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Conserved domains on  [gi|37574608|ref|NP_932094|]
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zinc finger protein 189 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-482 5.91e-17

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 83.59  E-value: 5.91e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608  96 RKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCN--ECGKSFSRSSFVIEHQRIHTGERPYECNYCGKT--F 171
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnS 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 172 SVSSTLIRHQrIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDC------GKAFSWKSHLIE---------- 235
Cdd:COG5048 104 KASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvnTPQSNSLHPPLPanslskdpss 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 236 ------HQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGK 309
Cdd:COG5048 183 nlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 310 SFSRSSFLIEHQRIHTGER-------PYQCKECGKSFSQLCNLTRHQR--IHTG--DKPHKCEE--CGKAFSRSSGLIQH 376
Cdd:COG5048 263 SSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 377 QRIHT--REKTYPYNETKESFDP----NCSLVIQQEVYPKEKSYKC--DECGKTFSVSAHLVQHQRIHTGEKPYL---CT 445
Cdd:COG5048 343 ILLHTsiSPAKEKLLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSEtlSNSCIRNFKRDSNLSLHIITHLSFRPYnckNP 422

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 37574608 446 VCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQL 482
Cdd:COG5048 423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-537 3.83e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.83e-04
                          10        20
                  ....*....|....*....|....*
gi 37574608   513 LIQHQRIHTGEKPYKCEKCDKSFSQ 537
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-509 4.12e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574608   484 NLIRHQGVHTGNKPHKCDECGKAFSR 509
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-482 5.91e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 83.59  E-value: 5.91e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608  96 RKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCN--ECGKSFSRSSFVIEHQRIHTGERPYECNYCGKT--F 171
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnS 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 172 SVSSTLIRHQrIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDC------GKAFSWKSHLIE---------- 235
Cdd:COG5048 104 KASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvnTPQSNSLHPPLPanslskdpss 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 236 ------HQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGK 309
Cdd:COG5048 183 nlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 310 SFSRSSFLIEHQRIHTGER-------PYQCKECGKSFSQLCNLTRHQR--IHTG--DKPHKCEE--CGKAFSRSSGLIQH 376
Cdd:COG5048 263 SSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 377 QRIHT--REKTYPYNETKESFDP----NCSLVIQQEVYPKEKSYKC--DECGKTFSVSAHLVQHQRIHTGEKPYL---CT 445
Cdd:COG5048 343 ILLHTsiSPAKEKLLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSEtlSNSCIRNFKRDSNLSLHIITHLSFRPYnckNP 422

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 37574608 446 VCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQL 482
Cdd:COG5048 423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-369 1.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 37574608   344 NLTRHQRIHTGDKPHKCEECGKAFSR 369
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-537 3.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.83e-04
                          10        20
                  ....*....|....*....|....*
gi 37574608   513 LIQHQRIHTGEKPYKCEKCDKSFSQ 537
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-509 4.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574608   484 NLIRHQGVHTGNKPHKCDECGKAFSR 509
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-482 5.91e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 83.59  E-value: 5.91e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608  96 RKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCN--ECGKSFSRSSFVIEHQRIHTGERPYECNYCGKT--F 171
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnS 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 172 SVSSTLIRHQrIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDC------GKAFSWKSHLIE---------- 235
Cdd:COG5048 104 KASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvnTPQSNSLHPPLPanslskdpss 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 236 ------HQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGK 309
Cdd:COG5048 183 nlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 310 SFSRSSFLIEHQRIHTGER-------PYQCKECGKSFSQLCNLTRHQR--IHTG--DKPHKCEE--CGKAFSRSSGLIQH 376
Cdd:COG5048 263 SSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 377 QRIHT--REKTYPYNETKESFDP----NCSLVIQQEVYPKEKSYKC--DECGKTFSVSAHLVQHQRIHTGEKPYL---CT 445
Cdd:COG5048 343 ILLHTsiSPAKEKLLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSEtlSNSCIRNFKRDSNLSLHIITHLSFRPYnckNP 422

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 37574608 446 VCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQL 482
Cdd:COG5048 423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
188-580 1.19e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 188 RPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSD--CGKAFSWKSHLIEHQRTHTGEKPYhcTKCKKSFSRNSLLVEHQ 265
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 266 RIHtgerphkcgeCGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCK-------ECGKS 338
Cdd:COG5048 110 LSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLSKD 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 339 FSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYPYNETKESFDPNCSLVIQQEVYPKEKSYKCDE 418
Cdd:COG5048 180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 419 CGKTFSVSAHLVQHQRIHTGE-------KPYLCTVCGKSFSRSSFLIEHQR--IHTGE--RPYLCR--QCGKSFSQLCNL 485
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDAL 339

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 486 IRHQGVHTGNKPHKC--DECGKAFSRNS-----GLIQHQRIHTGEKPYKCE--KCDKSFSQQRSLVNHQKIHAEVKTQET 556
Cdd:COG5048 340 KRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                       410       420
                ....*....|....*....|....
gi 37574608 557 HeCDACGEAFNCRISLIQHQKLHT 580
Cdd:COG5048 420 K-NPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-316 6.43e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 132 KPFQCNECGKSFSRSSFVIEHQR--IHTGE--RPYEC--NYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQRRSL 205
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 206 vkhqrihtGEKPHKCSDcgkafswKSHLIEHQRTHTGEKPyhctKCKKSFSRNSLLVEHQRIHTGERPH--KCGECGKAF 283
Cdd:COG5048 368 --------NNEPPQSLQ-------QYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSF 428

                       170       180       190
                ....*....|....*....|....*....|...
gi 37574608 284 RLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSF 316
Cdd:COG5048 429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-369 1.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 37574608   344 NLTRHQRIHTGDKPHKCEECGKAFSR 369
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 438-516 3.41e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574608 438 GEKPYLCTV--CGKSFsRSSFLIEHQRIHTgerpylcrQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQ 515
Cdd:COG5189 346 DGKPYKCPVegCNKKY-KNQNGLKYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 37574608 516 H 516
Cdd:COG5189 417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-537 3.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.83e-04
                          10        20
                  ....*....|....*....|....*
gi 37574608   513 LIQHQRIHTGEKPYKCEKCDKSFSQ 537
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
428-453 5.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.56e-04
                          10        20
                  ....*....|....*....|....*.
gi 37574608   428 HLVQHQRIHTGEKPYLCTVCGKSFSR 453
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
317-341 9.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.08e-04
                          10        20
                  ....*....|....*....|....*
gi 37574608   317 LIEHQRIHTGERPYQCKECGKSFSQ 341
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
204-228 1.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.23e-03
                          10        20
                  ....*....|....*....|....*
gi 37574608   204 SLVKHQRIHTGEKPHKCSDCGKAFS 228
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
232-257 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574608   232 HLIEHQRTHTGEKPYHCTKCKKSFSR 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-313 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574608   288 YLIQHQKIHTGEKPFLCIECGKSFSR 313
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
120-145 1.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574608   120 HFIQHQRVHTGEKPFQCNECGKSFSR 145
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 330-352 3.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.64e-03
                          10        20
                  ....*....|....*....|...
gi 37574608   330 YQCKECGKSFSQLCNLTRHQRIH 352
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-509 4.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574608   484 NLIRHQGVHTGNKPHKCDECGKAFSR 509
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-481 4.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.12e-03
                          10        20
                  ....*....|....*....|....*
gi 37574608   457 LIEHQRIHTGERPYLCRQCGKSFSQ 481
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
261-283 5.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.59e-03
                          10        20
                  ....*....|....*....|...
gi 37574608   261 LVEHQRIHTGERPHKCGECGKAF 283
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 162-184 6.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.32e-03
                          10        20
                  ....*....|....*....|...
gi 37574608   162 YECNYCGKTFSVSSTLIRHQRIH 184
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
177-201 7.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.14e-03
                          10        20
                  ....*....|....*....|....*
gi 37574608   177 LIRHQRIHTGERPYQCNQCKQSFSQ 201
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
151-172 7.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.73e-03
                          10        20
                  ....*....|....*....|..
gi 37574608   151 EHQRIHTGERPYECNYCGKTFS 172
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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