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Conserved domains on  [gi|530417877|ref|XP_005260357|]
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COMM domain-containing protein 7 isoform X2 [Homo sapiens]

Protein Classification

COMM domain-containing protein 7( domain architecture ID 10140835)

COMM domain-containing protein 7 (COMMD7) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and associates with the NF-kappa-B complex and suppresses its transcriptional activity

Gene Symbol:  COMMD7
Gene Ontology:  GO:0051059|GO:0006355
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 19-174 3.64e-92

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240103  Cd Length: 180  Bit Score: 268.55  E-value: 3.64e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417877  19 MQQLNQLGA-QFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFIT 97
Cdd:cd04755    1 IQNLNQLSEqQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530417877  98 LGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYI 174
Cdd:cd04755   81 LGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRKGNQTENVYM 157
 
Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 19-174 3.64e-92

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 268.55  E-value: 3.64e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417877  19 MQQLNQLGA-QFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFIT 97
Cdd:cd04755    1 IQNLNQLSEqQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530417877  98 LGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYI 174
Cdd:cd04755   81 LGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRKGNQTENVYM 157
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 129-187 2.45e-07

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 46.77  E-value: 2.45e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417877  129 MINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQ-TENVYIgesEFPLEPLHLF 187
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGsSEEVTF---ELSKEQLQDL 57
 
Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 19-174 3.64e-92

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 268.55  E-value: 3.64e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417877  19 MQQLNQLGA-QFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFIT 97
Cdd:cd04755    1 IQNLNQLSEqQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530417877  98 LGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYI 174
Cdd:cd04755   81 LGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRKGNQTENVYM 157
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 126-187 5.39e-09

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 51.93  E-value: 5.39e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530417877 126 QTLMINQLIDMEWKFGVTSGSSELEKVG--SIFLQLKLVVKKGNQTENVYIgesEFPLEPLHLF 187
Cdd:cd04748   16 QSLSLPQLVDFDWRLDVQISSSSLAKVKqpTILVQLKLQVGDNNSSEKICF---EMTKEELQNF 76
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 129-187 2.45e-07

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 46.77  E-value: 2.45e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417877  129 MINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQ-TENVYIgesEFPLEPLHLF 187
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGsSEEVTF---ELSKEQLQDL 57
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 65-171 1.24e-03

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 38.56  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417877  65 GSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTS 144
Cdd:cd04752   39 GDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYIL 118

                         90       100
                 ....*....|....*....|....*..
gi 530417877 145 GSSELEKVGSIFLQLKLVVKKGNQTEN 171
Cdd:cd04752  119 SSSELQEVNEPLVQLRLKVRNADTGEI 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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