|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
44-340 |
2.17e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 118.86 E-value: 2.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 44 RFLNVAFDGTGDCLIAGDHQGNIYVFDL-HGNRFNLVQRTAQACTALAFNLRRKSeFLVALADYSIKCFDTVTKELVSWM 122
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGKLLRTL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 123 RGHESSVFSISVHASGKYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLF 201
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDgTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 202 CKYQLPAPPES-SSIlykvfAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTkvRAIRHLEFLPDSfdagsnQVLG 280
Cdd:COG2319 238 LLRTLTGHSGSvRSV-----AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDG------KLLA 304
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 281 VLSQDGIMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYIASIMENGSLNIYSVQALTQ 340
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
39-334 |
1.88e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 110.50 E-value: 1.88e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 39 HPKVLRFlnVAFDGTGDCLIAGDHQGNIYVFDLHGNRFNLVQR----TAQACTALAFNLRrkseFLVALADYSIKCFDTV 114
Cdd:cd00200 8 HTGGVTC--VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgPVRDVAASADGTY----LASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 115 TKELVSWMRGHESSVFSISVHASGKYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIF 193
Cdd:cd00200 82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDkTIKVWDVETGKCLTTLRGHTD-WVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 194 AWECDTLFCKYQLPAPPESssilykVFAVT--RDGRILAAGGKSNHLHLWCLEARQLFRiiQMPTKVRAIRHLEFLPDsf 271
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGE------VNSVAfsPDGEKLLSSSSDGTIKLWDLSTGKCLG--TLRGHENGVNSVAFSPD-- 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223005859 272 dagsNQVLGVLSQDGIMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYIASIMENGSLNIYS 334
Cdd:cd00200 231 ----GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
684-962 |
1.96e-11 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 68.23 E-value: 1.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 684 IVDYQTQERERIRNDELDYL---RERQTVEDMQAKVDQQRVEDEAwyqkqELLRKAEETRREMLLQEEEKMIQQRQR--- 757
Cdd:pfam17380 277 IVQHQKAVSERQQQEKFEKMeqeRLRQEKEEKAREVERRRKLEEA-----EKARQAEMDRQAAIYAEQERMAMERERele 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 758 ---LAAVKREL---KVKEMHLQDAARRRFLKLQQD--------QQEMELRR----LDDEIGRKVYMRDREIAAT------ 813
Cdd:pfam17380 352 rirQEERKRELeriRQEEIAMEISRMRELERLQMErqqknervRQELEAARkvkiLEEERQRKIQQQKVEMEQIraeqee 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 814 ARDLEMRQLELESQK---RLYEKNLtENQEALAKEMRADADAYRRKVDLE-EHMFHKLIEagetqsQKTQKVIKENLAKA 889
Cdd:pfam17380 432 ARQREVRRLEEERARemeRVRLEEQ-ERQQQVERLRQQEEERKRKKLELEkEKRDRKRAE------EQRRKILEKELEER 504
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223005859 890 EQACLNTDWQIQSLHKQKcDDLQRNKCYQEVAKLLRENRRKEIEIinamveEEAKKWKEAEGKEFRLRSAKKA 962
Cdd:pfam17380 505 KQAMIEEERKRKLLEKEM-EERQKAIYEEERRREAEEERRKQQEM------EERRRIQEQMRKATEERSRLEA 570
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
696-1000 |
7.42e-11 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 66.70 E-value: 7.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 696 RNDELDYLRERQTVEDMQAKVDQQRVEDEawyQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKEMHLQDA 775
Cdd:PTZ00121 1183 KAEEVRKAEELRKAEDARKAEAARKAEEE---RKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEE 1259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 776 ARRRFLKLQQDQQEMELRRLDDEIGRKVYMRDREIAATARdlEMRQLElESQKRLYEKNLTENQEALAKEMRADADAYRR 855
Cdd:PTZ00121 1260 ARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE--EKKKAD-EAKKKAEEAKKADEAKKKAEEAKKKADAAKK 1336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 856 KVDLEEhmfhKLIEAGETQSQKTQKVIKENLAKAEQACLNTdwqiqSLHKQKCDDLQRN----KCYQEVAKLLRENRRKE 931
Cdd:PTZ00121 1337 KAEEAK----KAAEAAKAEAEAAADEAEAAEEKAEAAEKKK-----EEAKKKADAAKKKaeekKKADEAKKKAEEDKKKA 1407
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223005859 932 IEIINAmvEEEAKKWKEAEGKEFRLRSAKKASALSDASRKwflKQEINAAVEH---AENPCHKEEPRFQNEQ 1000
Cdd:PTZ00121 1408 DELKKA--AAAKKKADEAKKKAEEKKKADEAKKKAEEAKK---ADEAKKKAEEakkAEEAKKKAEEAKKADE 1474
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
690-948 |
1.69e-09 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 62.38 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 690 QERERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELK-VK 768
Cdd:TIGR02168 723 ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKaLR 802
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 769 EMH--LQDAA---RRRFLKLQQDQQEMELRRldDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYEK---------N 834
Cdd:TIGR02168 803 EALdeLRAELtllNEEAANLRERLESLERRI--AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEEleseleallN 880
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 835 LTENQEALAKEMRADADAYRRKVDLEEHMFHKLI-EAGETQSQKTQkvIKENLAKAEQACLNTDWQIQSLH--------- 904
Cdd:TIGR02168 881 ERASLEEALALLRSELEELSEELRELESKRSELRrELEELREKLAQ--LELRLEGLEVRIDNLQERLSEEYsltleeaea 958
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 223005859 905 KQKCDDLQRNKCYQEVAKLlrENRRKEIEIINAMVEEEAKKWKE 948
Cdd:TIGR02168 959 LENKIEDDEEEARRRLKRL--ENKIKELGPVNLAAIEEYEELKE 1000
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
688-892 |
6.06e-09 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 60.34 E-value: 6.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 688 QTQERERIRNDELDYL-----RERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVK 762
Cdd:COG1196 285 EAQAEEYELLAELARLeqdiaRLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 763 RELKVKEMHLQDAARRRfLKLQQDQQEMELRRLDDEIgrkvymRDREIAATARDLEMRQLELESQKRLYEKNLTENQEAL 842
Cdd:COG1196 365 EALLEAEAELAEAEEEL-EELAEELLEALRAAAELAA------QLEELEEAEEALLERLERLEEELEELEEALAELEEEE 437
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 223005859 843 AKEMRADADAYRRKVDLEEhmfhkLIEAGETQSQKTQKVIKENLAKAEQA 892
Cdd:COG1196 438 EEEEEALEEAAEEEAELEE-----EEEALLELLAELLEEAALLEAALAEL 482
|
|
| RabGAP-TBC |
pfam00566 |
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ... |
462-605 |
1.18e-08 |
|
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Pssm-ID: 459855 Cd Length: 178 Bit Score: 55.72 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 462 LQKKYPIKSRKLLRVLQRTLSALAHWsviFSDTPY---LPLLAFPFVkLFQNNQLICFEVIATLIINwcQHWFEYFPN-- 536
Cdd:pfam00566 20 FPHSFFFDNGPGQNSLRRILKAYSIY---NPDVGYcqgMNFIAAPLL-LVYLDEEDAFWCFVSLLEN--YLLRDFYTPdf 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 537 PPINILSMI-ENVLAFHDKELLQHFIDHDITSQLYAWPLLETVFSEVLTREEWLKLFDNIFSNHPSFLLM 605
Cdd:pfam00566 94 PGLKRDLYVfEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVLF 163
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
115-153 |
8.44e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.76 E-value: 8.44e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 223005859 115 TKELVSWMRGHESSVFSISVHASGKYAITTSSD-TAQLWD 153
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLWD 40
|
|
| TBC |
smart00164 |
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ... |
501-609 |
8.61e-05 |
|
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.
Pssm-ID: 214540 [Multi-domain] Cd Length: 216 Bit Score: 44.99 E-value: 8.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 501 AFP-FVKLFQNNQLIcFEVIATLIINWCQHWFEYFpnppinilsmienvLAFHDKELLQHFIDHDITSQLYAWPLLETVF 579
Cdd:smart00164 112 AFWcLVKLMERYGPN-FYLPDMSGLQLDLLQLDRL--------------VKEYDPDLYKHLKDLGITPSLYALRWFLTLF 176
|
90 100 110
....*....|....*....|....*....|
gi 223005859 580 SEVLTREEWLKLFDNIFSNHPSFLLMTVVA 609
Cdd:smart00164 177 ARELPLEIVLRIWDVLFAEGSDFLFRVALA 206
|
|
| growth_prot_Scy |
NF041483 |
polarized growth protein Scy; |
703-964 |
2.12e-04 |
|
polarized growth protein Scy;
Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 45.59 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 703 LRERQTVEDmQAKVDQQRVEDEAWYQKQELLRK-AEETRRemlLQEE--EKMIQQRQRLaavKREL----KVKEMHL-QD 774
Cdd:NF041483 78 LRNAQIQAD-QLRADAERELRDARAQTQRILQEhAEHQAR---LQAElhTEAVQRRQQL---DQELaerrQTVESHVnEN 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 775 AARRRFLKLQQDQQEmelRRLDDEiGRKvymrDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEMRADADAYR 854
Cdd:NF041483 151 VAWAEQLRARTESQA---RRLLDE-SRA----EAEQALAAARAEAERLAEEARQRLGSEAESARAEAEAILRRARKDAER 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 855 rkvdleehmfhkLIEAGETQSQktqkvikENLAKAEQacLNTDWQIQSLH-KQKCDDLQR--NKCYQEVAKLLRENRRKE 931
Cdd:NF041483 223 ------------LLNAASTQAQ-------EATDHAEQ--LRSSTAAESDQaRRQAAELSRaaEQRMQEAEEALREARAEA 281
|
250 260 270
....*....|....*....|....*....|....
gi 223005859 932 IEIINAMVEEEAKKWKEAEG-KEFRLRSAKKASA 964
Cdd:NF041483 282 EKVVAEAKEAAAKQLASAESaNEQRTRTAKEEIA 315
|
|
| growth_prot_Scy |
NF041483 |
polarized growth protein Scy; |
690-1060 |
1.13e-03 |
|
polarized growth protein Scy;
Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 43.28 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 690 QERERIRNDELDYLRE-RQTVEDMQAkvDQQRVEDEAWYQKQELLRKAEETRREML-----LQEeekmiQQRQRLAAvkr 763
Cdd:NF041483 728 QERERAREQSEELLASaRKRVEEAQA--EAQRLVEEADRRATELVSAAEQTAQQVRdsvagLQE-----QAEEEIAG--- 797
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 764 eLKVKEMHLQDAARRrflklqQDQQEMELRRLDDEIGRKvymRDREIAATARdlEMRQLELESQKRLYEKNLTEnQEALA 843
Cdd:NF041483 798 -LRSAAEHAAERTRT------EAQEEADRVRSDAYAERE---RASEDANRLR--REAQEETEAAKALAERTVSE-AIAEA 864
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 844 KEMRADADAYRRKVDLEEhmfHKLIEAGETQSQKTQKVIKE--NLAKAEQAClntdwQIQSLHKQKCDDLQRNKCY-QEV 920
Cdd:NF041483 865 ERLRSDASEYAQRVRTEA---SDTLASAEQDAARTRADAREdaNRIRSDAAA-----QADRLIGEATSEAERLTAEaRAE 936
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 921 AKLLRENRRKEIEIINAMVEEEAKKW-KEAEGKEFRLRsAKKASAlsdasrkwflkqeINAAVEHAENpCHKEEPRFQNE 999
Cdd:NF041483 937 AERLRDEARAEAERVRADAAAQAEQLiAEATGEAERLR-AEAAET-------------VGSAQQHAER-IRTEAERVKAE 1001
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223005859 1000 QDSSCLPRTSQLNDSSE--MDPSTQISLNRRA----------VEWDTTGQNLIKKVRNLRQRLTARARHRCQT 1060
Cdd:NF041483 1002 AAAEAERLRTEAREEADrtLDEARKDANKRRSeaaeqadtliTEAAAEADQLTAKAQEEALRTTTEAEAQADT 1074
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
116-153 |
1.50e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.32 E-value: 1.50e-03
10 20 30
....*....|....*....|....*....|....*....
gi 223005859 116 KELVSWMRGHESSVFSISVHASGKYAITTSSD-TAQLWD 153
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDgTVKVWD 39
|
|
| COG5210 |
COG5210 |
GTPase-activating protein [General function prediction only]; |
542-658 |
3.71e-03 |
|
GTPase-activating protein [General function prediction only];
Pssm-ID: 227535 [Multi-domain] Cd Length: 496 Bit Score: 40.94 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 542 LSMIENVLAFHDKELLQHFIDHDITSQLYAWPLLETVFSEVLTREEWLKLFDNIFSNHPSFLLMTVVAYNICSRTPLLSC 621
Cdd:COG5210 350 LKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAILKLLRDKLLKL 429
|
90 100 110
....*....|....*....|....*....|....*..
gi 223005859 622 NLKDDFEFFFHHRNNLDINVVIRQVYHLMETTPTDIH 658
Cdd:COG5210 430 DSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDIL 466
|
|
| GBP_C |
cd16269 |
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ... |
686-848 |
7.51e-03 |
|
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.
Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 39.48 E-value: 7.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 686 DYQTQERERIRNDEL--DYLRERQTVEDMQAKVDQQRVEDE----AWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLA 759
Cdd:cd16269 157 KYRQVPRKGVKAEEVlqEFLQSKEAEAEAILQADQALTEKEkeieAERAKAEAAEQERKLLEEQQRELEQKLEDQERSYE 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 760 AVKRELKvKEMhlqdaarrrflklqqdqqEMELRRLDDEIGRkvymrdreiaatardleMRQLELESQKRLYEKNLTENQ 839
Cdd:cd16269 237 EHLRQLK-EKM------------------EEERENLLKEQER-----------------ALESKLKEQEALLEEGFKEQA 280
|
....*....
gi 223005859 840 EALAKEMRA 848
Cdd:cd16269 281 ELLQEEIRS 289
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
44-340 |
2.17e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 118.86 E-value: 2.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 44 RFLNVAFDGTGDCLIAGDHQGNIYVFDL-HGNRFNLVQRTAQACTALAFNLRRKSeFLVALADYSIKCFDTVTKELVSWM 122
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGKLLRTL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 123 RGHESSVFSISVHASGKYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLF 201
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDgTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 202 CKYQLPAPPES-SSIlykvfAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTkvRAIRHLEFLPDSfdagsnQVLG 280
Cdd:COG2319 238 LLRTLTGHSGSvRSV-----AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDG------KLLA 304
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 281 VLSQDGIMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYIASIMENGSLNIYSVQALTQ 340
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
48-336 |
4.08e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 118.09 E-value: 4.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 48 VAFDGTGDCLIAGDHQGNIYVFDLH-GNRFNLVQRTAQACTALAFNlrRKSEFLV-ALADYSIKCFDTVTKELVSWMRGH 125
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAFS--PDGKLLAsGSDDGTVRLWDLATGKLLRTLTGH 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 126 ESSVFSISVHASGKYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLFCKY 204
Cdd:COG2319 204 TGAVRSVAFSPDGKLLASGSADgTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 205 QLPAPPES-SSIlykvfAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTkvRAIRHLEFLPDsfdagsNQVLGVLS 283
Cdd:COG2319 283 TLTGHSGGvNSV-----AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSPD------GKTLASGS 349
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 223005859 284 QDGIMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYIASIMENGSLNIYSVQ 336
Cdd:COG2319 350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
39-334 |
1.88e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 110.50 E-value: 1.88e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 39 HPKVLRFlnVAFDGTGDCLIAGDHQGNIYVFDLHGNRFNLVQR----TAQACTALAFNLRrkseFLVALADYSIKCFDTV 114
Cdd:cd00200 8 HTGGVTC--VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgPVRDVAASADGTY----LASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 115 TKELVSWMRGHESSVFSISVHASGKYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIF 193
Cdd:cd00200 82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDkTIKVWDVETGKCLTTLRGHTD-WVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 194 AWECDTLFCKYQLPAPPESssilykVFAVT--RDGRILAAGGKSNHLHLWCLEARQLFRiiQMPTKVRAIRHLEFLPDsf 271
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGE------VNSVAfsPDGEKLLSSSSDGTIKLWDLSTGKCLG--TLRGHENGVNSVAFSPD-- 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223005859 272 dagsNQVLGVLSQDGIMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYIASIMENGSLNIYS 334
Cdd:cd00200 231 ----GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
49-336 |
1.27e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 98.83 E-value: 1.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 49 AFDGTGDCLIAGDHQGNIYVFDLHGNRFNLVQRTAQACTALAFNLRRKSEFLVALADYSIKCFDTVTKELVSWMRGHESS 128
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 129 VFSISVHASGKYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLFCKYQLP 207
Cdd:COG2319 81 VLSVAFSPDGRLLASASADgTVRLWDLATGLLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 208 APPES-SSIlykvfAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTkvRAIRHLEFLPDSfdagsnQVLGVLSQDG 286
Cdd:COG2319 160 GHSGAvTSV-----AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDG------KLLASGSADG 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 223005859 287 IMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYIASIMENGSLNIYSVQ 336
Cdd:COG2319 227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
86-336 |
5.22e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.55 E-value: 5.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 86 CTALAFNlrRKSEFLV-ALADYSIKCFDTVTKELVSWMRGHESSVFSISVHASGKYAITTSSD-TAQLWDLDTFQRKRKL 163
Cdd:cd00200 12 VTCVAFS--PDGKLLAtGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDkTIRLWDLETGECVRTL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 164 NIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLFCKYQLPAPPESssilYKVFAVTRDGRILAAGGKSNHLHLWCL 243
Cdd:cd00200 90 TGHTS-YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW----VNSVAFSPDGTFVASSSQDGTIKLWDL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 244 EARQLFRIIQMPTKvrAIRHLEFLPD--SFDAGSNqvlgvlsqDGIMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYI 321
Cdd:cd00200 165 RTGKCVATLTGHTG--EVNSVAFSPDgeKLLSSSS--------DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLL 234
|
250
....*....|....*
gi 223005859 322 ASIMENGSLNIYSVQ 336
Cdd:cd00200 235 ASGSEDGTIRVWDLR 249
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
123-337 |
6.29e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 82.38 E-value: 6.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 123 RGHESSVFSISVHASGKYAITTSSD-TAQLWDLDTFQRKRKLNIrQSVGIQKVFFLPLSNTILSCFKDNSIFAWECDTLF 201
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDgTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 202 CKYQLPAppESSSILYkvFAVTRDGRILAAGGKSNHLHLWCLEARQLfrIIQMPTKVRAIRHLEFLPDsfdagsNQVLGV 281
Cdd:cd00200 85 CVRTLTG--HTSYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKC--LTTLRGHTDWVNSVAFSPD------GTFVAS 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 223005859 282 LSQDGIMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYIASIMENGSLNIYSVQA 337
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
684-962 |
1.96e-11 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 68.23 E-value: 1.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 684 IVDYQTQERERIRNDELDYL---RERQTVEDMQAKVDQQRVEDEAwyqkqELLRKAEETRREMLLQEEEKMIQQRQR--- 757
Cdd:pfam17380 277 IVQHQKAVSERQQQEKFEKMeqeRLRQEKEEKAREVERRRKLEEA-----EKARQAEMDRQAAIYAEQERMAMERERele 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 758 ---LAAVKREL---KVKEMHLQDAARRRFLKLQQD--------QQEMELRR----LDDEIGRKVYMRDREIAAT------ 813
Cdd:pfam17380 352 rirQEERKRELeriRQEEIAMEISRMRELERLQMErqqknervRQELEAARkvkiLEEERQRKIQQQKVEMEQIraeqee 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 814 ARDLEMRQLELESQK---RLYEKNLtENQEALAKEMRADADAYRRKVDLE-EHMFHKLIEagetqsQKTQKVIKENLAKA 889
Cdd:pfam17380 432 ARQREVRRLEEERARemeRVRLEEQ-ERQQQVERLRQQEEERKRKKLELEkEKRDRKRAE------EQRRKILEKELEER 504
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223005859 890 EQACLNTDWQIQSLHKQKcDDLQRNKCYQEVAKLLRENRRKEIEIinamveEEAKKWKEAEGKEFRLRSAKKA 962
Cdd:pfam17380 505 KQAMIEEERKRKLLEKEM-EERQKAIYEEERRREAEEERRKQQEM------EERRRIQEQMRKATEERSRLEA 570
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
696-1000 |
7.42e-11 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 66.70 E-value: 7.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 696 RNDELDYLRERQTVEDMQAKVDQQRVEDEawyQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKEMHLQDA 775
Cdd:PTZ00121 1183 KAEEVRKAEELRKAEDARKAEAARKAEEE---RKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEE 1259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 776 ARRRFLKLQQDQQEMELRRLDDEIGRKVYMRDREIAATARdlEMRQLElESQKRLYEKNLTENQEALAKEMRADADAYRR 855
Cdd:PTZ00121 1260 ARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE--EKKKAD-EAKKKAEEAKKADEAKKKAEEAKKKADAAKK 1336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 856 KVDLEEhmfhKLIEAGETQSQKTQKVIKENLAKAEQACLNTdwqiqSLHKQKCDDLQRN----KCYQEVAKLLRENRRKE 931
Cdd:PTZ00121 1337 KAEEAK----KAAEAAKAEAEAAADEAEAAEEKAEAAEKKK-----EEAKKKADAAKKKaeekKKADEAKKKAEEDKKKA 1407
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223005859 932 IEIINAmvEEEAKKWKEAEGKEFRLRSAKKASALSDASRKwflKQEINAAVEH---AENPCHKEEPRFQNEQ 1000
Cdd:PTZ00121 1408 DELKKA--AAAKKKADEAKKKAEEKKKADEAKKKAEEAKK---ADEAKKKAEEakkAEEAKKKAEEAKKADE 1474
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
693-953 |
9.97e-11 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 66.32 E-value: 9.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 693 ERIRNDELDYLRERQTVEDMQaKVDQQRVEDE---AWYQKQELLRKAEETRRE--MLLQEEEKMIQQRQRLAAVKRELKV 767
Cdd:PTZ00121 1544 EKKKADELKKAEELKKAEEKK-KAEEAKKAEEdknMALRKAEEAKKAEEARIEevMKLYEEEKKMKAEEAKKAEEAKIKA 1622
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 768 KEMHLQDAARRRFLKLQQDQQEmELRRLDDeigrkvyMRDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEMR 847
Cdd:PTZ00121 1623 EELKKAEEEKKKVEQLKKKEAE-EKKKAEE-------LKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEAL 1694
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 848 ADADAYRRKVDleehMFHKLIEAGETQSQKTQKVIKENLAKAEQACLNTDWQIQSLHKQKCDDLQRNKcyqeVAKLLREN 927
Cdd:PTZ00121 1695 KKEAEEAKKAE----ELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKK----IAHLKKEE 1766
|
250 260
....*....|....*....|....*....
gi 223005859 928 RRKEIEI---INAMVEEEAKKWKEAEGKE 953
Cdd:PTZ00121 1767 EKKAEEIrkeKEAVIEEELDEEDEKRRME 1795
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
688-863 |
4.74e-10 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 63.60 E-value: 4.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 688 QTQERERIRNDELDylrERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEE----KMIQQRQRLAAVKR 763
Cdd:pfam17380 444 RAREMERVRLEEQE---RQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEerkqAMIEEERKRKLLEK 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 764 ELKVKEMHLQDAARRRFLKLQQ-DQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYEKNLTENQEAL 842
Cdd:pfam17380 521 EMEERQKAIYEEERRREAEEERrKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEATTPITTI 600
|
170 180
....*....|....*....|.
gi 223005859 843 AKEMRADADAYRRKvDLEEHM 863
Cdd:pfam17380 601 KPIYRPRISEYQPP-DVESHM 620
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
690-876 |
6.67e-10 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 63.22 E-value: 6.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 690 QERERIRNdELDYLRERQTVE-DMQAKVDQQRVEDEAWYQKQE------LLRKAEETRREM--LLQEEEKMIQQRQRLAA 760
Cdd:pfam17380 389 QKNERVRQ-ELEAARKVKILEeERQRKIQQQKVEMEQIRAEQEearqreVRRLEEERAREMerVRLEEQERQQQVERLRQ 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 761 VKRELKVKEMHLQDAARRRFLKLQQD----QQEMELRR---LDDEIGRKVY---MRDREiAATARDLEMRQLELE--SQK 828
Cdd:pfam17380 468 QEEERKRKKLELEKEKRDRKRAEEQRrkilEKELEERKqamIEEERKRKLLekeMEERQ-KAIYEEERRREAEEErrKQQ 546
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 223005859 829 RLYEKNLTENQEALAKEMRADADAYRRkvdlEEHMFHKLIEAGETQSQ 876
Cdd:pfam17380 547 EMEERRRIQEQMRKATEERSRLEAMER----EREMMRQIVESEKARAE 590
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
686-1001 |
7.20e-10 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 63.62 E-value: 7.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 686 DYQTQERERIRNDELdYLRERQTVEDMQaKVDQQRVEDEAwyQKQELLRKAEETRR--EMLLQEEEKMIQQRQRLAAVKR 763
Cdd:PTZ00121 1078 DFDFDAKEDNRADEA-TEEAFGKAEEAK-KTETGKAEEAR--KAEEAKKKAEDARKaeEARKAEDARKAEEARKAEDAKR 1153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 764 ELKVKEMhlQDAARRRFLKLQQDQQEMELRRLDDEIGRKVYMRD----REIAATARDLEMRQLElesQKRLYEKNLTENQ 839
Cdd:PTZ00121 1154 VEIARKA--EDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKaedaRKAEAARKAEEERKAE---EARKAEDAKKAEA 1228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 840 EALAKEMRADADAYRR--KVDLEEHMfHKLIEAGETQSQKTQKVIK-------ENLAKAEQAcLNTDWQIQSLHKQKCDD 910
Cdd:PTZ00121 1229 VKKAEEAKKDAEEAKKaeEERNNEEI-RKFEEARMAHFARRQAAIKaeearkaDELKKAEEK-KKADEAKKAEEKKKADE 1306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 911 LQRN---KCYQEVAKLLRENRRKEIEIINAMVEE-----EAKKwKEAEGKEFRLRSAKKaSALSDASRKWFLKQEINAAV 982
Cdd:PTZ00121 1307 AKKKaeeAKKADEAKKKAEEAKKKADAAKKKAEEakkaaEAAK-AEAEAAADEAEAAEE-KAEAAEKKKEEAKKKADAAK 1384
|
330
....*....|....*....
gi 223005859 983 EHAENPCHKEEPRFQNEQD 1001
Cdd:PTZ00121 1385 KKAEEKKKADEAKKKAEED 1403
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
688-945 |
9.09e-10 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 61.47 E-value: 9.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 688 QTQERERIRndELDYLRERQTVEDMQAKVDQQRVEDEAwyQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRE-LK 766
Cdd:pfam13868 81 QIEEREQKR--QEEYEEKLQEREQMDEIVERIQEEDQA--EAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEdER 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 767 VKEMHLQDAARRRFLKLQQDQQEMELRRLDDEIGRKVYMRDREIAAT----------ARDLEMRQLELESQKRlYEKNLT 836
Cdd:pfam13868 157 ILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERdelraklyqeEQERKERQKEREEAEK-KARQRQ 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 837 ENQEALAKEMRADADAYRRKVDLEEHMFHKLIEAGETQSQKTQKVIKENLAKAEQACLNTDWQIQSLHKQKCDDLQRNkc 916
Cdd:pfam13868 236 ELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEE-- 313
|
250 260
....*....|....*....|....*....
gi 223005859 917 YQEVAKLlrenrRKEIEIINAMVEEEAKK 945
Cdd:pfam13868 314 LEEGERL-----REEEAERRERIEEERQK 337
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
690-948 |
1.69e-09 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 62.38 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 690 QERERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELK-VK 768
Cdd:TIGR02168 723 ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKaLR 802
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 769 EMH--LQDAA---RRRFLKLQQDQQEMELRRldDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYEK---------N 834
Cdd:TIGR02168 803 EALdeLRAELtllNEEAANLRERLESLERRI--AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEEleseleallN 880
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 835 LTENQEALAKEMRADADAYRRKVDLEEHMFHKLI-EAGETQSQKTQkvIKENLAKAEQACLNTDWQIQSLH--------- 904
Cdd:TIGR02168 881 ERASLEEALALLRSELEELSEELRELESKRSELRrELEELREKLAQ--LELRLEGLEVRIDNLQERLSEEYsltleeaea 958
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 223005859 905 KQKCDDLQRNKCYQEVAKLlrENRRKEIEIINAMVEEEAKKWKE 948
Cdd:TIGR02168 959 LENKIEDDEEEARRRLKRL--ENKIKELGPVNLAAIEEYEELKE 1000
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
48-156 |
1.88e-09 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 61.08 E-value: 1.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 48 VAFDGTGDCLIAGDHQGNIYVFDLH-GNRFNLVQRTAQACTALAFNlrRKSEFLV-ALADYSIKCFDTVTKELVSWMRGH 125
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFS--PDGKTLAsGSDDGTVRLWDLATGELLRTLTGH 371
|
90 100 110
....*....|....*....|....*....|..
gi 223005859 126 ESSVFSISVHASGKYAITTSSD-TAQLWDLDT 156
Cdd:COG2319 372 TGAVTSVAFSPDGRTLASGSADgTVRLWDLAT 403
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
693-986 |
2.29e-09 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 62.08 E-value: 2.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 693 ERIRNDELDYLRErqtvEDMQAKVDQQRVEDEAwYQKQELLRKAEETRR--EMLLQEEEKMIQQRQRLAAVKRELKVKEM 770
Cdd:PTZ00121 1590 EEARIEEVMKLYE----EEKKMKAEEAKKAEEA-KIKAEELKKAEEEKKkvEQLKKKEAEEKKKAEELKKAEEENKIKAA 1664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 771 HLQDAARRRFLKLQQDQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEMRADA 850
Cdd:PTZ00121 1665 EEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKK 1744
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 851 DAYRRKVDLEE-----HMFHKLIEAGETQSQKTQKVIKENLAKA-EQACLNTDWQIQSLhKQKCDDLQ----RNKCYQEV 920
Cdd:PTZ00121 1745 KAEEAKKDEEEkkkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEdEKRRMEVDKKIKDI-FDNFANIIeggkEGNLVIND 1823
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 223005859 921 AKLLRENRRKEIEIINAMVEEEAKKWKEAEGKEFRLrSAKKASALSDASRKWFLKQEINAAVEHAE 986
Cdd:PTZ00121 1824 SKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNE-NGEDGNKEADFNKEKDLKEDDEEEIEEAD 1888
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
688-892 |
6.06e-09 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 60.34 E-value: 6.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 688 QTQERERIRNDELDYL-----RERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVK 762
Cdd:COG1196 285 EAQAEEYELLAELARLeqdiaRLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 763 RELKVKEMHLQDAARRRfLKLQQDQQEMELRRLDDEIgrkvymRDREIAATARDLEMRQLELESQKRLYEKNLTENQEAL 842
Cdd:COG1196 365 EALLEAEAELAEAEEEL-EELAEELLEALRAAAELAA------QLEELEEAEEALLERLERLEEELEELEEALAELEEEE 437
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 223005859 843 AKEMRADADAYRRKVDLEEhmfhkLIEAGETQSQKTQKVIKENLAKAEQA 892
Cdd:COG1196 438 EEEEEALEEAAEEEAELEE-----EEEALLELLAELLEEAALLEAALAEL 482
|
|
| RabGAP-TBC |
pfam00566 |
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ... |
462-605 |
1.18e-08 |
|
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Pssm-ID: 459855 Cd Length: 178 Bit Score: 55.72 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 462 LQKKYPIKSRKLLRVLQRTLSALAHWsviFSDTPY---LPLLAFPFVkLFQNNQLICFEVIATLIINwcQHWFEYFPN-- 536
Cdd:pfam00566 20 FPHSFFFDNGPGQNSLRRILKAYSIY---NPDVGYcqgMNFIAAPLL-LVYLDEEDAFWCFVSLLEN--YLLRDFYTPdf 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 537 PPINILSMI-ENVLAFHDKELLQHFIDHDITSQLYAWPLLETVFSEVLTREEWLKLFDNIFSNHPSFLLM 605
Cdd:pfam00566 94 PGLKRDLYVfEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVLF 163
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
693-1016 |
1.31e-08 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 59.38 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 693 ERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRRemllQEEEKmiqqRQRLAAVKRELKVKEMHL 772
Cdd:PTZ00121 1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKK----KAEEA----KKAAEAAKAEAEAAADEA 1359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 773 QDAARRrflKLQQDQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEMRaDADA 852
Cdd:PTZ00121 1360 EAAEEK---AEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKK-KADE 1435
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 853 YRRKVDLEEhmfhkliEAGETQSQKTQKVIKENLA-KAEQACLNTDWQIQSLHKQKCDDLQRNKcyQEVAKLLRENRRKE 931
Cdd:PTZ00121 1436 AKKKAEEAK-------KADEAKKKAEEAKKAEEAKkKAEEAKKADEAKKKAEEAKKADEAKKKA--EEAKKKADEAKKAA 1506
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 932 IEIINAmveEEAKKWKEAEGKE--FRLRSAKKASALSDASRKWfLKQEINAA--VEHAENPCHKEEPRFQNEQDSSCLPR 1007
Cdd:PTZ00121 1507 EAKKKA---DEAKKAEEAKKADeaKKAEEAKKADEAKKAEEKK-KADELKKAeeLKKAEEKKKAEEAKKAEEDKNMALRK 1582
|
....*....
gi 223005859 1008 TSQLNDSSE 1016
Cdd:PTZ00121 1583 AEEAKKAEE 1591
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
684-960 |
3.51e-08 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 56.47 E-value: 3.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 684 IVDYQTQERERIRNDELDYLRErqtvEDMQAKVDQQRVEDEawYQKQELLRKAE------------ETRREMLLQEEEKM 751
Cdd:pfam13868 23 ERDAQIAEKKRIKAEEKEEERR----LDEMMEEERERALEE--EEEKEEERKEErkryrqeleeqiEEREQKRQEEYEEK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 752 IQQRQRLAAVKRELKVKEMHLQDAARRRFLKLQQDQQEM--ELRRLDDEIGRKVYMRDREIAATARDLEMRQLELESQKR 829
Cdd:pfam13868 97 LQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFneEQAEWKELEKEEEREEDERILEYLKEKAEREEEREAERE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 830 LYEKNLTENQEALAKEM------RADADAYRRKVDLEEHMF---HKLIEAGE---------TQSQKTQKVIKEnLAKAEQ 891
Cdd:pfam13868 177 EIEEEKEREIARLRAQQekaqdeKAERDELRAKLYQEEQERkerQKEREEAEkkarqrqelQQAREEQIELKE-RRLAEE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 892 ACLNTDWQIQSLHKQKCDD-----------LQRNKCYQEVAKLLRENRRKEIEIINAMVEEEAKKWKEAEGKEFRLRSAK 960
Cdd:pfam13868 256 AEREEEEFERMLRKQAEDEeieqeeaekrrMKRLEHRRELEKQIEEREEQRAAEREEELEEGERLREEEAERRERIEEER 335
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
692-1000 |
5.97e-08 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 57.46 E-value: 5.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 692 RERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREmllQEEEKMIQQRQRLAAVKRelkvkemh 771
Cdd:PTZ00121 1363 EEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKA---AAAKKKADEAKKKAEEKK-------- 1431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 772 lqdaarrrflKLQQDQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQLElESQKRLYEKNLTENQEALAKEMRADAD 851
Cdd:PTZ00121 1432 ----------KADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKAD-EAKKKAEEAKKADEAKKKAEEAKKKAD 1500
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 852 AYRRKVDLEEhmfhKLIEAGETQSQKTqkviKENLAKAEQAcLNTDWQIQSLHKQKCDDLQRNkcyQEVAKllRENRRKe 931
Cdd:PTZ00121 1501 EAKKAAEAKK----KADEAKKAEEAKK----ADEAKKAEEA-KKADEAKKAEEKKKADELKKA---EELKK--AEEKKK- 1565
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223005859 932 ieiinamvEEEAKkwKEAEGKEFRLRSAKKASALSDASRKWFLKQEINAAVEHAENPCHKEEPRFQNEQ 1000
Cdd:PTZ00121 1566 --------AEEAK--KAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEE 1624
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
691-981 |
8.36e-08 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 56.48 E-value: 8.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 691 ERERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKEM 770
Cdd:COG1196 233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 771 HLQDAARRRFLKLQQDQQEMELRRLDDEigrkvymrdrEIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEMRADA 850
Cdd:COG1196 313 ELEERLEELEEELAELEEELEELEEELE----------ELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 851 DAYRRKVDLEEHmfHKLIEAGETQSQKTQKVIKENLAKAEQACLntdwQIQSLHKQKCDDLQRNKcyQEVAKLLRENRRK 930
Cdd:COG1196 383 ELAEELLEALRA--AAELAAQLEELEEAEEALLERLERLEEELE----ELEEALAELEEEEEEEE--EALEEAAEEEAEL 454
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 223005859 931 EIEIINAMVEEEAKKWKEAEGKEfrLRSAKKASALSDASRKWFLKQEINAA 981
Cdd:COG1196 455 EEEEEALLELLAELLEEAALLEA--ALAELLEELAEAAARLLLLLEAEADY 503
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
688-995 |
1.84e-07 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 55.53 E-value: 1.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 688 QTQERERIRNDELDY-LRERQTVEDMQAKVDQQRVEDEAwYQKQELLRKAEETRREmllQEEEKMIQQRQRLAAVKR--- 763
Cdd:PTZ00121 1411 KKAAAAKKKADEAKKkAEEKKKADEAKKKAEEAKKADEA-KKKAEEAKKAEEAKKK---AEEAKKADEAKKKAEEAKkad 1486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 764 ELKVKEMHLQDAARRRFLKLQQDQQEMELRRLdDEIGRKVYMRDREIAATARDL----EMRQLE----LESQKRLYEKNL 835
Cdd:PTZ00121 1487 EAKKKAEEAKKKADEAKKAAEAKKKADEAKKA-EEAKKADEAKKAEEAKKADEAkkaeEKKKADelkkAEELKKAEEKKK 1565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 836 TENqealAKEMRADADAYRRKVDLEEHMFHKLIEAGETQSQKTQKVIKENLAKAEQACLNTDWQIQSLHKQKCDDLQRNK 915
Cdd:PTZ00121 1566 AEE----AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKK 1641
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 916 CYQEVAKllRENRRKEIEIINAMVEEEAKKWKEAEGKEFRLRSA-----KKASALS----DASRKWFLKQEINAAVEHAE 986
Cdd:PTZ00121 1642 EAEEKKK--AEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAeedekKAAEALKkeaeEAKKAEELKKKEAEEKKKAE 1719
|
....*....
gi 223005859 987 NPCHKEEPR 995
Cdd:PTZ00121 1720 ELKKAEEEN 1728
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
685-863 |
3.42e-07 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 54.19 E-value: 3.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 685 VDYQTQERE---RIRNDELDylRERQTVEDMQakVDQQRVEDEAWYQKQellRKAEETRRemllQEEEKMIQQRQRLAAV 761
Cdd:pfam15709 350 VERKRREQEeqrRLQQEQLE--RAEKMREELE--LEQQRRFEEIRLRKQ---RLEEERQR----QEEEERKQRLQLQAAQ 418
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 762 KRELKvkemhLQDAARRRFLKLQQDQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQLE-LESQKRLYEKNLTENQE 840
Cdd:pfam15709 419 ERARQ-----QQEEFRRKLQELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRLMEMAEEErLEYQRQKQEAEEKARLE 493
|
170 180
....*....|....*....|...
gi 223005859 841 ALAKEMRADADAyrrKVDLEEHM 863
Cdd:pfam15709 494 AEERRQKEEEAA---RLALEEAM 513
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
690-952 |
6.54e-07 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 53.92 E-value: 6.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 690 QERERIRNdELDYLreRQTVEDMQAKVDQQRVEdeawyqkQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKE 769
Cdd:TIGR02169 695 SELRRIEN-RLDEL--SQELSDASRKIGEIEKE-------IEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELE 764
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 770 MHLQDaARRRFLKLQQDQQEMElRRLDDEIGRKVYMRDREIAATARDLEMRQLELES--QKRLYEKnltenqeALAKEMR 847
Cdd:TIGR02169 765 ARIEE-LEEDLHKLEEALNDLE-ARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQklNRLTLEK-------EYLEKEI 835
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 848 ADADAYRRKVDLEEHMFHKLIEAGETQSQKTQKVIKENLAKAEQaclntdwqiqsLHKQKcDDLQRNKcyQEVAKLLREN 927
Cdd:TIGR02169 836 QELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRD-----------LESRL-GDLKKER--DELEAQLREL 901
|
250 260
....*....|....*....|....*
gi 223005859 928 RRKeIEIINAMVEEEAKKWKEAEGK 952
Cdd:TIGR02169 902 ERK-IEELEAQIEKKRKRLSELKAK 925
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
686-861 |
6.98e-07 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 53.77 E-value: 6.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 686 DYQTQERERIRNDELDYLRERQTVEDMQAKVD--QQRVED-EAWYQKQELLRKAEETRREMLLQEEEKMIQQR-----QR 757
Cdd:COG4913 260 LAERYAAARERLAELEYLRAALRLWFAQRRLEllEAELEElRAELARLEAELERLEARLDALREELDELEAQIrgnggDR 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 758 LAAVKRELKVKEMHLQDAARRRfLKLQQDQQEMELrrlddeigrkvymrdrEIAATARDLEMRQLELESQKRLYEKNLTE 837
Cdd:COG4913 340 LEQLEREIERLERELEERERRR-ARLEALLAALGL----------------PLPASAEEFAALRAEAAALLEALEEELEA 402
|
170 180
....*....|....*....|....
gi 223005859 838 NQEALAKEMRADADAYRRKVDLEE 861
Cdd:COG4913 403 LEEALAEAEAALRDLRRELRELEA 426
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
692-1002 |
1.69e-06 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 52.37 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 692 RERIRNDELDYL--------RERQTVEDMQAKVDQQRVEDEAwyQKQELLRKAEETRREMLLQEEEKMIQQrQRLAAVKR 763
Cdd:TIGR02168 219 KAELRELELALLvlrleelrEELEELQEELKEAEEELEELTA--ELQELEEKLEELRLEVSELEEEIEELQ-KELYALAN 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 764 ELKVKEMHLQdAARRRFLKLQQDQQEMELRRLDDEigrkvymRDREIAATarDLEMRQLELESQKrlyeKNLTENQEALA 843
Cdd:TIGR02168 296 EISRLEQQKQ-ILRERLANLERQLEELEAQLEELE-------SKLDELAE--ELAELEEKLEELK----EELESLEAELE 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 844 KEMRADADAYRRKVDLEEHMfhklieagETQSQKtqkvikENLAKAEQACLNTdwQIQSLHKQKCD-DLQRNKCYQEVAK 922
Cdd:TIGR02168 362 ELEAELEELESRLEELEEQL--------ETLRSK------VAQLELQIASLNN--EIERLEARLERlEDRRERLQQEIEE 425
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 923 LLRENRRKEIEIINAMVEEEAKKWKEAEGKEFRLRSAKKAsalsdasrkwfLKQEINAAvEHAENPCHKEEPRFQNEQDS 1002
Cdd:TIGR02168 426 LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEE-----------LREELEEA-EQALDAAERELAQLQARLDS 493
|
|
| DUF4659 |
pfam15558 |
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ... |
704-983 |
2.17e-06 |
|
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 51.19 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 704 RERQTVEDMQAKV-------DQQRVEDEAWyqkqELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKEMHLQDAA 776
Cdd:pfam15558 5 RDRKIAALMLARHkeeqrmrELQQQAALAW----EELRRRDQKRQETLERERRLLLQQSQEQWQAEKEQRKARLGREERR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 777 RRRFLKLQQDQQEMELRRLDDEIGRkvymRDREiaatarDLEMRQLELESQKRLYEKNLTEnQEALAKEMRADADAYRRK 856
Cdd:pfam15558 81 RADRREKQVIEKESRWREQAEDQEN----QRQE------KLERARQEAEQRKQCQEQRLKE-KEEELQALREQNSLQLQE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 857 VdLEEHMFHKLIEAGETQSQKTQ------------KVIKENLAKAEQACLNTDWQIQSLHKQKCDDLQRNKCYQEvaklL 924
Cdd:pfam15558 150 R-LEEACHKRQLKEREEQKKVQEnnlsellnhqarKVLVDCQAKAEELLRRLSLEQSLQRSQENYEQLVEERHRE----L 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223005859 925 RENRRKEIEIIN------AMVEEEAKKWKEA--EGKEFRLRSAKKASALSdASRKWFLKQEINAAVE 983
Cdd:pfam15558 225 REKAQKEEEQFQrakwraEEKEEERQEHKEAlaELADRKIQQARQVAHKT-VQDKAQRARELNLERE 290
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
688-980 |
4.32e-06 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 51.30 E-value: 4.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 688 QTQERERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRR---EMLLQEEEKMiQQRQRLAAVKRE 764
Cdd:PTZ00121 1676 KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKikaEEAKKEAEED-KKKAEEAKKDEE 1754
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 765 LKVKEMHLQDAARRRFLKLQQDQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQlELESQKRLYEKNLTENQEALAK 844
Cdd:PTZ00121 1755 EKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANII-EGGKEGNLVINDSKEMEDSAIK 1833
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 845 EMRADADAYRRKVD-LEEHMFHKLIEAGET-QSQKTQKVIKENLAKAEQACLNTDwQIQSLHKqkcDDLQRNKCYQEVAK 922
Cdd:PTZ00121 1834 EVADSKNMQLEEADaFEKHKFNKNNENGEDgNKEADFNKEKDLKEDDEEEIEEAD-EIEKIDK---DDIEREIPNNNMAG 1909
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223005859 923 llrenrrKEIEIINAMVE-EEAKKWKEAEGKEFRLRSAKKASALSDASRKW--FLKQEINA 980
Cdd:PTZ00121 1910 -------KNNDIIDDKLDkDEYIKRDAEETREEIIKISKKDMCINDFSSKFcdYMKDNISS 1963
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
722-893 |
4.82e-06 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 50.55 E-value: 4.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 722 EDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLaavKRELKVKEMHLQDAARRrflkLQqdQQEMELRRLDDEIGR 801
Cdd:PRK12704 37 EEEAKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEF---EKELRERRNELQKLEKR----LL--QKEENLDRKLELLEK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 802 kvymRDREIAATARDLEMRQLELESQKRLYEKNLTENQEAL----------AKEMRADadayrrkvDLEEHMFH---KLI 868
Cdd:PRK12704 108 ----REEELEKKEKELEQKQQELEKKEEELEELIEEQLQELerisgltaeeAKEILLE--------KVEEEARHeaaVLI 175
|
170 180
....*....|....*....|....*.
gi 223005859 869 EAGETQSQKT-QKVIKENLAKAEQAC 893
Cdd:PRK12704 176 KEIEEEAKEEaDKKAKEILAQAIQRC 201
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
649-959 |
6.57e-06 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 50.49 E-value: 6.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 649 LMETTPTDIHpDSMLNVFVALTKGQYpvfnqYPKFIVDYQTQ-ERERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWY 727
Cdd:pfam05483 444 LLQAREKEIH-DLEIQLTAIKTSEEH-----YLKEVEDLKTElEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKK 517
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 728 QKQELL--RKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKemhlQDAARRRFLKLQQDQQEMELRRLDDEIGRKVYM 805
Cdd:pfam05483 518 HQEDIIncKKQEERMLKQIENLEEKEMNLRDELESVREEFIQK----GDEVKCKLDKSEENARSIEYEVLKKEKQMKILE 593
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 806 RD-----REIAATARDLEMRQLElesQKRLYEKNLTENQEALAKEMRADadayrrKVDLE----EHMFHKLIEAGETQSQ 876
Cdd:pfam05483 594 NKcnnlkKQIENKNKNIEELHQE---NKALKKKGSAENKQLNAYEIKVN------KLELElasaKQKFEEIIDNYQKEIE 664
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 877 kTQKVIKEN-LAKAEQACLNTDwqiQSLHKQKCDDLqrnKCYQEVAKL--LRENRRKEIEIINAMVEEEAKKWKEAEGKE 953
Cdd:pfam05483 665 -DKKISEEKlLEEVEKAKAIAD---EAVKLQKEIDK---RCQHKIAEMvaLMEKHKHQYDKIIEERDSELGLYKNKEQEQ 737
|
....*.
gi 223005859 954 FRLRSA 959
Cdd:pfam05483 738 SSAKAA 743
|
|
| MAP7 |
pfam05672 |
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ... |
690-794 |
1.11e-05 |
|
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.
Pssm-ID: 461709 [Multi-domain] Cd Length: 153 Bit Score: 46.57 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 690 QERERIRNDEldylRERQTVEDMQAKVDQQRVEDEAWYQKQE---------LLRKAEETRREMLLQE-EEKMIQQRQRLA 759
Cdd:pfam05672 30 EEQERLEKEE----EERLRKEELRRRAEEERARREEEARRLEeerrreeeeRQRKAEEEAEEREQREqEEQERLQKQKEE 105
|
90 100 110
....*....|....*....|....*....|....*...
gi 223005859 760 AvkrELKVKEmhlqDAARRRF---LKLQQDQQEMELRR 794
Cdd:pfam05672 106 A---EAKARE----EAERQRQereKIMQQEEQERLERK 136
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
691-828 |
1.50e-05 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 48.79 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 691 ERERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMllQEEEKmiqqrQRLAAVKRELKVKEM 770
Cdd:pfam15709 387 EEIRLRKQRLEEERQRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQRKK--QQEEA-----ERAEAEKQRQKELEM 459
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 223005859 771 HLQDAARR--------RFLKLQQDQQEMELRRLDDEIGRKvymRDREIAATARDLEMRQLELESQK 828
Cdd:pfam15709 460 QLAEEQKRlmemaeeeRLEYQRQKQEAEEKARLEAEERRQ---KEEEAARLALEEAMKQAQEQARQ 522
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
704-1017 |
2.60e-05 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 48.63 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 704 RERQTVEDMQAKVDQQRVEDEawyQKQELLRKAEETRREMLLQEEEKMI---QQRQRLAAVKRELKVKEMHLQDAARRrf 780
Cdd:pfam01576 152 KERKLLEERISEFTSNLAEEE---EKAKSLSKLKNKHEAMISDLEERLKkeeKGRQELEKAKRKLEGESTDLQEQIAE-- 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 781 LKLQQDQQEMELRRLDDEIGRKVYMRDREiaATARDLEMRQL-ELESQkrlyeknLTENQEALAKEMRADADAYRRKVDL 859
Cdd:pfam01576 227 LQAQIAELRAQLAKKEEELQAALARLEEE--TAQKNNALKKIrELEAQ-------ISELQEDLESERAARNKAEKQRRDL 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 860 EEHMfhkliEAGETQ---------------SQKTQKVikENLAKA-EQACLNTDWQIQSL---HKQKCDDLQ-------R 913
Cdd:pfam01576 298 GEEL-----EALKTEledtldttaaqqelrSKREQEV--TELKKAlEEETRSHEAQLQEMrqkHTQALEELTeqleqakR 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 914 NKCYQEVAKLLRENRRKEIEI-----INAMVEEEAKKWK-EAEGKEFRLR---SAKKASALSDASRKWFLKQE-INAAVE 983
Cdd:pfam01576 371 NKANLEKAKQALESENAELQAelrtlQQAKQDSEHKRKKlEGQLQELQARlseSERQRAELAEKLSKLQSELEsVSSLLN 450
|
330 340 350
....*....|....*....|....*....|....
gi 223005859 984 HAENPCHKeeprfqNEQDSSCLprTSQLNDSSEM 1017
Cdd:pfam01576 451 EAEGKNIK------LSKDVSSL--ESQLQDTQEL 476
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
706-861 |
2.62e-05 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 48.02 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 706 RQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQ----RLAavKRELKVKEMHLQDAARRRFL 781
Cdd:pfam15709 335 RDRLRAERAEMRRLEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRfeeiRLR--KQRLEEERQRQEEEERKQRL 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 782 KLQQDQ-----QEMELRRLDDEIGRKvymRDREIAATARDLEMRQLELESQ-----KRLYEKNLTENQEALAKEMRADAd 851
Cdd:pfam15709 413 QLQAAQerarqQQEEFRRKLQELQRK---KQQEEAERAEAEKQRQKELEMQlaeeqKRLMEMAEEERLEYQRQKQEAEE- 488
|
170
....*....|
gi 223005859 852 ayRRKVDLEE 861
Cdd:pfam15709 489 --KARLEAEE 496
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
696-965 |
3.04e-05 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 48.13 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 696 RNDELDYLRERqtVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREmllQEEEKMIQQRQRLAAVKRELKVKEMHLQDA 775
Cdd:TIGR02168 675 RRREIEELEEK--IEELEEKIAELEKALAELRKELEELEEELEQLRK---ELEELSRQISALRKDLARLEAEVEQLEERI 749
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 776 ARRRFLKLQQDQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYEK----------NLTENQEALAKE 845
Cdd:TIGR02168 750 AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDElraeltllneEAANLRERLESL 829
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 846 MRADADAYRRKVDLEEhmfhklieagetqsqkTQKVIKENLAKAEQACLNTDWQIQSLHKQkcddLQRNKCYQEVAKLLR 925
Cdd:TIGR02168 830 ERRIAATERRLEDLEE----------------QIEELSEDIESLAAEIEELEELIEELESE----LEALLNERASLEEAL 889
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 223005859 926 ENRRKEIEIINAMVEEEAKKWKEAEGKEFRLRSAKKASAL 965
Cdd:TIGR02168 890 ALLRSELEELSEELRELESKRSELRRELEELREKLAQLEL 929
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
735-953 |
3.30e-05 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 47.64 E-value: 3.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 735 KAEETRREMLLQEEEKMIQQRQRL---AAVKRELKVKEMHLQDAARRRflkLQQDQQEMElRRLDDEIGRKVYMRDREIA 811
Cdd:pfam15709 315 RSEEDPSKALLEKREQEKASRDRLraeRAEMRRLEVERKRREQEEQRR---LQQEQLERA-EKMREELELEQQRRFEEIR 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 812 atardLEMRQLELESQKRLYEKNLTENQEALAKE-MRADADAYRRKV-DLEEHMFHKLIEAGETQSQKtQKVIKENLAkA 889
Cdd:pfam15709 391 -----LRKQRLEEERQRQEEEERKQRLQLQAAQErARQQQEEFRRKLqELQRKKQQEEAERAEAEKQR-QKELEMQLA-E 463
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 223005859 890 EQACLntdwqIQSLHKQKCDDLQRNKCYQEVAKLLRENRRKEIEIINAMVEEEAKKWKEAEGKE 953
Cdd:pfam15709 464 EQKRL-----MEMAEEERLEYQRQKQEAEEKARLEAEERRQKEEEAARLALEEAMKQAQEQARQ 522
|
|
| tolA |
PRK09510 |
cell envelope integrity inner membrane protein TolA; Provisional |
713-986 |
6.36e-05 |
|
cell envelope integrity inner membrane protein TolA; Provisional
Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 46.72 E-value: 6.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 713 QAKVDQQRvedeawyqKQELLRKAEETRREMLLQEEEKmiqQRQRLAAVKRE-LKVKEMHLQDAARRRFLKLQQDQQEme 791
Cdd:PRK09510 69 QQQKSAKR--------AEEQRKKKEQQQAEELQQKQAA---EQERLKQLEKErLAAQEQKKQAEEAAKQAALKQKQAE-- 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 792 lrrlddeigrkvymrdreiAATARDLEMRQLELESQ-KRLyeknltenqEALAKEMRADADAyrrkvdleehmfhklIEA 870
Cdd:PRK09510 136 -------------------EAAAKAAAAAKAKAEAEaKRA---------AAAAKKAAAEAKK---------------KAE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 871 GETQSQKTQKVIKENLAKAeqaclntdwqiqslhKQKCDDLQRNKCYQEVAKllrenrrkeieiinaMVEEEAKKWKEAE 950
Cdd:PRK09510 173 AEAAKKAAAEAKKKAEAEA---------------AAKAAAEAKKKAEAEAKK---------------KAAAEAKKKAAAE 222
|
250 260 270
....*....|....*....|....*....|....*.
gi 223005859 951 GKEFRLRSAKKASALSDASRKWFLKQEINAAVEHAE 986
Cdd:PRK09510 223 AKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAE 258
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
690-913 |
6.69e-05 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 46.97 E-value: 6.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 690 QERERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQR-----QRLAAVKRE 764
Cdd:TIGR02168 280 EEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKleelkEELESLEAE 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 765 LKVKEMHLQDAARRrflkLQQDQQEMELRRlddeigRKVYMRDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAK 844
Cdd:TIGR02168 360 LEELEAELEELESR----LEELEEQLETLR------SKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKK 429
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223005859 845 EMRADADAYRRKVDLEEHMFHKLIEAGETQSQKTQKvIKENLAKAEQACLNTDWQIQSLhKQKCDDLQR 913
Cdd:TIGR02168 430 LEEAELKELQAELEELEEELEELQEELERLEEALEE-LREELEEAEQALDAAERELAQL-QARLDSLER 496
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
115-153 |
8.44e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.76 E-value: 8.44e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 223005859 115 TKELVSWMRGHESSVFSISVHASGKYAITTSSD-TAQLWD 153
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLWD 40
|
|
| TBC |
smart00164 |
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ... |
501-609 |
8.61e-05 |
|
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.
Pssm-ID: 214540 [Multi-domain] Cd Length: 216 Bit Score: 44.99 E-value: 8.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 501 AFP-FVKLFQNNQLIcFEVIATLIINWCQHWFEYFpnppinilsmienvLAFHDKELLQHFIDHDITSQLYAWPLLETVF 579
Cdd:smart00164 112 AFWcLVKLMERYGPN-FYLPDMSGLQLDLLQLDRL--------------VKEYDPDLYKHLKDLGITPSLYALRWFLTLF 176
|
90 100 110
....*....|....*....|....*....|
gi 223005859 580 SEVLTREEWLKLFDNIFSNHPSFLLMTVVA 609
Cdd:smart00164 177 ARELPLEIVLRIWDVLFAEGSDFLFRVALA 206
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
744-972 |
8.91e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 45.91 E-value: 8.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 744 LLQEEEKMIQQRQRLAAVKRELKVKEMHLQDAARrrflklQQDQQEMELRRLDDEIGRKVyMRDREIAATARDLEMRQLE 823
Cdd:COG4942 15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKK------EEKALLKQLAALERRIAALA-RRIRALEQELAALEAELAE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 824 LESQKRLYEKNLTENQEALAKEMRAD------------------ADAYRRKVDLEEHMFHKLIEAGETQSQKTQKVIKEN 885
Cdd:COG4942 88 LEKEIAELRAELEAQKEELAELLRALyrlgrqpplalllspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 886 LAKAEQACLNTDWQIQSLHKQKCDDLQRNKcyQEVAKLLRENRRKEIEIINAMVEEEA---KKWKEAEGKEFRLRSAKKA 962
Cdd:COG4942 168 ELEAERAELEALLAELEEERAALEALKAER--QKLLARLEKELAELAAELAELQQEAEeleALIARLEAEAAAAAERTPA 245
|
250
....*....|
gi 223005859 963 SALSDASRKW 972
Cdd:COG4942 246 AGFAALKGKL 255
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
684-933 |
1.16e-04 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 46.19 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 684 IVDYQTQERERIrnDELDYLRE--RQTVEDMQAKVDqqRVED--EAWYQKQELLRKAE------ETRREMLLQEEEKMIQ 753
Cdd:PRK02224 466 HVETIEEDRERV--EELEAELEdlEEEVEEVEERLE--RAEDlvEAEDRIERLEERREdleeliAERRETIEEKRERAEE 541
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 754 QRQRL------AAVKRELKVKEMHLQDAARRRFLKLQQDQQEmelrrLDDEIGR--KVYMRDREIAATARDLEMRQlelE 825
Cdd:PRK02224 542 LRERAaeleaeAEEKREAAAEAEEEAEEAREEVAELNSKLAE-----LKERIESleRIRTLLAAIADAEDEIERLR---E 613
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 826 SQKRLYEKNlTENQEALAkEMRadadayRRKVDLEEHMFHKLIEagETQSQKTQkvikenlakAEQACLNTDWQIQSLHK 905
Cdd:PRK02224 614 KREALAELN-DERRERLA-EKR------ERKRELEAEFDEARIE--EAREDKER---------AEEYLEQVEEKLDELRE 674
|
250 260 270
....*....|....*....|....*....|....*.
gi 223005859 906 QKcDDLQ------RNkcyqEVAKL--LREnRRKEIE 933
Cdd:PRK02224 675 ER-DDLQaeigavEN----ELEELeeLRE-RREALE 704
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
693-884 |
1.41e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 46.06 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 693 ERIRN--DELDYLRE-RQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREM----LLQEEEKMIQQRQRLAAVKREL 765
Cdd:COG4913 225 EAADAlvEHFDDLERaHEALEDAREQIELLEPIRELAERYAAARERLAELEYLRaalrLWFAQRRLELLEAELEELRAEL 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 766 KVKEmhlqdaARRRFLKLQQDQQEMELRRLDDEI----GRKVYMRDREIAATARDLEMRQLELESQKRLY---------- 831
Cdd:COG4913 305 ARLE------AELERLEARLDALREELDELEAQIrgngGDRLEQLEREIERLERELEERERRRARLEALLaalglplpas 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 223005859 832 EKNLTENQEAlAKEMRADADAYRRKVDLEEHMFHKLIEAGETQSQKTQKVIKE 884
Cdd:COG4913 379 AEEFAALRAE-AAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIAS 430
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
697-987 |
1.79e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 45.28 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 697 NDELDYLRERQTvedmQAKVDQQRVEDEAWYQKQELLRKAEE--TRREMLLQEEEKMIQQRQRLAAVKRELKVKEMHLQD 774
Cdd:COG4372 44 QEELEQLREELE----QAREELEQLEEELEQARSELEQLEEEleELNEQLQAAQAELAQAQEELESLQEEAEELQEELEE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 775 AARRRFlklQQDQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEMRADADAYR 854
Cdd:COG4372 120 LQKERQ---DLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 855 RKVDLEEHMFHKLIEAGETQSQKTQKVIKENLAKAEQACLNTDWQIQSLHKQKCDDLQRN-KCYQEVAKLLRENRRKEIE 933
Cdd:COG4372 197 EKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVIlKEIEELELAILVEKDTEEE 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 223005859 934 IINAMVEEEAKKWKEAEGKEFRLRSAKKASALSDASRKWFLKQEINAAVEHAEN 987
Cdd:COG4372 277 ELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLEL 330
|
|
| growth_prot_Scy |
NF041483 |
polarized growth protein Scy; |
703-964 |
2.12e-04 |
|
polarized growth protein Scy;
Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 45.59 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 703 LRERQTVEDmQAKVDQQRVEDEAWYQKQELLRK-AEETRRemlLQEE--EKMIQQRQRLaavKREL----KVKEMHL-QD 774
Cdd:NF041483 78 LRNAQIQAD-QLRADAERELRDARAQTQRILQEhAEHQAR---LQAElhTEAVQRRQQL---DQELaerrQTVESHVnEN 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 775 AARRRFLKLQQDQQEmelRRLDDEiGRKvymrDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEMRADADAYR 854
Cdd:NF041483 151 VAWAEQLRARTESQA---RRLLDE-SRA----EAEQALAAARAEAERLAEEARQRLGSEAESARAEAEAILRRARKDAER 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 855 rkvdleehmfhkLIEAGETQSQktqkvikENLAKAEQacLNTDWQIQSLH-KQKCDDLQR--NKCYQEVAKLLRENRRKE 931
Cdd:NF041483 223 ------------LLNAASTQAQ-------EATDHAEQ--LRSSTAAESDQaRRQAAELSRaaEQRMQEAEEALREARAEA 281
|
250 260 270
....*....|....*....|....*....|....
gi 223005859 932 IEIINAMVEEEAKKWKEAEG-KEFRLRSAKKASA 964
Cdd:NF041483 282 EKVVAEAKEAAAKQLASAESaNEQRTRTAKEEIA 315
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
724-904 |
3.80e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 44.56 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 724 EAWYQKQELLRKAEETR--------REMLLQEEEKMIQQRQRLAAVKREL-KVKEMHLQDAArrrFLKLQQDQQEMELRR 794
Cdd:PRK04863 493 EAWDVARELLRRLREQRhlaeqlqqLRMRLSELEQRLRQQQRAERLLAEFcKRLGKNLDDED---ELEQLQEELEARLES 569
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 795 LDDEIgrkvymrdREIAATARDLEMRQLELESQKRLYEKNLTE---NQEALAK--EMRADADAYRRkvDLEEHMFHKLIE 869
Cdd:PRK04863 570 LSESV--------SEARERRMALRQQLEQLQARIQRLAARAPAwlaAQDALARlrEQSGEEFEDSQ--DVTEYMQQLLER 639
|
170 180 190
....*....|....*....|....*....|....*
gi 223005859 870 AGETQsqktqkVIKENLAKAEQAClntDWQIQSLH 904
Cdd:PRK04863 640 ERELT------VERDELAARKQAL---DEEIERLS 665
|
|
| DUF4515 |
pfam14988 |
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ... |
719-919 |
4.61e-04 |
|
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.
Pssm-ID: 405647 [Multi-domain] Cd Length: 206 Bit Score: 42.83 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 719 QRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKEMHLQdaARRRFLKLQQdQQEMELRRLDDE 798
Cdd:pfam14988 17 QKKIEKLWNQYVQECEEIERRRQELASRYTQQTAELQTQLLQKEKEQASLKKELQ--ALRPFAKLKE-SQEREIQDLEEE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 799 IgRKVymrDREIAATARDLEMRQLELES--QKRLYEKNLTENQEALAKEMRADADAYRR--KVDLEEHmfhklieagetq 874
Cdd:pfam14988 94 K-EKV---RAETAEKDREAHLQFLKEKAllEKQLQELRILELGERATRELKRKAQALKLaaKQALSEF------------ 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 223005859 875 sqkTQKVIKENlAKAEQACLNTDWQIQSLH--KQKCDD----LQRNKCYQE 919
Cdd:pfam14988 158 ---CRSIKREN-RQLQKELLQLIQETQALEaiKSKLENrkqrLKEEQWYLE 204
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
697-933 |
4.62e-04 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 43.75 E-value: 4.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 697 NDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQ-----ELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELkvkEMH 771
Cdd:pfam13868 5 SDELRELNSKLLAAKCNKERDAQIAEKKRIKAEEkeeerRLDEMMEEERERALEEEEEKEEERKEERKRYRQEL---EEQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 772 LQDAARRRFLKLQQDQQEmelRRLDDEIGRKVYMRDREIaatARDLEMRQLELESQKRLYEKNLTENQEALAKEMRAD-- 849
Cdd:pfam13868 82 IEEREQKRQEEYEEKLQE---REQMDEIVERIQEEDQAE---AEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEde 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 850 -ADAYRRKVDLEEHMFHKLIEAGETQSQKTQKVIKENLAKAEQaclntdwqiqslhKQKCDDLQRNKCYQEVAKllRENR 928
Cdd:pfam13868 156 rILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQD-------------EKAERDELRAKLYQEEQE--RKER 220
|
....*
gi 223005859 929 RKEIE 933
Cdd:pfam13868 221 QKERE 225
|
|
| growth_prot_Scy |
NF041483 |
polarized growth protein Scy; |
690-1060 |
1.13e-03 |
|
polarized growth protein Scy;
Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 43.28 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 690 QERERIRNDELDYLRE-RQTVEDMQAkvDQQRVEDEAWYQKQELLRKAEETRREML-----LQEeekmiQQRQRLAAvkr 763
Cdd:NF041483 728 QERERAREQSEELLASaRKRVEEAQA--EAQRLVEEADRRATELVSAAEQTAQQVRdsvagLQE-----QAEEEIAG--- 797
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 764 eLKVKEMHLQDAARRrflklqQDQQEMELRRLDDEIGRKvymRDREIAATARdlEMRQLELESQKRLYEKNLTEnQEALA 843
Cdd:NF041483 798 -LRSAAEHAAERTRT------EAQEEADRVRSDAYAERE---RASEDANRLR--REAQEETEAAKALAERTVSE-AIAEA 864
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 844 KEMRADADAYRRKVDLEEhmfHKLIEAGETQSQKTQKVIKE--NLAKAEQAClntdwQIQSLHKQKCDDLQRNKCY-QEV 920
Cdd:NF041483 865 ERLRSDASEYAQRVRTEA---SDTLASAEQDAARTRADAREdaNRIRSDAAA-----QADRLIGEATSEAERLTAEaRAE 936
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 921 AKLLRENRRKEIEIINAMVEEEAKKW-KEAEGKEFRLRsAKKASAlsdasrkwflkqeINAAVEHAENpCHKEEPRFQNE 999
Cdd:NF041483 937 AERLRDEARAEAERVRADAAAQAEQLiAEATGEAERLR-AEAAET-------------VGSAQQHAER-IRTEAERVKAE 1001
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223005859 1000 QDSSCLPRTSQLNDSSE--MDPSTQISLNRRA----------VEWDTTGQNLIKKVRNLRQRLTARARHRCQT 1060
Cdd:NF041483 1002 AAAEAERLRTEAREEADrtLDEARKDANKRRSeaaeqadtliTEAAAEADQLTAKAQEEALRTTTEAEAQADT 1074
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
116-153 |
1.50e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.32 E-value: 1.50e-03
10 20 30
....*....|....*....|....*....|....*....
gi 223005859 116 KELVSWMRGHESSVFSISVHASGKYAITTSSD-TAQLWD 153
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDgTVKVWD 39
|
|
| Pinin_SDK_memA |
pfam04696 |
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ... |
728-847 |
1.74e-03 |
|
pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.
Pssm-ID: 461396 [Multi-domain] Cd Length: 130 Bit Score: 39.58 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 728 QKQELLRKAEETRREMLLQE-EEKMIQQRQRLAAVKRElkvkemhlqdaaRRRFLKLQQDQQEMELRRLDDEIGRKVYMR 806
Cdd:pfam04696 22 KKEESKQKEKEERRAEIEKRlEEKAKQEKEELEERKRE------------EREELFEERRAEQIELRALEEKLELKELME 89
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 223005859 807 DREiaaTARDLEMRQLELESQKRLY--EKNLTENQEALAKEMR 847
Cdd:pfam04696 90 TWH---ENLKALANFLKTKTEPPIYylPWKLTEKTEELLEEQI 129
|
|
| vATP-synt_E |
pfam01991 |
ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as ... |
713-838 |
1.74e-03 |
|
ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.
Pssm-ID: 396537 [Multi-domain] Cd Length: 199 Bit Score: 40.83 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 713 QAKVD--QQRVEDEAWYQKQELLRKAEE---TRREMLLQEEEkMIQQRQR----LAAVKRELKVKEMHLQDA---ARRRF 780
Cdd:pfam01991 7 EEKAEeiRAKAEEEFAIEKAELVQEAEEkidEIYEKKEKQAE-MQKKIIIsnakNEARLKVLEAREEILDEVfneAEKKL 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223005859 781 LKLQQDQQEME--LRRLDDEIGRK-------VYMR--DREIAATARDLEMRQLELESQKRLYEKNLTEN 838
Cdd:pfam01991 86 AELEEDTDEYKdlLRKLIVQALVKlgepeviVRCRkrDEELVESALDKAAEEYKAKTKKVTVEKAGDEN 154
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
722-907 |
2.61e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 41.68 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 722 EDEAWYQKQELLRKAEETRREmLLQEEEKMIQQRQRLAAVKRELKVKEMHLQDAARRRFLKLQQDQQEMELRRLDDEIgR 801
Cdd:COG4717 72 ELKELEEELKEAEEKEEEYAE-LQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERL-E 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 802 KVYMRDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEMRADADAYRRkvdleehmfhklIEAGETQSQKTQKV 881
Cdd:COG4717 150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE------------LQQRLAELEEELEE 217
|
170 180
....*....|....*....|....*.
gi 223005859 882 IKENLAKAEQACLNTDWQIQSLHKQK 907
Cdd:COG4717 218 AQEELEELEEELEQLENELEAAALEE 243
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
719-999 |
2.79e-03 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 41.75 E-value: 2.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 719 QRVEDEAWYQKQELLRKAEETRREMLLQEEEkmIQQRQ----RLAAVKRElkVKEMHLQDAARRRFLKLQQDQQEMELRR 794
Cdd:pfam12128 219 NRQQVEHWIRDIQAIAGIMKIRPEFTKLQQE--FNTLEsaelRLSHLHFG--YKSDETLIASRQEERQETSAELNQLLRT 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 795 LDDEIGRKVYMRDREIAATARDLEMRQLELE---SQKRLYEKnltENQEALAKEMrADADAYRRKVDLEEhmfhKLIEAG 871
Cdd:pfam12128 295 LDDQWKEKRDELNGELSAADAAVAKDRSELEaleDQHGAFLD---ADIETAAADQ-EQLPSWQSELENLE----ERLKAL 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 872 ETQSQKTQKVIKENLAKAEQAClNTDwqIQSLHKqkcddlQRNKCYQEVAKLLRENR----------RKEIEIINAMVEE 941
Cdd:pfam12128 367 TGKHQDVTAKYNRRRSKIKEQN-NRD--IAGIKD------KLAKIREARDRQLAVAEddlqaleselREQLEAGKLEFNE 437
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223005859 942 EAKKWKEAEGKE-FRLRSAKkasalsdASRKWFLKQEIN-AAVEHAEN---PCHKEEPRFQNE 999
Cdd:pfam12128 438 EEYRLKSRLGELkLRLNQAT-------ATPELLLQLENFdERIERAREeqeAANAEVERLQSE 493
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
710-967 |
3.31e-03 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 41.70 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 710 EDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQ--------------RQRLA--AVKRELKVKEMH-- 771
Cdd:pfam01576 60 EEMRARLAARKQELEEILHELESRLEEEEERSQQLQNEKKKMQQHiqdleeqldeeeaaRQKLQleKVTTEAKIKKLEed 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 772 --LQDAARRRFLK----LQQDQQEMELRRLDDEIGRKVYMRDR-EIAATARDLEMR-------QLELESQKRLYEKNLTE 837
Cdd:pfam01576 140 ilLLEDQNSKLSKerklLEERISEFTSNLAEEEEKAKSLSKLKnKHEAMISDLEERlkkeekgRQELEKAKRKLEGESTD 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 838 NQEALAkEMRADADAYR----RKvdlEEHMFHKLIEAGETQSQKT--QKVIKENLA-----------------KAEQACL 894
Cdd:pfam01576 220 LQEQIA-ELQAQIAELRaqlaKK---EEELQAALARLEEETAQKNnaLKKIRELEAqiselqedleseraarnKAEKQRR 295
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223005859 895 NTDWQIQSLHKQKCDDLQRNKCYQEvaklLRENRRKEIEIINAMVEEEAKKwKEAEGKEFRLRSAKKASALSD 967
Cdd:pfam01576 296 DLGEELEALKTELEDTLDTTAAQQE----LRSKREQEVTELKKALEEETRS-HEAQLQEMRQKHTQALEELTE 363
|
|
| COG5210 |
COG5210 |
GTPase-activating protein [General function prediction only]; |
542-658 |
3.71e-03 |
|
GTPase-activating protein [General function prediction only];
Pssm-ID: 227535 [Multi-domain] Cd Length: 496 Bit Score: 40.94 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 542 LSMIENVLAFHDKELLQHFIDHDITSQLYAWPLLETVFSEVLTREEWLKLFDNIFSNHPSFLLMTVVAYNICSRTPLLSC 621
Cdd:COG5210 350 LKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAILKLLRDKLLKL 429
|
90 100 110
....*....|....*....|....*....|....*..
gi 223005859 622 NLKDDFEFFFHHRNNLDINVVIRQVYHLMETTPTDIH 658
Cdd:COG5210 430 DSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDIL 466
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
688-803 |
3.72e-03 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 40.67 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 688 QTQERERIRNDELDYLRERQTVEDMQAKvDQQRVEDEAWYQKQeLLRKAEETRREMLLQEEEKMIQQR-----QRLAAVK 762
Cdd:pfam13868 225 EEAEKKARQRQELQQAREEQIELKERRL-AEEAEREEEEFERM-LRKQAEDEEIEQEEAEKRRMKRLEhrrelEKQIEER 302
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 223005859 763 RELKVKEMhlqdAARRRFLKLQQDQQEMELRRLDDEIGRKV 803
Cdd:pfam13868 303 EEQRAAER----EEELEEGERLREEEAERRERIEEERQKKL 339
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
688-956 |
4.43e-03 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 41.11 E-value: 4.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 688 QTQERERIRNDELDYLRERQtvedMQAKVDQQRV--EDEAWYQKQELLRKAEETRREMLLQEEEKM------IQQRQRLA 759
Cdd:TIGR00618 601 EKLSEAEDMLACEQHALLRK----LQPEQDLQDVrlHLQQCSQELALKLTALHALQLTLTQERVREhalsirVLPKELLA 676
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 760 AVKRELKVKEMHLQDAARRR------FLKLQ-QDQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYE 832
Cdd:TIGR00618 677 SRQLALQKMQSEKEQLTYWKemlaqcQTLLReLETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVL 756
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 833 KNLTE-----NQEALAKEMRADADAyrrKVDLEEHMFHKLIEAGETQSQKTQKVIKENLAKAEQACLNTDWQIQslhkqk 907
Cdd:TIGR00618 757 KARTEahfnnNEEVTAALQTGAELS---HLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLV------ 827
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 223005859 908 cddlqrnKCYQEVAKLLRENRRKEIEIINAM--VEEEAKKWKEAEGKEFRL 956
Cdd:TIGR00618 828 -------QEEEQFLSRLEEKSATLGEITHQLlkYEECSKQLAQLTQEQAKI 871
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
688-854 |
4.61e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 41.09 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 688 QTQERERIRNDELDYLRERQT---VEDMQAKVDQQRVEDEAWYQKqelLRKAEETR---REMLLQEEEKMIQQRQRLAAV 761
Cdd:COG3096 948 EQQRRLKQQIFALSEVVQRRPhfsYEDAVGLLGENSDLNEKLRAR---LEQAEEARreaREQLRQAQAQYSQYNQVLASL 1024
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 762 KRELKVKEMHLQDaarrrflkLQQDQQEMELrRLDDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYEKnlteNQEA 841
Cdd:COG3096 1025 KSSRDAKQQTLQE--------LEQELEELGV-QADAEAEERARIRRDELHEELSQNRSRRSQLEKQLTRCEA----EMDS 1091
|
170
....*....|...
gi 223005859 842 LAKEMRADADAYR 854
Cdd:COG3096 1092 LQKRLRKAERDYK 1104
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
695-961 |
5.21e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 40.82 E-value: 5.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 695 IRNDELD-YLRERQTVEDMQAKVDQQRVEDEAWYQKQELLR--KAEETRREMLLQEEE----KMIQQRQRLAAVKRELKV 767
Cdd:PRK03918 132 IRQGEIDaILESDESREKVVRQILGLDDYENAYKNLGEVIKeiKRRIERLEKFIKRTEnieeLIKEKEKELEEVLREINE 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 768 KEMHLQDAaRRRFLKLQQDQQEMELRRlddEIGRKVYMRDREIAATARDLEMRQLELESQ---KRLYEKNLTENQEALaK 844
Cdd:PRK03918 212 ISSELPEL-REELEKLEKEVKELEELK---EEIEELEKELESLEGSKRKLEEKIRELEERieeLKKEIEELEEKVKEL-K 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 845 EMRADADAYRrkvdleehmfhKLIEAGETQSQKTQKVIKEnLAKAEQACLNTDWQIQSLHKQKcddlqrnkcyQEVAKLl 924
Cdd:PRK03918 287 ELKEKAEEYI-----------KLSEFYEEYLDELREIEKR-LSRLEEEINGIEERIKELEEKE----------ERLEEL- 343
|
250 260 270
....*....|....*....|....*....|....*..
gi 223005859 925 rENRRKEIEIINAMVEEEAKKWKEAEGKEFRLRSAKK 961
Cdd:PRK03918 344 -KKKLKELEKRLEELEERHELYEEAKAKKEELERLKK 379
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
682-832 |
5.29e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 40.53 E-value: 5.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 682 KFIVDYQTQERERIRNDELdyLRERQTVEDMQAKVDQQRVEDEAWYQKQEL-LRKAEET---RREMLLQEEEKMIQQRQR 757
Cdd:PRK12704 41 KRILEEAKKEAEAIKKEAL--LEAKEEIHKLRNEFEKELRERRNELQKLEKrLLQKEENldrKLELLEKREEELEKKEKE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 758 LAAVKRELKVKEMHLQDAARRRFLKLQQ-------DQQEMELRRLDDEIgrkvymrDREIAATARDLEMrQLELESQKRL 830
Cdd:PRK12704 119 LEQKQQELEKKEEELEELIEEQLQELERisgltaeEAKEILLEKVEEEA-------RHEAAVLIKEIEE-EAKEEADKKA 190
|
..
gi 223005859 831 YE 832
Cdd:PRK12704 191 KE 192
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
649-1065 |
5.53e-03 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 40.72 E-value: 5.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 649 LMETTPTDIHPDSMLNVF----------VALTKgQYPVFNQYPKFIVDYQTqERERIRNDELDYLRE-RQTVEDMQAKVD 717
Cdd:TIGR00618 169 LMNLFPLDQYTQLALMEFakkkslhgkaELLTL-RSQLLTLCTPCMPDTYH-ERKQVLEKELKHLREaLQQTQQSHAYLT 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 718 QQRVEDEAWYQKQ----ELLRKAEETR-REMLLQEEEKMIQQRQRLAAVKRELKvkemHLQDAARRRFLKLQQDQQEMEL 792
Cdd:TIGR00618 247 QKREAQEEQLKKQqllkQLRARIEELRaQEAVLEETQERINRARKAAPLAAHIK----AVTQIEQQAQRIHTELQSKMRS 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 793 RrlddeigRKVYMRDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEmradaDAYRRKVDLEEHMfHKLieage 872
Cdd:TIGR00618 323 R-------AKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIR-----EISCQQHTLTQHI-HTL----- 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 873 tQSQKTQKVIKENLAKAEQACLNTDWQIQSLHKQKCDDLQRNKCyqeVAKLLRENRRKEIEIINAMVEEEAKKWKEAEGK 952
Cdd:TIGR00618 385 -QQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLA---HAKKQQELQQRYAELCAAAITCTAQCEKLEKIH 460
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 953 EFRLRSAKKASALSDASRKWFLKQ--EINAAVEHAENPcHKEEPRFQNEQDSSCLPRTSQLNDSSEMDPSTQISLNRRA- 1029
Cdd:TIGR00618 461 LQESAQSLKEREQQLQTKEQIHLQetRKKAVVLARLLE-LQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAq 539
|
410 420 430
....*....|....*....|....*....|....*....
gi 223005859 1030 ---VEWDTTGQnlIKKVRNLRQRLTARARHRCQTPHLLA 1065
Cdd:TIGR00618 540 letSEEDVYHQ--LTSERKQRASLKEQMQEIQQSFSILT 576
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
691-844 |
7.40e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 40.14 E-value: 7.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 691 ERERIRNDELDYLRERQTVEDmQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKEm 770
Cdd:COG4717 312 ALEELEEEELEELLAALGLPP-DLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRA- 389
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 223005859 771 HLQDAARRRFLKLQQDQQEMELRRLDDEIGRKVYMRDREiaatarDLEMRQLELESQKRLYEKNLTENQEALAK 844
Cdd:COG4717 390 ALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEE------ELEEELEELEEELEELEEELEELREELAE 457
|
|
| GBP_C |
cd16269 |
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ... |
686-848 |
7.51e-03 |
|
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.
Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 39.48 E-value: 7.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 686 DYQTQERERIRNDEL--DYLRERQTVEDMQAKVDQQRVEDE----AWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLA 759
Cdd:cd16269 157 KYRQVPRKGVKAEEVlqEFLQSKEAEAEAILQADQALTEKEkeieAERAKAEAAEQERKLLEEQQRELEQKLEDQERSYE 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 760 AVKRELKvKEMhlqdaarrrflklqqdqqEMELRRLDDEIGRkvymrdreiaatardleMRQLELESQKRLYEKNLTENQ 839
Cdd:cd16269 237 EHLRQLK-EKM------------------EEERENLLKEQER-----------------ALESKLKEQEALLEEGFKEQA 280
|
....*....
gi 223005859 840 EALAKEMRA 848
Cdd:cd16269 281 ELLQEEIRS 289
|
|
| GBP_C |
cd16269 |
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ... |
713-795 |
7.98e-03 |
|
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.
Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 39.48 E-value: 7.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005859 713 QAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKEMHLQDAARRRFLKLQQDQQEMEL 792
Cdd:cd16269 208 EAAEQERKLLEEQQRELEQKLEDQERSYEEHLRQLKEKMEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQEEI 287
|
...
gi 223005859 793 RRL 795
Cdd:cd16269 288 RSL 290
|
|
| |
