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Conserved domains on  [gi|530376455|ref|XP_005262694|]
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toll-like receptor 6 isoform X1 [Homo sapiens]

Protein Classification

toll-like receptor( domain architecture ID 17988233)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 2.54e-38

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 139.38  E-value: 2.54e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455   641 QFHAFISYSEHDsaWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530376455   719 AHHNLFHEGSNNLILILLEPIPQNsIPNKYHKLKALMtQRTYLQWPKEKSKRglFWANIRAA 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-531 4.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 249 STLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVF 328
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 329 SEMNIMMLTISDTPFIHMLcphapSTFKFLNFTQNVFTDsIFEKCSTLVKLETLILQKNGLKDLFKVglmTKDMPSLEIL 408
Cdd:COG4886   94 DLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 409 DVSWNSLES-GRHKENCTwveSIVVLNLSSNMLTD--SVFRCLPpRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSL 485
Cdd:COG4886  165 DLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530376455 486 TDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 531
Cdd:COG4886  241 TDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
55-327 3.09e-10

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  55 KVLDMSQNYIAELqVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQdLEYLDLSHNQLQKISCH--PIVSFRHLDLSFND 132
Cdd:COG4886  116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 133 FKALPicKEFGNLSQLNFLGLSAMKLQKLDlLPIAHL-HLSYILLD---------------LRNYYIKENE----TESLQ 192
Cdd:COG4886  194 ITDLP--EPLGNLTNLEELDLSGNQLTDLP-EPLANLtNLETLDLSnnqltdlpelgnltnLEELDLSNNQltdlPPLAN 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 193 ILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQF 272
Cdd:COG4886  271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530376455 273 LWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTV 327
Cdd:COG4886  351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 1.63e-09

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 53.97  E-value: 1.63e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 530376455   529 NPFQCTCELREFVKNIDQvssEVLEGWPDSYKCDYPESYRGsPLKDFHMSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 2.54e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 139.38  E-value: 2.54e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455   641 QFHAFISYSEHDsaWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530376455   719 AHHNLFHEGSNNLILILLEPIPQNsIPNKYHKLKALMtQRTYLQWPKEKSKRglFWANIRAA 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-778 2.35e-21

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 91.66  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  642 FHAFISYSEHDS-AWVKSELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530376455  721 HNLFhEGSNNLILILLEPIPQ------NSIPNKYHKLKALMTQRTYLQWP------------KEKSKRGLFWANIR 778
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSdvrkqtGSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIA 155
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-531 4.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 249 STLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVF 328
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 329 SEMNIMMLTISDTPFIHMLcphapSTFKFLNFTQNVFTDsIFEKCSTLVKLETLILQKNGLKDLFKVglmTKDMPSLEIL 408
Cdd:COG4886   94 DLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 409 DVSWNSLES-GRHKENCTwveSIVVLNLSSNMLTD--SVFRCLPpRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSL 485
Cdd:COG4886  165 DLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530376455 486 TDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 531
Cdd:COG4886  241 TDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-327 3.09e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  55 KVLDMSQNYIAELqVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQdLEYLDLSHNQLQKISCH--PIVSFRHLDLSFND 132
Cdd:COG4886  116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 133 FKALPicKEFGNLSQLNFLGLSAMKLQKLDlLPIAHL-HLSYILLD---------------LRNYYIKENE----TESLQ 192
Cdd:COG4886  194 ITDLP--EPLGNLTNLEELDLSGNQLTDLP-EPLANLtNLETLDLSnnqltdlpelgnltnLEELDLSNNQltdlPPLAN 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 193 ILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQF 272
Cdd:COG4886  271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530376455 273 LWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTV 327
Cdd:COG4886  351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 1.63e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 53.97  E-value: 1.63e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 530376455   529 NPFQCTCELREFVKNIDQvssEVLEGWPDSYKCDYPESYRGsPLKDFHMSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
76-133 3.04e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.04e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530376455   76 SELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKIS---CHPIVSFRHLDLSFNDF 133
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-565 1.50e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 353 STFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMtkDMPSLEILDVSWNSLeSGRHKENCTWVESIVV 432
Cdd:PLN00113 236 TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSL-SGEIPELVIQLQNLEI 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 433 LNLSSNMLTDSVFRCLP--PRIKVLDLHSNKIK-SVPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSV 507
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSL 392

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530376455 508 SHPSADFFQSCQKMRSIKAGDNPFqcTCEL-REFVK----NIDQVSSEVLEGWPDSYKCDYPE 565
Cdd:PLN00113 393 EGEIPKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-208 2.54e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  43 LIHVPKDLPLKTKVLDMSQNYIAELQvsdMSFLSELTVLRLSHNRIQLLDLSVfkfNQDLEYLDLSHNQLQKISCHPIVS 122
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELP---ERLPSALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPSG 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 123 FRHLDLSFNDFKALP-----------------ICKEFGNLSQLNFLGLSAMKLQKL-DLLP--IAHLHLSYILLdlrnYY 182
Cdd:PRK15370 306 ITHLNVQSNSLTALPetlppglktleagenalTSLPASLPPELQVLDVSKNQITVLpETLPptITTLDVSRNAL----TN 381

                        170       180
                 ....*....|....*....|....*.
gi 530376455 183 IKENETESLQILNAKTLHLVFHPTSL 208
Cdd:PRK15370 382 LPENLPAALQIMQASRNNLVRLPESL 407
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 558-582 8.44e-04

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 37.42  E-value: 8.44e-04
                          10        20
                  ....*....|....*....|....*
gi 530376455  558 SYKCDYPESYRGSPLKDFHMSELSC 582
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-140 1.37e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.37e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530376455  78 LTVLRLSHNRIQllDLSVFKFNQDLEYLDLSHNQLQKIS--CHPIVSFRHL---DLSFNdfkalPICK 140
Cdd:cd21340  122 LRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLrelDLTGN-----PVCK 182
LRR_8 pfam13855
Leucine rich repeat;
450-505 2.08e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  450 PRIKVLDLHSNKIKSVPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 505
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 2.54e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 139.38  E-value: 2.54e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455   641 QFHAFISYSEHDsaWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530376455   719 AHHNLFHEGSNNLILILLEPIPQNsIPNKYHKLKALMtQRTYLQWPKEKSKRglFWANIRAA 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-778 2.35e-21

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 91.66  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  642 FHAFISYSEHDS-AWVKSELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530376455  721 HNLFhEGSNNLILILLEPIPQ------NSIPNKYHKLKALMTQRTYLQWP------------KEKSKRGLFWANIR 778
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSdvrkqtGSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIA 155
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 645-738 3.45e-18

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 80.82  E-value: 3.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  645 FISYSEHDSAWVKsELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 724
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 530376455  725 HEGSNNLILILLEP 738
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-531 4.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 249 STLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVF 328
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 329 SEMNIMMLTISDTPFIHMLcphapSTFKFLNFTQNVFTDsIFEKCSTLVKLETLILQKNGLKDLFKVglmTKDMPSLEIL 408
Cdd:COG4886   94 DLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 409 DVSWNSLES-GRHKENCTwveSIVVLNLSSNMLTD--SVFRCLPpRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSL 485
Cdd:COG4886  165 DLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530376455 486 TDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 531
Cdd:COG4886  241 TDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-546 1.66e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 356 KFLNFTQNVFTDsIFEKCSTLVKLETLILQKNGLKDLFKVglmTKDMPSLEILDVSWNSLESGRHK-ENCTwveSIVVLN 434
Cdd:COG4886  139 KELDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPlGNLT---NLEELD 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 435 LSSNMLTD---SVFRClpPRIKVLDLHSNKIKSVPkQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPS 511
Cdd:COG4886  212 LSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 530376455 512 ADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQ 546
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-327 3.09e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  55 KVLDMSQNYIAELqVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQdLEYLDLSHNQLQKISCH--PIVSFRHLDLSFND 132
Cdd:COG4886  116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 133 FKALPicKEFGNLSQLNFLGLSAMKLQKLDlLPIAHL-HLSYILLD---------------LRNYYIKENE----TESLQ 192
Cdd:COG4886  194 ITDLP--EPLGNLTNLEELDLSGNQLTDLP-EPLANLtNLETLDLSnnqltdlpelgnltnLEELDLSNNQltdlPPLAN 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 193 ILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQF 272
Cdd:COG4886  271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530376455 273 LWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTV 327
Cdd:COG4886  351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-283 5.06e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 5.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  55 KVLDMSQNYIAELQVSdMSFLSELTVLRLSHNRIQLLDLSVFKFNQdLEYLDLSHNQLQKISC-HPIVSFRHLDLSFNDF 133
Cdd:COG4886  185 KELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDLPElGNLTNLEELDLSNNQL 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 134 KALPICKEFGNLSQLNFLG--LSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAI 211
Cdd:COG4886  263 TDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530376455 212 QVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNI 283
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 1.63e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 53.97  E-value: 1.63e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 530376455   529 NPFQCTCELREFVKNIDQvssEVLEGWPDSYKCDYPESYRGsPLKDFHMSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
76-133 3.04e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.04e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530376455   76 SELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKIS---CHPIVSFRHLDLSFNDF 133
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-565 1.50e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 353 STFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMtkDMPSLEILDVSWNSLeSGRHKENCTWVESIVV 432
Cdd:PLN00113 236 TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSL-SGEIPELVIQLQNLEI 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 433 LNLSSNMLTDSVFRCLP--PRIKVLDLHSNKIK-SVPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSV 507
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSL 392

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530376455 508 SHPSADFFQSCQKMRSIKAGDNPFqcTCEL-REFVK----NIDQVSSEVLEGWPDSYKCDYPE 565
Cdd:PLN00113 393 EGEIPKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-529 2.31e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 353 STFKFLNFTQNVFTDSIfeKCSTLVKLETLILQKNGLKdlfkvGLMTKDM---PSLEILDVSWNSLeSGRHKENCTWVES 429
Cdd:PLN00113 118 SSLRYLNLSNNNFTGSI--PRGSIPNLETLDLSNNMLS-----GEIPNDIgsfSSLKVLDLGGNVL-VGKIPNSLTNLTS 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 430 IVVLNLSSNMLTDSVFRCLpPRIKVLDL----HSNKIKSVPKQVVKLEALQELNVAFNSLTDL--PGCGSFSSLSVLIID 503
Cdd:PLN00113 190 LEFLTLASNQLVGQIPREL-GQMKSLKWiylgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPipSSLGNLKNLQYLFLY 268

                        170       180
                 ....*....|....*....|....*.
gi 530376455 504 HNSVSHPSADFFQSCQKMRSIKAGDN 529
Cdd:PLN00113 269 QNKLSGPIPPSIFSLQKLISLDLSDN 294
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
352-489 6.32e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.61  E-value: 6.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 352 PSTFKFLNFTQNVFTDsIFEKCSTlvKLETLILQKNglkdlfKVGLMTKDMPS-LEILDVSWNSLES-GRHKENctwveS 429
Cdd:PRK15370 240 PDTIQEMELSINRITE-LPERLPS--ALQSLDLFHN------KISCLPENLPEeLRYLSVYDNSIRTlPAHLPS-----G 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 430 IVVLNLSSNMLT----------------DSVFRCLP----PRIKVLDLHSNKIKSVPKQVVKleALQELNVAFNSLTDLP 489
Cdd:PRK15370 306 ITHLNVQSNSLTalpetlppglktleagENALTSLPaslpPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLP 383
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-180 1.18e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  47 PKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRiQLLDLSvfkfnqDLEYLDLSHNQLQKI--SCHPIVSFR 124
Cdd:COG4886   67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-ELSNLT------NLESLDLSGNQLTDLpeELANLTNLK 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530376455 125 HLDLSFNDFKALPicKEFGNLSQLNFLGLSAMKLQKLDlLPIAHL-HLSYilLDLRN 180
Cdd:COG4886  140 ELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLP-EELGNLtNLKE--LDLSN 191
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
378-545 1.42e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 378 KLETLILQKNGLKDLFKvglmtKDMPSLEILDVSWNSLESGRHkencTWVESIVVLNLSSNMLTDSVFRcLPPRIKVLDL 457
Cdd:PRK15370 200 QITTLILDNNELKSLPE-----NLQGNIKTLYANSNQLTSIPA----TLPDTIQEMELSINRITELPER-LPSALQSLDL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 458 HSNKIKSVPKQVVklEALQELNVAFNSLTDLPGCGSfSSLSVLIIDHNSVSHPSADFFQScqkMRSIKAGDNPFQCTCE- 536
Cdd:PRK15370 270 FHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLP-SGITHLNVQSNSLTALPETLPPG---LKTLEAGENALTSLPAs 343


                 ....*....
gi 530376455 537 LREFVKNID 545
Cdd:PRK15370 344 LPPELQVLD 352
LRR_8 pfam13855
Leucine rich repeat;
55-112 1.81e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530376455   55 KVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQL 112
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-208 2.54e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  43 LIHVPKDLPLKTKVLDMSQNYIAELQvsdMSFLSELTVLRLSHNRIQLLDLSVfkfNQDLEYLDLSHNQLQKISCHPIVS 122
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELP---ERLPSALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPSG 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 123 FRHLDLSFNDFKALP-----------------ICKEFGNLSQLNFLGLSAMKLQKL-DLLP--IAHLHLSYILLdlrnYY 182
Cdd:PRK15370 306 ITHLNVQSNSLTALPetlppglktleagenalTSLPASLPPELQVLDVSKNQITVLpETLPptITTLDVSRNAL----TN 381

                        170       180
                 ....*....|....*....|....*.
gi 530376455 183 IKENETESLQILNAKTLHLVFHPTSL 208
Cdd:PRK15370 382 LPENLPAALQIMQASRNNLVRLPESL 407
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 558-582 8.44e-04

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 37.42  E-value: 8.44e-04
                          10        20
                  ....*....|....*....|....*
gi 530376455  558 SYKCDYPESYRGSPLKDFHMSELSC 582
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-140 1.37e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.37e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530376455  78 LTVLRLSHNRIQllDLSVFKFNQDLEYLDLSHNQLQKIS--CHPIVSFRHL---DLSFNdfkalPICK 140
Cdd:cd21340  122 LRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLrelDLTGN-----PVCK 182
LRR_8 pfam13855
Leucine rich repeat;
450-505 2.08e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  450 PRIKVLDLHSNKIKSVPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 505
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 358-450 5.98e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 5.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455 358 LNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLmtKDMPSLEILDVSWNSLeSGRHKENCTWVESIVVLNLSS 437
Cdd:PLN00113 504 LKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASF--SEMPVLSQLDLSQNQL-SGEIPKNLGNVESLVQVNISH 580

                         90
                 ....*....|...
gi 530376455 438 NMLTDSvfrcLPP 450
Cdd:PLN00113 581 NHLHGS----LPS 589
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-148 9.30e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 9.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376455  53 KTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQ-----KISCHPIVSfrHLD 127
Cdd:PLN00113 476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgqipaSFSEMPVLS--QLD 553

                         90       100
                 ....*....|....*....|.
gi 530376455 128 LSFNDFKAlPICKEFGNLSQL 148
Cdd:PLN00113 554 LSQNQLSG-EIPKNLGNVESL 573
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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