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Conserved domains on  [gi|40549422|ref|NP_954672|]
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sperm microtubule associated protein 2 isoform 2 [Homo sapiens]

Protein Classification

THEG domain-containing protein( domain architecture ID 10633003)

THEG domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 193-251 2.60e-17

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 74.93  E-value: 2.60e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 40549422   193 WPIPRSSLEYRASSRLKELAAPKIRDNFWSMPMSEVSQVSRAAQMAVPSSRILQLSKPK 251
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 231-319 1.03e-08

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 51.05  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40549422   231 VSRAAQMAVPSSRILQLSKPKAPAtlleewdpvpkpkphvsdhnrllhlarpkaqsDKCVPDRDPRWEVLDVTKKVVASP 310
Cdd:pfam14912   3 VSRAALKAKASPRLKELAKPKEPH--------------------------------DIYEPDRPVEWKVSPAALKAKPSP 50


                  ....*....
gi 40549422   311 RIISLAKPK 319
Cdd:pfam14912  51 RIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 167-215 1.59e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 44.89  E-value: 1.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 40549422   167 SRRVEELSRPKRFYLEYYNNNrtTPVWPIPRSSLEYRASSRLKELAAPK 215
Cdd:pfam14912  13 SPRLKELAKPKEPHDIYEPDR--PVEWKVSPAALKAKPSPRIEELAKPK 59
 
Name Accession Description Interval E-value
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 193-251 2.60e-17

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 74.93  E-value: 2.60e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 40549422   193 WPIPRSSLEYRASSRLKELAAPKIRDNFWSMPMSEVSQVSRAAQMAVPSSRILQLSKPK 251
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 231-319 1.03e-08

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 51.05  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40549422   231 VSRAAQMAVPSSRILQLSKPKAPAtlleewdpvpkpkphvsdhnrllhlarpkaqsDKCVPDRDPRWEVLDVTKKVVASP 310
Cdd:pfam14912   3 VSRAALKAKASPRLKELAKPKEPH--------------------------------DIYEPDRPVEWKVSPAALKAKPSP 50


                  ....*....
gi 40549422   311 RIISLAKPK 319
Cdd:pfam14912  51 RIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 167-215 1.59e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 44.89  E-value: 1.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 40549422   167 SRRVEELSRPKRFYLEYYNNNrtTPVWPIPRSSLEYRASSRLKELAAPK 215
Cdd:pfam14912  13 SPRLKELAKPKEPHDIYEPDR--PVEWKVSPAALKAKPSPRIEELAKPK 59
 
Name Accession Description Interval E-value
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 193-251 2.60e-17

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 74.93  E-value: 2.60e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 40549422   193 WPIPRSSLEYRASSRLKELAAPKIRDNFWSMPMSEVSQVSRAAQMAVPSSRILQLSKPK 251
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 231-319 1.03e-08

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 51.05  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40549422   231 VSRAAQMAVPSSRILQLSKPKAPAtlleewdpvpkpkphvsdhnrllhlarpkaqsDKCVPDRDPRWEVLDVTKKVVASP 310
Cdd:pfam14912   3 VSRAALKAKASPRLKELAKPKEPH--------------------------------DIYEPDRPVEWKVSPAALKAKPSP 50


                  ....*....
gi 40549422   311 RIISLAKPK 319
Cdd:pfam14912  51 RIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 167-215 1.59e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 44.89  E-value: 1.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 40549422   167 SRRVEELSRPKRFYLEYYNNNrtTPVWPIPRSSLEYRASSRLKELAAPK 215
Cdd:pfam14912  13 SPRLKELAKPKEPHDIYEPDR--PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 297-329 5.85e-03

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 34.87  E-value: 5.85e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 40549422   297 WEVLDVTKKVVASPRIISLAKPKVRKGLNEGYD 329
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKPKEPHDIYEPDR 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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