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Conserved domains on  [gi|41055590|ref|NP_766610|]
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KICSTOR subunit 2 isoform 1 [Mus musculus]

Protein Classification

DUF2003 domain-containing protein( domain architecture ID 10559425)

DUF2003 domain-containing protein similar to Homo sapiens KICSTOR complex protein C12orf66, part of the KICSTOR complex that functions in the amino acid-sensing branch of the TORC1 signaling pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C12orf66_like pfam09404
KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is ...
 10-444 0e+00

KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is part of the KICSTOR complex that functions in the amino acid-sensing branch of the TORC1 signaling pathway.


:

Pssm-ID: 401380  Cd Length: 440  Bit Score: 792.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590    10 PVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDS 89
Cdd:pfam09404   5 PVPQERAILETFFHALGQFAFDKAKDYVEKERDSRKSAGSIWVSLLAALAHLAAAEKIYHSLTFLGQKLGGQSFFSRKDS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590    90 IRTIYTSLHNELKKVVA-GRGAPGGTAPHVEELLPHLSEQLCFFVQARMEIADFYEKMYALSTQKFINTEELVSTLDTIL 168
Cdd:pfam09404  85 IRTIYTSLLNELKKVVEmGRVAPGGTAPVLEELLAHLSEQLCHFVQARMEIADFYEKMHSLGSQKVINYEELVITLDAIL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590   169 RKYSSRFHHPILSPLESSFQLEVGVLSHLLKAQAQISEWKFLPSLVTLHNAHTKLQSWGQTFEKQRETKKHLFGGQSQKA 248
Cdd:pfam09404 165 HKYSSRFHHPILSPLESSFQFEVDVLTHLLRAQAQMSEWKFLPSLLHLHGAHSKLTSWGQLFQRQKETRKHLFGGQSQKA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590   249 VQPPHLFLWLMKLKTMLLAKFSFYFHEALSRQTTASEMKALTAKANPDLFGKISSFIRKYDAANVSLIFDNRGSESFQGH 328
Cdd:pfam09404 245 VQPPHLYLWLQKLKAALLAKFSFYFHEALSRQTTPAEMKTLTARTSPDYFGKISSFIRKSDASNVSLVFDNRGSESFQGH 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590   329 GYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRASDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVVIF 408
Cdd:pfam09404 325 GYHHPQSYREAPKGVDQFPAVVSLPGERPLTHWPNVIMIMMDRAADLNTLEKVVHFYDDKVQSTYFLTRPEPHFTLVVIF 404

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 41055590   409 ESKKSERDSHFISFLNELSLALKNPKVFASLKPGSK 444
Cdd:pfam09404 405 ESKKSEKDSYITSFLQEIALSLRNSKVFASLKPGSK 440
 
Name Accession Description Interval E-value
C12orf66_like pfam09404
KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is ...
 10-444 0e+00

KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is part of the KICSTOR complex that functions in the amino acid-sensing branch of the TORC1 signaling pathway.


Pssm-ID: 401380  Cd Length: 440  Bit Score: 792.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590    10 PVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDS 89
Cdd:pfam09404   5 PVPQERAILETFFHALGQFAFDKAKDYVEKERDSRKSAGSIWVSLLAALAHLAAAEKIYHSLTFLGQKLGGQSFFSRKDS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590    90 IRTIYTSLHNELKKVVA-GRGAPGGTAPHVEELLPHLSEQLCFFVQARMEIADFYEKMYALSTQKFINTEELVSTLDTIL 168
Cdd:pfam09404  85 IRTIYTSLLNELKKVVEmGRVAPGGTAPVLEELLAHLSEQLCHFVQARMEIADFYEKMHSLGSQKVINYEELVITLDAIL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590   169 RKYSSRFHHPILSPLESSFQLEVGVLSHLLKAQAQISEWKFLPSLVTLHNAHTKLQSWGQTFEKQRETKKHLFGGQSQKA 248
Cdd:pfam09404 165 HKYSSRFHHPILSPLESSFQFEVDVLTHLLRAQAQMSEWKFLPSLLHLHGAHSKLTSWGQLFQRQKETRKHLFGGQSQKA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590   249 VQPPHLFLWLMKLKTMLLAKFSFYFHEALSRQTTASEMKALTAKANPDLFGKISSFIRKYDAANVSLIFDNRGSESFQGH 328
Cdd:pfam09404 245 VQPPHLYLWLQKLKAALLAKFSFYFHEALSRQTTPAEMKTLTARTSPDYFGKISSFIRKSDASNVSLVFDNRGSESFQGH 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590   329 GYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRASDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVVIF 408
Cdd:pfam09404 325 GYHHPQSYREAPKGVDQFPAVVSLPGERPLTHWPNVIMIMMDRAADLNTLEKVVHFYDDKVQSTYFLTRPEPHFTLVVIF 404

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 41055590   409 ESKKSERDSHFISFLNELSLALKNPKVFASLKPGSK 444
Cdd:pfam09404 405 ESKKSEKDSYITSFLQEIALSLRNSKVFASLKPGSK 440
 
Name Accession Description Interval E-value
C12orf66_like pfam09404
KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is ...
 10-444 0e+00

KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is part of the KICSTOR complex that functions in the amino acid-sensing branch of the TORC1 signaling pathway.


Pssm-ID: 401380  Cd Length: 440  Bit Score: 792.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590    10 PVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDS 89
Cdd:pfam09404   5 PVPQERAILETFFHALGQFAFDKAKDYVEKERDSRKSAGSIWVSLLAALAHLAAAEKIYHSLTFLGQKLGGQSFFSRKDS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590    90 IRTIYTSLHNELKKVVA-GRGAPGGTAPHVEELLPHLSEQLCFFVQARMEIADFYEKMYALSTQKFINTEELVSTLDTIL 168
Cdd:pfam09404  85 IRTIYTSLLNELKKVVEmGRVAPGGTAPVLEELLAHLSEQLCHFVQARMEIADFYEKMHSLGSQKVINYEELVITLDAIL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590   169 RKYSSRFHHPILSPLESSFQLEVGVLSHLLKAQAQISEWKFLPSLVTLHNAHTKLQSWGQTFEKQRETKKHLFGGQSQKA 248
Cdd:pfam09404 165 HKYSSRFHHPILSPLESSFQFEVDVLTHLLRAQAQMSEWKFLPSLLHLHGAHSKLTSWGQLFQRQKETRKHLFGGQSQKA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590   249 VQPPHLFLWLMKLKTMLLAKFSFYFHEALSRQTTASEMKALTAKANPDLFGKISSFIRKYDAANVSLIFDNRGSESFQGH 328
Cdd:pfam09404 245 VQPPHLYLWLQKLKAALLAKFSFYFHEALSRQTTPAEMKTLTARTSPDYFGKISSFIRKSDASNVSLVFDNRGSESFQGH 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055590   329 GYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRASDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVVIF 408
Cdd:pfam09404 325 GYHHPQSYREAPKGVDQFPAVVSLPGERPLTHWPNVIMIMMDRAADLNTLEKVVHFYDDKVQSTYFLTRPEPHFTLVVIF 404

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 41055590   409 ESKKSERDSHFISFLNELSLALKNPKVFASLKPGSK 444
Cdd:pfam09404 405 ESKKSEKDSYITSFLQEIALSLRNSKVFASLKPGSK 440
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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