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Conserved domains on  [gi|20070380|ref|NP_612640|]
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pro-neuregulin-4, membrane-bound isoform [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03099 super family cl31525
epidermal growth factor-like protein (EGF-like protein); Provisional
 9-83 1.92e-05

epidermal growth factor-like protein (EGF-like protein); Provisional


The actual alignment was detected with superfamily member PHA03099:

Pssm-ID: 165381  Cd Length: 139  Bit Score: 41.16  E-value: 1.92e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20070380    9 CGPSHKSFCLNGgLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFLC 83
Cdd:PHA03099  45 CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSYIPSPGIVLVLVGIIITCC 118
 
Name Accession Description Interval E-value
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 9-83 1.92e-05

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 41.16  E-value: 1.92e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20070380    9 CGPSHKSFCLNGgLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFLC 83
Cdd:PHA03099  45 CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSYIPSPGIVLVLVGIIITCC 118
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 17-46 7.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 32.22  E-value: 7.14e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 20070380  17 CLNGGLCyvIPTIPSPFCRCVENYTGARCE 46
Cdd:cd00054  11 CQNGGTC--VNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 9-83 1.92e-05

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 41.16  E-value: 1.92e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20070380    9 CGPSHKSFCLNGgLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFLC 83
Cdd:PHA03099  45 CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSYIPSPGIVLVLVGIIITCC 118
PHA02887 PHA02887
EGF-like protein; Provisional
 7-48 6.58e-04

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 36.83  E-value: 6.58e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 20070380    7 EPCGPSHKSFCLNGgLCYVIPTIPSPFCRCVENYTGARCEEV 48
Cdd:PHA02887  84 EKCKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCDEV 124
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 17-46 7.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 32.22  E-value: 7.14e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 20070380  17 CLNGGLCyvIPTIPSPFCRCVENYTGARCE 46
Cdd:cd00054  11 CQNGGTC--VNTVGSYRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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