNKKCIPVNLRCNGQDDCGDEEDEKDC 3381
Cdd:pfam00057    3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1977-2144 1.15e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1977 DVVTNGLGRVEGIAVDWIAGN-IYWTDHGFNLIEVARLNgSFRYV-IISQGlDQPRSIAVHPEKGFLFWTEW--GQVpci 2052
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRrLYVANSGSGRVSVIDLA-TGKVVaTIPVG-GGPRGLAVDPDGGRLYVADSgnGRV--- 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2053 gkARLDGS--EKVMIVSVGiTWPNGISIDYEENKLYWCDARSDKI----ERIDLDTGANREVLLSGSNVDLFSVAVFGAY 2126
Cdd:COG3391   135 --SVIDTAtgKVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNTVsvivSVIDTATGKVVATIPVGGGPVGVAVSPDGRR 211

                         170
                  ....*....|....*...
gi 568914587 2127 IYWSDRaHANGSVRRGHK 2144
Cdd:COG3391   212 LYVANR-GSNTSNGGSNT 228
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 642-685 1.27e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 1.27e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568914587   642 NNLYWTNDGHRKTINVARLEkaSQSRKTLLEGGMSHPRAIVVDP 685
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLN--GSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1635-1670 1.57e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 1.57e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568914587   1635 DIDDVAVIDFDASEERLYWTDIKTQTITRAFINGTG 1670
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 599-639 2.53e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.38  E-value: 2.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587   599 NYIYFAD-TTSFLIGRQKIDGTERETILKDDLDNVEGIAVDW 639
Cdd:pfam00058    1 GRLYWTDsSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2581-2617 2.54e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 2.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568914587  2581 RSCRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDC 2617
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1736-1773 3.34e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.99  E-value: 3.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  1736 GKLYWTDGN---TINMANMDGSNSKILFQ-NQKEPVGLSIDY 1773
Cdd:pfam00058    1 GRLYWTDSSlraSISSADLNGSDRKTLFTdDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1716-1755 4.00e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 4.00e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587   1716 KTSIIHGIDKPQCLAAHPVRGKLYWTD--GNTINMANMDGSN 1755
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDwgLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 580-621 4.64e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 4.64e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587    580 MIPIENLVNPRALDFHAEANYIYFADTTSFLIGRQKIDGTER 621
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2887-2916 4.87e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 4.87e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568914587  2887 GCSQDCQDLPVSYKCKCWPGFQLKDDGKTC 2916
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 2900-2921 5.36e-04

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 39.70  E-value: 5.36e-04
                           10        20
                   ....*....|....*....|..
gi 568914587  2900 KCKCWPGFQLKDDGKTCVDIDE 2921
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
3794-3828 5.61e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 5.61e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568914587   3794 DLNECLLFGICSHH--CLNTRGSYKCVCDQNFQEKNN 3828
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYTDGRN 37
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1609-1801 6.25e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 6.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1609 YARRSEIRGVDIDNPYVNFITAFTVPDIDDVAVIDFDASEERLYWTDIKTQTITraFINGTGLETVISRDI-QSIRGLAV 1687
Cdd:COG3391    40 ASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS--VIDLATGKVVATIPVgGGPRGLAV 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1688 DWVSRNLYwISSEFDETqinVARLD---GSLKTSIIHGiDKPQCLAAHPVRGKLYWTD--GNTINM--ANMDGSNSKIL- 1759
Cdd:COG3391   118 DPDGGRLY-VADSGNGR---VSVIDtatGKVVATIPVG-AGPHGIAVDPDGKRLYVANsgSNTVSVivSVIDTATGKVVa 192

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 568914587 1760 -FQNQKEPVGLSIDYVENKLYWISSGNGTINRcnlDGGNLEVI 1801
Cdd:COG3391   193 tIPVGGGPVGVAVSPDGRRLYVANRGSNTSNG---GSNTVSVI 232
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 2814-2883 8.77e-04

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 43.24  E-value: 8.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  2814 QCDGDF-DCPDSSDEAPINprcrsaehSCNSSFFMCKNGRCIPS--------DGLCDiRDDCGDGSDETNCHI-NECLSK 2883
Cdd:pfam12999   52 QVNDDYcDCPDGSDEPGTN--------ACSNGKFYCANEGFIPGyipsfkvdDGVCD-YDICCDGSDEALGKCpNKCGEI 122
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 326-366 1.13e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587   326 RNIYFVDHVSD-RIFVCNFNGSVCVTLIESELHNPKAIAADP 366
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1167-1202 1.18e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.11  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 1167 CGPPKYPCANDTsvCLQPEKLCNGRKDCPDGSDEGD 1202
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEEN 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2913-2953 1.38e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 1.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568914587 2913 GKTCVDIDECSSG-FPCSQQCINTYGTYKCHCAEGYETQPDN 2953
Cdd:cd01475   181 GKICVVPDLCATLsHVCQQVCISTPGSYLCACTEGYALLEDN 222
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1167-1200 1.53e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.77  E-value: 1.53e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   1167 CGPPKYPCANdtSVCLQPEKLCNGRKDCPDGSDE 1200
Cdd:smart00192    2 CPPGEFQCDN--GRCIPSSWVCDGVDDCGDGSDE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-225 2.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 2.18e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587    186 DQDECSIYGICSQ--TCKNTYGSYACSCVEGYimqSDNRSCK 225
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2676-2705 2.57e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.34  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568914587 2676 RCNStSLCVLPSWICDGSNDCGDYSDELKC 2705
Cdd:cd00112     7 RCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 186-219 2.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 2.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587  186 DQDECSIYGICS--QTCKNTYGSYACSCVEGYIMQS 219
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2349-2384 2.81e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.81e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568914587   2349 DHPHVLALDECQNLMFWTNWNeqHPSIMRATLTGKN 2384
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGTN 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
589-746 2.85e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.76  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  589 PRALDFHAEANYIYFADTTSFLIgrQKIDGTERETILKDDL-DNVEGIAVDWIGNNLYWTNDGHRKtinVARLEKASQSR 667
Cdd:COG3391    70 ADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGR---VSVIDTATGKV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  668 KTLLEGGmSHPRAIVVDPVNGWMYWTDWKED-------KIDDSVGRIEKAWMDGVNrqvfvtskmlwPNGLTLDFHTSTL 740
Cdd:COG3391   145 VATIPVG-AGPHGIAVDPDGKRLYVANSGSNtvsvivsVIDTATGKVVATIPVGGG-----------PVGVAVSPDGRRL 212


                  ....*.
gi 568914587  741 YWCDAY 746
Cdd:COG3391   213 YVANRG 218
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2545-2574 2.90e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 2.90e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568914587 2545 SEFECGNGDCVDYVLTCDGIPHCKDKSDEK 2574
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 319-490 2.90e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.08  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  319 MAFDwLTRNIYFVDHVSDRIFVCNFNGSVCVTLI-----ESELHNPKAIAADPiAGKLFFTDYGNVpKIERCDLDGMNRT 393
Cdd:cd05819    60 VAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsgdgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587  394 RIVYSKAE-----QPSALALDLVNRlVYWVD------LYLDYVG-VVDYQGKNRHTIVQGRQVkhlYGITVFED-YLYAT 460
Cdd:cd05819   137 TFGSGGSGpgqfnGPTGVAVDSDGN-IYVADtgnhriQVFDPDGnFLTTFGSTGTGPGQFNYP---TGIAVDSDgNIYVA 212

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 568914587  461 SSDNFNIIRINRF------NGTDIHSIIKMESARGI 490
Cdd:cd05819   213 DSGNNRVQVFDPDgagfggNGNFLGSDGQFNRPSGL 248
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 107-140 3.22e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.00  E-value: 3.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587    107 KCPLNHIAChGSSACVHLSKLCNGVVDCPDGFDE 140
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2928-2953 3.44e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 3.44e-03
                           10        20
                   ....*....|....*....|....*.
gi 568914587  2928 CSQQCINTYGTYKCHCAEGYETQPDN 2953
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDG 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3092-3133 3.50e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 3.50e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568914587  3092 GNLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDY 3133
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1311-1352 3.55e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 3.55e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568914587   1311 YSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESG 1352
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1333-1487 3.71e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.57  E-value: 3.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1333 LYWTDVVEDRIYR-----GKLSE----SGGVSAIE-------VVVEHG---------------LATPEG--------LTV 1373
Cdd:COG3386    21 LYWVDIPGGRIHRydpdgGAVEVfaepSGRPNGLAfdpdgrlLVADHGrglvrfdpadgevtvLADEYGkplnrpndGVV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1374 DWiAGNIYWIDSNLDQIE--VSKLDGSLRATLIAGAMEHPRAIALDPRYGILFWTDWDANfpRIESASMSGAGR---KTI 1448
Cdd:COG3386   101 DP-DGRLYFTDMGEYLPTgaLYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAG--RIYRFDLDADGTlgnRRV 177

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568914587 1449 YKDMKTGA-WPNGLTVDhferrivwtdaRSDAIYSAFYDG 1487
Cdd:COG3386   178 FADLPDGPgGPDGLAVD-----------ADGNLWVALWGG 206
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4200-4234 4.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 4.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568914587 4200 VNHCS--NYCQNGGTCIPsTLGRPTCICALGFTGPNC 4234
Cdd:cd00054     2 IDECAsgNPCQNGGTCVN-TVGSYRCSCPPGYTGRNC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2545-2573 4.46e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.61  E-value: 4.46e-03
                            10        20
                    ....*....|....*....|....*....
gi 568914587   2545 SEFECGNGDCVDYVLTCDGIPHCKDKSDE 2573
Cdd:smart00192    5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2675-2705 5.51e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.23  E-value: 5.51e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568914587  2675 IRCNSTSlCVLPSWICDGSNDCGDYSDELKC 2705
Cdd:pfam00057    8 FQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3794-3827 5.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 5.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568914587 3794 DLNECLLFGICSHH--CLNTRGSYKCVCDQNFQEKN 3827
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3665-3698 5.93e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.23  E-value: 5.93e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568914587   3665 CPPTRpYRCRNdRICLQLEKICNGINDCGDNSDE 3698
Cdd:smart00192    2 CPPGE-FQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 108-140 6.62e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.19  E-value: 6.62e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568914587  108 CPLNHIAChGSSACVHLSKLCNGVVDCPDGFDE 140
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32
DUF5050 pfam16472
Domain of unknown function (DUF5050);
599-694 7.19e-03

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 41.84  E-value: 7.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587   599 NYIYF---ADTTSFLIGRQKIDGTERETILKDDLDNvegIAVDwiGNNLYWTN--DGHrktiNVARLEKASQSRKTLLEG 673
Cdd:pfam16472  107 NYIYYqhyDNSDGGTLYKIKIDGKEKTKLSDEPISP---ASVS--DGWIYYSGtsDDH----YIYKLNTDGDSISKLYDG 177

                           90       100
                   ....*....|....*....|.
gi 568914587   674 GMSHPraIVVDpvnGWMYWTD 694
Cdd:pfam16472  178 NSYMP--NVNG---DYIYYID 193
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1303-1381 7.35e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.80  E-value: 7.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1303 RIDlHKGDYSLLVPGLR--NTIAL--DfhfnQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVE--HGLATPEGLTVDwI 1376
Cdd:COG3386   122 RVD-PDGSLRVLADGLTfpNGIAFspD----GRTLYVADTGAGRIYRFDLDADGTLGNRRVFADlpDGPGGPDGLAVD-A 195


                  ....*
gi 568914587 1377 AGNIY 1381
Cdd:COG3386   196 DGNLW 200
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3891-4123 7.45e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 7.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 3891 FNPGGIFYKMIDARekrqaNSGLicPEFKRPRDIAVDwVAGNVYWTD--HSRMHWFSYYTTHWTSL-RYSINVGQLNGpn 3967
Cdd:cd05819    34 FDPDGNFITSFGSF-----GSGD--GQFNEPAGVAVD-SDGNLYVADtgNHRIQKFDPDGNFLASFgGSGDGDGEFNG-- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 3968 ctrlltnmagePYAIAVNPkRGMMYwtvIGDHSH--IEEAAMDGTLRRVLVQKN-----LQRPTGLTVDHFGErIYWADF 4040
Cdd:cd05819   104 -----------PRGIAVDS-SGNIY---VADTGNhrIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVDSDGN-IYVADT 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 4041 E-------------LSIIGSvlydgsspvvSVSSKQGLLHPHRIDVFED-YIYGAGPKNGifRVQKFGHGSVEVLALGVD 4106
Cdd:cd05819   168 GnhriqvfdpdgnfLTTFGS----------TGTGPGQFNYPTGIAVDSDgNIYVADSGNN--RVQVFDPDGAGFGGNGNF 235

                         250
                  ....*....|....*..
gi 568914587 4107 KTKSilvshryKQLNLP 4123
Cdd:cd05819   236 LGSD-------GQFNRP 245
EGF_CA smart00179
Calcium-binding EGF-like domain;
2877-2917 7.46e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 7.46e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568914587   2877 INECLSKKISGCSQDCQDLPVSYKCKCWPGFQlkdDGKTCV 2917
Cdd:smart00179    2 IDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2671-2702 9.23e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.46  E-value: 9.23e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568914587   2671 STGFIRCNStSLCVLPSWICDGSNDCGDYSDE 2702
Cdd:smart00192    3 PPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1926-2096 9.32e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 41.42  E-value: 9.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 1926 EPRDKVDALMPISGAAFA--VGIDFhAENDTIYWTDMGLNKISRAKRDQTwKEDVVTNGLG--RVEGIAVDWIAGNIYWT 2001
Cdd:cd14962    40 LPNGKVFVIGNAGPNRFVspIGVAI-DANGNLYVSDAELGKVFVFDRDGK-FLRAIGAGALfkRPTGIAVDPAGKRLYVV 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914587 2002 DHGFNLIEVARLNGSFRYVIISQG-----LDQPRSIAVHPeKGFLFWTEwgqvpcIGKAR-----LDGSEKVMIVSVGIT 2071
Cdd:cd14962   118 DTLAHKVKVFDLDGRLLFDIGKRGsgpgeFNLPTDLAVDR-DGNLYVTD------TMNFRvqifdADGKFLRSFGERGDG 190

                         170       180       190
                  ....*....|....*....|....*....|
gi 568914587 2072 W-----PNGISIDYEENkLYWCDARSDKIE 2096
Cdd:cd14962   191 PgsfarPKGIAVDSEGN-IYVVDAAFDNVQ 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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