NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530404459|ref|XP_005268045|]
View 

protein sel-1 homolog 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
340-492 2.39e-41

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 151.23  E-value: 2.39e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 340 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKK 419
Cdd:COG0790   87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEG-VPKDPAKAAEWYRK 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530404459 420 AADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLA 492
Cdd:COG0790  165 AAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKA 237
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 115-147 3.25e-15

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 70.02  E-value: 3.25e-15
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530404459   115 KEYDECTSDGREDGRLWCATTYDYKADEKWGFC 147
Cdd:smart00059  17 KKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 643-676 6.13e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


:

Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.36  E-value: 6.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530404459  643 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 676
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 608-641 1.46e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.46  E-value: 1.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530404459   608 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 641
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 445-687 7.14e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 7.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 445 NYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFYNLAQMHASgTGVMRScht 520
Cdd:COG2956   23 QPDKAIDLLEEALELdpETVEAHLALGNLYRR----RGEYDRAIRIHQklLERDPDRAEALLELAQDYLK-AGLLDR--- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 521 AVELFKNVCERGRWSE----RLMTAYnsYKDGDYNAAviqyLLLAEQGYEVAQSNAAFILDQreASIVGENETYPRALLH 596
Cdd:COG2956   95 AEELLEKLLELDPDDAealrLLAEIY--EQEGDWEKA----IEVLERLLKLGPENAHAYCEL--AELYLEQGDYDEAIEA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 597 WNRA--ASQGYTVARIKLGDYHFYGFgtdvDYETAFIHYRLASEQQH-SAQAMFNLGYMHEKgLGIKQDihlAKRFYDMA 673
Cdd:COG2956  167 LEKAlkLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQDPdYLPALPRLAELYEK-LGDPEE---ALELLRKA 238

                        250
                 ....*....|....
gi 530404459 674 AEASPDAQVPVFLA 687
Cdd:COG2956  239 LELDPSDDLLLALA 252
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 234-269 6.56e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.84  E-value: 6.56e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530404459   234 PKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGN 269
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
340-492 2.39e-41

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 151.23  E-value: 2.39e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 340 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKK 419
Cdd:COG0790   87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEG-VPKDPAKAAEWYRK 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530404459 420 AADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLA 492
Cdd:COG0790  165 AAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKA 237
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 115-147 3.25e-15

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 70.02  E-value: 3.25e-15
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530404459   115 KEYDECTSDGREDGRLWCATTYDYKADEKWGFC 147
Cdd:smart00059  17 KKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn2 pfam00040
Fibronectin type II domain;
114-147 3.83e-15

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 69.52  E-value: 3.83e-15
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530404459  114 DKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 147
Cdd:pfam00040   9 GKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 115-147 1.07e-14

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 68.49  E-value: 1.07e-14
                         10        20        30
                 ....*....|....*....|....*....|...
gi 530404459 115 KEYDECTSDGREDGRLWCATTYDYKADEKWGFC 147
Cdd:cd00062   16 KWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 462-497 8.76e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 48.71  E-value: 8.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530404459   462 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGH 497
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 426-460 4.75e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.75e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530404459  426 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 460
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 643-676 6.13e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.36  E-value: 6.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530404459  643 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 676
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 643-675 9.47e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 45.63  E-value: 9.47e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530404459   643 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAE 675
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 608-641 1.46e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.46  E-value: 1.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530404459   608 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 641
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 445-687 7.14e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 7.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 445 NYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFYNLAQMHASgTGVMRScht 520
Cdd:COG2956   23 QPDKAIDLLEEALELdpETVEAHLALGNLYRR----RGEYDRAIRIHQklLERDPDRAEALLELAQDYLK-AGLLDR--- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 521 AVELFKNVCERGRWSE----RLMTAYnsYKDGDYNAAviqyLLLAEQGYEVAQSNAAFILDQreASIVGENETYPRALLH 596
Cdd:COG2956   95 AEELLEKLLELDPDDAealrLLAEIY--EQEGDWEKA----IEVLERLLKLGPENAHAYCEL--AELYLEQGDYDEAIEA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 597 WNRA--ASQGYTVARIKLGDYHFYGFgtdvDYETAFIHYRLASEQQH-SAQAMFNLGYMHEKgLGIKQDihlAKRFYDMA 673
Cdd:COG2956  167 LEKAlkLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQDPdYLPALPRLAELYEK-LGDPEE---ALELLRKA 238

                        250
                 ....*....|....
gi 530404459 674 AEASPDAQVPVFLA 687
Cdd:COG2956  239 LELDPSDDLLLALA 252
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 502-532 3.29e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.61  E-value: 3.29e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530404459   502 YNLAQMHASGTGVMRSCHTAVELFKNVCERG 532
Cdd:smart00671   5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 234-269 6.56e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.84  E-value: 6.56e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530404459   234 PKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGN 269
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 608-639 8.02e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 34.80  E-value: 8.02e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 530404459  608 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ 639
Cdd:pfam08238   3 AQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
340-492 2.39e-41

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 151.23  E-value: 2.39e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 340 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKK 419
Cdd:COG0790   87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEG-VPKDPAKAAEWYRK 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530404459 420 AADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLA 492
Cdd:COG0790  165 AAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKA 237
TPR COG0790
TPR repeat [General function prediction only];
341-532 1.18e-39

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 146.61  E-value: 1.18e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 341 QYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKKA 420
Cdd:COG0790   15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRG-VPKDYEKALEWFEKA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 421 ADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILA 500
Cdd:COG0790   94 AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADA 173

                        170       180       190
                 ....*....|....*....|....*....|..
gi 530404459 501 FYNLAQMHASGTGVMRSCHTAVELFKNVCERG 532
Cdd:COG0790  174 QYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205
TPR COG0790
TPR repeat [General function prediction only];
376-677 3.90e-38

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 142.37  E-value: 3.90e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 376 AFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQK 455
Cdd:COG0790   13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 456 AAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKnvcergrws 535
Cdd:COG0790   93 AAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR--------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 536 erlmtaynsykdgdynaaviqylllaeqgyevaqsnaafildqreasivgenetyprallhwnRAASQGYTVARIKLGDY 615
Cdd:COG0790  164 ---------------------------------------------------------------KAAEQGDADAQYNLGVL 180

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530404459 616 HFYGFGTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEAS 677
Cdd:COG0790  181 YENGRGVPKDPAKALEWYRKAAEQGD-ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQA 241
TPR COG0790
TPR repeat [General function prediction only];
136-459 7.53e-30

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 118.49  E-value: 7.53e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 136 YDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLP 215
Cdd:COG0790    1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 216 QNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKAlvyytfgalggnliahmvlgyrywagigvlqscesalt 295
Cdd:COG0790   81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKA-------------------------------------- 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 296 hyrlvanhvasdisltggsvvqrirlpdevenpgmnsgmleedlIQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQR 375
Cdd:COG0790  123 --------------------------------------------LEWYEKAAEQGDADAQYNLGLLYLN-GEGVPKDPAK 157

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 376 AFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQK 455
Cdd:COG0790  158 AAEWYRKAAEQGDADAQYNLGVLYENGRG-VPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRK 236


                 ....
gi 530404459 456 AAEQ 459
Cdd:COG0790  237 AAEQ 240
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 115-147 3.25e-15

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 70.02  E-value: 3.25e-15
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530404459   115 KEYDECTSDGREDGRLWCATTYDYKADEKWGFC 147
Cdd:smart00059  17 KKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn2 pfam00040
Fibronectin type II domain;
114-147 3.83e-15

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 69.52  E-value: 3.83e-15
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530404459  114 DKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 147
Cdd:pfam00040   9 GKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 115-147 1.07e-14

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 68.49  E-value: 1.07e-14
                         10        20        30
                 ....*....|....*....|....*....|...
gi 530404459 115 KEYDECTSDGREDGRLWCATTYDYKADEKWGFC 147
Cdd:cd00062   16 KWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 462-497 8.76e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 48.71  E-value: 8.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530404459   462 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGH 497
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 426-460 2.81e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 47.17  E-value: 2.81e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 530404459   426 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 460
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 426-460 4.75e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.75e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530404459  426 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 460
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 643-676 6.13e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.36  E-value: 6.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530404459  643 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 676
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 643-675 9.47e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 45.63  E-value: 9.47e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530404459   643 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAE 675
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 337-509 1.15e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 337 EDLIQYYQFLAEKGD--VQAQVGLGQLHLHGGRgveqnHQRAFDYFN--LAANAGNSHAMAFLGKMYSEGSDIvpqsnET 412
Cdd:COG2956   59 DRAIRIHQKLLERDPdrAEALLELAQDYLKAGL-----LDRAEELLEklLELDPDDAEALRLLAEIYEQEGDW-----EK 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 413 ALHYFKKAADMGNPVGQSGLGMAYLYGRgvQVNYDLALKYFQKA--AEQGWVDGQLQLGSMYYNgigvKRDYKQALKYFN 490
Cdd:COG2956  129 AIEVLERLLKLGPENAHAYCELAELYLE--QGDYDEAIEALEKAlkLDPDCARALLLLAELYLE----QGDYEEAIAALE 202

                        170       180
                 ....*....|....*....|.
gi 530404459 491 --LASQGGHILAFYNLAQMHA 509
Cdd:COG2956  203 raLEQDPDYLPALPRLAELYE 223
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 462-496 1.26e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.51  E-value: 1.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530404459  462 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGG 496
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 389-425 2.77e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.78  E-value: 2.77e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 530404459   389 SHAMAFLGKMYSEGsDIVPQSNETALHYFKKAADMGN 425
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 389-424 8.87e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 8.87e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530404459  389 SHAMAFLGKMYSEGSDiVPQSNETALHYFKKAADMG 424
Cdd:pfam08238   1 AEAQYRLGYLYLYGLG-VPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 352-388 1.03e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.03e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 530404459   352 VQAQVGLGQLHLHGgRGVEQNHQRAFDYFNLAANAGN 388
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
351-603 1.22e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 351 DVQAQVGLGQLHLHGGRgveqnHQRAFDYFN--LAANAGNSHAMAFLGKMYSEGSDivpqsNETALHYFKKAADM--GNP 426
Cdd:COG0457    7 DAEAYNNLGLAYRRLGR-----YEEAIEDYEkaLELDPDDAEALYNLGLAYLRLGR-----YEEALADYEQALELdpDDA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 427 VGQSGLGMAYLYgRGvqvNYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFY 502
Cdd:COG0457   77 EALNNLGLALQA-LG---RYEEALEDYDKALELdpDDAEALYNLGLALLE----LGRYDEAIEAYEraLELDPDDADALY 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 503 NLAQMHASgtgvMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREAS 582
Cdd:COG0457  149 NLGIALEK----LGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLL 224

                        250       260
                 ....*....|....*....|.
gi 530404459 583 IVGENETYPRALLHWNRAASQ 603
Cdd:COG0457  225 LALALLLALRLAALALYQYRA 245
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 608-641 1.46e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.46  E-value: 1.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530404459   608 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 641
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 352-387 3.34e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 38.66  E-value: 3.34e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530404459  352 VQAQVGLGQLHLHGgRGVEQNHQRAFDYFNLAANAG 387
Cdd:pfam08238   1 AEAQYRLGYLYLYG-LGVPKDPEKALEWYEKAAELG 35
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 445-687 7.14e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 7.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 445 NYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFYNLAQMHASgTGVMRScht 520
Cdd:COG2956   23 QPDKAIDLLEEALELdpETVEAHLALGNLYRR----RGEYDRAIRIHQklLERDPDRAEALLELAQDYLK-AGLLDR--- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 521 AVELFKNVCERGRWSE----RLMTAYnsYKDGDYNAAviqyLLLAEQGYEVAQSNAAFILDQreASIVGENETYPRALLH 596
Cdd:COG2956   95 AEELLEKLLELDPDDAealrLLAEIY--EQEGDWEKA----IEVLERLLKLGPENAHAYCEL--AELYLEQGDYDEAIEA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404459 597 WNRA--ASQGYTVARIKLGDYHFYGFgtdvDYETAFIHYRLASEQQH-SAQAMFNLGYMHEKgLGIKQDihlAKRFYDMA 673
Cdd:COG2956  167 LEKAlkLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQDPdYLPALPRLAELYEK-LGDPEE---ALELLRKA 238

                        250
                 ....*....|....
gi 530404459 674 AEASPDAQVPVFLA 687
Cdd:COG2956  239 LELDPSDDLLLALA 252
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 502-532 3.29e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.61  E-value: 3.29e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530404459   502 YNLAQMHASGTGVMRSCHTAVELFKNVCERG 532
Cdd:smart00671   5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 234-269 6.56e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.84  E-value: 6.56e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530404459   234 PKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGN 269
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 608-639 8.02e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 34.80  E-value: 8.02e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 530404459  608 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ 639
Cdd:pfam08238   3 AQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH