NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|46559763|ref|NP_997287|]
View 

zinc finger protein 662 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-401 7.54e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 7.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 246 KPYECQECAKAFVWKSNLIRHQR--IHTGE--KPFECKE--CGKGFSQNTSLTQHQRIHTGEKPYTCK--ECGKSFTRNP 317
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 318 ALLRHQRMH-----TGEKPYEC--KDCGKGFMWNSDLSQHQRVHTGDKPHECTD--CGKSFfcKAH--LIRHQRIHTGER 386
Cdd:COG5048 368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSF--NRHynLIPHKKIHTNHA 445

                       170
                ....*....|....*
gi 46559763 387 PYKCNDCGKAFSQNS 401
Cdd:COG5048 446 PLLCSILKSFRRDLD 460
KRAB super family cl42959
krueppel associated box;
1-32 1.75e-08

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 50.67  E-value: 1.75e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 46559763      1 MLENYGAVASLaAFPFPKPALISQLERGETPW 32
Cdd:smart00349  30 MLENYSNLVSL-GFQVPKPDLISQLEQGEEPW 60
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-401 7.54e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 7.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 246 KPYECQECAKAFVWKSNLIRHQR--IHTGE--KPFECKE--CGKGFSQNTSLTQHQRIHTGEKPYTCK--ECGKSFTRNP 317
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 318 ALLRHQRMH-----TGEKPYEC--KDCGKGFMWNSDLSQHQRVHTGDKPHECTD--CGKSFfcKAH--LIRHQRIHTGER 386
Cdd:COG5048 368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSF--NRHynLIPHKKIHTNHA 445

                       170
                ....*....|....*
gi 46559763 387 PYKCNDCGKAFSQNS 401
Cdd:COG5048 446 PLLCSILKSFRRDLD 460
KRAB smart00349
krueppel associated box;
1-32 1.75e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 50.67  E-value: 1.75e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 46559763      1 MLENYGAVASLaAFPFPKPALISQLERGETPW 32
Cdd:smart00349  30 MLENYSNLVSL-GFQVPKPDLISQLEQGEEPW 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
262-287 7.48e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 7.48e-06
                          10        20
                  ....*....|....*....|....*.
gi 46559763   262 NLIRHQRIHTGEKPFECKECGKGFSQ 287
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 275-322 4.24e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 4.24e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 46559763  275 PFECKECGKGFSQNTSLTQHQRIHTGEKpyTCKECGKSFTRNPALLRH 322
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 274-326 4.73e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 4.73e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 46559763 274 KPFeCKECGKGFSQNTSLTQHQRIHTgekpYTCKECGKSFTRNPALLRH-QRMH 326
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-401 7.54e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 7.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 246 KPYECQECAKAFVWKSNLIRHQR--IHTGE--KPFECKE--CGKGFSQNTSLTQHQRIHTGEKPYTCK--ECGKSFTRNP 317
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 318 ALLRHQRMH-----TGEKPYEC--KDCGKGFMWNSDLSQHQRVHTGDKPHECTD--CGKSFfcKAH--LIRHQRIHTGER 386
Cdd:COG5048 368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSF--NRHynLIPHKKIHTNHA 445

                       170
                ....*....|....*
gi 46559763 387 PYKCNDCGKAFSQNS 401
Cdd:COG5048 446 PLLCSILKSFRRDLD 460
KRAB smart00349
krueppel associated box;
1-32 1.75e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 50.67  E-value: 1.75e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 46559763      1 MLENYGAVASLaAFPFPKPALISQLERGETPW 32
Cdd:smart00349  30 MLENYSNLVSL-GFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-421 1.90e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 1.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 249 ECQECAKAFVWKSNLIRHQRIHTGE-------KPFECKECGKGFSQNTSLTQHQR--IHTGE--KPYTCKE--CGKSFTR 315
Cdd:COG5048 256 SASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSR 335

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 316 NPALLRHQRMHTGEKPYECKDC-------GKGFMWNSDLSQHQRVHTGDKPHECTDCGKSFFCK--AHLIRHQRIHTGER 386
Cdd:COG5048 336 NDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKrdSNLSLHIITHLSFR 415

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 46559763 387 P--YKCNDCGKAFSQNSVLIKHQRRHARDKPYNCQIS 421
Cdd:COG5048 416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
274-339 6.30e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 6.30e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46559763 274 KPFECKECGKGFSQNTSLTQHQRIHTGEKPYTC--KECGKSFTRNPALLRHQRMHTGEKPYECKDCGK 339
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
262-287 7.48e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 7.48e-06
                          10        20
                  ....*....|....*....|....*.
gi 46559763   262 NLIRHQRIHTGEKPFECKECGKGFSQ 287
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-399 9.75e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 9.75e-06
                          10        20
                  ....*....|....*....|....*.
gi 46559763   374 HLIRHQRIHTGERPYKCNDCGKAFSQ 399
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
290-315 1.20e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.20e-05
                          10        20
                  ....*....|....*....|....*.
gi 46559763   290 SLTQHQRIHTGEKPYTCKECGKSFTR 315
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-306 1.61e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.61e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46559763 246 KPYECQECAKAFVWKSNLIRHQRIHTGEKPFEC--KECGKGFSQNTSLTQHQRIHTGEKPYTC 306
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-426 5.57e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 5.57e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46559763 357 DKPHECTDCGKSFFCKAHLIRHQRIHTGERPYKCND--CGKAFSQNSVLIKHQRRHARDKPYNCQISHLLEH 426
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSN 102
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-341 5.63e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 5.63e-05
                          10        20
                  ....*....|....*....|....
gi 46559763   318 ALLRHQRMHTGEKPYECKDCGKGF 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
343-422 1.08e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 343 WNSDLSQHQRVhtgDKPHECTDCGKSFFCKAHLIRHQR--IHTGE--RPYKC--NDCGKAFSQNSVLIKHQRRHARDKPY 416
Cdd:COG5048 276 NESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352


                ....*.
gi 46559763 417 NCQISH 422
Cdd:COG5048 353 KEKLLN 358
zf-H2C2_2 pfam13465
Zinc-finger double domain;
346-369 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....
gi 46559763   346 DLSQHQRVHTGDKPHECTDCGKSF 369
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-378 3.09e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 191 FYICEECGKCFDQNEDFDQHQKT--HNGE--KVYGCKE--CGKAFSFRSHCIAHQRIHSGVKPYECqecakafvwksNLI 264
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE-----------KLL 357

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 265 RHQRIHTGEKPfeckecgkgfSQNTSLTQHQRIHTGEKPYTC--KECGKSFTRNPALLRHQRMHTGEKPYECKD--CGKG 340
Cdd:COG5048 358 NSSSKFSPLLN----------NEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKS 427

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 46559763 341 FMWNSDLSQHQRVHTGDKPHECTDCGKSFFCkAHLIRH 378
Cdd:COG5048 428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRD-LDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 304-326 3.81e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 3.81e-04
                          10        20
                  ....*....|....*....|...
gi 46559763   304 YTCKECGKSFTRNPALLRHQRMH 326
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 388-410 4.41e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 4.41e-04
                          10        20
                  ....*....|....*....|...
gi 46559763   388 YKCNDCGKAFSQNSVLIKHQRRH 410
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 272-357 9.84e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 9.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559763 272 GEKPFECK--ECGKGFSQNTSLTQHqRIHtgekpytcKECGKSFTRNPALLRHQRMHTGEKPYECKDCGKGFMWNSDLSQ 349
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*...
gi 46559763 350 HqRVHTGD 357
Cdd:COG5189 417 H-RKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 276-298 1.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|...
gi 46559763   276 FECKECGKGFSQNTSLTQHQRIH 298
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 275-322 4.24e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 4.24e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 46559763  275 PFECKECGKGFSQNTSLTQHQRIHTGEKpyTCKECGKSFTRNPALLRH 322
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 274-326 4.73e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 4.73e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 46559763 274 KPFeCKECGKGFSQNTSLTQHQRIHTgekpYTCKECGKSFTRNPALLRH-QRMH 326
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
248-272 8.02e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 33.68  E-value: 8.02e-03
                          10        20
                  ....*....|....*....|....*
gi 46559763   248 YECQECAKAFVWKSNLIRHQRIHTG 272
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-258 9.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.01e-03
                          10        20
                  ....*....|....*....|.
gi 46559763   238 HQRIHSGVKPYECQECAKAFV 258
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH