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Conserved domains on  [gi|530402148|ref|XP_005266339|]
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ubiquitin carboxyl-terminal hydrolase 12 isoform X1 [Homo sapiens]

Protein Classification

ubiquitin carboxyl-terminal hydrolase family protein( domain architecture ID 10119250)

ubiquitin carboxyl-terminal hydrolase family protein is a C19 family peptidase that may deubiquitinate polyubiquitinated target proteins

CATH:  3.90.70.10
EC:  3.4.19.12
Gene Ontology:  GO:0016579|GO:0004843
MEROPS:  C19
PubMed:  7845226|11517925
SCOP:  4003158

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 1.14e-163

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


:

Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 457.16  E-value: 1.14e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFcrpfrekvlayksqprkkESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDN 119
Cdd:cd02663    1 GLENFGNTCYCNSVLQALYF------------------ENLLTCLKDLFESISEQKKRTGVISPKKFITRLKRENELFDN 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 120 YMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLpngnidNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDF 199
Cdd:cd02663   63 YMHQDAHEFLNFLLNEIAEILDAERKAEKANRKL------NNNNNAEPQPTWVHEIFQGILTNETRCLTCETVSSRDETF 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 200 LDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV 279
Cdd:cd02663  137 LDLSIDVEQNTSITSCLRQFSATETLCGRNKFYCDECCSLQEAEKRMKIKKLPKILALHLKRFKYDEQLNRYIKLFYRVV 216

                        250       260       270
                 ....*....|....*....|....*....|.
gi 530402148 280 FPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02663  217 FPLELRLFNTTDDAENPDRLYELVAVVVHIG 247
 
Name Accession Description Interval E-value
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 1.14e-163

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 457.16  E-value: 1.14e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFcrpfrekvlayksqprkkESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDN 119
Cdd:cd02663    1 GLENFGNTCYCNSVLQALYF------------------ENLLTCLKDLFESISEQKKRTGVISPKKFITRLKRENELFDN 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 120 YMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLpngnidNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDF 199
Cdd:cd02663   63 YMHQDAHEFLNFLLNEIAEILDAERKAEKANRKL------NNNNNAEPQPTWVHEIFQGILTNETRCLTCETVSSRDETF 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 200 LDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV 279
Cdd:cd02663  137 LDLSIDVEQNTSITSCLRQFSATETLCGRNKFYCDECCSLQEAEKRMKIKKLPKILALHLKRFKYDEQLNRYIKLFYRVV 216

                        250       260       270
                 ....*....|....*....|....*....|.
gi 530402148 280 FPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02663  217 FPLELRLFNTTDDAENPDRLYELVAVVVHIG 247
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
39-310 9.30e-78

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 239.65  E-value: 9.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148   39 FGLVNFGNTCYCNSVLQALYFCRPFREKVLAY-----KSQPRKKESLLTCLADLFHSIaTQKKKVGVIPPKKFITRLRKE 113
Cdd:pfam00443   1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRIsplseDSRYNKDINLLCALRDLFKAL-QKNSKSSSVSPKMFKKSLGKL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  114 NELFDNYMQQDAHEFLNYLLNTiadiLQEERKQekqngrlpngnidnenNNSTPDPTWVHEIFQGTLTNETRCLTCETIS 193
Cdd:pfam00443  80 NPDFSGYKQQDAQEFLLFLLDG----LHEDLNG----------------NHSTENESLITDLFRGQLKSRLKCLSCGEVS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  194 SKDEDFLDLSVDVEQNTSITH------CLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYmdQ 267
Cdd:pfam00443 140 ETFEPFSDLSLPIPGDSAELKtaslqiCFLQFSKLEELDDEEKYYCDKCGCKQDAIKQLKISRLPPVLIIHLKRFSY--N 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 530402148  268 LHRYTKLSYRVVFPLELRLFNTSGDATNPD----RMYDLVAVVVHCG 310
Cdd:pfam00443 218 RSTWEKLNTEVEFPLELDLSRYLAEELKPKtnnlQDYRLVAVVVHSG 264
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
 38-310 3.70e-24

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 103.03  E-value: 3.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148   38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKKKVGVippkkfiTRLRKEN-- 114
Cdd:COG5077   193 YVGLRNQGATCYMNSLLQSLFFIAKFRKDVYGIPTDhPRGRDSVALALQRLFYNLQTGEEPVDT-------TELTRSFgw 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  115 ELFDNYMQQDAHEFLNYLLntiaDILQEERKQEKQNGRLpngnidnennnstpdptwvHEIFQGTLTNETRCLTCETISS 194
Cdd:COG5077   266 DSDDSFMQHDIQEFNRVLQ----DNLEKSMRGTVVENAL-------------------NGIFVGKMKSYIKCVNVNYESA 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  195 KDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEEcRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKL 274
Cdd:COG5077   323 RVEDFWDIQLNVKGMKNLQESFRRYIQVETLDGDNRYNAEK-HGLQDAKKGVIFESLPPVLHLQLKRFEYDFERDMMVKI 401

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 530402148  275 SYRVVFPLELRLF----NTSGDATNPDRMYDLVAVVVHCG 310
Cdd:COG5077   402 NDRYEFPLEIDLLpfldRDADKSENSDAVYVLYGVLVHSG 441
 
Name Accession Description Interval E-value
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 1.14e-163

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 457.16  E-value: 1.14e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFcrpfrekvlayksqprkkESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDN 119
Cdd:cd02663    1 GLENFGNTCYCNSVLQALYF------------------ENLLTCLKDLFESISEQKKRTGVISPKKFITRLKRENELFDN 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 120 YMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLpngnidNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDF 199
Cdd:cd02663   63 YMHQDAHEFLNFLLNEIAEILDAERKAEKANRKL------NNNNNAEPQPTWVHEIFQGILTNETRCLTCETVSSRDETF 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 200 LDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV 279
Cdd:cd02663  137 LDLSIDVEQNTSITSCLRQFSATETLCGRNKFYCDECCSLQEAEKRMKIKKLPKILALHLKRFKYDEQLNRYIKLFYRVV 216

                        250       260       270
                 ....*....|....*....|....*....|.
gi 530402148 280 FPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02663  217 FPLELRLFNTTDDAENPDRLYELVAVVVHIG 247
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
39-310 9.30e-78

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 239.65  E-value: 9.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148   39 FGLVNFGNTCYCNSVLQALYFCRPFREKVLAY-----KSQPRKKESLLTCLADLFHSIaTQKKKVGVIPPKKFITRLRKE 113
Cdd:pfam00443   1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRIsplseDSRYNKDINLLCALRDLFKAL-QKNSKSSSVSPKMFKKSLGKL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  114 NELFDNYMQQDAHEFLNYLLNTiadiLQEERKQekqngrlpngnidnenNNSTPDPTWVHEIFQGTLTNETRCLTCETIS 193
Cdd:pfam00443  80 NPDFSGYKQQDAQEFLLFLLDG----LHEDLNG----------------NHSTENESLITDLFRGQLKSRLKCLSCGEVS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  194 SKDEDFLDLSVDVEQNTSITH------CLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYmdQ 267
Cdd:pfam00443 140 ETFEPFSDLSLPIPGDSAELKtaslqiCFLQFSKLEELDDEEKYYCDKCGCKQDAIKQLKISRLPPVLIIHLKRFSY--N 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 530402148  268 LHRYTKLSYRVVFPLELRLFNTSGDATNPD----RMYDLVAVVVHCG 310
Cdd:pfam00443 218 RSTWEKLNTEVEFPLELDLSRYLAEELKPKtnnlQDYRLVAVVVHSG 264
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 40-310 4.09e-53

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 174.59  E-value: 4.09e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFcrpfrekvlayksqprkkeslltcladlfhsiatqkkkvgvippkkfitrlrkenelfdn 119
Cdd:cd02257    1 GLNNLGNTCYLNSVLQALFS------------------------------------------------------------ 20

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 120 yMQQDAHEFLNYLLNTIADILQEERKQEKqngrlpngnidnennNSTPDPTWVHEIFQGTLTNETRCLTC--ETISSKDE 197
Cdd:cd02257   21 -EQQDAHEFLLFLLDKLHEELKKSSKRTS---------------DSSSLKSLIHDLFGGKLESTIVCLECghESVSTEPE 84

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 198 DFLDLSVDVEQ--NTSITHCLRGFSNTETLCSEYKYYCEeCRSKQEAHKRMKVKKLPMILALHLKRFKYmDQLHRYTKLS 275
Cdd:cd02257   85 LFLSLPLPVKGlpQVSLEDCLEKFFKEEILEGDNCYKCE-KKKKQEATKRLKIKKLPPVLIIHLKRFSF-NEDGTKEKLN 162

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530402148 276 YRVVFPLELRLFN------TSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02257  163 TKVSFPLELDLSPylsegeKDSDSDNGSYKYELVAVVVHSG 203
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 38-310 6.52e-50

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 168.59  E-value: 6.52e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKE--SLLTCLADLFHSIATQKKKVGVippkkfiTRLRKENE 115
Cdd:cd02659    2 YVGLKNQGATCYMNSLLQQLYMTPEFRNAVYSIPPTEDDDDnkSVPLALQRLFLFLQLSESPVKT-------TELTDKTR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 116 LFDN-----YMQQDAHEFLNYLLntiaDILQEERKQEKQNGRLPngnidnennnstpdptwvhEIFQGTLTNETRCLTCE 190
Cdd:cd02659   75 SFGWdslntFEQHDVQEFFRVLF----DKLEEKLKGTGQEGLIK-------------------NLFGGKLVNYIICKECP 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 191 TISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKY-MDQLH 269
Cdd:cd02659  132 HESEREEYFLDLQVAVKGKKNLEESLDAYVQGETLEGDNKYFCEKCGKKVDAEKGVCFKKLPPVLTLQLKRFEFdFETMM 211

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530402148 270 RYtKLSYRVVFPLEL-----------RLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02659  212 RI-KINDRFEFPLELdmepytekglaKKEGDSEKKDSESYIYELHGVLVHSG 262
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 2.93e-48

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 163.60  E-value: 2.93e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPFREKVL--AYKSQPRKKESLLTCLADLF--HSIATQKKkvgVIPPKKFITRLRKENE 115
Cdd:cd02661    3 GLQNLGNTCFLNSVLQCLTHTPPLANYLLsrEHSKDCCNEGFCMMCALEAHveRALASSGP---GSAPRIFSSNLKQISK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 116 LFDNYMQQDAHEFLNYLLNTiadilqeerkqeKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSK 195
Cdd:cd02661   80 HFRIGRQEDAHEFLRYLLDA------------MQKACLDRFKKLKAVDPSSQETTLVQQIFGGYLRSQVKCLNCKHVSNT 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 196 DEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYmdqlHRYTKLS 275
Cdd:cd02661  148 YDPFLDLSLDIKGADSLEDALEQFTKPEQLDGENKYKCERCKKKVKASKQLTIHRAPNVLTIHLKRFSN----FRGGKIN 223

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 530402148 276 YRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02661  224 KQISFPETLDLSPYMSQPNDGPLKYKLYAVLVHSG 258
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 3.26e-38

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 137.55  E-value: 3.26e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ------------PRKKESLLTCLADLFHSIATQKKKVgvIPPKKFI 107
Cdd:cd02668    1 GLKNLGATCYVNSFLQLWFMNLEFRKAVYECNSTedaelknmppdkPHEPQTIIDQLQLIFAQLQFGNRSV--VDPSGFV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 108 TRLRkenelFDNYMQQDAHEFLNYLLNTIADILQeerKQEKQNGRlpngnidnennnstpdpTWVHEIFQGTLTNETRCL 187
Cdd:cd02668   79 KALG-----LDTGQQQDAQEFSKLFLSLLEAKLS---KSKNPDLK-----------------NIVQDLFRGEYSYVTQCS 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 188 TCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQ 267
Cdd:cd02668  134 KCGRESSLPSKFYELELQLKGHKTLEECIDEFLKEEQLTGDNQYFCESCNSKTDATRRIRLTTLPPTLNFQLLRFVFDRK 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530402148 268 LHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02668  214 TGAKKKLNASISFPEILDMGEYLAESDEGSYVYELSGVLIHQG 256
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 7.93e-37

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 134.25  E-value: 7.93e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESL-LTCLA--DLFHSIATQKkkvgviPPKKFITRLRKENEL 116
Cdd:cd02671   26 GLNNLGNTCYLNSVLQVLYFCPGFKHGLKHLVSLISSVEQLqSSFLLnpEKYNDELANQ------APRRLLNALREVNPM 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 117 FDNYMQQDAHEFLNYLLNTIADILQEerkqekqngrlpngnidnennnstpdptwvheIFQGTLTNETRCLTCETISSKD 196
Cdd:cd02671  100 YEGYLQHDAQEVLQCILGNIQELVEK--------------------------------DFQGQLVLRTRCLECETFTERR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 197 EDFLDLSVDVE-------------------QNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILAL 257
Cdd:cd02671  148 EDFQDISVPVQeselskseesseispdpktEMKTLKWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKLPEVITI 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530402148 258 HLKRF----KYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDrmYDLVAVVVHCG 310
Cdd:cd02671  228 HLKCFaangSEFDCYGGLSKVNTPLLTPLKLSLEEWSTKPKNDV--YRLFAVVMHSG 282
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 8.90e-37

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 134.04  E-value: 8.90e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPFREKVLA--YKSQPRKKESL--LTC-LADLFHSIATQKKKVGVIPPKKFITRLRKEN 114
Cdd:cd02660    2 GLINLGATCFMNVILQALLHNPLLRNYFLSdrHSCTCLSCSPNscLSCaMDEIFQEFYYSGDRSPYGPINLLYLSWKHSR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 115 ELfDNYMQQDAHEFLNYLLNTIAdilQEERKQEKQNGRLPngnidnennnstPDPTWVHEIFQGTLTNETRCLTCETISS 194
Cdd:cd02660   82 NL-AGYSQQDAHEFFQFLLDQLH---THYGGDKNEANDES------------HCNCIIHQTFSGSLQSSVTCQRCGGVST 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 195 KDEDFLDLSVDVEQNT---------------SITHCLRGFSNTETLCSeYKYYCEECRSKQEAHKRMKVKKLPMILALHL 259
Cdd:cd02660  146 TVDPFLDLSLDIPNKStpswalgesgvsgtpTLSDCLDRFTRPEKLGD-FAYKCSGCGSTQEATKQLSIKKLPPVLCFQL 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 260 KRFKYmDQLHRYTKLSYRVVFPLELRL--FNTSGDAT-------NPDRMYDLVAVVVHCG 310
Cdd:cd02660  225 KRFEH-SLNKTSRKIDTYVQFPLELNMtpYTSSSIGDtqdsnslDPDYTYDLFAVVVHKG 283
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 1.49e-35

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 128.17  E-value: 1.49e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQalyfcrpfrekvlayksqprkkeslltCLADlfhsiatqkkkvgvippkkfitrlrkenelfdn 119
Cdd:cd02674    1 GLRNLGNTCYMNSILQ---------------------------CLSA--------------------------------- 20

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 120 yMQQDAHEFLNYLLNTIADILQEErkqekqngrlpngnidnennnstpdptwvheiFQGTLTNETRCLTCETISSKDEDF 199
Cdd:cd02674   21 -DQQDAQEFLLFLLDGLHSIIVDL--------------------------------FQGQLKSRLTCLTCGKTSTTFEPF 67

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 200 LDLSVDVEQNT------SITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYmdQLHRYTK 273
Cdd:cd02674   68 TYLSLPIPSGSgdapkvTLEDCLRLFTKEETLDGDNAWKCPKCKKKRKATKKLTISRLPKVLIIHLKRFSF--SRGSTRK 145

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 530402148 274 LSYRVVFPLE---LRLFNTSGDATNPDRmYDLVAVVVHCG 310
Cdd:cd02674  146 LTTPVTFPLNdldLTPYVDTRSFTGPFK-YDLYAVVNHYG 184
Peptidase_C19H cd02664
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 7.57e-35

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239129 [Multi-domain]  Cd Length: 327  Bit Score: 128.76  E-value: 7.57e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKE-SLLTCLADLFHSIATQKKKVGViPPKKFITRLRKENelFD 118
Cdd:cd02664    1 GLINLGNTCYMNSVLQALFMAKDFRRQVLSLNLPRLGDSqSVMKKLQLLQAHLMHTQRRAEA-PPDYFLEASRPPW--FT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 119 NYMQQDAHEFLNYLLntiaDILQeerkqekqngrlpngnidnennnstpdpTWVHEIFQGTLTNETRCLTCETISSKDED 198
Cdd:cd02664   78 PGSQQDCSEYLRYLL----DRLH----------------------------TLIEKMFGGKLSTTIRCLNCNSTSARTER 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 199 FLDLSVDVeqnTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRV 278
Cdd:cd02664  126 FRDLDLSF---PSVQDLLNYFLSPEKLTGDNQYYCEKCASLQDAEKEMKVTGAPEYLILTLLRFSYDQKTHVREKIMDNV 202

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530402148 279 VFPLELRL-----FNTSGDATNPDRM--------------YDLVAVVVHCG 310
Cdd:cd02664  203 SINEVLSLpvrveSKSSESPLEKKEEesgddgelvtrqvhYRLYAVVVHSG 253
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 1.77e-34

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 126.73  E-value: 1.77e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALyfcrpfrekvlayksqprkkeSLLTCLADLFHSiatqkkkvgviPPKKFITRLRKENELFDN 119
Cdd:cd02667    1 GLSNLGNTCFFNAVMQNL---------------------SQTPALRELLSE-----------TPKELFSQVCRKAPQFKG 48

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 120 YMQQDAHEFLNYLLNTIAdilqeerkqekqngrlpngnidnennnstpdpTWVHEIFQGTLTNETRCLTCETISSKDEDF 199
Cdd:cd02667   49 YQQQDSHELLRYLLDGLR--------------------------------TFIDSIFGGELTSTIMCESCGTVSLVYEPF 96

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 200 LDLS----VDVEQNTSITHCLRGFSNTETLCSEYKYYCEECrskQEAHKRMKVKKLPMILALHLKRFKyMDQLHRYTKLS 275
Cdd:cd02667   97 LDLSlprsDEIKSECSIESCLKQFTEVEILEGNNKFACENC---TKAKKQYLISKLPPVLVIHLKRFQ-QPRSANLRKVS 172

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 530402148 276 YRVVFP--LELRLF---NTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02667  173 RHVSFPeiLDLAPFcdpKCNSSEDKSSVLYRLYGVVEHSG 212
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-311 1.98e-25

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 103.18  E-value: 1.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKES----LLTCLADLFHSIatqKKKVGVIPPKKFITRLRK--- 112
Cdd:cd02657    1 GLTNLGNTCYLNSTLQCLRSVPELRDALKNYNPARRGANQssdnLTNALRDLFDTM---DKKQEPVPPIEFLQLLRMafp 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 113 ---ENELFDNYMQQDAHEFLNYLLNTIADILqeerkqekqngrlpngnidnenNNSTPDPTWVHEIFQGTLTNETRCL-- 187
Cdd:cd02657   78 qfaEKQNQGGYAQQDAEECWSQLLSVLSQKL----------------------PGAGSKGSFIDQLFGIELETKMKCTes 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 188 -TCETISSKDEDFLDLSVDVEQNTSITH--CLRGFSNTETLCSeykyycEECRSKQEAHKRMKVKKLPMILALHLKRFKY 264
Cdd:cd02657  136 pDEEEVSTESEYKLQCHISITTEVNYLQdgLKKGLEEEIEKHS------PTLGRDAIYTKTSRISRLPKYLTVQFVRFFW 209

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530402148 265 MDQLHRYTKLSYRVVFPLELRLFntsgDATNPDRMYDLVAVVVHCGR 311
Cdd:cd02657  210 KRDIQKKAKILRKVKFPFELDLY----ELCTPSGYYELVAVITHQGR 252
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
 38-310 3.70e-24

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 103.03  E-value: 3.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148   38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKKKVGVippkkfiTRLRKEN-- 114
Cdd:COG5077   193 YVGLRNQGATCYMNSLLQSLFFIAKFRKDVYGIPTDhPRGRDSVALALQRLFYNLQTGEEPVDT-------TELTRSFgw 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  115 ELFDNYMQQDAHEFLNYLLntiaDILQEERKQEKQNGRLpngnidnennnstpdptwvHEIFQGTLTNETRCLTCETISS 194
Cdd:COG5077   266 DSDDSFMQHDIQEFNRVLQ----DNLEKSMRGTVVENAL-------------------NGIFVGKMKSYIKCVNVNYESA 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  195 KDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEEcRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKL 274
Cdd:COG5077   323 RVEDFWDIQLNVKGMKNLQESFRRYIQVETLDGDNRYNAEK-HGLQDAKKGVIFESLPPVLHLQLKRFEYDFERDMMVKI 401

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 530402148  275 SYRVVFPLELRLF----NTSGDATNPDRMYDLVAVVVHCG 310
Cdd:COG5077   402 NDRYEFPLEIDLLpfldRDADKSENSDAVYVLYGVLVHSG 441
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-310 3.44e-21

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 91.62  E-value: 3.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALY----FCRPFREKVLAYKSQPRKKESLLTC-LADLFHSIATQKKKVGV------------IP 102
Cdd:cd02658    1 GLRNLGNSCYLNSVLQVLFsipsFQWRYDDLENKFPSDVVDPANDLNCqLIKLADGLLSGRYSKPAslksendpyqvgIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 103 PKKFITRLRKENELFDNYMQQDAHEFLNYLLntiaDILQEERKQEkqngrlpngnidnennnSTPDPTwvhEIFQGTLTN 182
Cdd:cd02658   81 PSMFKALIGKGHPEFSTMRQQDALEFLLHLI----DKLDRESFKN-----------------LGLNPN---DLFKFMIED 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 183 ETRCLTCETISSKDEDFLDLSVDVE--------------QNTSITHCLRGFSNTETLcseyKYYCEECRSKQEAHKRMKV 248
Cdd:cd02658  137 RLECLSCKKVKYTSELSEILSLPVPkdeatekeegelvyEPVPLEDCLKAYFAPETI----EDFCSTCKEKTTATKTTGF 212

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530402148 249 KKLPMILALHLKRFKYMDQlHRYTKLSYRVVFPLELRlfntSGDatnpdrmYDLVAVV------VHCG 310
Cdd:cd02658  213 KTFPDYLVINMKRFQLLEN-WVPKKLDVPIDVPEELG----PGK-------YELIAFIshkgtsVHSG 268
Peptidase_C19F cd02662
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-311 2.86e-20

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239127 [Multi-domain]  Cd Length: 240  Bit Score: 87.81  E-value: 2.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPFREkvlayksqprkkeslltcladlfhsiatqkkkvgvippkkFITRLRKenelfdn 119
Cdd:cd02662    1 GLVNLGNTCFMNSVLQALASLPSLIE----------------------------------------YLEEFLE------- 33

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 120 ymQQDAHEFLNYLLNTIADILqeerkqekqngrlpngnidnennnSTPdptwvheiFQGTLTNETRCLTCETISSKDED- 198
Cdd:cd02662   34 --QQDAHELFQVLLETLEQLL------------------------KFP--------FDGLLASRIVCLQCGESSKVRYEs 79

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 199 FLDLSVDVEQNTSIT-----HCLRGFSNTETlCSEYKyyCEECRSKqeahkrmkVKKLPMILALHLKRFKYmDQLHRYTK 273
Cdd:cd02662   80 FTMLSLPVPNQSSGSgttleHCLDDFLSTEI-IDDYK--CDRCQTV--------IVRLPQILCIHLSRSVF-DGRGTSTK 147

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 530402148 274 LSYRVVFPLELrlfntsgdatnPDRMYDLVAVVVHCGR 311
Cdd:cd02662  148 NSCKVSFPERL-----------PKVLYRLRAVVVHYGS 174
UCH_1 pfam13423
Ubiquitin carboxyl-terminal hydrolase;
40-308 2.93e-16

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 463872 [Multi-domain]  Cd Length: 305  Bit Score: 77.70  E-value: 2.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148   40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTC-LADLFHSIATQKKK----------VGVIPPKKFIT 108
Cdd:pfam13423   2 GLETHIPNSYTNSLLQLLRFIPPLRNLALSHLATECLKEHCLLCeLGFLFDMLEKAKGKncqasnflraLSSIPEASALG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  109 RLRKENELFDNY----MQQDaheFLNYLLNTIAdilQEERKQEKQNgrlpngnidnennnsTPDPTWVHEIFQGTLTNET 184
Cdd:pfam13423  82 LLDEDRETNSAIslssLIQS---FNRFLLDQLS---SEENSTPPNP---------------SPAESPLEQLFGIDAETTI 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  185 RCLTCETISSKDEDF--LDLSV--------DVEQNTSITHCLRGFSNTETLcseYKYYCEECRSKQEAHKRMKVKKLPMI 254
Cdd:pfam13423 141 RCSNCGHESVRESSThvLDLIYprkpssnnKKPPNQTFSSILKSSLERETT---TKAWCEKCKRYQPLESRRTVRNLPPV 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530402148  255 LALHLKRFkymDQLHRYTKLSYRVvFPLELRLFNTSGDATNPD-RMYDLVAVVVH 308
Cdd:pfam13423 218 LSLNAALT---NEEWRQLWKTPGW-LPPEIGLTLSDDLQGDNEiVKYELRGVVVH 268
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
211-310 2.29e-14

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 73.76  E-value: 2.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 211 SIT--HCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYmdQLHRYTKLSYRVVFPL-ELRLF 287
Cdd:COG5560  674 TITlqDCLNEFSKPEQLGLSDSWYCPGCKEFRQASKQMELWRLPMILIIHLKRFSS--VRSFRDKIDDLVEYPIdDLDLS 751

                         90       100
                 ....*....|....*....|...
gi 530402148 288 NTSGDATNPDRMYDLVAVVVHCG 310
Cdd:COG5560  752 GVEYMVDDPRLIYDLYAVDNHYG 774
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
40-204 2.44e-14

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 73.38  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPFREKVLA--YKSQPRKKE------SLLTCLADLFHSIATQkkKVGVIPPKKFITRLR 111
Cdd:COG5560  267 GLRNLGNTCYMNSALQCLMHTWELRDYFLSdeYEESINEENplgmhgSVASAYADLIKQLYDG--NLHAFTPSGFKKTIG 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 112 KENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEkQNGRLPNGNIDNENNNSTPDPTW----------VHEIFQGTLT 181
Cdd:COG5560  345 SFNEEFSGYDQQDSQEFIAFLLDGLHEDLNRIIKKP-YTSKPDLSPGDDVVVKKKAKECWwehlkrndsiITDLFQGMYK 423

                        170       180
                 ....*....|....*....|...
gi 530402148 182 NETRCLTCETISSKDEDFLDLSV 204
Cdd:COG5560  424 STLTCPGCGSVSITFDPFMDLTL 446
COG5533 COG5533
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
40-310 1.39e-11

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444284 [Multi-domain]  Cd Length: 284  Bit Score: 63.67  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPfreKVLAYKSQPRKKeslltcLADLFHSIATQKKKVGVIPPKKFITRLRKENE---- 115
Cdd:COG5533    1 GLPNLGNTCFMNSVLQILALYLP---KLDELLDDLSKE------LKVLKNVIRKPEPDLNQEEALKLFTALWSSKEhkvg 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 116 -LFDNYMQQDAHEFLNYLLNTIadilqeERKQEKQNGRLPNGNIDNENNNSTPDptwvheIFQGTLTNETRclTCETISS 194
Cdd:COG5533   72 wIPPMGSQEDAHELLGKLLDEL------KLDLVNSFTIRIFKTTKDKKKTSTGD------WFDIIIELPDQ--TWVNNLK 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 195 KDEDFLDlsvdveqntsithCLRGFSNTETLCSEYKYYCEECRSKQEAHkrMKVKKLPMILALHLKRFKYmdqLHRYTKL 274
Cdd:COG5533  138 TLQEFID-------------NMEELVDDETGVKAKENEELEVQAKQEYE--VSFVKLPKILTIQLKRFAN---LGGNQKI 199

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 530402148 275 SYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:COG5533  200 DTEVDEKFELPVKHDQILNIVKETYYDLVGFVLHQG 235
Peptidase_C19M cd02669
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 38-310 2.45e-11

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239134 [Multi-domain]  Cd Length: 440  Bit Score: 63.88  E-value: 2.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLA---YKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKF---ITRLR 111
Cdd:cd02669  119 FVGLNNIKNNDYANVIIQALSHVKPIRNFFLLyenYENIKDRKSELVKRLSELIRKIWNPRNFKGHVSPHELlqaVSKVS 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 112 KENelFDNYMQQDAHEFLNYLLNTIADILQEERKqekqngrlpngnidnennnstPDPTWVHEIFQGTLTNETRCLTCET 191
Cdd:cd02669  199 KKK--FSITEQSDPVEFLSWLLNTLHKDLGGSKK---------------------PNSSIIHDCFQGKVQIETQKIKPHA 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 192 IS-SKDEDFLDLSVDVEQNTSITHCLR---------GFSNTETLCSEY-------KYYCEECRSKQEAHKRMKVKKLPMI 254
Cdd:cd02669  256 EEeGSKDKFFKDSRVKKTSVSPFLLLTldlpppplfKDGNEENIIPQVplkqllkKYDGKTETELKDSLKRYLISRLPKY 335

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530402148 255 LALHLKRFkymdqlhryTKLSYR-------VVFPLELRLF----NTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02669  336 LIFHIKRF---------SKNNFFkeknptiVNFPIKNLDLsdyvHFDKPSLNLSTKYNLVANIVHEG 393
Peptidase_C19Q cd02673
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 41-310 3.19e-11

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239138 [Multi-domain]  Cd Length: 245  Bit Score: 62.16  E-value: 3.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148  41 LVNFGNTCYCNSVLQALyfcrpfrekvlayksqprkkeslltcladlfhsiatqkkkvgvippkkfiTRLRKENELFDNY 120
Cdd:cd02673    2 LVNTGNSCYFNSTMQAL--------------------------------------------------SSIGKINTEFDND 31

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 121 MQQDAHEFLNYLLNTIADILQEERKQEKQNGrlpngnidneNNNSTPDPTwvhEIFQGTLTNETRCLTCETISSKDEDFL 200
Cdd:cd02673   32 DQQDAHEFLLTLLEAIDDIMQVNRTNVPPSN----------IEIKRLNPL---EAFKYTIESSYVCIGCSFEENVSDVGN 98

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530402148 201 DLSVDVEQNTSITHCLRGFSNTETLCSEYKyyCEECrSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVF 280
Cdd:cd02673   99 FLDVSMIDNKLDIDELLISNFKTWSPIEKD--CSSC-KCESAISSERIMTFPECLSINLKRYKLRIATSDYLKKNEEIMK 175

                        250       260       270
                 ....*....|....*....|....*....|
gi 530402148 281 PLELRLFNtsgdatnpdrmYDLVAVVVHCG 310
Cdd:cd02673  176 KYCGTDAK-----------YSLVAVICHLG 194
Peptidase_C19J cd02666
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-70 1.73e-05

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239131 [Multi-domain]  Cd Length: 343  Bit Score: 45.95  E-value: 1.73e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 530402148  40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAY 70
Cdd:cd02666    3 GLDNIGNTCYLNSLLQYFFTIKPLRDLVLNF 33
Peptidase_C19P cd02672
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 38-92 2.62e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239137 [Multi-domain]  Cd Length: 268  Bit Score: 38.65  E-value: 2.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530402148  38 YFGLVNFGNTCYCNSVLQALYFCRPFReKVLAYKSQPRKKES-LLTCLADLFHSIA 92
Cdd:cd02672   15 YAGLENHITNSYCNSLLQLLYFIPPFR-NFTAIILVACPKEScLLCELGYLFSTLI 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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