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Conserved domains on  [gi|20270273|ref|NP_620083|]
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afadin- and alpha-actinin-binding protein isoform a [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ADIP pfam11559
Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at ...
63-214 1.02e-46

Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at cell-cell adherens junctions, and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins localized at Cell-Cell Adherens Junctions.


:

Pssm-ID: 463295 [Multi-domain]  Cd Length: 151  Bit Score: 161.33  E-value: 1.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273    63 EQSISYLDQELTTFGFPSLYEESKSKEaKRELNIVAVLNCMNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLK 142
Cdd:pfam11559   1 ENAITYINQTLLSRGFLRSGLLFDTAE-GVEENIARIINVIYELLQQRDRDLEFRESLNETIRTLEAEIERLQSKIERLK 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20270273   143 EQLETSRREMIGLQERDRQLQCKNRSLHQLLKNEKDEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQ 214
Cdd:pfam11559  80 TQLEDLERELALLQAKERQLEKKLKTLEQKLKNEKEELQRLKNALQQIKTQFAHEVKKRDREIEKLKERLAQ 151
SCP-1 super family cl30946
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
63-392 5.97e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


The actual alignment was detected with superfamily member pfam05483:

Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 42.79  E-value: 5.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273    63 EQSISYLDQELTTFGFPSLYEESKSKEAKREL------NIVAVLNCmnELLVLQRKNLLAQESVETqnLKLGSDMDHLQS 136
Cdd:pfam05483 449 EKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELekeklkNIELTAHC--DKLLLENKELTQEASDMT--LELKKHQEDIIN 524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273   137 CyaklKEQLETSRREMIGLQERDRQLQCKNRSLHQLLKNEKDEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQLV 216
Cdd:pfam05483 525 C----KKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK 600
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273   217 MNKKDKNIAMDVLNYVGRADGKRGSWRTDKtearnedemykilLNDYEYRQKQILMENAELKKVLQQMKKEMISLLSPQK 296
Cdd:pfam05483 601 KQIENKNKNIEELHQENKALKKKGSAENKQ-------------LNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKK 667
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273   297 KKPRERAEDGTGTVAISDieddsgelsrdsvwglscDTVREQLTNSIRKQWRI--LKSHVEKLDNQASKVHSEGLNEEDV 374
Cdd:pfam05483 668 ISEEKLLEEVEKAKAIAD------------------EAVKLQKEIDKRCQHKIaeMVALMEKHKHQYDKIIEERDSELGL 729
                         330
                  ....*....|....*...
gi 20270273   375 ISRQDHEQETEKLELEIE 392
Cdd:pfam05483 730 YKNKEQEQSSAKAALEIE 747
 
Name Accession Description Interval E-value
ADIP pfam11559
Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at ...
63-214 1.02e-46

Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at cell-cell adherens junctions, and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins localized at Cell-Cell Adherens Junctions.


Pssm-ID: 463295 [Multi-domain]  Cd Length: 151  Bit Score: 161.33  E-value: 1.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273    63 EQSISYLDQELTTFGFPSLYEESKSKEaKRELNIVAVLNCMNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLK 142
Cdd:pfam11559   1 ENAITYINQTLLSRGFLRSGLLFDTAE-GVEENIARIINVIYELLQQRDRDLEFRESLNETIRTLEAEIERLQSKIERLK 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20270273   143 EQLETSRREMIGLQERDRQLQCKNRSLHQLLKNEKDEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQ 214
Cdd:pfam11559  80 TQLEDLERELALLQAKERQLEKKLKTLEQKLKNEKEELQRLKNALQQIKTQFAHEVKKRDREIEKLKERLAQ 151
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
63-392 5.97e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 42.79  E-value: 5.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273    63 EQSISYLDQELTTFGFPSLYEESKSKEAKREL------NIVAVLNCmnELLVLQRKNLLAQESVETqnLKLGSDMDHLQS 136
Cdd:pfam05483 449 EKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELekeklkNIELTAHC--DKLLLENKELTQEASDMT--LELKKHQEDIIN 524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273   137 CyaklKEQLETSRREMIGLQERDRQLQCKNRSLHQLLKNEKDEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQLV 216
Cdd:pfam05483 525 C----KKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK 600
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273   217 MNKKDKNIAMDVLNYVGRADGKRGSWRTDKtearnedemykilLNDYEYRQKQILMENAELKKVLQQMKKEMISLLSPQK 296
Cdd:pfam05483 601 KQIENKNKNIEELHQENKALKKKGSAENKQ-------------LNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKK 667
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273   297 KKPRERAEDGTGTVAISDieddsgelsrdsvwglscDTVREQLTNSIRKQWRI--LKSHVEKLDNQASKVHSEGLNEEDV 374
Cdd:pfam05483 668 ISEEKLLEEVEKAKAIAD------------------EAVKLQKEIDKRCQHKIaeMVALMEKHKHQYDKIIEERDSELGL 729
                         330
                  ....*....|....*...
gi 20270273   375 ISRQDHEQETEKLELEIE 392
Cdd:pfam05483 730 YKNKEQEQSSAKAALEIE 747
 
Name Accession Description Interval E-value
ADIP pfam11559
Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at ...
63-214 1.02e-46

Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at cell-cell adherens junctions, and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins localized at Cell-Cell Adherens Junctions.


Pssm-ID: 463295 [Multi-domain]  Cd Length: 151  Bit Score: 161.33  E-value: 1.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273    63 EQSISYLDQELTTFGFPSLYEESKSKEaKRELNIVAVLNCMNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLK 142
Cdd:pfam11559   1 ENAITYINQTLLSRGFLRSGLLFDTAE-GVEENIARIINVIYELLQQRDRDLEFRESLNETIRTLEAEIERLQSKIERLK 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20270273   143 EQLETSRREMIGLQERDRQLQCKNRSLHQLLKNEKDEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQ 214
Cdd:pfam11559  80 TQLEDLERELALLQAKERQLEKKLKTLEQKLKNEKEELQRLKNALQQIKTQFAHEVKKRDREIEKLKERLAQ 151
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
63-392 5.97e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 42.79  E-value: 5.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273    63 EQSISYLDQELTTFGFPSLYEESKSKEAKREL------NIVAVLNCmnELLVLQRKNLLAQESVETqnLKLGSDMDHLQS 136
Cdd:pfam05483 449 EKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELekeklkNIELTAHC--DKLLLENKELTQEASDMT--LELKKHQEDIIN 524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273   137 CyaklKEQLETSRREMIGLQERDRQLQCKNRSLHQLLKNEKDEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQLV 216
Cdd:pfam05483 525 C----KKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK 600
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273   217 MNKKDKNIAMDVLNYVGRADGKRGSWRTDKtearnedemykilLNDYEYRQKQILMENAELKKVLQQMKKEMISLLSPQK 296
Cdd:pfam05483 601 KQIENKNKNIEELHQENKALKKKGSAENKQ-------------LNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKK 667
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270273   297 KKPRERAEDGTGTVAISDieddsgelsrdsvwglscDTVREQLTNSIRKQWRI--LKSHVEKLDNQASKVHSEGLNEEDV 374
Cdd:pfam05483 668 ISEEKLLEEVEKAKAIAD------------------EAVKLQKEIDKRCQHKIaeMVALMEKHKHQYDKIIEERDSELGL 729
                         330
                  ....*....|....*...
gi 20270273   375 ISRQDHEQETEKLELEIE 392
Cdd:pfam05483 730 YKNKEQEQSSAKAALEIE 747
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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