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Conserved domains on  [gi|170014712|ref|NP_766018|]
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A-kinase anchor protein SPHKAP isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKAP_110 super family cl14906
A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein ...
 1556-1655 6.35e-07

A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


The actual alignment was detected with superfamily member pfam05716:

Pssm-ID: 449376  Cd Length: 692  Bit Score: 54.16  E-value: 6.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170014712  1556 PGRAASPQrsLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQESRIEKFLDVVKLVQQKSWKVGDIFHAVVQ 1635
Cdd:pfam05716  588 PEGCAAPK--VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGRSVGEVLQSVLR 665

                           90       100       110
                   ....*....|....*....|....*....|
gi 170014712  1636 YcklhaeQKER---------TP-SLFDWLL 1655
Cdd:pfam05716  666 Y------EKERqldeavgnvTRlQLLDWLM 689
 
Name Accession Description Interval E-value
AKAP_110 pfam05716
A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein ...
 1556-1655 6.35e-07

A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 428603  Cd Length: 692  Bit Score: 54.16  E-value: 6.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170014712  1556 PGRAASPQrsLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQESRIEKFLDVVKLVQQKSWKVGDIFHAVVQ 1635
Cdd:pfam05716  588 PEGCAAPK--VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGRSVGEVLQSVLR 665

                           90       100       110
                   ....*....|....*....|....*....|
gi 170014712  1636 YcklhaeQKER---------TP-SLFDWLL 1655
Cdd:pfam05716  666 Y------EKERqldeavgnvTRlQLLDWLM 689
AKAP_110 smart00807
A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A ...
 1540-1655 1.42e-06

A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 214827  Cd Length: 851  Bit Score: 53.10  E-value: 1.42e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170014712   1540 ILKEQSESIKEHASGLPGRA--ASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQESRIEKFLDVVK 1617
Cdd:smart00807  727 VLQNAYQAIHNELRGLSGQPpeGCLGPEVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSA 806

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 170014712   1618 LVQQKSWKVGDIFHAVVQYcklhaeQKERTP----------SLFDWLL 1655
Cdd:smart00807  807 KAVEKGYSVGEVLQSVLRY------EKERQLdeavgnvtrlQLLDWLM 848
 
Name Accession Description Interval E-value
AKAP_110 pfam05716
A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein ...
 1556-1655 6.35e-07

A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 428603  Cd Length: 692  Bit Score: 54.16  E-value: 6.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170014712  1556 PGRAASPQrsLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQESRIEKFLDVVKLVQQKSWKVGDIFHAVVQ 1635
Cdd:pfam05716  588 PEGCAAPK--VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGRSVGEVLQSVLR 665

                           90       100       110
                   ....*....|....*....|....*....|
gi 170014712  1636 YcklhaeQKER---------TP-SLFDWLL 1655
Cdd:pfam05716  666 Y------EKERqldeavgnvTRlQLLDWLM 689
AKAP_110 smart00807
A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A ...
 1540-1655 1.42e-06

A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 214827  Cd Length: 851  Bit Score: 53.10  E-value: 1.42e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170014712   1540 ILKEQSESIKEHASGLPGRA--ASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQESRIEKFLDVVK 1617
Cdd:smart00807  727 VLQNAYQAIHNELRGLSGQPpeGCLGPEVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSA 806

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 170014712   1618 LVQQKSWKVGDIFHAVVQYcklhaeQKERTP----------SLFDWLL 1655
Cdd:smart00807  807 KAVEKGYSVGEVLQSVLRY------EKERQLdeavgnvtrlQLLDWLM 848
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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