NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21703808|ref|NP_663379|]
View 

protein arginine N-methyltransferase 7 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
38-188 2.95e-43

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 155.58  E-value: 2.95e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703808  38 MLHDKDRNIKYYQGIRAAVSrvkdrgQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIK 117
Cdd:COG4076  15 MLNDVERNDAFKAAIERVVK------PGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRIT 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21703808 118 VINKHSTEVtvgpdgDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVESR 188
Cdd:COG4076  89 VINADATDL------DLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESP 153
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
382-523 2.46e-13

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 70.07  E-value: 2.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703808 382 INDQDRTDHYAQALRTVLLPGSVCLCVSDGS-LLSMLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLEDKISVINKRP- 459
Cdd:COG4076  16 LNDVERNDAFKAAIERVVKPGDVVLDIGTGSgLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADAt 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21703808 460 --ELLTAADLegkKVSLLLGEPFFTTSLLPwhnlyfwyVRTSVDQH-LAPGAVVMPQAASLHAVIVE 523
Cdd:COG4076  96 dlDLPEKADV---IISEMLDTALLDEGQVP--------ILNHARKRlLKPGGRIIPERITNAAQPVE 151
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
38-188 2.95e-43

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 155.58  E-value: 2.95e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703808  38 MLHDKDRNIKYYQGIRAAVSrvkdrgQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIK 117
Cdd:COG4076  15 MLNDVERNDAFKAAIERVVK------PGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRIT 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21703808 118 VINKHSTEVtvgpdgDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVESR 188
Cdd:COG4076  89 VINADATDL------DLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESP 153
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
382-523 2.46e-13

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 70.07  E-value: 2.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703808 382 INDQDRTDHYAQALRTVLLPGSVCLCVSDGS-LLSMLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLEDKISVINKRP- 459
Cdd:COG4076  16 LNDVERNDAFKAAIERVVKPGDVVLDIGTGSgLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADAt 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21703808 460 --ELLTAADLegkKVSLLLGEPFFTTSLLPwhnlyfwyVRTSVDQH-LAPGAVVMPQAASLHAVIVE 523
Cdd:COG4076  96 dlDLPEKADV---IISEMLDTALLDEGQVP--------ILNHARKRlLKPGGRIIPERITNAAQPVE 151
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 68-120 5.24e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.11  E-value: 5.24e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 21703808  68 VLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAvKIVERNGFSDKIKVIN 120
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPVALELA-RKAAAALLADNVEVLK 53
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 68-141 7.65e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 42.25  E-value: 7.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703808    68 VLDIGTGTGLLSMMAVTAGADFCYAIEVfKPMA-EAAVKIVERNGFSDKIKVINKhstevtvgpdGDLPCR------ANI 140
Cdd:pfam06325 165 VLDVGCGSGILAIAALKLGAKKVVGVDI-DPVAvRAAKENAELNGVEARLEVYLP----------GDLPKEkadvvvANI 233


                  .
gi 21703808   141 L 141
Cdd:pfam06325 234 L 234
PRK14968 PRK14968
putative methyltransferase; Provisional
 52-120 1.39e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 40.27  E-value: 1.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21703808   52 IRAAVSRVKDRgqkalVLDIGTGTGLLSMMAVTAGADFcYAIEVfKPMA-EAAVKIVERNGFSD-KIKVIN 120
Cdd:PRK14968  16 AENAVDKKGDR-----VLEVGTGSGIVAIVAAKNGKKV-VGVDI-NPYAvECAKCNAKLNNIRNnGVEVIR 79
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
38-188 2.95e-43

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 155.58  E-value: 2.95e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703808  38 MLHDKDRNIKYYQGIRAAVSrvkdrgQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIK 117
Cdd:COG4076  15 MLNDVERNDAFKAAIERVVK------PGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRIT 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21703808 118 VINKHSTEVtvgpdgDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVESR 188
Cdd:COG4076  89 VINADATDL------DLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESP 153
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
382-523 2.46e-13

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 70.07  E-value: 2.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703808 382 INDQDRTDHYAQALRTVLLPGSVCLCVSDGS-LLSMLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLEDKISVINKRP- 459
Cdd:COG4076  16 LNDVERNDAFKAAIERVVKPGDVVLDIGTGSgLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADAt 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21703808 460 --ELLTAADLegkKVSLLLGEPFFTTSLLPwhnlyfwyVRTSVDQH-LAPGAVVMPQAASLHAVIVE 523
Cdd:COG4076  96 dlDLPEKADV---IISEMLDTALLDEGQVP--------ILNHARKRlLKPGGRIIPERITNAAQPVE 151
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 37-147 5.89e-09

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 57.08  E-value: 5.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703808  37 DMLHDKDrnIKYYQ-------GIR----AAVSRVKDRGQkalVLDIGTGTGLLSMMAV--TAGADFcYAIEVFKPMAEAA 103
Cdd:COG4123   4 DGFLFKQ--FRIIQprcgyrfGTDavllAAFAPVKKGGR---VLDLGTGTGVIALMLAqrSPGARI-TGVEIQPEAAELA 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 21703808 104 VKIVERNGFSDKIKVINkhstevtvgpdGDLPCRANILITELFD 147
Cdd:COG4123  78 RRNVALNGLEDRITVIH-----------GDLKEFAAELPPGSFD 110
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
68-119 2.77e-05

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 46.32  E-value: 2.77e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 21703808  68 VLDIGTGTGLLSMMAVTAGADFCYAIEVfKPMA-EAAVKIVERNGFSDKIKVI 119
Cdd:COG2264 152 VLDVGCGSGILAIAAAKLGAKRVLAVDI-DPVAvEAARENAELNGVEDRIEVV 203
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 43-112 4.01e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 41.13  E-value: 4.01e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21703808  43 DRNIKYYQGIRAAVSRVKDR-GQKalVLDIGTGTGLLSMMAVTAGADfCYAIEVFKPMAEAAVKIVERNGF 112
Cdd:COG2226   2 DRVAARYDGREALLAALGLRpGAR--VLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAAEAGL 69
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 68-120 5.24e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.11  E-value: 5.24e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 21703808  68 VLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAvKIVERNGFSDKIKVIN 120
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPVALELA-RKAAAALLADNVEVLK 53
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 68-141 7.65e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 42.25  E-value: 7.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703808    68 VLDIGTGTGLLSMMAVTAGADFCYAIEVfKPMA-EAAVKIVERNGFSDKIKVINKhstevtvgpdGDLPCR------ANI 140
Cdd:pfam06325 165 VLDVGCGSGILAIAALKLGAKKVVGVDI-DPVAvRAAKENAELNGVEARLEVYLP----------GDLPKEkadvvvANI 233


                  .
gi 21703808   141 L 141
Cdd:pfam06325 234 L 234
PRK14968 PRK14968
putative methyltransferase; Provisional
 52-120 1.39e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 40.27  E-value: 1.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21703808   52 IRAAVSRVKDRgqkalVLDIGTGTGLLSMMAVTAGADFcYAIEVfKPMA-EAAVKIVERNGFSD-KIKVIN 120
Cdd:PRK14968  16 AENAVDKKGDR-----VLEVGTGSGIVAIVAAKNGKKV-VGVDI-NPYAvECAKCNAKLNNIRNnGVEVIR 79
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 68-112 3.95e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 37.16  E-value: 3.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 21703808    68 VLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGF 112
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL 45
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 68-119 4.99e-03

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 38.92  E-value: 4.99e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21703808  68 VLDIGTGTG----LLSMMA--VtagadfcYAIEVFKPMAEAAVKIVERNGFsDKIKVI 119
Cdd:COG2518  70 VLEIGTGSGyqaaVLARLAgrV-------YSVERDPELAERARERLAALGY-DNVTVR 119
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
68-141 6.80e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 38.98  E-value: 6.80e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21703808   68 VLDIGTGTGLLSMMAVTAGADFCYAIEVfKPMA-EAAVKIVERNGFSDKIKVinkhstevtvgPDGDLPCR---ANIL 141
Cdd:PRK00517 123 VLDVGCGSGILAIAAAKLGAKKVLAVDI-DPQAvEAARENAELNGVELNVYL-----------PQGDLKADvivANIL 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH