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Conserved domains on  [gi|28893139|ref|NP_796131|]
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GTP cyclohydrolase 1 feedback regulatory protein [Mus musculus]

Protein Classification

GFRP domain-containing protein( domain architecture ID 10533972)

GFRP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GFRP pfam06399
GTP cyclohydrolase I feedback regulatory protein (GFRP); Tetrahydrobiopterin, the cofactor ...
 2-84 1.02e-59

GTP cyclohydrolase I feedback regulatory protein (GFRP); Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP).


:

Pssm-ID: 461897  Cd Length: 83  Bit Score: 176.38  E-value: 1.02e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28893139    2 PYLLISTQIRMEVGPTMVGDEHSDPELMQHLGASKRSVLGNNFYEYYVNDPPRIVLDKLECKGFRVLSMTGVGQTLVWCL 81
Cdd:pfam06399  1 PYLLISTQIRLELGPTMVGDEHSDPALMKYLGAKLRKVLGNNFKEYHVDDPPRVVLNKLEKMGYRVVSMTGIGQTLVWTL 80


                 ...
gi 28893139   82 HKE 84
Cdd:pfam06399 81 HKE 83
 
Name Accession Description Interval E-value
GFRP pfam06399
GTP cyclohydrolase I feedback regulatory protein (GFRP); Tetrahydrobiopterin, the cofactor ...
 2-84 1.02e-59

GTP cyclohydrolase I feedback regulatory protein (GFRP); Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP).


Pssm-ID: 461897  Cd Length: 83  Bit Score: 176.38  E-value: 1.02e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28893139    2 PYLLISTQIRMEVGPTMVGDEHSDPELMQHLGASKRSVLGNNFYEYYVNDPPRIVLDKLECKGFRVLSMTGVGQTLVWCL 81
Cdd:pfam06399  1 PYLLISTQIRLELGPTMVGDEHSDPALMKYLGAKLRKVLGNNFKEYHVDDPPRVVLNKLEKMGYRVVSMTGIGQTLVWTL 80


                 ...
gi 28893139   82 HKE 84
Cdd:pfam06399 81 HKE 83
 
Name Accession Description Interval E-value
GFRP pfam06399
GTP cyclohydrolase I feedback regulatory protein (GFRP); Tetrahydrobiopterin, the cofactor ...
 2-84 1.02e-59

GTP cyclohydrolase I feedback regulatory protein (GFRP); Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP).


Pssm-ID: 461897  Cd Length: 83  Bit Score: 176.38  E-value: 1.02e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28893139    2 PYLLISTQIRMEVGPTMVGDEHSDPELMQHLGASKRSVLGNNFYEYYVNDPPRIVLDKLECKGFRVLSMTGVGQTLVWCL 81
Cdd:pfam06399  1 PYLLISTQIRLELGPTMVGDEHSDPALMKYLGAKLRKVLGNNFKEYHVDDPPRVVLNKLEKMGYRVVSMTGIGQTLVWTL 80


                 ...
gi 28893139   82 HKE 84
Cdd:pfam06399 81 HKE 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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