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Conserved domains on  [gi|30425553|ref|NP_848663|]
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reticulon-4 receptor-like 1 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-255 1.63e-28

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.19  E-value: 1.63e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  57 ERVFLQNNRIGLLqPGHFS--PAMVTLWIYSNNITYIhPSTFEGFVHLEELDLGDNrQLRTLaPETFQGLVKLHALYLYK 134
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-QLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 135 CGLSALPAgVFGGLHSLQYLYLQDNHIEYLQDDIfVDLVNLSHLFLHGNKLWSLgPGtFRGLVNLDRLLLHENQLQWVhh 214
Cdd:COG4886 192 NQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL-PE-LGNLTNLEELDLSNNQLTDL-- 265

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 30425553 215 KAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
Cdd:COG4886 266 PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
255-300 1.20e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 30425553    255 NPWDCGCRARSLWEWLQRFRGSSSAVP--CVSPGLRHGQDLKLLRAED 300
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSLRGPLLELLHSEF 48
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-255 1.63e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.19  E-value: 1.63e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  57 ERVFLQNNRIGLLqPGHFS--PAMVTLWIYSNNITYIhPSTFEGFVHLEELDLGDNrQLRTLaPETFQGLVKLHALYLYK 134
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-QLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 135 CGLSALPAgVFGGLHSLQYLYLQDNHIEYLQDDIfVDLVNLSHLFLHGNKLWSLgPGtFRGLVNLDRLLLHENQLQWVhh 214
Cdd:COG4886 192 NQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL-PE-LGNLTNLEELDLSNNQLTDL-- 265

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 30425553 215 KAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
Cdd:COG4886 266 PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
174-233 4.75e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 4.75e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553   174 NLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSL 233
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-255 4.35e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 4.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 126 KLHALYLYKCGLSALPAgvFGGLHSLQYLYLQDNHIEYLQDdiFVDLVNLSHLFLHGNKLWSLGPgtFRGLVNLDRLLLH 205
Cdd:cd21340   3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 206 ENQLQWVhhKAFHDLRRLTTL------------FLF------------------NNSLSELqgECLAPLGALEFLRLNGN 255
Cdd:cd21340  77 GNRISVV--EGLENLTNLEELhienqrlppgekLTFdprslaalsnslrvlnisGNNIDSL--EPLAPLRNLEQLDASNN 152
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-255 5.34e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 5.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553   61 LQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNrQLRTLAPETFQGLVKLHALYLYKCGLSAL 140
Cdd:PLN00113 125 LSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN-VLVGKIPNSLTNLTSLEFLTLASNQLVGQ 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  141 PAGVFGGLHSLQYLYLQDNHieyLQDDIFVD---LVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAF 217
Cdd:PLN00113 204 IPRELGQMKSLKWIYLGYNN---LSGEIPYEiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSI 280

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 30425553  218 HDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
Cdd:PLN00113 281 FSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318
LRRCT smart00082
Leucine rich repeat C-terminal domain;
255-300 1.20e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 30425553    255 NPWDCGCRARSLWEWLQRFRGSSSAVP--CVSPGLRHGQDLKLLRAED 300
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSLRGPLLELLHSEF 48
LRR smart00370
Leucine-rich repeats, outliers;
172-195 9.60e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 9.60e-03
                           10        20
                   ....*....|....*....|....
gi 30425553    172 LVNLSHLFLHGNKLWSLGPGTFRG 195
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-255 1.63e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.19  E-value: 1.63e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  57 ERVFLQNNRIGLLqPGHFS--PAMVTLWIYSNNITYIhPSTFEGFVHLEELDLGDNrQLRTLaPETFQGLVKLHALYLYK 134
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-QLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 135 CGLSALPAgVFGGLHSLQYLYLQDNHIEYLQDDIfVDLVNLSHLFLHGNKLWSLgPGtFRGLVNLDRLLLHENQLQWVhh 214
Cdd:COG4886 192 NQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL-PE-LGNLTNLEELDLSNNQLTDL-- 265

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 30425553 215 KAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
Cdd:COG4886 266 PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-255 1.05e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 1.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  92 HPSTFEGFVHLEELDLGDNrQLRTLaPETFQGLVKLHALYLYKCGLSALPAgVFGGLHSLQYLYLQDNHIEYLQDDIFvD 171
Cdd:COG4886 105 GNEELSNLTNLESLDLSGN-QLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELG-N 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 172 LVNLSHLFLHGNKLWSLgPGTFRGLVNLDRLLLHENQLQWVhHKAFHDLRRLTTLFLFNNSLSELqgECLAPLGALEFLR 251
Cdd:COG4886 181 LTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELD 256


                ....
gi 30425553 252 LNGN 255
Cdd:COG4886 257 LSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-255 6.83e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 6.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 100 VHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLsalpagvFGGLHSLQYLYLQDNHIEYLQDDIFvDLVNLSHLF 179
Cdd:COG4886  71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELD 142

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30425553 180 LHGNKLWSLgPGTFRGLVNLDRLLLHENQLQWVhHKAFHDLRRLTTLFLFNNSLSELQGEcLAPLGALEFLRLNGN 255
Cdd:COG4886 143 LSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
174-233 4.75e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 4.75e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553   174 NLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSL 233
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-255 7.89e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 7.89e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  57 ERVFLQNNRIGLLqPGHFS--PAMVTLWIYSNNITYIhPSTFEGFVHLEELDLGDNrQLRTLaPEtFQGLVKLHALYLYK 134
Cdd:COG4886 185 KELDLSNNQITDL-PEPLGnlTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN-QLTDL-PE-LGNLTNLEELDLSN 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 135 CGLSALPAgvFGGLHSLQYLYLQDNHIEYLqddifvdlvNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHH 214
Cdd:COG4886 260 NQLTDLPP--LANLTNLKTLDLSNNQLTDL---------KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 30425553 215 KAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
LRR_8 pfam13855
Leucine rich repeat;
150-209 2.20e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 2.20e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553   150 SLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQL 209
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-255 4.35e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 4.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 126 KLHALYLYKCGLSALPAgvFGGLHSLQYLYLQDNHIEYLQDdiFVDLVNLSHLFLHGNKLWSLGPgtFRGLVNLDRLLLH 205
Cdd:cd21340   3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 206 ENQLQWVhhKAFHDLRRLTTL------------FLF------------------NNSLSELqgECLAPLGALEFLRLNGN 255
Cdd:cd21340  77 GNRISVV--EGLENLTNLEELhienqrlppgekLTFdprslaalsnslrvlnisGNNIDSL--EPLAPLRNLEQLDASNN 152
LRR_8 pfam13855
Leucine rich repeat;
126-185 5.14e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 5.14e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553   126 KLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKL 185
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
101-161 5.50e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 5.50e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30425553   101 HLEELDLGDNRqLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHI 161
Cdd:pfam13855   2 NLRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-255 5.34e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 5.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553   61 LQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNrQLRTLAPETFQGLVKLHALYLYKCGLSAL 140
Cdd:PLN00113 125 LSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN-VLVGKIPNSLTNLTSLEFLTLASNQLVGQ 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  141 PAGVFGGLHSLQYLYLQDNHieyLQDDIFVD---LVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAF 217
Cdd:PLN00113 204 IPRELGQMKSLKWIYLGYNN---LSGEIPYEiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSI 280

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 30425553  218 HDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
Cdd:PLN00113 281 FSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318
LRR_8 pfam13855
Leucine rich repeat;
198-256 9.49e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 9.49e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 30425553   198 NLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNP 256
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
85-132 1.10e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.10e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 30425553    85 SNNITYIHPSTFEGFVHLEELDLGDNRqLRTLAPETFQGLVKLHALYL 132
Cdd:pfam13855  10 NNRLTSLDDGAFKGLSNLKVLDLSNNL-LTTLSPGAFSGLPSLRYLDL 56
LRR_8 pfam13855
Leucine rich repeat;
57-111 9.04e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 9.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30425553    57 ERVFLQNNRIGLLQPGHFS--PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNR 111
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-183 1.31e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 1.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  60 FLQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPstFEGFVHLEELDLGDNR-----------QLRTL------------ 116
Cdd:cd21340  30 YLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRisvveglenltNLEELhienqrlppgek 107

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30425553 117 ---APETFQGLVK-LHALYLYKCGLSALpaGVFGGLHSLQYLYLQDNHIEYLQD--DIFVDLVNLSHLFLHGN 183
Cdd:cd21340 108 ltfDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-255 3.65e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553   82 WIY--SNNITYIHPSTFEGFVHLEELDLGDNrQLRTLAPETFQGLVKLHALYLYKCGLSA-LPAGVFGgLHSLQYLYLQD 158
Cdd:PLN00113 216 WIYlgYNNLSGEIPYEIGGLTSLNHLDLVYN-NLTGPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFS-LQKLISLDLSD 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  159 NHIEYLQDDIFVDLVNLSHLFLHGNK-------------------LWSlgpGTFRGLV--------NLDRLLLHENQLQW 211
Cdd:PLN00113 294 NSLSGEIPELVIQLQNLEILHLFSNNftgkipvaltslprlqvlqLWS---NKFSGEIpknlgkhnNLTVLDLSTNNLTG 370

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 30425553  212 VHHKAFHDLRRLTTLFLFNNSlseLQGECLAPLGA---LEFLRLNGN 255
Cdd:PLN00113 371 EIPEGLCSSGNLFKLILFSNS---LEGEIPKSLGAcrsLRRVRLQDN 414
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
37-176 4.28e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 4.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553   37 TVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLqPGHFSPAMVTLWIYSNNITYIHPSTFEGfvhLEELDLGDNrQLRTL 116
Cdd:PRK15370 224 TLYANSNQLTSIPATLPDTIQEMELSINRITEL-PERLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDN-SIRTL 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  117 APETFQGLVKlhaLYLYKCGLSALPAGVFGGLHSLQylyLQDNHIEYLQDDIFVDLVNLS 176
Cdd:PRK15370 299 PAHLPSGITH---LNVQSNSLTALPETLPPGLKTLE---AGENALTSLPASLPPELQVLD 352
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 102-256 7.00e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 7.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 102 LEELDLGDN------RQLRtLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLH---SLQYLYLQDNHIEYLQDDIFVD- 171
Cdd:cd00116  53 LKELCLSLNetgripRGLQ-SLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKg 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 172 ----LVNLSHLFLHGNKLWSLG----PGTFRGLVNLDRLLLHENQL--QWVHH--KAFHDLRRLTTLFLFNNSLSELQG- 238
Cdd:cd00116 132 lkdlPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEGAs 211

                       170       180
                ....*....|....*....|.
gi 30425553 239 ---ECLAPLGALEFLRLNGNP 256
Cdd:cd00116 212 alaETLASLKSLEVLNLGDNN 232
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
150-256 7.03e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 7.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553 150 SLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENqlqwvhhKAFHDLRRLTTLFLF 229
Cdd:COG4886  49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLS 121

                        90       100
                ....*....|....*....|....*..
gi 30425553 230 NNSLSELqGECLAPLGALEFLRLNGNP 256
Cdd:COG4886 122 GNQLTDL-PEELANLTNLKELDLSNNQ 147
LRRCT smart00082
Leucine rich repeat C-terminal domain;
255-300 1.20e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 30425553    255 NPWDCGCRARSLWEWLQRFRGSSSAVP--CVSPGLRHGQDLKLLRAED 300
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSLRGPLLELLHSEF 48
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 80-118 2.05e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30425553    80 TLWIYSNNITYIhpSTFEGFVHLEELDLGDNRQLRTLAP 118
Cdd:pfam12799   5 VLDLSNNQITDI--PPLAKLPNLETLDLSGNNKITDLSD 41
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 150-187 3.13e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 3.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 30425553   150 SLQYLYLQDNHIEYLqdDIFVDLVNLSHLFLHGNKLWS 187
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKIT 37
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-255 4.26e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 4.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553   81 LWIYSNNIT-YIHPSTFeGFVHLEELDLGDNrQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDN 159
Cdd:PLN00113 265 LFLYQNKLSgPIPPSIF-SLQKLISLDLSDN-SLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425553  160 HieyLQDDIFVDL---VNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLS-E 235
Cdd:PLN00113 343 K---FSGEIPKNLgkhNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgE 419

                        170       180
                 ....*....|....*....|
gi 30425553  236 LQGEcLAPLGALEFLRLNGN 255
Cdd:PLN00113 420 LPSE-FTKLPLVYFLDISNN 438
LRR smart00370
Leucine-rich repeats, outliers;
172-195 9.60e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 9.60e-03
                           10        20
                   ....*....|....*....|....
gi 30425553    172 LVNLSHLFLHGNKLWSLGPGTFRG 195
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
172-195 9.60e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 9.60e-03
                           10        20
                   ....*....|....*....|....
gi 30425553    172 LVNLSHLFLHGNKLWSLGPGTFRG 195
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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