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Conserved domains on  [gi|124517672|ref|NP_663756|]
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oocyte-specific homeobox protein 6 [Mus musculus]

Protein Classification

homeodomain domain-containing protein( domain architecture ID 13432595)

homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
146-202 3.77e-20

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 82.55  E-value: 3.77e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 124517672  146 RKIRTVYTEEQKCVLKKHFHKCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSKR 202
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
86-204 1.37e-12

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 64.77  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517672  86 QPGLVMDPaLPILRSLLMHSPHQIPSRSSVRAGFQGSLGPMVRSPSYGDRrvslvtPRKHRKIRTvyTEEQKCVLKKHFH 165
Cdd:COG5576    1 SPVQPMQP-LSALESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDGSS------PPKSKRRRT--TDEQLMVLEREFE 71

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 124517672 166 KCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSKRES 204
Cdd:COG5576   72 INPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 2-139 3.83e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.02  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517672    2 LQYNQ-SPHMPQDPSLhSKFQMSSSAPieisfQMHQepaRNLPFQMCQSPLVIPRSPMQSSHSVPERDLCPQ-----ESQ 75
Cdd:TIGR01628 373 DQFMQlQPRMRQLPMG-SPMGGAMGQP-----PYYG---QGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNglapmNAV 443

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124517672   76 GPSGKSSIQMQPGLVMDP--ALPILRSLLMHSPHQIPSRSSVRAGFQGSLGPMVRSPSYGDRRVSL 139
Cdd:TIGR01628 444 RAPSRNAQNAAQKPPMQPvmYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQVL 509
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
146-202 3.77e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 82.55  E-value: 3.77e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 124517672  146 RKIRTVYTEEQKCVLKKHFHKCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSKR 202
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 146-204 5.40e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 82.29  E-value: 5.40e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124517672 146 RKIRTVYTEEQKCVLKKHFHKCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSKRES 204
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 146-201 1.56e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 78.06  E-value: 1.56e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 124517672   146 RKIRTVYTEEQKCVLKKHFHKCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSK 201
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
86-204 1.37e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 64.77  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517672  86 QPGLVMDPaLPILRSLLMHSPHQIPSRSSVRAGFQGSLGPMVRSPSYGDRrvslvtPRKHRKIRTvyTEEQKCVLKKHFH 165
Cdd:COG5576    1 SPVQPMQP-LSALESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDGSS------PPKSKRRRT--TDEQLMVLEREFE 71

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 124517672 166 KCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSKRES 204
Cdd:COG5576   72 INPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 2-139 3.83e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.02  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517672    2 LQYNQ-SPHMPQDPSLhSKFQMSSSAPieisfQMHQepaRNLPFQMCQSPLVIPRSPMQSSHSVPERDLCPQ-----ESQ 75
Cdd:TIGR01628 373 DQFMQlQPRMRQLPMG-SPMGGAMGQP-----PYYG---QGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNglapmNAV 443

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124517672   76 GPSGKSSIQMQPGLVMDP--ALPILRSLLMHSPHQIPSRSSVRAGFQGSLGPMVRSPSYGDRRVSL 139
Cdd:TIGR01628 444 RAPSRNAQNAAQKPPMQPvmYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQVL 509
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
146-202 3.77e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 82.55  E-value: 3.77e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 124517672  146 RKIRTVYTEEQKCVLKKHFHKCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSKR 202
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 146-204 5.40e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 82.29  E-value: 5.40e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124517672 146 RKIRTVYTEEQKCVLKKHFHKCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSKRES 204
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 146-201 1.56e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 78.06  E-value: 1.56e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 124517672   146 RKIRTVYTEEQKCVLKKHFHKCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSK 201
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
86-204 1.37e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 64.77  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517672  86 QPGLVMDPaLPILRSLLMHSPHQIPSRSSVRAGFQGSLGPMVRSPSYGDRrvslvtPRKHRKIRTvyTEEQKCVLKKHFH 165
Cdd:COG5576    1 SPVQPMQP-LSALESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDGSS------PPKSKRRRT--TDEQLMVLEREFE 71

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 124517672 166 KCTYPSREQRMALAVLVGVTANEIQIWFKNHRAKSKRES 204
Cdd:COG5576   72 INPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 160-197 3.58e-03

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 34.80  E-value: 3.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 124517672  160 LKKHFHkCTYPSREQRMALAVLVGVTANEIQIWFKNHR 197
Cdd:pfam05920   1 LYEHLH-NPYPSEEEKAELAKETGLSRKQISNWFINAR 37
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 2-139 3.83e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.02  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517672    2 LQYNQ-SPHMPQDPSLhSKFQMSSSAPieisfQMHQepaRNLPFQMCQSPLVIPRSPMQSSHSVPERDLCPQ-----ESQ 75
Cdd:TIGR01628 373 DQFMQlQPRMRQLPMG-SPMGGAMGQP-----PYYG---QGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNglapmNAV 443

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124517672   76 GPSGKSSIQMQPGLVMDP--ALPILRSLLMHSPHQIPSRSSVRAGFQGSLGPMVRSPSYGDRRVSL 139
Cdd:TIGR01628 444 RAPSRNAQNAAQKPPMQPvmYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQVL 509
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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