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Conserved domains on  [gi|41152074|ref|NP_955805|]
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coiled-coil domain-containing protein 80 precursor [Homo sapiens]

Protein Classification

similar to coiled-coil domain-containing protein( domain architecture ID 10618755)

protein similar to coiled-coil domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 771-902 3.50e-42

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


:

Pssm-ID: 463980  Cd Length: 120  Bit Score: 149.71  E-value: 3.50e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   771 FLSRFRWRRRLLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGvlelfpingssVVEREDVPAHLV 850
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETG-----------KIEHEQLSPDLI 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41152074   851 KDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMwSMVIVYDLIDSMQLRRQE 902
Cdd:pfam13778  70 EELRKELGIPRNYFSMVLIGKDGGVKERYPAPV-SLEALFDLIDAMPMRQQE 120
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 615-748 2.15e-40

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


:

Pssm-ID: 463980  Cd Length: 120  Bit Score: 144.70  E-value: 2.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   615 LLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNSTMKIDHFQLDNEkpmrvvddedlvd 694
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPD------------- 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 41152074   695 qrLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPITMKSVFDLIDTFQSRIK 748
Cdd:pfam13778  68 --LIEELRKELGIPRNYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQ 119
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 142-270 2.08e-38

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


:

Pssm-ID: 463980  Cd Length: 120  Bit Score: 138.92  E-value: 2.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   142 LASFAGKNRVWVISAPHASEGYYRLMMSLLkDDVYCELAERHIQQIVLFHQAGEEGGKvrritsegqILEQPLDPSLIPK 221
Cdd:pfam13778   2 LDQFRWKRRLLIISAPSADDPYYRQQLDAL-QAAECGLAERDLTVIELVGSGPNETGK---------IEHEQLSPDLIEE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 41152074   222 LMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIE 270
Cdd:pfam13778  72 LRKELGIPRNYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 313-461 2.27e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   313 EDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPA-----------PATTVTRSTSRAVTVAARPMTTTAF 381
Cdd:PHA03247 2681 QRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGpaaarqaspalPAAPAPPAVPAGPATPGGPARPARP 2760

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   382 PTTQRPWTPSPSHRPPTTTEVITARRP----SVSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRA 457
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAvaslSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840


                  ....
gi 41152074   458 AGPG 461
Cdd:PHA03247 2841 PPPG 2844
 
Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 771-902 3.50e-42

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 149.71  E-value: 3.50e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   771 FLSRFRWRRRLLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGvlelfpingssVVEREDVPAHLV 850
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETG-----------KIEHEQLSPDLI 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41152074   851 KDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMwSMVIVYDLIDSMQLRRQE 902
Cdd:pfam13778  70 EELRKELGIPRNYFSMVLIGKDGGVKERYPAPV-SLEALFDLIDAMPMRQQE 120
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 615-748 2.15e-40

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 144.70  E-value: 2.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   615 LLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNSTMKIDHFQLDNEkpmrvvddedlvd 694
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPD------------- 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 41152074   695 qrLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPITMKSVFDLIDTFQSRIK 748
Cdd:pfam13778  68 --LIEELRKELGIPRNYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQ 119
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 142-270 2.08e-38

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 138.92  E-value: 2.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   142 LASFAGKNRVWVISAPHASEGYYRLMMSLLkDDVYCELAERHIQQIVLFHQAGEEGGKvrritsegqILEQPLDPSLIPK 221
Cdd:pfam13778   2 LDQFRWKRRLLIISAPSADDPYYRQQLDAL-QAAECGLAERDLTVIELVGSGPNETGK---------IEHEQLSPDLIEE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 41152074   222 LMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIE 270
Cdd:pfam13778  72 LRKELGIPRNYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
PHA03247 PHA03247
large tegument protein UL36; Provisional
 313-461 2.27e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   313 EDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPA-----------PATTVTRSTSRAVTVAARPMTTTAF 381
Cdd:PHA03247 2681 QRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGpaaarqaspalPAAPAPPAVPAGPATPGGPARPARP 2760

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   382 PTTQRPWTPSPSHRPPTTTEVITARRP----SVSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRA 457
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAvaslSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840


                  ....
gi 41152074   458 AGPG 461
Cdd:PHA03247 2841 PPPG 2844
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 319-463 3.29e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   319 QVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTT--AFPTTQRPWTPSPSHRP 396
Cdd:pfam03154 425 PPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTssAMPGIQPPSSASVSSSG 504

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41152074   397 PTTTeVITARRPSVSENLYPPSRKDQHRERPQTTRRPSkatslesftnAPPTTISEPStRAAGPGRF 463
Cdd:pfam03154 505 PVPA-AVSCPLPPVQIKEEALDEAEEPESPPPPPRSPS----------PEPTVVNTPS-HASQSARF 559
 
Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 771-902 3.50e-42

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 149.71  E-value: 3.50e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   771 FLSRFRWRRRLLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGvlelfpingssVVEREDVPAHLV 850
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETG-----------KIEHEQLSPDLI 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41152074   851 KDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMwSMVIVYDLIDSMQLRRQE 902
Cdd:pfam13778  70 EELRKELGIPRNYFSMVLIGKDGGVKERYPAPV-SLEALFDLIDAMPMRQQE 120
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 615-748 2.15e-40

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 144.70  E-value: 2.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   615 LLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNSTMKIDHFQLDNEkpmrvvddedlvd 694
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPD------------- 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 41152074   695 qrLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPITMKSVFDLIDTFQSRIK 748
Cdd:pfam13778  68 --LIEELRKELGIPRNYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQ 119
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 142-270 2.08e-38

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 138.92  E-value: 2.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   142 LASFAGKNRVWVISAPHASEGYYRLMMSLLkDDVYCELAERHIQQIVLFHQAGEEGGKvrritsegqILEQPLDPSLIPK 221
Cdd:pfam13778   2 LDQFRWKRRLLIISAPSADDPYYRQQLDAL-QAAECGLAERDLTVIELVGSGPNETGK---------IEHEQLSPDLIEE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 41152074   222 LMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIE 270
Cdd:pfam13778  72 LRKELGIPRNYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
PHA03247 PHA03247
large tegument protein UL36; Provisional
 313-461 2.27e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   313 EDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPA-----------PATTVTRSTSRAVTVAARPMTTTAF 381
Cdd:PHA03247 2681 QRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGpaaarqaspalPAAPAPPAVPAGPATPGGPARPARP 2760

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   382 PTTQRPWTPSPSHRPPTTTEVITARRP----SVSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRA 457
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAvaslSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840


                  ....
gi 41152074   458 AGPG 461
Cdd:PHA03247 2841 PPPG 2844
PHA03247 PHA03247
large tegument protein UL36; Provisional
 303-462 3.18e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 3.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   303 RPSLGSEKKKEDPRRAQV--PPTRESRVKVlrklAATAPALPQPPSTPrattlPPAPATTVTRSTSRAVTVAARPMTTTA 380
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAagPPRRLTRPAV----ASLSESRESLPSPW-----DPADPPAAVLAPAAALPPAASPAGPLP 2829

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   381 FPTTQRPWTPSPSHRPPTTTEVI---------TARRPSVSenlyPPSRKDQHRERPQTTR--RPSKATSLESFTNAPPTT 449
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLPLggsvapggdVRRRPPSR----SPAAKPAAPARPPVRRlaRPAVSRSTESFALPPDQP 2905

                         170
                  ....*....|...
gi 41152074   450 ISEPSTRAAGPGR 462
Cdd:PHA03247 2906 ERPPQPQAPPPPQ 2918
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 310-478 1.30e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 49.30  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  310 KKKEDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAFPTTQRPWT 389
Cdd:PTZ00449 577 KKPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKS 656

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  390 PSP--SHRPP------------------TTTEVITARRPSVSENLYPPSRKDQHRERPQTTRR--PSKATSLESFTNAPP 447
Cdd:PTZ00449 657 PKPpkSPKPPfdpkfkekfyddyldaaaKSKETKTTVVLDESFESILKETLPETPGTPFTTPRplPPKLPRDEEFPFEPI 736

                        170       180       190
                 ....*....|....*....|....*....|.
gi 41152074  448 ttiSEPSTRAAGPGRFRDNRMDRREHGHRDP 478
Cdd:PTZ00449 737 ---GDPDAEQPDDIEFFTPPEEERTFFHETP 764
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
303-469 3.57e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.56  E-value: 3.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  303 RPSLGSEKKKEDPRRAQVPPTRESRVKvlRKLAATAPAlPQPPSTPRATTLPP-APATTVTRSTSRAVTVAARPMTTTAF 381
Cdd:PRK12323 416 ARAVAAAPARRSPAPEALAAARQASAR--GPGGAPAPA-PAPAAAPAAAARPAaAGPRPVAAAAAAAPARAAPAAAPAPA 492

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  382 PTTQRPWTPSPSHRP-PTTTEVITARRPSVSENLYPPSRKDQHRERPQTTRRPSKATslesftnAPPTTISEPSTRAAGP 460
Cdd:PRK12323 493 DDDPPPWEELPPEFAsPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAP-------APRAAAATEPVVAPRP 565


                 ....*....
gi 41152074  461 GRFRDNRMD 469
Cdd:PRK12323 566 PRASASGLP 574
PHA03247 PHA03247
large tegument protein UL36; Provisional
 317-470 4.51e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 4.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   317 RAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTVTRSTS--RAVTVAARPMTTTAFPTTQRPWTPS--P 392
Cdd:PHA03247 2729 RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGppRRLTRPAVASLSESRESLPSPWDPAdpP 2808

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   393 SHRPPTTTEVITARRPSVSEnlyPPSRKDQHRERPQTTRRPSKATSLES-------FTNAPPTtiSEPSTRAAGPGRFRD 465
Cdd:PHA03247 2809 AAVLAPAAALPPAASPAGPL---PPPTSAQPTAPPPPPGPPPPSLPLGGsvapggdVRRRPPS--RSPAAKPAAPARPPV 2883


                  ....*
gi 41152074   466 NRMDR 470
Cdd:PHA03247 2884 RRLAR 2888
PHA03247 PHA03247
large tegument protein UL36; Provisional
 334-461 4.29e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   334 LAATAPALPQPPSTPrattlPPAPATTV--TRSTSRAVTVAA-----RPMTTTAFPTTQRP-WTPSPS-------HRPPT 398
Cdd:PHA03247  302 LAGAPLALPAPPDPP-----PPAPAGDAeeEDDEDGAMEVVSplprpRQHYPLGFPKRRRPtWTPPSSledlsagRHHPK 376

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41152074   399 TTEVITARRPSVSENLYPPSR----KDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRAAGPG 461
Cdd:PHA03247  377 RASLPTRKRRSARHAATPFARgpggDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSD 443
PRK10905 PRK10905
cell division protein DamX; Validated
 315-458 5.71e-04

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 43.00  E-value: 5.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  315 PRRAQVPPTRE--SRVKVLRKL--AATAPALPQPPSTPRA-TTLPPAPATTVtrstsrAVTVAARPMTTTAFPTTQRPWT 389
Cdd:PRK10905  80 PTQGQTPVATDgqQRVEVQGDLnnALTQPQNQQQLNNVAVnSTLPTEPATVA------PVRNGNASRQTAKTQTAERPAT 153

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  390 PspshRPPTTTEVITARRPSVSENLYP-PSRKDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRAA 458
Cdd:PRK10905 154 T----RPARKQAVIEPKKPQATAKTEPkPVAQTPKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTAS 219
PHA03247 PHA03247
large tegument protein UL36; Provisional
 312-462 8.01e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   312 KEDPRRAQVPPtRESRVKVLRKLAATAPAlPQPPSTPRATTLPP--APATTVTRSTSRAVTVAARPM-TTTAFPTTQRPW 388
Cdd:PHA03247 2649 PERPRDDPAPG-RVSRPRRARRLGRAAQA-SSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEPAPHaLVSATPLPPGPA 2726

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41152074   389 TPSPSHRPPTTTeviTARRPSVSENLYPPSrkDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRAAGPGR 462
Cdd:PHA03247 2727 AARQASPALPAA---PAPPAVPAGPATPGG--PARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
335-459 9.08e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 9.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  335 AATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVA------ARPMTTTAFPTTQRPWTPSPSHRPPTTTEVITARRP 408
Cdd:PRK07003 413 KAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPakanarASADSRCDERDAQPPADSGSASAPASDAPPDAAFEP 492

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 41152074  409 S-----VSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRAAG 459
Cdd:PRK07003 493 ApraaaPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGG 548
PHA03378 PHA03378
EBNA-3B; Provisional
 338-450 1.05e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  338 APALPQPPstPRATT-LPPAPATTVTRSTSRAVTVAARPMTTTafPTTQRPWTPSPSHRPPTTTEVITARRPSVSENLYP 416
Cdd:PHA03378 690 APGTMQPP--PRAPTpMRPPAAPPGRAQRPAAATGRARPPAAA--PGRARPPAAAPGRARPPAAAPGRARPPAAAPGRAR 765

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 41152074  417 PSRKDQHRERPQ--------TTRRPSKATSLESFTNAPPTTI 450
Cdd:PHA03378 766 PPAAAPGAPTPQpppqappaPQQRPRGAPTPQPPPQAGPTSM 807
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 303-433 1.55e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  303 RPSLGSEKKKEDPRRAQVPPTRESRVKVLRKLAATAPAlPQPPstPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAFP 382
Cdd:PRK14951 365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPA-PAAA--PAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAA 441

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 41152074  383 TTQRPWTPSPSHRPPTTTEVITARrpsVSENLYPPSRKDQHRERPQTTRRP 433
Cdd:PRK14951 442 PAAVALAPAPPAQAAPETVAIPVR---VAPEPAVASAAPAPAAAPAAARLT 489
PRK10905 PRK10905
cell division protein DamX; Validated
 311-393 1.68e-03

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 41.85  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  311 KKEDPRRAQVP-PTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTvTRSTSRAVTVAARPMTTTAFPTTQRPWT 389
Cdd:PRK10905 144 KTQTAERPATTrPARKQAVIEPKKPQATAKTEPKPVAQTPKRTEPAAPVAS-TKAPAATSTPAPKETATTAPVQTASPAQ 222


                 ....
gi 41152074  390 PSPS 393
Cdd:PRK10905 223 TTAT 226
PHA03247 PHA03247
large tegument protein UL36; Provisional
 320-460 1.79e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   320 VPPTRESRVKVLRKLA---ATAPALPQPPS-----------TPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAfPTTQ 385
Cdd:PHA03247 2529 VHPRMLTWIRGLEELAsddAGDPPPPLPPAappaapdrsvpPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVD-DRGD 2607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   386 RPWTPSPSHRPPTTTEV---ITARRPSVSE------NLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTiSEPSTR 456
Cdd:PHA03247 2608 PRGPAPPSPLPPDTHAPdppPPSPSPAANEpdphppPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP-QRPRRR 2686


                  ....
gi 41152074   457 AAGP 460
Cdd:PHA03247 2687 AARP 2690
PHA03381 PHA03381
tegument protein VP22; Provisional
 303-390 2.42e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 41.15  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  303 RPSLGSEKKKEDPRRAQVPP-TRESRVKVLRKLAATAPALPQPPSTPR--------ATTLPPAPATTVTRSTSRAVTVAA 373
Cdd:PHA03381  92 RPHAQPEASGPGPARGARGPaGSRGRGRRAESPSPRDPPNPKGASAPRgrksacadSAALLDAPAPAAPKRQKTPAGLAR 171

                         90
                 ....*....|....*..
gi 41152074  374 RPMTTTAFPTTQRPWTP 390
Cdd:PHA03381 172 KLHFSTAPTSPTAPWTP 188
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 330-424 2.75e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.33  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  330 VLRKLAATAPALPQPPSTP-----RATTLPPAPATTVTRSTSRAVTVAARPMTTTAFPTTQRPWTPSPShRPPTTTEVIT 404
Cdd:PRK14950 359 LLVPVPAPQPAKPTAAAPSpvrptPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPES-APKLTRAAIP 437

                         90       100
                 ....*....|....*....|
gi 41152074  405 ARRPSVSENlyPPSRKDQHR 424
Cdd:PRK14950 438 VDEKPKYTP--PAPPKEEEK 455
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 319-463 3.29e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   319 QVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTT--AFPTTQRPWTPSPSHRP 396
Cdd:pfam03154 425 PPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTssAMPGIQPPSSASVSSSG 504

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41152074   397 PTTTeVITARRPSVSENLYPPSRKDQHRERPQTTRRPSkatslesftnAPPTTISEPStRAAGPGRF 463
Cdd:pfam03154 505 PVPA-AVSCPLPPVQIKEEALDEAEEPESPPPPPRSPS----------PEPTVVNTPS-HASQSARF 559
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
339-434 3.46e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 40.80  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   339 PALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAFPTTQRPWTPSPSHRPPTTTEVITARRPSVSenlypPS 418
Cdd:pfam05539 232 PQTEPPPSQRGPSGSPQHPPSTTSQDQSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTTKRQETGRPTPR-----PT 306

                          90
                  ....*....|....*.
gi 41152074   419 RKDQHRERPQTTRRPS 434
Cdd:pfam05539 307 ATTQSGSSPPHSSPPG 322
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
315-462 4.05e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  315 PRRAQVPPTRESRVKVLRklAATAPALPQPPSTPRATTLPPAPATTvTRSTSRAVTVAARPMTT-----TAFPTTQRPWT 389
Cdd:PRK12323 381 PVAQPAPAAAAPAAAAPA--PAAPPAAPAAAPAAAAAARAVAAAPA-RRSPAPEALAAARQASArgpggAPAPAPAPAAA 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074  390 PSPSHRPPT----TTEVITARRPSVSENLYPPSRKDQH----RERPQTTRRPSKATSLESFTNAPPTTISEPSTRAAGPG 461
Cdd:PRK12323 458 PAAAARPAAagprPVAAAAAAAPARAAPAAAPAPADDDpppwEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDA 537


                 .
gi 41152074  462 R 462
Cdd:PRK12323 538 F 538
PHA03247 PHA03247
large tegument protein UL36; Provisional
 303-408 5.63e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   303 RPSLGSEKKKEdPRRAQVPPTRESRVKVLRKLAATAPA-LPQPPSTPRATTLPPAPATTVTRST-----SRAVTVAARPM 376
Cdd:PHA03247  377 RASLPTRKRRS-ARHAATPFARGPGGDDQTRPAAPVPAsVPTPAPTPVPASAPPPPATPLPSAEpgsddGPAPPPERQPP 455

                          90       100       110
                  ....*....|....*....|....*....|..
gi 41152074   377 TTTAFPTtqrpwTPSPSHRPPTTTEVITARRP 408
Cdd:PHA03247  456 APATEPA-----PDDPDDATRKALDALRERRP 482
PHA03247 PHA03247
large tegument protein UL36; Provisional
 307-456 5.97e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   307 GSEKKKEDPRRAQVPPTRESRVKVlRKLAATAPA-----LPQPPSTPRATTLPPAPATTVTRSTSRAvtvaaRPMTTTAF 381
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPARPPV-RRLARPAVSrstesFALPPDQPERPPQPQAPPPPQPQPQPPP-----PPQPQPPP 2933

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41152074   382 PTTQRPWTPSPSHRPPTTTEVITARRPSVSENLYPPSRKDQHRerpqtTRRPSKATSLESFTNAPPTTISEPSTR 456
Cdd:PHA03247 2934 PPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR-----FRVPQPAPSREAPASSTPPLTGHSLSR 3003
PHA03247 PHA03247
large tegument protein UL36; Provisional
 304-459 7.88e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   304 PSLGSEKKKEDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAFP- 382
Cdd:PHA03247 2891 VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPg 2970

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   383 ---------TTQRPWTPSPSHRPPTTTEVITAR----------------RP-SVSENLYPPSrKDQHRERPQTTRRPSKA 436
Cdd:PHA03247 2971 rvavprfrvPQPAPSREAPASSTPPLTGHSLSRvsswasslalheetdpPPvSLKQTLWPPD-DTEDSDADSLFDSDSER 3049

                         170       180
                  ....*....|....*....|....*....
gi 41152074   437 TSLESF------TNAPPTTISEPSTRAAG 459
Cdd:PHA03247 3050 SDLEALdplppePHDPFAHEPDPATPEAG 3078
PHA03247 PHA03247
large tegument protein UL36; Provisional
 304-461 9.82e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152074   304 PSLGSEKKKEDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAFPT 383
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD 2639

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41152074   384 TQRPWTPSPSHRPPTTTEVITARRPSVSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAP-PTTISEPSTRAAGPG 461
Cdd:PHA03247 2640 PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPpPPPTPEPAPHALVSA 2718
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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