NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27437045|ref|NP_758519|]
View 

granulocyte colony-stimulating factor receptor isoform d precursor [Homo sapiens]

Protein Classification

Lep_receptor_Ig and FN3 domain-containing protein( domain architecture ID 11162505)

Lep_receptor_Ig and FN3 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 24-110 3.19e-36

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 131.21  E-value: 3.19e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045    24 EECGHISVSAPIVHLGDPITASCIIKQN-CSHLDPEPQ-ILWRLGAELQPGGRQQRLSDGTqeSIITLPHLNHTQAFLSC 101
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENcCSHLGVEAQiIVWKLGLELIPGSQYTVLNDTV--SSVTLPNLNSTRALLTC 78


                  ....*....
gi 27437045   102 CLNWGNSLQ 110
Cdd:pfam06328  79 CLLWGGQLQ 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 527-607 2.94e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 2.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045    527 PSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 27437045    607 G 607
Cdd:smart00060  81 G 81
fn3 pfam00041
Fibronectin type III domain;
430-514 5.00e-06

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045   430 PALTRLHAMARDPHSLWVGWEPPNPWP---QGYVIEWglgppSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTP 506
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEY-----RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 27437045   507 LYQDTMGP 514
Cdd:pfam00041  76 VNGGGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 249-329 1.00e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 1.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 249 LQLCWEPWQPGLHINQKCELRHKPQrGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRwplPGHWSDWSPSLELR 328
Cdd:cd00063  17 VTLSWTPPEDDGGPITGYVVEYREK-GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN---GGGESPPSESVTVT 92


                .
gi 27437045 329 T 329
Cdd:cd00063  93 T 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 345-423 2.83e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 2.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 345 RQLDPRTVQLFWKPVPleEDSGRIQGYVVSWRPSGQAGAI-LPLCNTTELSCTFH--LPSEAQEVALVAYNSAGTSRPTP 421
Cdd:cd00063  10 TDVTSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKeVEVTPGSETSYTLTglKPGTEYEFRVRAVNGGGESPPSE 87


                ..
gi 27437045 422 VV 423
Cdd:cd00063  88 SV 89
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 24-110 3.19e-36

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 131.21  E-value: 3.19e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045    24 EECGHISVSAPIVHLGDPITASCIIKQN-CSHLDPEPQ-ILWRLGAELQPGGRQQRLSDGTqeSIITLPHLNHTQAFLSC 101
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENcCSHLGVEAQiIVWKLGLELIPGSQYTVLNDTV--SSVTLPNLNSTRALLTC 78


                  ....*....
gi 27437045   102 CLNWGNSLQ 110
Cdd:pfam06328  79 CLLWGGQLQ 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 527-607 2.94e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 2.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045    527 PSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 27437045    607 G 607
Cdd:smart00060  81 G 81
fn3 pfam00041
Fibronectin type III domain;
530-607 6.45e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 6.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045   530 APE-LHLKHIGKTWAQLEWvpEPPELGKSPLTHYTIFW--TNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:pfam00041   2 APSnLTVTDVTSTSLTVSW--TPPPDGNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  .
gi 27437045   607 G 607
Cdd:pfam00041  80 G 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 527-607 2.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 2.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 527 PSHAPELHLKHIGKTWAQLEWvpEPPELGKSPLTHYTIFWTNAQNQSFSAILN--ASSRGFVLHGLEPASLYHIHLMAAS 604
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSW--TPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVN 78


                ...
gi 27437045 605 QAG 607
Cdd:cd00063  79 GGG 81
fn3 pfam00041
Fibronectin type III domain;
430-514 5.00e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045   430 PALTRLHAMARDPHSLWVGWEPPNPWP---QGYVIEWglgppSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTP 506
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEY-----RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 27437045   507 LYQDTMGP 514
Cdd:pfam00041  76 VNGGGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 249-329 1.00e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 1.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 249 LQLCWEPWQPGLHINQKCELRHKPQrGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRwplPGHWSDWSPSLELR 328
Cdd:cd00063  17 VTLSWTPPEDDGGPITGYVVEYREK-GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN---GGGESPPSESVTVT 92


                .
gi 27437045 329 T 329
Cdd:cd00063  93 T 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 345-423 2.83e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 2.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 345 RQLDPRTVQLFWKPVPleEDSGRIQGYVVSWRPSGQAGAI-LPLCNTTELSCTFH--LPSEAQEVALVAYNSAGTSRPTP 421
Cdd:cd00063  10 TDVTSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKeVEVTPGSETSYTLTglKPGTEYEFRVRAVNGGGESPPSE 87


                ..
gi 27437045 422 VV 423
Cdd:cd00063  88 SV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 345-417 3.70e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.21  E-value: 3.70e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27437045    345 RQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPlCNTTELSCTFH--LPSEAQEVALVAYNSAGTS 417
Cdd:smart00060  10 TDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVN-VTPSSTSYTLTglKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 430-514 4.40e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 4.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 430 PALTRLHAMARDPHSLWVGWEPPNPWP---QGYVIEWGlgppsaSNSNKTWRM--EQNGRATGFLLKeNIRPFQLYEIIV 504
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYR------EKGSGDWKEveVTPGSETSYTLT-GLKPGTEYEFRV 74

                        90
                ....*....|
gi 27437045 505 TPLYQDTMGP 514
Cdd:cd00063  75 RAVNGGGESP 84
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 24-110 3.19e-36

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 131.21  E-value: 3.19e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045    24 EECGHISVSAPIVHLGDPITASCIIKQN-CSHLDPEPQ-ILWRLGAELQPGGRQQRLSDGTqeSIITLPHLNHTQAFLSC 101
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENcCSHLGVEAQiIVWKLGLELIPGSQYTVLNDTV--SSVTLPNLNSTRALLTC 78


                  ....*....
gi 27437045   102 CLNWGNSLQ 110
Cdd:pfam06328  79 CLLWGGQLQ 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 527-607 2.94e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 2.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045    527 PSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 27437045    607 G 607
Cdd:smart00060  81 G 81
fn3 pfam00041
Fibronectin type III domain;
530-607 6.45e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 6.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045   530 APE-LHLKHIGKTWAQLEWvpEPPELGKSPLTHYTIFW--TNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:pfam00041   2 APSnLTVTDVTSTSLTVSW--TPPPDGNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  .
gi 27437045   607 G 607
Cdd:pfam00041  80 G 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 527-607 2.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 2.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 527 PSHAPELHLKHIGKTWAQLEWvpEPPELGKSPLTHYTIFWTNAQNQSFSAILN--ASSRGFVLHGLEPASLYHIHLMAAS 604
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSW--TPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVN 78


                ...
gi 27437045 605 QAG 607
Cdd:cd00063  79 GGG 81
fn3 pfam00041
Fibronectin type III domain;
430-514 5.00e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045   430 PALTRLHAMARDPHSLWVGWEPPNPWP---QGYVIEWglgppSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTP 506
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEY-----RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 27437045   507 LYQDTMGP 514
Cdd:pfam00041  76 VNGGGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 249-329 1.00e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 1.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 249 LQLCWEPWQPGLHINQKCELRHKPQrGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRwplPGHWSDWSPSLELR 328
Cdd:cd00063  17 VTLSWTPPEDDGGPITGYVVEYREK-GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN---GGGESPPSESVTVT 92


                .
gi 27437045 329 T 329
Cdd:cd00063  93 T 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 345-423 2.83e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 2.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 345 RQLDPRTVQLFWKPVPleEDSGRIQGYVVSWRPSGQAGAI-LPLCNTTELSCTFH--LPSEAQEVALVAYNSAGTSRPTP 421
Cdd:cd00063  10 TDVTSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKeVEVTPGSETSYTLTglKPGTEYEFRVRAVNGGGESPPSE 87


                ..
gi 27437045 422 VV 423
Cdd:cd00063  88 SV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 345-417 3.70e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.21  E-value: 3.70e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27437045    345 RQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPlCNTTELSCTFH--LPSEAQEVALVAYNSAGTS 417
Cdd:smart00060  10 TDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVN-VTPSSTSYTLTglKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 430-514 4.40e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 4.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27437045 430 PALTRLHAMARDPHSLWVGWEPPNPWP---QGYVIEWGlgppsaSNSNKTWRM--EQNGRATGFLLKeNIRPFQLYEIIV 504
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYR------EKGSGDWKEveVTPGSETSYTLT-GLKPGTEYEFRV 74

                        90
                ....*....|
gi 27437045 505 TPLYQDTMGP 514
Cdd:cd00063  75 RAVNGGGESP 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH