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Conserved domains on  [gi|29171318|ref|NP_780312|]
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bolA-like protein 2 [Mus musculus]

Protein Classification

BolA family protein( domain architecture ID 10484200)

BolA family protein may be a stress-responsive transcriptional regulator and may also participate in iron metabolism; similar to mammalian BolA-like proteins that act as iron-sulfur (Fe-S) cluster assembly factors that facilitate [2Fe-2S] cluster insertion into a subset of cytosolic proteins, and to Arabidopsis thaliana BOLA proteins that function as redox-regulated transcriptional regulators

CATH:  3.30.300.90
Gene Ontology:  GO:0051536|GO:0097428
SCOP:  4003220

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 12-79 3.95e-24

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


:

Pssm-ID: 460305  Cd Length: 75  Bit Score: 86.35  E-value: 3.95e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29171318   12 LRQDLEAEHVEVEDTTLN------RCATSFRVLVVSAKFEGKPLLQRHRLVNECLAEELPH-IHAFEQKTLTPEQ 79
Cdd:pfam01722  1 LTEALAPTHLEVEDESHKhaghagGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGgIHALSIKTYTPEE 75
 
Name Accession Description Interval E-value
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 12-79 3.95e-24

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 86.35  E-value: 3.95e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29171318   12 LRQDLEAEHVEVEDTTLN------RCATSFRVLVVSAKFEGKPLLQRHRLVNECLAEELPH-IHAFEQKTLTPEQ 79
Cdd:pfam01722  1 LTEALAPTHLEVEDESHKhaghagGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGgIHALSIKTYTPEE 75
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 5-83 4.96e-22

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 81.39  E-value: 4.96e-22
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171318  5 ADYLREKLRQDLEAEHVEVEDTTL-------NRCATSFRVLVVSAKFEGKPLLQRHRLVNECLAEELPH-IHAFEQKTLT 76
Cdd:COG0271  4 QERIEEKLTAALAPEHLEVIDESHlhaghagAGGESHFKVVIVSDAFAGKSRVARHRLVYAALADELAGgIHALAIHAYT 83


               ....*..
gi 29171318 77 PEQWTRQ 83
Cdd:COG0271 84 PEEWQAR 90
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 8-80 1.39e-08

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 47.47  E-value: 1.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171318    8 LREKLRQDLEAEHVEVEDTTL--NRCATS---FRVLVVSAKFEGKPLLQRHRLVNECLAEELPH-IHAFEQKTLTPEQW 80
Cdd:PRK11628   7 IEEKLRAAFQPVFLEVVDESYrhNVPAGSeshFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTtVHALALHTYTIKEW 85
 
Name Accession Description Interval E-value
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 12-79 3.95e-24

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 86.35  E-value: 3.95e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29171318   12 LRQDLEAEHVEVEDTTLN------RCATSFRVLVVSAKFEGKPLLQRHRLVNECLAEELPH-IHAFEQKTLTPEQ 79
Cdd:pfam01722  1 LTEALAPTHLEVEDESHKhaghagGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGgIHALSIKTYTPEE 75
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 5-83 4.96e-22

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 81.39  E-value: 4.96e-22
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171318  5 ADYLREKLRQDLEAEHVEVEDTTL-------NRCATSFRVLVVSAKFEGKPLLQRHRLVNECLAEELPH-IHAFEQKTLT 76
Cdd:COG0271  4 QERIEEKLTAALAPEHLEVIDESHlhaghagAGGESHFKVVIVSDAFAGKSRVARHRLVYAALADELAGgIHALAIHAYT 83


               ....*..
gi 29171318 77 PEQWTRQ 83
Cdd:COG0271 84 PEEWQAR 90
IbaG COG5007
Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];
3-84 3.81e-16

Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];


Pssm-ID: 444031  Cd Length: 81  Bit Score: 66.33  E-value: 3.81e-16
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171318  3 LSADYLREKLRQDLEAEHVEVEDTtlnrcATSFRVLVVSAKFEGKPLLQRHRLVNECLAEELP--HIHAFEQKTLTPEQW 80
Cdd:COG5007  1 MTPEEIKQLIEAGLPCAEVEVEGD-----GSHFEAIVVSDAFEGLSRVKRQQLVYAPLGDYIAsgEIHALSIKTYTPEEW 75


               ....
gi 29171318 81 TRQR 84
Cdd:COG5007 76 AAQR 79
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 8-80 1.39e-08

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 47.47  E-value: 1.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171318    8 LREKLRQDLEAEHVEVEDTTL--NRCATS---FRVLVVSAKFEGKPLLQRHRLVNECLAEELPH-IHAFEQKTLTPEQW 80
Cdd:PRK11628   7 IEEKLRAAFQPVFLEVVDESYrhNVPAGSeshFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTtVHALALHTYTIKEW 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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