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Conserved domains on  [gi|31712002|ref|NP_853625|]
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enhancer of mRNA-decapping protein 4 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ge1_WD40 super family cl25640
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 114-440 2.62e-180

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


The actual alignment was detected with superfamily member pfam16529:

Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 537.04  E-value: 2.62e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    114 GSNKVKIQPVAKYDWEQKYYYGNLIAV--SNSFLAYAIRAaNNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQ 191
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKV-KNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    192 LACLDEAGNLFVWRLALVKGKIQEEILVHIRQPEGTALNHFRRIIWCPFIPEESEDCCEE--SSPTVALLHEDRAEVWDL 269
Cdd:pfam16529   80 LACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETESDDddESKLLVLLRGDKAEIWNV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    270 DMLRSSHNTWPVDVSQIKQGFIVVKGHStCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLS 349
Cdd:pfam16529  160 DMIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    350 CLLFCDNHKKQdPEVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSvPPSLKVCLDLSAEYLILSDVQRK 429
Cdd:pfam16529  239 SLFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQ-PPNLKAGLDLSANYLVLSDLDNK 316

                          330
                   ....*....|.
gi 31712002    430 VLYVMELLQNQ 440
Cdd:pfam16529  317 VLYVLQLGQDG 327
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 114-440 2.62e-180

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 537.04  E-value: 2.62e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    114 GSNKVKIQPVAKYDWEQKYYYGNLIAV--SNSFLAYAIRAaNNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQ 191
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKV-KNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    192 LACLDEAGNLFVWRLALVKGKIQEEILVHIRQPEGTALNHFRRIIWCPFIPEESEDCCEE--SSPTVALLHEDRAEVWDL 269
Cdd:pfam16529   80 LACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETESDDddESKLLVLLRGDKAEIWNV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    270 DMLRSSHNTWPVDVSQIKQGFIVVKGHStCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLS 349
Cdd:pfam16529  160 DMIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    350 CLLFCDNHKKQdPEVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSvPPSLKVCLDLSAEYLILSDVQRK 429
Cdd:pfam16529  239 SLFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQ-PPNLKAGLDLSANYLVLSDLDNK 316

                          330
                   ....*....|.
gi 31712002    430 VLYVMELLQNQ 440
Cdd:pfam16529  317 VLYVLQLGQDG 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 260-409 2.60e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 2.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  260 HEDraEVWDLDMLRSSH--------NT---WPVDVSQIKQgfiVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyi 328
Cdd:cd00200   92 HTS--YVSSVAFSPDGRilssssrdKTikvWDVETGKCLT---TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  329 egqDEPRCLHEWKPHDGrPLSCLLFCDNHKKqdpevpfwrfLITGADqNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPP 408
Cdd:cd00200  165 ---RTGKCVATLTGHTG-EVNSVAFSPDGEK----------LLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229


                 .
gi 31712002  409 S 409
Cdd:cd00200  230 D 230
WD40 COG2319
WD40 repeat [General function prediction only];
159-399 3.28e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  159 VRVISVST-SERTLLKGFTGSVADLAFahlnSP---QLACLDEAGNLFVWRLAlvKGKIQEEILVHIRQPEGTALNHFRR 234
Cdd:COG2319  144 VRLWDLATgKLLRTLTGHSGAVTSVAF----SPdgkLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGK 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  235 II-----------WcpfipeesedcCEESSPTVALLHEDRAEVWDLDMLR--------SSHNT---WPVDVSQIKQgfiV 292
Cdd:COG2319  218 LLasgsadgtvrlW-----------DLATGKLLRTLTGHSGSVRSVAFSPdgrllasgSADGTvrlWDLATGELLR---T 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  293 VKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLSCLLFCDNhkkqdpevpfwRFLIT 372
Cdd:COG2319  284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL-----ATGKLLRTLTGHTGAVRSVAFSPDG-----------KTLAS 347

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 31712002  373 GADQNReLKMWCTVSWTCLQTIR----------FSPD 399
Cdd:COG2319  348 GSDDGT-VRLWDLATGELLRTLTghtgavtsvaFSPD 383
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-324 5.97e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 5.97e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 31712002     292 VVKGHS---TCLsegALSPDGTVLATASHDGFVKFW 324
Cdd:smart00320    7 TLKGHTgpvTSV---AFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 114-440 2.62e-180

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 537.04  E-value: 2.62e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    114 GSNKVKIQPVAKYDWEQKYYYGNLIAV--SNSFLAYAIRAaNNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQ 191
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKV-KNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    192 LACLDEAGNLFVWRLALVKGKIQEEILVHIRQPEGTALNHFRRIIWCPFIPEESEDCCEE--SSPTVALLHEDRAEVWDL 269
Cdd:pfam16529   80 LACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETESDDddESKLLVLLRGDKAEIWNV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    270 DMLRSSHNTWPVDVSQIKQGFIVVKGHStCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLS 349
Cdd:pfam16529  160 DMIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002    350 CLLFCDNHKKQdPEVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSvPPSLKVCLDLSAEYLILSDVQRK 429
Cdd:pfam16529  239 SLFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQ-PPNLKAGLDLSANYLVLSDLDNK 316

                          330
                   ....*....|.
gi 31712002    430 VLYVMELLQNQ 440
Cdd:pfam16529  317 VLYVLQLGQDG 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 260-409 2.60e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 2.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  260 HEDraEVWDLDMLRSSH--------NT---WPVDVSQIKQgfiVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyi 328
Cdd:cd00200   92 HTS--YVSSVAFSPDGRilssssrdKTikvWDVETGKCLT---TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  329 egqDEPRCLHEWKPHDGrPLSCLLFCDNHKKqdpevpfwrfLITGADqNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPP 408
Cdd:cd00200  165 ---RTGKCVATLTGHTG-EVNSVAFSPDGEK----------LLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229


                 .
gi 31712002  409 S 409
Cdd:cd00200  230 D 230
WD40 COG2319
WD40 repeat [General function prediction only];
159-399 3.28e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  159 VRVISVST-SERTLLKGFTGSVADLAFahlnSP---QLACLDEAGNLFVWRLAlvKGKIQEEILVHIRQPEGTALNHFRR 234
Cdd:COG2319  144 VRLWDLATgKLLRTLTGHSGAVTSVAF----SPdgkLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGK 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  235 II-----------WcpfipeesedcCEESSPTVALLHEDRAEVWDLDMLR--------SSHNT---WPVDVSQIKQgfiV 292
Cdd:COG2319  218 LLasgsadgtvrlW-----------DLATGKLLRTLTGHSGSVRSVAFSPdgrllasgSADGTvrlWDLATGELLR---T 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  293 VKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLSCLLFCDNhkkqdpevpfwRFLIT 372
Cdd:COG2319  284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL-----ATGKLLRTLTGHTGAVRSVAFSPDG-----------KTLAS 347

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 31712002  373 GADQNReLKMWCTVSWTCLQTIR----------FSPD 399
Cdd:COG2319  348 GSDDGT-VRLWDLATGELLRTLTghtgavtsvaFSPD 383
WD40 COG2319
WD40 repeat [General function prediction only];
304-399 1.15e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  304 ALSPDGTVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLSCLLFCDNhkkqdpevpfwRFLITGADQNReLKMW 383
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDL-----ATGKLLRTLTGHSGAVTSVAFSPDG-----------KLLASGSDDGT-VRLW 189

                         90       100
                 ....*....|....*....|....*.
gi 31712002  384 CTVSWTCLQTIR----------FSPD 399
Cdd:COG2319  190 DLATGKLLRTLTghtgavrsvaFSPD 215
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-405 1.63e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  159 VRVISVSTSE-RTLLKGFTGSVADLAFaHLNSPQLACLDEAGNLFVWRLAlvKGKIQEEIlvhirqpEGtalnHFRRIIW 237
Cdd:cd00200   33 IKVWDLETGElLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLE--TGECVRTL-------TG----HTSYVSS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  238 CPFIPEEsedcceessPTVALLHEDR-AEVWDLD-----MLRSSHNTWPVDVSQIKQGFIVV------------------ 293
Cdd:cd00200   99 VAFSPDG---------RILSSSSRDKtIKVWDVEtgkclTTLRGHTDWVNSVAFSPDGTFVAsssqdgtiklwdlrtgkc 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  294 ----KGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGrPLSCLLFCDNhkkqdpevpfwRF 369
Cdd:cd00200  170 vatlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-----STGKCLGTLRGHEN-GVNSVAFSPD-----------GY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 31712002  370 LITGADQNRELKMWCTVSWTCLQTIR----------FSPDIFSSVS 405
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSghtnsvtslaWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
159-399 1.96e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 1.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  159 VRVISVSTSER-TLLKGFTGSVADLAFahlnSP---QLACLDEAGNLFVWRLAlvKGKIQEEILVHIRQPEGTAlnhfrr 234
Cdd:COG2319  102 VRLWDLATGLLlRTLTGHTGAVRSVAF----SPdgkTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVA------ 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  235 iiwcpFIPEESedcceesspTVALLHEDR-AEVWDLDMLRSSHntwpvdvsqikqgfiVVKGHSTCLSEGALSPDGTVLA 313
Cdd:COG2319  170 -----FSPDGK---------LLASGSDDGtVRLWDLATGKLLR---------------TLTGHTGAVRSVAFSPDGKLLA 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  314 TASHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLScLLFCDNHKkqdpevpfwrfLITGADQNRELKMWCTVSWTCLQT 393
Cdd:COG2319  221 SGSADGTVRLWDL-----ATGKLLRTLTGHSGSVRS-VAFSPDGR-----------LLASGSADGTVRLWDLATGELLRT 283

                        250
                 ....*....|....*.
gi 31712002  394 ----------IRFSPD 399
Cdd:COG2319  284 ltghsggvnsVAFSPD 299
WD40 COG2319
WD40 repeat [General function prediction only];
158-349 7.04e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  158 MVRVISVST-SERTLLKGFTGSVADLAFAHlNSPQLACLDEAGNLFVWRLAlvKGKIQEEILVHIRQPEGTAlnhfrrii 236
Cdd:COG2319  227 TVRLWDLATgKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA--TGELLRTLTGHSGGVNSVA-------- 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  237 wcpFIPEESedcceesspTVALLHEDR-AEVWDLDMLRSSHntwpvdvsqikqgfiVVKGHSTCLSEGALSPDGTVLATA 315
Cdd:COG2319  296 ---FSPDGK---------LLASGSDDGtVRLWDLATGKLLR---------------TLTGHTGAVRSVAFSPDGKTLASG 348

                        170       180       190
                 ....*....|....*....|....*....|....
gi 31712002  316 SHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLS 349
Cdd:COG2319  349 SDDGTVRLWDL-----ATGELLRTLTGHTGAVTS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 158-325 6.94e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 6.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  158 MVRVISVST-SERTLLKGFTGSVADLAFAHLNSPQLAC-LDeaGNLFVWRLAlvKGKIQEEILVHIRQPEGTALNHFRRI 235
Cdd:cd00200  158 TIKLWDLRTgKCVATLTGHTGEVNSVAFSPDGEKLLSSsSD--GTIKLWDLS--TGKCLGTLRGHENGVNSVAFSPDGYL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  236 IwcpfipeesedcceessptVALLHEDRAEVWDLDMLRSSHntwpvdvsqikqgfiVVKGHS---TCLsegALSPDGTVL 312
Cdd:cd00200  234 L-------------------ASGSEDGTIRVWDLRTGECVQ---------------TLSGHTnsvTSL---AWSPDGKRL 276

                        170
                 ....*....|...
gi 31712002  313 ATASHDGFVKFWQ 325
Cdd:cd00200  277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
151-326 1.58e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  151 AANNGSAMVRVISVSTSER-TLLKGFTGSVADLAFahlnSP---QLACLDEAGNLFVWRLAlvKGKIQEEILVHIRQPEG 226
Cdd:COG2319  262 ASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAF----SPdgkLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRS 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  227 TALNHFRRiiwcpfipeesedcceesspTVALLHEDR-AEVWDLDMLRSSHntwpvdvsqikqgfiVVKGHSTCLSEGAL 305
Cdd:COG2319  336 VAFSPDGK--------------------TLASGSDDGtVRLWDLATGELLR---------------TLTGHTGAVTSVAF 380

                        170       180
                 ....*....|....*....|.
gi 31712002  306 SPDGTVLATASHDGFVKFWQI 326
Cdd:COG2319  381 SPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-324 5.97e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 5.97e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 31712002     292 VVKGHS---TCLsegALSPDGTVLATASHDGFVKFW 324
Cdd:smart00320    7 TLKGHTgpvTSV---AFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
292-324 1.59e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.59e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 31712002    292 VVKGHS---TCLsegALSPDGTVLATASHDGFVKFW 324
Cdd:pfam00400    6 TLEGHTgsvTSL---AFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
272-399 2.80e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31712002  272 LRSSHNTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLSCL 351
Cdd:COG2319   53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-----ATGLLLRTLTGHTGAVRSVA 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 31712002  352 LFCDNhkkqdpevpfwRFLITGADqNRELKMWCTVSWTCLQTIR----------FSPD 399
Cdd:COG2319  128 FSPDG-----------KTLASGSA-DGTVRLWDLATGKLLRTLTghsgavtsvaFSPD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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