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Conserved domains on  [gi|110735428|ref|NP_598424|]
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integrin beta-4 isoform 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 38-455 0e+00

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member smart00187:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 423  Bit Score: 558.86  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428     38 SCTECIRVDKSCAYCTDELFKER---RCNTQAELLAAGCRGESILVMESSLEITENTQID---TSLHRSQVSPQGLQVRL 111
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    112 RPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 191
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    192 KEPWPN----SDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESA 267
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    268 FHYEADGAnvLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLG 347
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    348 VLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSdTLQKTETGSFHikRGEVGTYNVHLRAVEDIDGTHVCQl 427
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*....
gi 110735428    428 aKEDQGGNIHLKP-SFSDGLRMDASVICD 455
Cdd:smart00187  395 -PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 991-1085 2.72e-27

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


:

Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 106.96  E-value: 2.72e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    991 GVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLelqeVDS 1070
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDD 77

                            90
                    ....*....|....*
gi 110735428   1071 LLRGrqVRRFQVQLS 1085
Cdd:smart00237   78 IYEK--DETFYVRLS 90
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 628-710 3.07e-24

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


:

Pssm-ID: 462325  Cd Length: 84  Bit Score: 98.12  E-value: 3.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   628 CEDLRSCVQCQAWGTGEKKGRACD-DCPFKVKMVDELK--KEEVVEYCSFRDEdDDCTYSYNVEGDgsPGPNSTVLVHKK 704
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCSrNCKFEIILVEVLKedEEPGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 110735428   705 KDCPPG 710
Cdd:pfam07965   78 RECPPG 83
fn3 pfam00041
Fibronectin type III domain;
1572-1657 9.39e-22

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 90.94  E-value: 9.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1572 SAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQARTT 1651
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 110735428  1652 EGFGPE 1657
Cdd:pfam00041   79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1458-1539 7.83e-19

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 82.93  E-value: 7.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1458 PDTPTRLVFSALGPTSLKVSWQEPQCD-RMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                  ...
gi 110735428 1537 GWG 1539
Cdd:cd00063    81 GES 83
fn3 pfam00041
Fibronectin type III domain;
1129-1209 5.38e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.76  E-value: 5.38e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 110735428  1205 EGPYS 1209
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1221-1314 2.44e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 2.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1300
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....
gi 110735428 1301 ARNGAGWGPEREAI 1314
Cdd:cd00063    76 AVNGGGESPPSESV 89
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 459-487 1.26e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


:

Pssm-ID: 465729  Cd Length: 29  Bit Score: 54.80  E-value: 1.26e-09
                           10        20
                   ....*....|....*....|....*....
gi 110735428   459 CELQKEVRSARCHFRGDFMCGHCVCNEGW 487
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 38-455 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 558.86  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428     38 SCTECIRVDKSCAYCTDELFKER---RCNTQAELLAAGCRGESILVMESSLEITENTQID---TSLHRSQVSPQGLQVRL 111
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    112 RPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 191
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    192 KEPWPN----SDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESA 267
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    268 FHYEADGAnvLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLG 347
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    348 VLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSdTLQKTETGSFHikRGEVGTYNVHLRAVEDIDGTHVCQl 427
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*....
gi 110735428    428 aKEDQGGNIHLKP-SFSDGLRMDASVICD 455
Cdd:smart00187  395 -PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 126-371 4.01e-147

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 452.34  E-value: 4.01e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   126 PLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 201
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   202 FSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGAnvLAGI 281
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   282 MNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLE 361
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 110735428   362 EAFYRIRSNL 371
Cdd:pfam00362  239 EAYEKIRSKV 248
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 991-1085 2.72e-27

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 106.96  E-value: 2.72e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    991 GVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLelqeVDS 1070
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDD 77

                            90
                    ....*....|....*
gi 110735428   1071 LLRGrqVRRFQVQLS 1085
Cdd:smart00237   78 IYEK--DETFYVRLS 90
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 628-710 3.07e-24

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 98.12  E-value: 3.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   628 CEDLRSCVQCQAWGTGEKKGRACD-DCPFKVKMVDELK--KEEVVEYCSFRDEdDDCTYSYNVEGDgsPGPNSTVLVHKK 704
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCSrNCKFEIILVEVLKedEEPGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 110735428   705 KDCPPG 710
Cdd:pfam07965   78 RECPPG 83
fn3 pfam00041
Fibronectin type III domain;
1572-1657 9.39e-22

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 90.94  E-value: 9.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1572 SAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQARTT 1651
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 110735428  1652 EGFGPE 1657
Cdd:pfam00041   79 GGEGPP 84
Calx-beta pfam03160
Calx-beta domain;
991-1085 4.28e-21

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 89.23  E-value: 4.28e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   991 GVVSFEQPEYSVSRGDQVARIPVIRHILD-NGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLElqevD 1069
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 110735428  1070 SLLRGRqvRRFQVQLS 1085
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1458-1539 7.83e-19

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 82.93  E-value: 7.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1458 PDTPTRLVFSALGPTSLKVSWQEPQCD-RMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                  ...
gi 110735428 1537 GWG 1539
Cdd:cd00063    81 GES 83
fn3 pfam00041
Fibronectin type III domain;
1459-1541 2.64e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 81.31  E-value: 2.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1459 DTPTRLVFSALGPTSLKVSWQEP-QCDRMLLGYSVEYQLLNGGEM-HRLNIPNPgQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEPwNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 110735428  1537 GWGRE 1541
Cdd:pfam00041   80 GEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1571-1656 1.88e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 76.00  E-value: 1.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1571 PSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQART 1650
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78


                  ....*.
gi 110735428 1651 TEGFGP 1656
Cdd:cd00063    79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1129-1209 5.38e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.76  E-value: 5.38e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 110735428  1205 EGPYS 1209
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1458-1539 2.96e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 72.26  E-value: 2.96e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   1458 PDTPTRLVFSALGPTSLKVSWQEPQCDRmLLGYSVEYQLLNGGEMHRLN--IPNPGQTSVVVEDLLPNHSYVFRVRAQSQ 1535
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 110735428   1536 EGWG 1539
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1571-1655 4.16e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.88  E-value: 4.16e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   1571 PSAPGPLVFTALSPDSLQLSWERPRRPNGDilGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQART 1650
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 110735428   1651 TEGFG 1655
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1221-1314 2.44e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 2.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1300
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....
gi 110735428 1301 ARNGAGWGPEREAI 1314
Cdd:cd00063    76 AVNGGGESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
1222-1310 3.45e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 3.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1222 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1301
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 110735428  1302 RNGAGWGPE 1310
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1129-1216 1.16e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 110735428 1205 EGPYSSLVSCRT 1216
Cdd:cd00063    82 ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1457-1676 2.55e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.96  E-value: 2.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1457 VPDTPTRLVFSALGPTSLKVSWQEPQCDRmLLGYSVEYQLLNGGEMHRlnIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:COG3401   232 PPSAPTGLTATADTPGSVTLSWDPVTESD-ATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1537 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDILGYLVTcemaQGGA 1615
Cdd:COG3401   309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110735428 1616 PARTFR-VDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLG 1676
Cdd:COG3401   366 GGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1129-1206 9.15e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 9.15e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   1129 GAPQNPNAKAAGSRKIHFNWLPPPGK-PMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 110735428   1205 EG 1206
Cdd:smart00060   82 EG 83
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 459-487 1.26e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 54.80  E-value: 1.26e-09
                           10        20
                   ....*....|....*....|....*....
gi 110735428   459 CELQKEVRSARCHFRGDFMCGHCVCNEGW 487
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1221-1308 2.14e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.14e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNednRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1300
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 110735428   1301 ARNGAGWG 1308
Cdd:smart00060   76 AVNGAGEG 83
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 993-1107 7.80e-08

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 7.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   993 VSFEQPEYSVSRGDQVARIPVIRHILDNGKS-QVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLL--ELQEVD 1069
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 110735428  1070 sllrgrqvRRFQVQLSNPKFG--------------ARLGQPSTTTVILGEHD 1107
Cdd:TIGR00845  482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1509-1653 1.79e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.16  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1509 NPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1587
Cdd:COG3401   188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110735428 1588 QLSWERPrrPNGDILGYLVtcemAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEG 1653
Cdd:COG3401   250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1147-1306 2.65e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1147 NWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1226
Cdd:COG3401   159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1227 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGlvnedNRPIGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1306
Cdd:COG3401   239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRS-----NSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 38-455 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 558.86  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428     38 SCTECIRVDKSCAYCTDELFKER---RCNTQAELLAAGCRGESILVMESSLEITENTQID---TSLHRSQVSPQGLQVRL 111
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    112 RPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 191
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    192 KEPWPN----SDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESA 267
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    268 FHYEADGAnvLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLG 347
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    348 VLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSdTLQKTETGSFHikRGEVGTYNVHLRAVEDIDGTHVCQl 427
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*....
gi 110735428    428 aKEDQGGNIHLKP-SFSDGLRMDASVICD 455
Cdd:smart00187  395 -PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 126-371 4.01e-147

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 452.34  E-value: 4.01e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   126 PLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 201
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   202 FSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGAnvLAGI 281
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   282 MNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLE 361
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 110735428   362 EAFYRIRSNL 371
Cdd:pfam00362  239 EAYEKIRSKV 248
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 991-1085 2.72e-27

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 106.96  E-value: 2.72e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428    991 GVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLelqeVDS 1070
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDD 77

                            90
                    ....*....|....*
gi 110735428   1071 LLRGrqVRRFQVQLS 1085
Cdd:smart00237   78 IYEK--DETFYVRLS 90
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 628-710 3.07e-24

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 98.12  E-value: 3.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   628 CEDLRSCVQCQAWGTGEKKGRACD-DCPFKVKMVDELK--KEEVVEYCSFRDEdDDCTYSYNVEGDgsPGPNSTVLVHKK 704
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCSrNCKFEIILVEVLKedEEPGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 110735428   705 KDCPPG 710
Cdd:pfam07965   78 RECPPG 83
fn3 pfam00041
Fibronectin type III domain;
1572-1657 9.39e-22

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 90.94  E-value: 9.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1572 SAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQARTT 1651
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 110735428  1652 EGFGPE 1657
Cdd:pfam00041   79 GGEGPP 84
Calx-beta pfam03160
Calx-beta domain;
991-1085 4.28e-21

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 89.23  E-value: 4.28e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   991 GVVSFEQPEYSVSRGDQVARIPVIRHILD-NGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLElqevD 1069
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 110735428  1070 SLLRGRqvRRFQVQLS 1085
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1458-1539 7.83e-19

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 82.93  E-value: 7.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1458 PDTPTRLVFSALGPTSLKVSWQEPQCD-RMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                  ...
gi 110735428 1537 GWG 1539
Cdd:cd00063    81 GES 83
fn3 pfam00041
Fibronectin type III domain;
1459-1541 2.64e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 81.31  E-value: 2.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1459 DTPTRLVFSALGPTSLKVSWQEP-QCDRMLLGYSVEYQLLNGGEM-HRLNIPNPgQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEPwNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 110735428  1537 GWGRE 1541
Cdd:pfam00041   80 GEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1571-1656 1.88e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 76.00  E-value: 1.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1571 PSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQART 1650
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78


                  ....*.
gi 110735428 1651 TEGFGP 1656
Cdd:cd00063    79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1129-1209 5.38e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.76  E-value: 5.38e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 110735428  1205 EGPYS 1209
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1458-1539 2.96e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 72.26  E-value: 2.96e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   1458 PDTPTRLVFSALGPTSLKVSWQEPQCDRmLLGYSVEYQLLNGGEMHRLN--IPNPGQTSVVVEDLLPNHSYVFRVRAQSQ 1535
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 110735428   1536 EGWG 1539
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1571-1655 4.16e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.88  E-value: 4.16e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   1571 PSAPGPLVFTALSPDSLQLSWERPRRPNGDilGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQART 1650
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 110735428   1651 TEGFG 1655
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1221-1314 2.44e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 2.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1300
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....
gi 110735428 1301 ARNGAGWGPEREAI 1314
Cdd:cd00063    76 AVNGGGESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
1222-1310 3.45e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 3.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428  1222 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1301
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 110735428  1302 RNGAGWGPE 1310
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1129-1216 1.16e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 110735428 1205 EGPYSSLVSCRT 1216
Cdd:cd00063    82 ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1457-1676 2.55e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.96  E-value: 2.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1457 VPDTPTRLVFSALGPTSLKVSWQEPQCDRmLLGYSVEYQLLNGGEMHRlnIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:COG3401   232 PPSAPTGLTATADTPGSVTLSWDPVTESD-ATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1537 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDILGYLVTcemaQGGA 1615
Cdd:COG3401   309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110735428 1616 PARTFR-VDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLG 1676
Cdd:COG3401   366 GGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 29-74 5.14e-11

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 59.10  E-value: 5.14e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 110735428    29 NRCKKAQvKSCTECIRVDKSCAYCTDELF--KERRCNTQAELLAAGCR 74
Cdd:pfam17205    1 NRCTSAS-TSCEECIQSGPDCAWCTDENFtsGSPRCDTRENLLARGCS 47
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1130-1306 1.02e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.56  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1130 APQNPNAKAAGSRKIHFNWLPPPGKP-MGYRVKYWIQGDSESEahlldsKVPSVELTNlypYCD--------YEMKVCAY 1200
Cdd:COG3401   235 APTGLTATADTPGSVTLSWDPVTESDaTGYRVYRSNSGDGPFT------KVATVTTTS---YTDtgltngttYYYRVTAV 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1201 GAQG-EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPaeTNGEITAYEVcYglvnEDNRPIGPMKKVlVDNP 1279
Cdd:COG3401   306 DAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNV-Y----RSTSGGGTYTKI-AETV 377

                         170       180
                  ....*....|....*....|....*..
gi 110735428 1280 KNRMLLIENLRESQPYRYTVKARNGAG 1306
Cdd:COG3401   378 TTTSYTDTGLTPGTTYYYKVTAVDAAG 404
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1129-1206 9.15e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 9.15e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   1129 GAPQNPNAKAAGSRKIHFNWLPPPGK-PMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 110735428   1205 EG 1206
Cdd:smart00060   82 EG 83
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 459-487 1.26e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 54.80  E-value: 1.26e-09
                           10        20
                   ....*....|....*....|....*....
gi 110735428   459 CELQKEVRSARCHFRGDFMCGHCVCNEGW 487
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1221-1308 2.14e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.14e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNednRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1300
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 110735428   1301 ARNGAGWG 1308
Cdd:smart00060   76 AVNGAGEG 83
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 993-1107 7.80e-08

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 7.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   993 VSFEQPEYSVSRGDQVARIPVIRHILDNGKS-QVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLL--ELQEVD 1069
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 110735428  1070 sllrgrqvRRFQVQLSNPKFG--------------ARLGQPSTTTVILGEHD 1107
Cdd:TIGR00845  482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1509-1653 1.79e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.16  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1509 NPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1587
Cdd:COG3401   188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110735428 1588 QLSWERPrrPNGDILGYLVtcemAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEG 1653
Cdd:COG3401   250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 979-1092 1.77e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 53.26  E-value: 1.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428   979 LVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTA-HGHRDYVPVEGELLFHPGETWKE 1057
Cdd:TIGR00845  516 TATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTArGGGKDFEDTCGELEFENDETEKT 595

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 110735428  1058 LQVKLLELQEVDsllrgRQVrRFQVQLSNPKFGAR 1092
Cdd:TIGR00845  596 IRVKIVDDEEYE-----KND-TFFIELGEPRWAKR 624
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1147-1306 2.65e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1147 NWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1226
Cdd:COG3401   159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1227 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGlvnedNRPIGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1306
Cdd:COG3401   239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRS-----NSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
1571-1653 1.42e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 42.84  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735428 1571 PSAPGPLVFTALSPDSLQLSWErPRRPNGDILGYLVTcemaQGGAPARTfrVDGDNpesRLTVPGLSENVPYKFKVQART 1650
Cdd:COG3979     3 PTAPTGLTASNVTSSSVSLSWD-ASTDNVGVTGYDVY----RGGDQVAT--VTGLT---AWTVTGLTPGTEYTFTVGACD 72


                  ...
gi 110735428 1651 TEG 1653
Cdd:COG3979    73 AAG 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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