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Conserved domains on  [gi|27734186|ref|NP_775564|]
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large neutral amino acids transporter small subunit 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FucP super family cl43255
Fucose permease [Carbohydrate transport and metabolism];
87-250 3.07e-05

Fucose permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0738:

Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.39  E-value: 3.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  87 ILNLAFTVGSFLLSaitLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASnpdslSVLIFIALALNGFG-GMCMTFTS 165
Cdd:COG0738  47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186 166 LTLPNMFGDLRSTFIALM---------IGSYASSAVTFPGIKLIYDAGASFIGILVVwagcsGLVFFNCFFNWPLEPFPG 236
Cdd:COG0738 119 PYVAALGPETAASRLNLLhaffslgalLGPLLGGLLILLGLSLSWHLPYLILAVLLL-----LLALLFLRSKLPEIEEEE 193

                       170
                ....*....|....
gi 27734186 237 PEDMDYSVKIKFSW 250
Cdd:COG0738 194 EEAAGSAASLKSLL 207
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
87-250 3.07e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.39  E-value: 3.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  87 ILNLAFTVGSFLLSaitLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASnpdslSVLIFIALALNGFG-GMCMTFTS 165
Cdd:COG0738  47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186 166 LTLPNMFGDLRSTFIALM---------IGSYASSAVTFPGIKLIYDAGASFIGILVVwagcsGLVFFNCFFNWPLEPFPG 236
Cdd:COG0738 119 PYVAALGPETAASRLNLLhaffslgalLGPLLGGLLILLGLSLSWHLPYLILAVLLL-----LLALLFLRSKLPEIEEEE 193

                       170
                ....*....|....
gi 27734186 237 PEDMDYSVKIKFSW 250
Cdd:COG0738 194 EEAAGSAASLKSLL 207
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 90-239 3.47e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.27  E-value: 3.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  90 LAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYgasnPDSLSVLIFIALALNGFGGMCMTFTSLTLP 169
Cdd:cd06174  35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF----APSFWLLLLGRFLLGLGSGLIDPAVLALIA 110

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27734186 170 NMFGDLRSTF---IALMIGSYASSAVTFPGIKLIYDAGASFIGILVVWAGCSGLVFFNCFFNWPLEPFPGPED 239
Cdd:cd06174 111 DLFPERERGRalgLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
MFS_1 pfam07690
Major Facilitator Superfamily;
88-227 9.62e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.72  E-value: 9.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186    88 LNLAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASNPDSLSVLIFIALALNGFGGMCMTFTSLT 167
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186   168 LPnmfGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGASFIGILVVWAGCSGLVFFNCFF 227
Cdd:pfam07690 114 FP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 94-183 2.44e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 40.44  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186    94 VGSFLLSAITlplGIIMDKYGPRKLRLLGSACFAVSCLLIAYGAsNPDSLSVLIFIALALNGFGGMC--MTFTSLTLPNM 171
Cdd:TIGR00711 302 LAPMLSSPIA---GRMGDKIDPRKLVTIGLILYAVGFYWRAFTF-TPDTPFLAIALPQFIRGFGMGCffMPLTTIALSGL 377

                          90
                  ....*....|..
gi 27734186   172 FGDLRSTFIALM 183
Cdd:TIGR00711 378 PPHKIARGSSLS 389
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
87-250 3.07e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.39  E-value: 3.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  87 ILNLAFTVGSFLLSaitLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASnpdslSVLIFIALALNGFG-GMCMTFTS 165
Cdd:COG0738  47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186 166 LTLPNMFGDLRSTFIALM---------IGSYASSAVTFPGIKLIYDAGASFIGILVVwagcsGLVFFNCFFNWPLEPFPG 236
Cdd:COG0738 119 PYVAALGPETAASRLNLLhaffslgalLGPLLGGLLILLGLSLSWHLPYLILAVLLL-----LLALLFLRSKLPEIEEEE 193

                       170
                ....*....|....
gi 27734186 237 PEDMDYSVKIKFSW 250
Cdd:COG0738 194 EEAAGSAASLKSLL 207
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 90-239 3.47e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.27  E-value: 3.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  90 LAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYgasnPDSLSVLIFIALALNGFGGMCMTFTSLTLP 169
Cdd:cd06174  35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF----APSFWLLLLGRFLLGLGSGLIDPAVLALIA 110

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27734186 170 NMFGDLRSTF---IALMIGSYASSAVTFPGIKLIYDAGASFIGILVVWAGCSGLVFFNCFFNWPLEPFPGPED 239
Cdd:cd06174 111 DLFPERERGRalgLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 90-195 5.11e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 45.72  E-value: 5.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  90 LAFTVGsFLLSAITLPL-GIIMDKYGPRKLRLLGSACFAVSCLLIAYgASNPDSLSVLIFIaLALNGFGGMCMTFTSLTL 168
Cdd:cd17355  42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLAL-ATSLWQLYLLWGL-LGGGGAGTLAAVAFATVA 118

                        90       100
                ....*....|....*....|....*..
gi 27734186 169 PNMFGDLRSTFIALMIGSYASSAVTFP 195
Cdd:cd17355 119 AWWFERRRGLALGILTAGGGLGSLVFL 145
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 98-167 5.19e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 45.64  E-value: 5.19e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27734186  98 LLSAITLPL-GIIMDKYGPRKLRLLGSACFAVSCLLIAYgaSNPDSLSVLIFIALALNGFgGMCMTFTSLT 167
Cdd:cd17503 225 LASAILSPLvGRLLDKFGPRLLLLAGLLLLALGTLLLAF--LTPDTSLWLIILPLFIRGL-GMGLVFMPLN 292
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
90-158 6.81e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.26  E-value: 6.81e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27734186  90 LAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGasnpDSLSVLIFIALALnGFGG 158
Cdd:COG2223  44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA----VSYWLLLLLGLLL-GIGG 107
MFS_1 pfam07690
Major Facilitator Superfamily;
88-227 9.62e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.72  E-value: 9.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186    88 LNLAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASNPDSLSVLIFIALALNGFGGMCMTFTSLT 167
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186   168 LPnmfGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGASFIGILVVWAGCSGLVFFNCFF 227
Cdd:pfam07690 114 FP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
91-231 1.04e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 1.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  91 AFTVGSFLLSaitLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYgASNPdslsVLIFIALALNGFG-GMCMTFTSLTLP 169
Cdd:COG2271  53 AFFLGYALGQ---IPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-ATSF----WQLLLLRFLLGLGeAGFFPAALKLIA 124

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27734186 170 NMF-GDLRSTFIAL-MIGSYASSAVTFPGIKLIYDA--------GASFIGILVVWAGCSGLVFFNCFFNWPL 231
Cdd:COG2271 125 EWFpPKERGRALGIfNAGGPLGGALAPPLLGWLLAAfgwraaflILGLPGLLLALLRFWLLALAYFLVYFAL 196
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 86-194 1.68e-04

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 44.16  E-value: 1.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  86 EILNLAFtVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASNPD-SLSV-LIFIALALNGFGGMCMTF 163
Cdd:cd17354  38 QQNNLLS-VAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVVTGLIsDLSFwLMCLCFFLIGNSTSSLYT 116

                        90       100       110
                ....*....|....*....|....*....|..
gi 27734186 164 TSLTLPN-MFGDLRSTFIALMIGSYASSAVTF 194
Cdd:cd17354 117 AALVTCAkNFPESRGLAIGIPKGCYGLSGAIG 148
MFS_1 pfam07690
Major Facilitator Superfamily;
90-195 8.58e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 8.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186    90 LAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASNPDSLSVLIFIALALNGFGGMCMTFTSLTLP 169
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318

                          90       100
                  ....*....|....*....|....*.
gi 27734186   170 NMFGDLRSTFIALMIGSYASSAVTFP 195
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 90-140 8.60e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.83  E-value: 8.60e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 27734186  90 LAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASNP 140
Cdd:cd17353  42 LAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLP 92
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
87-216 1.30e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 1.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  87 ILNLAFTVGSFLlsaITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYgaSNPDSLsVLIFIALALNGFGgmcMTFTSL 166
Cdd:COG2211 268 LLLALYFLAALL---GAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF--LGPGNL-WLLLVLAALAGIG---LGAILV 338

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 27734186 167 TLPNMFGDL----RSTFIALMIGSYAsSAVTFpGIKLIYDAGASFIGILVVWAG 216
Cdd:COG2211 339 LPWAMLADVvdydEWKTGRRREGLYF-GIFTF-AIKLGQALAGALAGLLLALFG 390
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 92-214 1.58e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.04  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  92 FTVGSFLLSAIT--LPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASnpdslSVLIFIALALNGFG------------ 157
Cdd:cd17489  35 LVVGLFTLAALLarPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS-----VALLLVLRLIHGIGwgafttaaatlv 109

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27734186 158 -----------GMCMTFTSLTLPNMFGdlrstfiaLMIGSYASSAVTFPGIkLIYDAGASFIGILVVW 214
Cdd:cd17489 110 adiippsrrgeGIGYYGLATTLAMALG--------PALGLFLYQHLGFAVL-FIVAAVLALLALLLVF 168
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 90-167 1.94e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.62  E-value: 1.94e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27734186  90 LAFTVGSFLLSAITlplGIIMDKYGPRKLRLLGSACFAVSCLLIAYgaSNPDSLSVLIFIALALNGFgGMCMTFTSLT 167
Cdd:cd17321 211 LPLALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLAL--LGADSSVWLLLPGLVLLGL-GLGLFATPLT 282
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
90-230 2.37e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 2.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  90 LAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGasnpDSLSVLIFIALALNGFGGMCMTFTSLTLP 169
Cdd:COG2814  49 LVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA----PSLWLLLAARFLQGLGAGALFPAALALIA 124

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27734186 170 NMF-GDLRSTFIALMIGSYASSAVTFPGIKLIYDAGASFIGILVVWAGCSGLVFFNCFFNWP 230
Cdd:COG2814 125 DLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLP 186
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 94-183 2.44e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 40.44  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186    94 VGSFLLSAITlplGIIMDKYGPRKLRLLGSACFAVSCLLIAYGAsNPDSLSVLIFIALALNGFGGMC--MTFTSLTLPNM 171
Cdd:TIGR00711 302 LAPMLSSPIA---GRMGDKIDPRKLVTIGLILYAVGFYWRAFTF-TPDTPFLAIALPQFIRGFGMGCffMPLTTIALSGL 377

                          90
                  ....*....|..
gi 27734186   172 FGDLRSTFIALM 183
Cdd:TIGR00711 378 PPHKIARGSSLS 389
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
90-187 4.73e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.57  E-value: 4.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  90 LAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASNPDSLSVLIFIALALNGFGGMCMTFTSLTLP 169
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                        90
                ....*....|....*...
gi 27734186 170 nmfGDLRSTFIALMIGSY 187
Cdd:COG2814 327 ---PEARGRASGLYNSAF 341
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 87-171 9.91e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 38.33  E-value: 9.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734186  87 ILNLAFTVGSFLLSAITlplGIIMDKYGPRKLRLLGSACFAVSCLLIAYgasNPDSLSVLIFIALALNGFGGMCMTftsl 166
Cdd:cd17504 221 LLLLPGALVMLIAGPLA---GRLIARVGPRRVLLIGLVISAVGLLLLAL---LHSSLWALVVALLLIGIGLGLAFA---- 290


                ....*
gi 27734186 167 TLPNM 171
Cdd:cd17504 291 SLPNI 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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