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Conserved domains on  [gi|113681194|ref|NP_899139|]
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snRNA-activating protein complex subunit 5 [Mus musculus]

Protein Classification

SNAPC5 domain-containing protein( domain architecture ID 10634615)

SNAPC5 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNAPC5 pfam15497
snRNA-activating protein complex subunit 19, SNAPc subunit 19; SNAPc19 is a family of proteins ...
 1-82 2.30e-17

snRNA-activating protein complex subunit 19, SNAPc subunit 19; SNAPc19 is a family of proteins found in eukaryotes. It is one of the five core components of the snRNA-activating protein complex or SNAPc that helps direct the nucleation of RNA polymerases II and III. The core RNA polymerase II snRNA promoters consist of a single essential element, the proximal sequence element (PSE), whereas the core RNA polymerase III snRNA promoters consist of both a PSE and a TATA box. The SNAPc binds to the PSE of both of these. SNAPc recognizes the PSE sequence common to all human snRNA genes, irrespective of polymerase specificity. SNAPc is also known as the PSE transcription factor (PTF) or PSE-binding protein (PBP). The human SNAP19 and SNAP45 subunits are dispensable for transcription in vitro and are not as widely conserved as the other three, SNAP190, SNAP43 and SNAP50, suggesting that these vertebrate-specific SNAPc subunits may have adapted specialized regulatory roles for snRNA gene transcription.


:

Pssm-ID: 464748  Cd Length: 101  Bit Score: 70.45  E-value: 2.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113681194    1 MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMINSRGRTETLSSQPAPEQLC-----DMSLHVDNEVTINQTT 75
Cdd:pfam15497   1 LLKELQELKEEEKKLLKLLSKLNDQLNRLKVEELALKSMIRKQEGENQTTSPEPSQQSSngnspSMESSVDNEEEINQTE 80


                  ....*..
gi 113681194   76 LKLSTRS 82
Cdd:pfam15497  81 LDLSVNP 87
 
Name Accession Description Interval E-value
SNAPC5 pfam15497
snRNA-activating protein complex subunit 19, SNAPc subunit 19; SNAPc19 is a family of proteins ...
 1-82 2.30e-17

snRNA-activating protein complex subunit 19, SNAPc subunit 19; SNAPc19 is a family of proteins found in eukaryotes. It is one of the five core components of the snRNA-activating protein complex or SNAPc that helps direct the nucleation of RNA polymerases II and III. The core RNA polymerase II snRNA promoters consist of a single essential element, the proximal sequence element (PSE), whereas the core RNA polymerase III snRNA promoters consist of both a PSE and a TATA box. The SNAPc binds to the PSE of both of these. SNAPc recognizes the PSE sequence common to all human snRNA genes, irrespective of polymerase specificity. SNAPc is also known as the PSE transcription factor (PTF) or PSE-binding protein (PBP). The human SNAP19 and SNAP45 subunits are dispensable for transcription in vitro and are not as widely conserved as the other three, SNAP190, SNAP43 and SNAP50, suggesting that these vertebrate-specific SNAPc subunits may have adapted specialized regulatory roles for snRNA gene transcription.


Pssm-ID: 464748  Cd Length: 101  Bit Score: 70.45  E-value: 2.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113681194    1 MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMINSRGRTETLSSQPAPEQLC-----DMSLHVDNEVTINQTT 75
Cdd:pfam15497   1 LLKELQELKEEEKKLLKLLSKLNDQLNRLKVEELALKSMIRKQEGENQTTSPEPSQQSSngnspSMESSVDNEEEINQTE 80


                  ....*..
gi 113681194   76 LKLSTRS 82
Cdd:pfam15497  81 LDLSVNP 87
 
Name Accession Description Interval E-value
SNAPC5 pfam15497
snRNA-activating protein complex subunit 19, SNAPc subunit 19; SNAPc19 is a family of proteins ...
 1-82 2.30e-17

snRNA-activating protein complex subunit 19, SNAPc subunit 19; SNAPc19 is a family of proteins found in eukaryotes. It is one of the five core components of the snRNA-activating protein complex or SNAPc that helps direct the nucleation of RNA polymerases II and III. The core RNA polymerase II snRNA promoters consist of a single essential element, the proximal sequence element (PSE), whereas the core RNA polymerase III snRNA promoters consist of both a PSE and a TATA box. The SNAPc binds to the PSE of both of these. SNAPc recognizes the PSE sequence common to all human snRNA genes, irrespective of polymerase specificity. SNAPc is also known as the PSE transcription factor (PTF) or PSE-binding protein (PBP). The human SNAP19 and SNAP45 subunits are dispensable for transcription in vitro and are not as widely conserved as the other three, SNAP190, SNAP43 and SNAP50, suggesting that these vertebrate-specific SNAPc subunits may have adapted specialized regulatory roles for snRNA gene transcription.


Pssm-ID: 464748  Cd Length: 101  Bit Score: 70.45  E-value: 2.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113681194    1 MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMINSRGRTETLSSQPAPEQLC-----DMSLHVDNEVTINQTT 75
Cdd:pfam15497   1 LLKELQELKEEEKKLLKLLSKLNDQLNRLKVEELALKSMIRKQEGENQTTSPEPSQQSSngnspSMESSVDNEEEINQTE 80


                  ....*..
gi 113681194   76 LKLSTRS 82
Cdd:pfam15497  81 LDLSVNP 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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