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Conserved domains on  [gi|24497589|ref|NP_620689|]
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homeobox protein ARX [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11079034)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; also contains an OAR domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
329-385 1.46e-32

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 118.76  E-value: 1.46e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24497589   329 RRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRK 385
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 526-544 2.24e-06

OAR motif; The entry represents the OAR motif.


:

Pssm-ID: 461067  Cd Length: 19  Bit Score: 43.94  E-value: 2.24e-06
                          10
                  ....*....|....*....
gi 24497589   526 DRRASSIAALRLKAKEHAA 544
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHSA 19
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
329-385 1.46e-32

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 118.76  E-value: 1.46e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24497589   329 RRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRK 385
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 329-387 3.80e-27

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 103.86  E-value: 3.80e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24497589 329 RRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKRE 387
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 328-384 4.92e-27

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 103.48  E-value: 4.92e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24497589    328 QRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWR 384
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
326-385 2.34e-14

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 70.54  E-value: 2.34e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497589 326 RKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRK 385
Cdd:COG5576  49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 526-544 2.24e-06

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 43.94  E-value: 2.24e-06
                          10
                  ....*....|....*....
gi 24497589   526 DRRASSIAALRLKAKEHAA 544
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHSA 19
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
329-385 1.46e-32

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 118.76  E-value: 1.46e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24497589   329 RRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRK 385
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 329-387 3.80e-27

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 103.86  E-value: 3.80e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24497589 329 RRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKRE 387
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 328-384 4.92e-27

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 103.48  E-value: 4.92e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24497589    328 QRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWR 384
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
326-385 2.34e-14

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 70.54  E-value: 2.34e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497589 326 RKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRK 385
Cdd:COG5576  49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 526-544 2.24e-06

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 43.94  E-value: 2.24e-06
                          10
                  ....*....|....*....
gi 24497589   526 DRRASSIAALRLKAKEHAA 544
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHSA 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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