|
Name |
Accession |
Description |
Interval |
E-value |
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
482-702 |
1.12e-48 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 177.29 E-value: 1.12e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 482 LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVK 561
Cdd:COG5238 210 VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 562 NSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLA 641
Cdd:COG5238 290 GNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALA 369
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530384400 642 EMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTgITEICLNGNLIKPE-EAKVYEDEKRI 702
Cdd:COG5238 370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEaQQRLEQLLERI 430
|
|
| P-loop_NTPase super family |
cl38936 |
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ... |
3-119 |
3.36e-26 |
|
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.
The actual alignment was detected with superfamily member pfam05729:
Pssm-ID: 476819 [Multi-domain] Cd Length: 166 Bit Score: 105.46 E-value: 3.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 3 RDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSscpwepahPLVLLANLLSGKLLKGASKLL 82
Cdd:pfam05729 54 ADLLFSQWPEPAAPVSEVWAVILELPERLLLILDGLDELVSDLGQLDGPCP--------VLTLLSSLLRKKLLPGASLLL 125
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 530384400 83 TARTGI--EVPRQFLRKKVL-LRGFSPSHLRAYARRMFPE 119
Cdd:pfam05729 126 TVRPDAlrDLRRGLEEPRYLeVRGFSESDRKQYVRKYFSD 165
|
|
| NACHT super family |
cl26020 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
4-294 |
2.38e-13 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
The actual alignment was detected with superfamily member COG5635:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 73.69 E-value: 2.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 4 DLLFKHYCYPERDPEEVFAFLLRFPHVALFtFDGLDELHSDLDLSRVpdsscpwepahpLVLLANLLSGklLKGASKLLT 83
Cdd:COG5635 232 DLLAEALEKRGGEPEDALERLLRNGRLLLL-LDGLDEVPDEADRDEV------------LNQLRRFLER--YPKARVIIT 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 84 ARTgIEVPRQFLR--KKVLLRGFSPSHLRAYARRMFPERALQ-DRLLSQLEANPNLCSLCSVPLFCWIIfrCfqhfrAAF 160
Cdd:COG5635 297 SRP-EGYDSSELEgfEVLELAPLSDEQIEEFLKKWFEATERKaERLLEALEENPELRELARNPLLLTLL--A-----LLL 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 161 EGSPQLPDctmTLTDVFLLVTEVHLNRMQpsslVQRNTRSPVETLHAGRDTLcsLGQVAHRGMEKSLFVFTQEEVQASGL 240
Cdd:COG5635 369 RERGELPD---TRAELYEQFVELLLERWD----EQRGLTIYRELSREELREL--LSELALAMQENGRTEFAREELEEILR 439
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530384400 241 QERDMQLG---FLRALpELGPG----GDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLR 294
Cdd:COG5635 440 EYLGRRKDaeaLLDEL-LLRTGllveRGEGRYSFAHRSFQEYLAARALVEELDEELLELLA 499
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
269-417 |
5.57e-12 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 63.08 E-value: 5.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 269 HLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMppagaaTTSCYPPFLpfqclqgsgpaREDLFKNKDHFQFTNLFLCGLL 348
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLR------KRESLKSLL-----------DKALKSKNGHLDLFLRFLFGLL 63
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530384400 349 SKAKQKLLRHLVPAAALRRKRKalwahlfsSLRGYLKSLPRVQVESFNqvqamptFIWMLRCIYETQSQ 417
Cdd:pfam17776 64 NEENQRLLEGLLGCKLSSEIKQ--------ELLQWIKSLIQKELSSER-------FLNLFHCLYELQDE 117
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
482-702 |
1.12e-48 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 177.29 E-value: 1.12e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 482 LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVK 561
Cdd:COG5238 210 VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 562 NSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLA 641
Cdd:COG5238 290 GNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALA 369
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530384400 642 EMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTgITEICLNGNLIKPE-EAKVYEDEKRI 702
Cdd:COG5238 370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEaQQRLEQLLERI 430
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
3-119 |
3.36e-26 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 105.46 E-value: 3.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 3 RDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSscpwepahPLVLLANLLSGKLLKGASKLL 82
Cdd:pfam05729 54 ADLLFSQWPEPAAPVSEVWAVILELPERLLLILDGLDELVSDLGQLDGPCP--------VLTLLSSLLRKKLLPGASLLL 125
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 530384400 83 TARTGI--EVPRQFLRKKVL-LRGFSPSHLRAYARRMFPE 119
Cdd:pfam05729 126 TVRPDAlrDLRRGLEEPRYLeVRGFSESDRKQYVRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
428-693 |
2.35e-25 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 107.44 E-value: 2.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 428 CANYLKLTYCNACSADCSALSFVLHHFP--KRLALDLDNNNLNDYGVRELqPCF----SRLTVLRLSVNQITDGGVKVLs 501
Cdd:cd00116 24 CLQVLRLEGNTLGEEAAKALASALRPQPslKELCLSLNETGRIPRGLQSL-LQGltkgCGLQELDLSDNALGPDGCGVL- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 502 EELTKYKIVTYLGLYNNQITDVGARYVTKILDECK-GLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEG 580
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 581 AKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAE-MLKVNQTLKHLWLIQNQ 659
Cdd:cd00116 182 IRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASaLLSPNISLLTLSLSCND 261
|
250 260 270
....*....|....*....|....*....|....
gi 530384400 660 ITAKGTAQLADALQSNTGITEICLNGNLIKPEEA 693
Cdd:cd00116 262 ITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
4-294 |
2.38e-13 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 73.69 E-value: 2.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 4 DLLFKHYCYPERDPEEVFAFLLRFPHVALFtFDGLDELHSDLDLSRVpdsscpwepahpLVLLANLLSGklLKGASKLLT 83
Cdd:COG5635 232 DLLAEALEKRGGEPEDALERLLRNGRLLLL-LDGLDEVPDEADRDEV------------LNQLRRFLER--YPKARVIIT 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 84 ARTgIEVPRQFLR--KKVLLRGFSPSHLRAYARRMFPERALQ-DRLLSQLEANPNLCSLCSVPLFCWIIfrCfqhfrAAF 160
Cdd:COG5635 297 SRP-EGYDSSELEgfEVLELAPLSDEQIEEFLKKWFEATERKaERLLEALEENPELRELARNPLLLTLL--A-----LLL 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 161 EGSPQLPDctmTLTDVFLLVTEVHLNRMQpsslVQRNTRSPVETLHAGRDTLcsLGQVAHRGMEKSLFVFTQEEVQASGL 240
Cdd:COG5635 369 RERGELPD---TRAELYEQFVELLLERWD----EQRGLTIYRELSREELREL--LSELALAMQENGRTEFAREELEEILR 439
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530384400 241 QERDMQLG---FLRALpELGPG----GDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLR 294
Cdd:COG5635 440 EYLGRRKDaeaLLDEL-LLRTGllveRGEGRYSFAHRSFQEYLAARALVEELDEELLELLA 499
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
269-417 |
5.57e-12 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 63.08 E-value: 5.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 269 HLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMppagaaTTSCYPPFLpfqclqgsgpaREDLFKNKDHFQFTNLFLCGLL 348
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLR------KRESLKSLL-----------DKALKSKNGHLDLFLRFLFGLL 63
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530384400 349 SKAKQKLLRHLVPAAALRRKRKalwahlfsSLRGYLKSLPRVQVESFNqvqamptFIWMLRCIYETQSQ 417
Cdd:pfam17776 64 NEENQRLLEGLLGCKLSSEIKQ--------ELLQWIKSLIQKELSSER-------FLNLFHCLYELQDE 117
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
210-267 |
1.71e-06 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 45.63 E-value: 1.71e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 530384400 210 DTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRALPELgPGGDQQSYEF 267
Cdd:pfam17779 1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQK-DLGCEKVYSF 57
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
482-702 |
1.12e-48 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 177.29 E-value: 1.12e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 482 LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVK 561
Cdd:COG5238 210 VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 562 NSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLA 641
Cdd:COG5238 290 GNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALA 369
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530384400 642 EMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTgITEICLNGNLIKPE-EAKVYEDEKRI 702
Cdd:COG5238 370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEaQQRLEQLLERI 430
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
3-119 |
3.36e-26 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 105.46 E-value: 3.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 3 RDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSscpwepahPLVLLANLLSGKLLKGASKLL 82
Cdd:pfam05729 54 ADLLFSQWPEPAAPVSEVWAVILELPERLLLILDGLDELVSDLGQLDGPCP--------VLTLLSSLLRKKLLPGASLLL 125
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 530384400 83 TARTGI--EVPRQFLRKKVL-LRGFSPSHLRAYARRMFPE 119
Cdd:pfam05729 126 TVRPDAlrDLRRGLEEPRYLeVRGFSESDRKQYVRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
428-693 |
2.35e-25 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 107.44 E-value: 2.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 428 CANYLKLTYCNACSADCSALSFVLHHFP--KRLALDLDNNNLNDYGVRELqPCF----SRLTVLRLSVNQITDGGVKVLs 501
Cdd:cd00116 24 CLQVLRLEGNTLGEEAAKALASALRPQPslKELCLSLNETGRIPRGLQSL-LQGltkgCGLQELDLSDNALGPDGCGVL- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 502 EELTKYKIVTYLGLYNNQITDVGARYVTKILDECK-GLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEG 580
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 581 AKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAE-MLKVNQTLKHLWLIQNQ 659
Cdd:cd00116 182 IRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASaLLSPNISLLTLSLSCND 261
|
250 260 270
....*....|....*....|....*....|....
gi 530384400 660 ITAKGTAQLADALQSNTGITEICLNGNLIKPEEA 693
Cdd:cd00116 262 ITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
471-688 |
1.37e-24 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 105.13 E-value: 1.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 471 GVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYL--GLYNNQITDVGARYVTKILDECKGLTHLKLGKNKI 548
Cdd:cd00116 14 RATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELclSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 549 TSEGGKYLALAVKNSkSISEVGMWGNQVGDEGAKAFAEALRNH-PSLTTLSLASNGISTEGGKSLARALQQNTSLEILWL 627
Cdd:cd00116 94 GPDGCGVLESLLRSS-SLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530384400 628 TQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLI 688
Cdd:cd00116 173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNL 233
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
475-648 |
1.96e-23 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 101.66 E-value: 1.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 475 LQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGK 554
Cdd:cd00116 132 LKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGAS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 555 YLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRN-HPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELN 633
Cdd:cd00116 212 ALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFG 291
|
170
....*....|....*
gi 530384400 634 DEVAESLAEMLKVNQ 648
Cdd:cd00116 292 EEGAQLLAESLLEPG 306
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
480-672 |
9.06e-18 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 84.71 E-value: 9.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 480 SRLTVLRLSVNQITDGGVKVLSEELTKYKI-VTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLAL 558
Cdd:cd00116 108 SSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAE 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 559 AVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARAL-QQNTSLEILWLTQNELNDEVA 637
Cdd:cd00116 188 GLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALlSPNISLLTLSLSCNDITDDGA 267
|
170 180 190
....*....|....*....|....*....|....*
gi 530384400 638 ESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADAL 672
Cdd:cd00116 268 KDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL 302
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
479-688 |
5.78e-16 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 80.75 E-value: 5.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 479 FSRLTVLRLSVNQITDggvkvLSEELTKYKIVTYLGLYNNQITDVGAryvtkILDECKGLTHLKLGKNKITSeggkyLAL 558
Cdd:COG4886 135 LTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTDLPE-----ELGNLTNLKELDLSNNQITD-----LPE 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 559 AVKNSKSISEVGMWGNQVGDegakaFAEALRNHPSLTTLSLASNGISTeggkslARALQQNTSLEILWLTQNELNDevAE 638
Cdd:COG4886 200 PLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD--LP 266
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 530384400 639 SLAEMlkvnQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLI 688
Cdd:COG4886 267 PLANL----TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE 312
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
479-694 |
1.49e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.59 E-value: 1.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 479 FSRLTVLRLSVNqitdggvkvlsEELTKYKIVTYLGLYNNQITDVGARyvtkiLDECKGLTHLKLGKNKITSeggkyLAL 558
Cdd:COG4886 95 LTNLTELDLSGN-----------EELSNLTNLESLDLSGNQLTDLPEE-----LANLTNLKELDLSNNQLTD-----LPE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 559 AVKNSKSISEVGMWGNQVGDegakaFAEALRNHPSLTTLSLASNGISteggkSLARALQQNTSLEILWLTQNELNDeVAE 638
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQIT-----DLPEPLGNLTNLEELDLSGNQLTD-LPE 222
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 530384400 639 SLAEMlkvnQTLKHLWLIQNQITAkgtaqlADALQSNTGITEICLNGNLIK--PEEAK 694
Cdd:COG4886 223 PLANL----TNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTdlPPLAN 270
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
479-694 |
1.39e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 73.43 E-value: 1.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 479 FSRLTVLRLSVNQITDggvkvLSEELTKYKIVTYLGLYNNQITDVGaryvtKILDECKGLTHLKLGKNKITSeggkyLAL 558
Cdd:COG4886 158 LTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITDLP-----EPLGNLTNLEELDLSGNQLTD-----LPE 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 559 AVKNSKSISEVGMWGNQVGDegakafAEALRNHPSLTTLSLASNGISTEGgkslarALQQNTSLEILWLTQNELNDEVAE 638
Cdd:COG4886 223 PLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTDLP------PLANLTNLKTLDLSNNQLTDLKLK 290
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 530384400 639 SLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAK 694
Cdd:COG4886 291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
4-294 |
2.38e-13 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 73.69 E-value: 2.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 4 DLLFKHYCYPERDPEEVFAFLLRFPHVALFtFDGLDELHSDLDLSRVpdsscpwepahpLVLLANLLSGklLKGASKLLT 83
Cdd:COG5635 232 DLLAEALEKRGGEPEDALERLLRNGRLLLL-LDGLDEVPDEADRDEV------------LNQLRRFLER--YPKARVIIT 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 84 ARTgIEVPRQFLR--KKVLLRGFSPSHLRAYARRMFPERALQ-DRLLSQLEANPNLCSLCSVPLFCWIIfrCfqhfrAAF 160
Cdd:COG5635 297 SRP-EGYDSSELEgfEVLELAPLSDEQIEEFLKKWFEATERKaERLLEALEENPELRELARNPLLLTLL--A-----LLL 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 161 EGSPQLPDctmTLTDVFLLVTEVHLNRMQpsslVQRNTRSPVETLHAGRDTLcsLGQVAHRGMEKSLFVFTQEEVQASGL 240
Cdd:COG5635 369 RERGELPD---TRAELYEQFVELLLERWD----EQRGLTIYRELSREELREL--LSELALAMQENGRTEFAREELEEILR 439
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530384400 241 QERDMQLG---FLRALpELGPG----GDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLR 294
Cdd:COG5635 440 EYLGRRKDaeaLLDEL-LLRTGllveRGEGRYSFAHRSFQEYLAARALVEELDEELLELLA 499
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
269-417 |
5.57e-12 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 63.08 E-value: 5.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 269 HLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMppagaaTTSCYPPFLpfqclqgsgpaREDLFKNKDHFQFTNLFLCGLL 348
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLR------KRESLKSLL-----------DKALKSKNGHLDLFLRFLFGLL 63
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530384400 349 SKAKQKLLRHLVPAAALRRKRKalwahlfsSLRGYLKSLPRVQVESFNqvqamptFIWMLRCIYETQSQ 417
Cdd:pfam17776 64 NEENQRLLEGLLGCKLSSEIKQ--------ELLQWIKSLIQKELSSER-------FLNLFHCLYELQDE 117
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
210-267 |
1.71e-06 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 45.63 E-value: 1.71e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 530384400 210 DTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRALPELgPGGDQQSYEF 267
Cdd:pfam17779 1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQK-DLGCEKVYSF 57
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
479-663 |
8.45e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 44.39 E-value: 8.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 479 FSRLTVLRLSVNQITDggvkvlSEELTKYKIVTYLGLYNNQITdvgaryvtKI--LDECKGLTHLKLGKNKITS-EGgky 555
Cdd:cd21340 1 LKRITHLYLNDKNITK------IDNLSLCKNLKVLYLYDNKIT--------KIenLEFLTNLTHLYLQNNQIEKiEN--- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 556 LALAVKNSK------SISEV-GMWG----------NQVGDEGAK-AF----AEALRNhpSLTTLSLASNGISTeggkslA 613
Cdd:cd21340 64 LENLVNLKKlylggnRISVVeGLENltnleelhieNQRLPPGEKlTFdprsLAALSN--SLRVLNISGNNIDS------L 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 530384400 614 RALQQNTSLEILWLTQNELNDevAESLAEMLKVNQTLKHLWLIQNQITAK 663
Cdd:cd21340 136 EPLAPLRNLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVCKK 183
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
479-662 |
1.56e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.54 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 479 FSRLTVLRLSVNQITDggVKVLSEeLTKykiVTYLGLYNNQITDVGAryvtkiLDECKGLTHLKLGKNKITSEGGKYLAL 558
Cdd:COG4886 227 LTNLETLDLSNNQLTD--LPELGN-LTN---LEELDLSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELEL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384400 559 AVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAE 638
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374
|
170 180
....*....|....*....|....
gi 530384400 639 SLAEMLKVNQTLKHLWLIQNQITA 662
Cdd:COG4886 375 LEATLLTLALLLLTLLLLLLTTTA 398
|
|
| |
