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Conserved domains on  [gi|37574068|ref|NP_932106|]
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cyclin-Q [Mus musculus]

Protein Classification

cyclin-like FAM58 family protein( domain architecture ID 15334275)

cyclin-like FAM58 family protein similar to Homo sapiens cyclin-related protein FAM58A/B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 28-137 1.41e-61

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 188.92  E-value: 1.41e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  28 VHFRVTRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNPGS 107
Cdd:cd20534   1 EHFKVLRFIREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRRLRDIINVSYRILHPDK 80

                        90       100       110
                ....*....|....*....|....*....|
gi 37574068 108 EPLELDSRFWELRDSIVQCELLMLRVLRFQ 137
Cdd:cd20534  81 PPLELDDEYWELRDSIVNCELLLLRILKFD 110
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 142-245 1.76e-56

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 175.52  E-value: 1.76e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 142 HPHKYLLHYLISLKNWLNRYSWQRTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPAEGEAEKPWWQ 221
Cdd:cd20535   1 LPHKYLLHYLKSLRDWLNPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEAEKPWWQ 80

                        90       100
                ....*....|....*....|....
gi 37574068 222 VFSDDLTKPIIDNIVSDLIQIYTM 245
Cdd:cd20535  81 AFCEDLTKETIDEIIEDIINVYDL 104
 
Name Accession Description Interval E-value
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 28-137 1.41e-61

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 188.92  E-value: 1.41e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  28 VHFRVTRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNPGS 107
Cdd:cd20534   1 EHFKVLRFIREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRRLRDIINVSYRILHPDK 80

                        90       100       110
                ....*....|....*....|....*....|
gi 37574068 108 EPLELDSRFWELRDSIVQCELLMLRVLRFQ 137
Cdd:cd20534  81 PPLELDDEYWELRDSIVNCELLLLRILKFD 110
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 142-245 1.76e-56

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 175.52  E-value: 1.76e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 142 HPHKYLLHYLISLKNWLNRYSWQRTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPAEGEAEKPWWQ 221
Cdd:cd20535   1 LPHKYLLHYLKSLRDWLNPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEAEKPWWQ 80

                        90       100
                ....*....|....*....|....
gi 37574068 222 VFSDDLTKPIIDNIVSDLIQIYTM 245
Cdd:cd20535  81 AFCEDLTKETIDEIIEDIINVYDL 104
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 35-248 2.43e-19

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 84.78  E-value: 2.43e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  35 FIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQhlrTRDIINVSHRYFNPGSEPLELDs 114
Cdd:COG5333  51 LIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDT---PRDISIESFEARDLWSEEPKSS- 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 115 rfwelRDSIVQCELLMLRVLRFQVSFQHPHKYLLHYLISLKNWLNRYSWQRtpisvtAWALLRDSYHGGLCLRFQAQHLA 194
Cdd:COG5333 127 -----RERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKDKYKLLQI------AWKIINDALRTDLCLLYPPHIIA 195

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 37574068 195 VAVLYLALQVYGVEVPaegeaeKPWWQVFSDDLTKPIIDNIVSDL-IQIYTMDTE 248
Cdd:COG5333 196 LAALLIACEVLGMPII------KLLDFVSYETKEEVIALNYKSIVkNKIKTFKAE 244
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 34-132 8.65e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 51.05  E-value: 8.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068     34 RFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFnpgsepleld 113
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFT---------- 70

                           90
                   ....*....|....*....
gi 37574068    114 srfwelRDSIVQCELLMLR 132
Cdd:smart00385  71 ------EEEILRMERLLLE 83
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 35-139 5.69e-05

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 41.73  E-value: 5.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068    35 FIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRT-RDIINVShryfnpgseplelD 113
Cdd:pfam00134  37 WLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPTvEDLVYIT-------------D 103

                          90       100
                  ....*....|....*....|....*.
gi 37574068   114 SRFweLRDSIVQCELLMLRVLRFQVS 139
Cdd:pfam00134 104 NAY--TREEILRMERLILETLNFDLS 127
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 50-217 1.79e-04

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 42.13  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068    50 IATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEqhlrtrdiINVSHRYF--NPGSEPLeldsrfwELRDSIVQCE 127
Cdd:TIGR00569  79 VGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEE--------FNVSIDQFvgNLKETPL-------KALEQVLEYE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068   128 LLMLRVLRFQVSFQHPHKYLLHYLISLKnwlNRYSWQRTP--ISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVY 205
Cdd:TIGR00569 144 LLLIQQLNFHLIVHNPYRPLEGFLIDIK---TRLPGLENPeyLRKHADKFLNRTLLTDAYLLYTPSQIALAAILHTASRA 220

                         170
                  ....*....|...
gi 37574068   206 GVEVPA-EGEAEK 217
Cdd:TIGR00569 221 GLNMESyLTEQLS 233
 
Name Accession Description Interval E-value
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 28-137 1.41e-61

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 188.92  E-value: 1.41e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  28 VHFRVTRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNPGS 107
Cdd:cd20534   1 EHFKVLRFIREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRRLRDIINVSYRILHPDK 80

                        90       100       110
                ....*....|....*....|....*....|
gi 37574068 108 EPLELDSRFWELRDSIVQCELLMLRVLRFQ 137
Cdd:cd20534  81 PPLELDDEYWELRDSIVNCELLLLRILKFD 110
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 142-245 1.76e-56

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 175.52  E-value: 1.76e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 142 HPHKYLLHYLISLKNWLNRYSWQRTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPAEGEAEKPWWQ 221
Cdd:cd20535   1 LPHKYLLHYLKSLRDWLNPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEAEKPWWQ 80

                        90       100
                ....*....|....*....|....
gi 37574068 222 VFSDDLTKPIIDNIVSDLIQIYTM 245
Cdd:cd20535  81 AFCEDLTKETIDEIIEDIINVYDL 104
CYCLIN_CCNL_rpt1 cd20532
first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 36-136 6.90e-25

first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410235 [Multi-domain]  Cd Length: 127  Bit Score: 95.32  E-value: 6.90e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  36 IMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFN------PGSEP 109
Cdd:cd20532  19 IQDAGILLKLPQVVMATAQVLFHRFYYRKSLRKFDVKIVAMACLFLASKIEETPRRLRDVINVFHRLLQrrlgkpAEVLP 98

                        90       100
                ....*....|....*....|....*...
gi 37574068 110 LELDS-RFWELRDSIVQCELLMLRVLRF 136
Cdd:cd20532  99 LDIGSaEYEELKNDIIKAERRILKELGF 126
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 35-248 2.43e-19

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 84.78  E-value: 2.43e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  35 FIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQhlrTRDIINVSHRYFNPGSEPLELDs 114
Cdd:COG5333  51 LIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDT---PRDISIESFEARDLWSEEPKSS- 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 115 rfwelRDSIVQCELLMLRVLRFQVSFQHPHKYLLHYLISLKNWLNRYSWQRtpisvtAWALLRDSYHGGLCLRFQAQHLA 194
Cdd:COG5333 127 -----RERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKDKYKLLQI------AWKIINDALRTDLCLLYPPHIIA 195

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 37574068 195 VAVLYLALQVYGVEVPaegeaeKPWWQVFSDDLTKPIIDNIVSDL-IQIYTMDTE 248
Cdd:COG5333 196 LAALLIACEVLGMPII------KLLDFVSYETKEEVIALNYKSIVkNKIKTFKAE 244
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 34-136 2.41e-16

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 72.65  E-value: 2.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  34 RFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNPGSEPLELD 113
Cdd:cd20530  16 RFIQDVGTKLGLPYDTIATGIVYFHRFYMFHSFKDFDRYVTAACCLFLAGKVEETPKKCKDIIKTARSLLNDKQFAQFGD 95

                        90       100
                ....*....|....*....|...
gi 37574068 114 srfwELRDSIVQCELLMLRVLRF 136
Cdd:cd20530  96 ----DPKEEVMVLERILLQTIKF 114
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 35-136 1.03e-14

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 68.22  E-value: 1.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  35 FIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNPGSEPL--EL 112
Cdd:cd20545  11 FIIRVGSRLKLPQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKVEESGRKLRDIVIACAKVAQKNPNLVidEQ 90

                        90       100
                ....*....|....*....|....
gi 37574068 113 DSRFWELRDSIVQCELLMLRVLRF 136
Cdd:cd20545  91 SKEVWRWRDSILYNEEVLLETLCF 114
CYCLIN_CCNL2_rpt1 cd20590
first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA ...
 24-136 1.03e-12

first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA polymerase II-associated cyclin that is involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. CCNL2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410293 [Multi-domain]  Cd Length: 156  Bit Score: 63.87  E-value: 1.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  24 PEARVHFRVT--RFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHR 101
Cdd:cd20590  37 VDTETDLRVVgcELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHR 116

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 37574068 102 YFN----PGSEPLELDSRFWELRDSIVQCELLMLRVLRF 136
Cdd:cd20590 117 LRQlrekKKPVPLILDQEYVNLKNQIIKAERRVLKELGF 155
CYCLIN_CCNL_rpt2 cd20533
second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 142-245 1.17e-12

second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410236 [Multi-domain]  Cd Length: 92  Bit Score: 62.23  E-value: 1.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 142 HPHKYLLHYLISLknwlnrYSWQRTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPaegeAEKPWWQ 221
Cdd:cd20533   1 HPHKFILMYLQVL------EGEDNKKLAQTAWNYMNDSLRTDLCVRYPPEVIACACIYLAARELGIPLP----LPPPWWE 70

                        90       100
                ....*....|....*....|....
gi 37574068 222 VFsdDLTKPIIDNIVSDLIQIYTM 245
Cdd:cd20533  71 LF--DVSKEDIEEICLTILELYTR 92
CYCLIN_AcCycL_rpt1 cd20591
first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ...
 36-136 2.41e-12

first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410294 [Multi-domain]  Cd Length: 128  Bit Score: 62.16  E-value: 2.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  36 IMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYF----NPGSEPLE 111
Cdd:cd20591  22 IQESGILLKLPQAVMATGQVLFQRFYCKKSFARFNVKRVAASCVWLAAKLEESPRKIRQVLMVFHRMEcrreNLPLEPLE 101

                        90       100
                ....*....|....*....|....*.
gi 37574068 112 LDSR-FWELRDSIVQCELLMLRVLRF 136
Cdd:cd20591 102 PESKkYDEMKEDLIRTERHLLKEMGF 127
CYCLIN_CCNK_rpt2 cd20531
second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA ...
 141-243 7.64e-12

second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410234 [Multi-domain]  Cd Length: 101  Bit Score: 60.04  E-value: 7.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 141 QHPHKYLLHYLISLKNWLNryswQRTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPA--EGEAEKP 218
Cdd:cd20531   1 EHPYKYLLKYAKQLKGDKN----KIQKLVQMAWTFVNDSLCTTLCLQWEPEIIAVALMYLAAKLSKFDLQDwtSKPPGKR 76

                        90       100
                ....*....|....*....|....*
gi 37574068 219 WWQVFSDDLTKPIIDNIVSDLIQIY 243
Cdd:cd20531  77 WWEQFVEDVSLEVLEDICHQVLDLY 101
CYCLIN_CCNL1_rpt1 cd20589
first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin ...
 24-136 1.15e-11

first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410292 [Multi-domain]  Cd Length: 124  Bit Score: 60.14  E-value: 1.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  24 PEARVHFRV--TRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSH- 100
Cdd:cd20589   5 HETETDLRIlgCELIQTAGILLRLPQVAMATGQVLFQRFFYSKSFVKHSMEIVAMACINLASKIEEAPRRIRDVINVFHh 84

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 37574068 101 ---RYFNPGSEPLELDSRFWELRDSIVQCELLMLRVLRF 136
Cdd:cd20589  85 ikqVRGKRTISPLILDQNYINLKNQVIKAERRVLKELGF 123
CYCLIN_AcCycT_rpt2 cd20588
second cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 141-243 1.11e-10

second cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410291 [Multi-domain]  Cd Length: 93  Bit Score: 56.77  E-value: 1.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 141 QHPHKYLLhylislkNWLNRYSWQRTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPAEGeaEKPWW 220
Cdd:cd20588   1 EHPYKPLV-------AAIKKFNVAQNALAQAAWNFVNDGLRTSLCLQFKPHHIAAGAIFLAAKFLKVKLPCDG--RKVWW 71

                        90       100
                ....*....|....*....|...
gi 37574068 221 QVFsdDLTKPIIDNIVSDLIQIY 243
Cdd:cd20588  72 QEF--DVTPRQLEEVSNQMLELY 92
CYCLIN_CCNT2_rpt1 cd20596
first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit ...
 35-137 7.38e-10

first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410299 [Multi-domain]  Cd Length: 139  Bit Score: 55.82  E-value: 7.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  35 FIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNPGSEPLELDS 114
Cdd:cd20596  36 LIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFHRNIISPTALFLAAKVEEQPRKLEHVIKVAHACLNPLEPQLDTKS 115

                        90       100
                ....*....|....*....|....
gi 37574068 115 R-FWELRDSIVQCELLMLRVLRFQ 137
Cdd:cd20596 116 DaYLQQAQELVILETIMLQTLGFE 139
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 31-100 1.12e-09

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 53.57  E-value: 1.12e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  31 RVTRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSH 100
Cdd:cd00043   1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSG 70
CYCLIN_CCNT_rpt1 cd20538
first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ...
 24-136 1.13e-09

first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410241 [Multi-domain]  Cd Length: 137  Bit Score: 55.09  E-value: 1.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  24 PEARVHFR--VTRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHR 101
Cdd:cd20538  21 PDKELSYRqqAANLIQEMGQRLQVSQLCINTAIVYMHRFYMFHSFTKFHRNSIAAAALFLAAKVEEQPRKLEHVIKVAHA 100

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 37574068 102 YFNPGSEPLELDS-RFWELRDSIVQCELLMLRVLRF 136
Cdd:cd20538 101 CLHRGEPDLDTKSeAYLQQAQELVINENILLQTLGF 136
CYCLIN_SpCG1C_ScCTK2-like_rpt2 cd20546
second cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1), Saccharomyces ...
 142-244 1.42e-09

second cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1), Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2), and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. This group also includes yeast RNA polymerase II holoenzyme cyclin-like subunit, a component of the SRB8-11 complex, a regulatory module of the Mediator complex which is involved in regulation of basal and activated RNA polymerase II-dependent transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410249 [Multi-domain]  Cd Length: 97  Bit Score: 53.91  E-value: 1.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 142 HPHKYLLHYLISLknwlNRYSWQRtpISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVP-AEGEAEKPWW 220
Cdd:cd20546   1 HPYQYLIKFAKKL----GVSDPKE--LAQLAWAFLNDSYRTPLCLLYPPHVIAAAAIYLAAKLLGIDLElSPNEKLNEWW 74

                        90       100
                ....*....|....*....|....
gi 37574068 221 QVFsdDLTKPIIDNIVSDLIQIYT 244
Cdd:cd20546  75 ELF--GVDEEEIADAINEILDLYS 96
CYCLIN_AcCycL_rpt2 cd20594
second cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ...
 141-243 2.09e-09

second cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410297 [Multi-domain]  Cd Length: 101  Bit Score: 53.33  E-value: 2.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 141 QHPHKYLLHYLISLKnwlnryswQRTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPaegeAEKPWW 220
Cdd:cd20594   3 EHPHKFILNYLAMLM--------APPELRQEAWNLANDSLRTTLCVRFKSEVVACGVVYAAARRFQVPLP----ENPPWW 70

                        90       100
                ....*....|....*....|...
gi 37574068 221 QVFsdDLTKPIIDNIVSDLIQIY 243
Cdd:cd20594  71 KVF--DAEKAEIDVVCKVLADLY 91
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 34-132 8.65e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 51.05  E-value: 8.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068     34 RFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFnpgsepleld 113
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFT---------- 70

                           90
                   ....*....|....*....
gi 37574068    114 srfwelRDSIVQCELLMLR 132
Cdd:smart00385  71 ------EEEILRMERLLLE 83
CYCLIN_AcCycT_rpt1 cd20587
first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 33-136 2.46e-08

first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410290 [Multi-domain]  Cd Length: 124  Bit Score: 50.98  E-value: 2.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  33 TRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNP----GSE 108
Cdd:cd20587  16 CTFLQDLGMRLKVPQVTIATAIVFCHRFFLRQSHAKNDRQTIATVCMFLAGKVEETPRPLKDVIVVSYEIIFKkdpsAAQ 95

                        90       100
                ....*....|....*....|....*...
gi 37574068 109 PLELDSRFWELRDSIVQCELLMLRVLRF 136
Cdd:cd20587  96 RIKQKEVYEQQKELVLNGEKLVLSTLGF 123
CYCLIN_CCNT1_rpt1 cd20595
first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ...
 10-137 1.15e-07

first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410298 [Multi-domain]  Cd Length: 138  Bit Score: 49.67  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  10 ESGPAApRAEERPAPEARVHFRVTRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQH 89
Cdd:cd20595  11 ENSPSR-RFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRNSVAPAALFLAAKVEEQP 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 37574068  90 LRTRDIINVSHRYFNPgSEPLElDSR---FWELRDSIVQCELLMLRVLRFQ 137
Cdd:cd20595  90 KKLEHVIKVAHTCLHP-QESLP-DTRseaYLQQVQDLVILESIILQTLGFE 138
CYCLIN_CCNL1_rpt2 cd20592
second cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin ...
 141-244 6.01e-07

second cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410295 [Multi-domain]  Cd Length: 123  Bit Score: 47.30  E-value: 6.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 141 QHPHKYLLHYLISLKnwlnrysWQRTPISV-TAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPaegeaEKP- 218
Cdd:cd20592   1 KHPHKIIVMYLQVLE-------CERNQTLVqTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLP-----NRPh 68

                        90       100
                ....*....|....*....|....*.
gi 37574068 219 WWQVFSddLTKPIIDNIVSDLIQIYT 244
Cdd:cd20592  69 WFLLFG--ATEEEIQEICITTLKLYT 92
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 29-136 1.06e-06

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 46.18  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  29 HFRVTRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNPgSE 108
Cdd:cd20547   2 RLAAFQFISQLCKKLKFPRRTLGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKIEDTQKKSKDILAASYNLRHP-DK 80

                        90       100
                ....*....|....*....|....*...
gi 37574068 109 PLELDSRFWELRDSIVQCELLMLRVLRF 136
Cdd:cd20547  81 ISVDDQMLEEFRKAILGLERLLLETICF 108
CYCLIN_CCNL2_rpt2 cd20593
second cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA ...
 142-244 1.52e-06

second cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA polymerase II-associated cyclin that is involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. CCNL2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410296 [Multi-domain]  Cd Length: 123  Bit Score: 46.11  E-value: 1.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 142 HPHKYLLHYLISLKNWLNRYSWQrtpisvTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPaegeaEKP-WW 220
Cdd:cd20593   1 HPHKIIVMYLQVLECERNRHLVQ------TSWNYMNDSLRTDVFVRFNPETIACACIYLAARTLEIPLP-----NRPhWF 69

                        90       100
                ....*....|....*....|....
gi 37574068 221 QVFSddLTKPIIDNIVSDLIQIYT 244
Cdd:cd20593  70 LLFG--ATEEEIQEICLKILQLYT 91
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 27-134 1.61e-05

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 42.58  E-value: 1.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  27 RVHFrvTRFIMEAGVKLGMQSIPIATAcTIYHK-FFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNP 105
Cdd:cd20513   2 HIFF--ANFIQALGERLKLRQRVIATA-IVYFKrFYARNSFKDIDPRLVAPTCLYLASKVEECPSHARLIVAEAKVLKTK 78

                        90       100
                ....*....|....*....|....*....
gi 37574068 106 GSEPLELDsrfwelRDSIVQCELLMLRVL 134
Cdd:cd20513  79 FSYEFPYR------VNDILECEFYLLEAL 101
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 35-139 5.69e-05

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 41.73  E-value: 5.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068    35 FIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRT-RDIINVShryfnpgseplelD 113
Cdd:pfam00134  37 WLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPTvEDLVYIT-------------D 103

                          90       100
                  ....*....|....*....|....*.
gi 37574068   114 SRFweLRDSIVQCELLMLRVLRFQVS 139
Cdd:pfam00134 104 NAY--TREEILRMERLILETLNFDLS 127
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 50-217 1.79e-04

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 42.13  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068    50 IATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEqhlrtrdiINVSHRYF--NPGSEPLeldsrfwELRDSIVQCE 127
Cdd:TIGR00569  79 VGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEE--------FNVSIDQFvgNLKETPL-------KALEQVLEYE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068   128 LLMLRVLRFQVSFQHPHKYLLHYLISLKnwlNRYSWQRTP--ISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVY 205
Cdd:TIGR00569 144 LLLIQQLNFHLIVHNPYRPLEGFLIDIK---TRLPGLENPeyLRKHADKFLNRTLLTDAYLLYTPSQIALAAILHTASRA 220

                         170
                  ....*....|...
gi 37574068   206 GVEVPA-EGEAEK 217
Cdd:TIGR00569 221 GLNMESyLTEQLS 233
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 11-101 1.31e-03

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 38.66  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  11 SGPAAPRAEERPAPEARVHFRVTRF----IMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVE 86
Cdd:cd20585  56 GGSNGKAAKLPEPLSADEELLMLKYyeqkIQEVCRALRLPNKIQATALLYFKRFYLQWSVMEHDPKRIMLTCIYLACKVE 135

                        90
                ....*....|....*...
gi 37574068  87 EQHLRTRDI---INVSHR 101
Cdd:cd20585 136 EYHVSAEELgkgIQQDHQ 153
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
35-206 2.66e-03

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 38.60  E-value: 2.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  35 FIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINvshryfnpgsepLELDS 114
Cdd:COG5024 219 WLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLV------------YATDG 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068 115 RFweLRDSIVQCELLMLRVLRFQVSFQHPHKYLLhYLISLKNWlnrYSWQRTPISvtawALLRDSYHGGLCLRFQAQHLA 194
Cdd:COG5024 287 AF--TRDDIIRAERYMLEVLDFNISWPSPMSFLR-RISKASDY---DIFSRTPAK----FSSEISPVDYKFIQISPSWCA 356

                       170
                ....*....|..
gi 37574068 195 VAVLYLALQVYG 206
Cdd:COG5024 357 AAAMYLSRKILS 368
CYCLIN_AtCycC_rpt1 cd20571
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
 30-136 6.79e-03

first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410274 [Multi-domain]  Cd Length: 107  Bit Score: 35.22  E-value: 6.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574068  30 FRVTRFIMEAGVKLGMQSIPI-----ATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFN 104
Cdd:cd20571   3 VKLIKIHMSNYIKKLAQHIKVrqrvvATAITYFRRVYTRKSFTEYDPRLVAPTCLYLASKAEESTVQAKLLVFYMKRLYA 82

                        90       100       110
                ....*....|....*....|....*....|...
gi 37574068 105 pgseplelDSRF-WELRDsIVQCELLMLRVLRF 136
Cdd:cd20571  83 --------DEYHrYEIKD-ILEMEMKLLEALDY 106
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 153-212 9.33e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 34.31  E-value: 9.33e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37574068 153 SLKNWLNRYSWQ---RTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPAE 212
Cdd:cd00043   1 KAVDFIRRLCSKlglPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLK 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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