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Conserved domains on  [gi|530427416|ref|XP_005272364|]
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endosomal/lysosomal proton channel TMEM175 isoform X6 [Homo sapiens]

Protein Classification

TMEM175 family protein( domain architecture ID 10535616)

transmembrane protein 175 (TMEM175) family protein is a DUF1211 domain-containing protein; similar to vertebrate transmembrane protein 175 (TMEM175), an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes

Gene Ontology:  GO:0022841|GO:0071805
PubMed:  26317472

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 35-124 3.37e-19

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


:

Pssm-ID: 429088  Cd Length: 88  Bit Score: 80.27  E-value: 3.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530427416   35 RMLSFSDALLSIIATVMILPVTHteisPEQQFDRSVQRLLA--TRIAVYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALL 112
Cdd:pfam06736   1 RLEAFSDGVFAIAITLLVLEIKV----PDGADGELLAALLElwPSFLAYLLSFLVVGIFWINHHRLFRRIKKVDGRLLWL 76

                          90
                  ....*....|..
gi 530427416  113 NLACMMTITFLP 124
Cdd:pfam06736  77 NLLLLFFISLLP 88
TMEM175 super family cl01421
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 251-280 1.44e-05

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


The actual alignment was detected with superfamily member COG3548:

Pssm-ID: 470197  Cd Length: 203  Bit Score: 44.91  E-value: 1.44e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 530427416 251 DLHEPLSKERVEAFSDGVYAIVATLLILDI 280
Cdd:COG3548    5 DEEAERGKERLEAFSDGVFAIAITLLVLEL 34
 
Name Accession Description Interval E-value
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 35-124 3.37e-19

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


Pssm-ID: 429088  Cd Length: 88  Bit Score: 80.27  E-value: 3.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530427416   35 RMLSFSDALLSIIATVMILPVTHteisPEQQFDRSVQRLLA--TRIAVYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALL 112
Cdd:pfam06736   1 RLEAFSDGVFAIAITLLVLEIKV----PDGADGELLAALLElwPSFLAYLLSFLVVGIFWINHHRLFRRIKKVDGRLLWL 76

                          90
                  ....*....|..
gi 530427416  113 NLACMMTITFLP 124
Cdd:pfam06736  77 NLLLLFFISLLP 88
COG3548 COG3548
Uncharacterized membrane protein [Function unknown];
251-280 1.44e-05

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 442769  Cd Length: 203  Bit Score: 44.91  E-value: 1.44e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 530427416 251 DLHEPLSKERVEAFSDGVYAIVATLLILDI 280
Cdd:COG3548    5 DEEAERGKERLEAFSDGVFAIAITLLVLEL 34
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 260-280 2.81e-05

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


Pssm-ID: 429088  Cd Length: 88  Bit Score: 41.75  E-value: 2.81e-05
                          10        20
                  ....*....|....*....|.
gi 530427416  260 RVEAFSDGVYAIVATLLILDI 280
Cdd:pfam06736   1 RLEAFSDGVFAIAITLLVLEI 21
 
Name Accession Description Interval E-value
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 35-124 3.37e-19

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


Pssm-ID: 429088  Cd Length: 88  Bit Score: 80.27  E-value: 3.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530427416   35 RMLSFSDALLSIIATVMILPVTHteisPEQQFDRSVQRLLA--TRIAVYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALL 112
Cdd:pfam06736   1 RLEAFSDGVFAIAITLLVLEIKV----PDGADGELLAALLElwPSFLAYLLSFLVVGIFWINHHRLFRRIKKVDGRLLWL 76

                          90
                  ....*....|..
gi 530427416  113 NLACMMTITFLP 124
Cdd:pfam06736  77 NLLLLFFISLLP 88
COG3548 COG3548
Uncharacterized membrane protein [Function unknown];
251-280 1.44e-05

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 442769  Cd Length: 203  Bit Score: 44.91  E-value: 1.44e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 530427416 251 DLHEPLSKERVEAFSDGVYAIVATLLILDI 280
Cdd:COG3548    5 DEEAERGKERLEAFSDGVFAIAITLLVLEL 34
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 260-280 2.81e-05

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


Pssm-ID: 429088  Cd Length: 88  Bit Score: 41.75  E-value: 2.81e-05
                          10        20
                  ....*....|....*....|.
gi 530427416  260 RVEAFSDGVYAIVATLLILDI 280
Cdd:pfam06736   1 RLEAFSDGVFAIAITLLVLEI 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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