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Conserved domains on  [gi|23956242|ref|NP_444425|]
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sodium/potassium/calcium exchanger 3 isoform 2 [Mus musculus]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 39-581 4.07e-108

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 349.68  E-value: 4.07e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242     39 PALH---EFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 115
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    116 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVL 195
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    196 MYLIYIVIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 242
Cdd:TIGR00927  594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    243 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 305
Cdd:TIGR00927  674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    306 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDIVAETDNETENENEDNENNENDEEEEEDEDDDEG 385
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    386 -------------------------------------------------------------PYTpFDPPSGKLETVKWAF 404
Cdd:TIGR00927  832 tgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneePLS-LEWPETRQKQAIYLF 910

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    405 TWPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIV 484
Cdd:TIGR00927  911 LLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIV 990

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    485 ARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGC 564
Cdd:TIGR00927  991 ARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGF 1069

                          650
                   ....*....|....*..
gi 23956242    565 GCLFLYGVFLCFSIMTE 581
Cdd:TIGR00927 1070 TMFLLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 39-581 4.07e-108

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 349.68  E-value: 4.07e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242     39 PALH---EFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 115
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    116 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVL 195
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    196 MYLIYIVIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 242
Cdd:TIGR00927  594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    243 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 305
Cdd:TIGR00927  674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    306 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDIVAETDNETENENEDNENNENDEEEEEDEDDDEG 385
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    386 -------------------------------------------------------------PYTpFDPPSGKLETVKWAF 404
Cdd:TIGR00927  832 tgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneePLS-LEWPETRQKQAIYLF 910

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    405 TWPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIV 484
Cdd:TIGR00927  911 LLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIV 990

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    485 ARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGC 564
Cdd:TIGR00927  991 ARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGF 1069

                          650
                   ....*....|....*..
gi 23956242    565 GCLFLYGVFLCFSIMTE 581
Cdd:TIGR00927 1070 TMFLLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
79-204 1.95e-28

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 115.23  E-value: 1.95e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  79 DFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALS 158
Cdd:COG0530   2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 23956242 159 SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIVIM 204
Cdd:COG0530  80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL 125
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 62-204 6.48e-27

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 106.53  E-value: 6.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    62 HVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNIL 141
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23956242   142 CIIGVCGLFAGQVVALS----SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIVIM 204
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLllklDLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 57-590 6.77e-15

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 77.88  E-value: 6.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   57 GAVVLHVlCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSvIGVFI--TKGDVGVGTIVG 134
Cdd:PLN03151 139 GYAVLGV-WLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVgkDAGEVGLNSVLG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  135 SAVFNILCIIGVCGL-FAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNAcIHQC 213
Cdd:PLN03151 217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANE-ILRK 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  214 FERRTKgagnmvnglannaeiddssnCDATVVLLKKANFHRKASvimVDELLSAYPHQL-SFSEAGlrimitshfPPKTR 292
Cdd:PLN03151 296 HARRLK--------------------LDVVTPLLPVQGSIFSPS---VEEDESMYSPLLeSDTESD---------VPRLQ 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  293 LSMASRMLinerqrlinsraytngESEVAIKipIKHTVENGTGPSSAPDRGVN--GTRRDDIVAETDNETENENEDNENN 370
Cdd:PLN03151 344 TSLPQWMW----------------ASNVAIY--SNHFAKGSVHDEERPPWGWTdeGAEVESSLFSCSKLFSLLEMPLTIP 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  371 ENDEEEEEDEDDDEGPYTpfdPPSGKLETVKWAFTW-----------------------PLSFVLY-FTVPncNKPHWE- 425
Cdd:PLN03151 406 RRLTIPIVEEDRWSKTYA---VASASLAPVLLAFLWssqddvslqariaayfigvaigsTLGFLAYkYTEP--DRPPRRf 480

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  426 --KWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGmGD---MAVSNSIGS 500
Cdd:PLN03151 481 liPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAG 559

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  501 NVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFSIMT 580
Cdd:PLN03151 560 PMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRVST 639

                        570
                 ....*....|
gi 23956242  581 EFNVFTFVNL 590
Cdd:PLN03151 640 AMGFIPWAGL 649
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 39-581 4.07e-108

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 349.68  E-value: 4.07e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242     39 PALH---EFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 115
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    116 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVL 195
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    196 MYLIYIVIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 242
Cdd:TIGR00927  594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    243 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 305
Cdd:TIGR00927  674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    306 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDIVAETDNETENENEDNENNENDEEEEEDEDDDEG 385
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    386 -------------------------------------------------------------PYTpFDPPSGKLETVKWAF 404
Cdd:TIGR00927  832 tgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneePLS-LEWPETRQKQAIYLF 910

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    405 TWPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIV 484
Cdd:TIGR00927  911 LLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIV 990

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    485 ARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGC 564
Cdd:TIGR00927  991 ARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGF 1069

                          650
                   ....*....|....*..
gi 23956242    565 GCLFLYGVFLCFSIMTE 581
Cdd:TIGR00927 1070 TMFLLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 61-557 2.12e-41

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 152.09  E-value: 2.12e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    61 LHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNI 140
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   141 LCIIGVCGLFAGQVVAlsSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYivimkynacihqcferrtkg 220
Cdd:TIGR00367  81 LLILGLSAIFSPIIVD--KDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVY-------------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   221 agnmvnglannaeiddssncdaTVVLLKKanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasrml 300
Cdd:TIGR00367 139 ----------------------LLFLVKN--------------------------------------------------- 145

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   301 inerQRLINSRAYTNgesevaikipiKHTVENGTGPSSapdrgvngtrrddivaetdnetenenednennendeeeeede 380
Cdd:TIGR00367 146 ----ERWVKYDTYTE-----------ENLDENNRRPQI------------------------------------------ 168

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   381 dddegpytpfdppsgkletvkwaftwPLSFVlyftvpncnkphwekWFMVTFAsstlWIAAFSYMMVWMVTIIGYTLGIP 460
Cdd:TIGR00367 169 --------------------------FFSLV---------------LLIIGLI----GLVVGSRLLVDGAVKIAEILGIS 203

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   461 DVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLL 540
Cdd:TIGR00367 204 EKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPIPVEPLAYNLDAPVMVIVTLLLM 283

                         490
                  ....*....|....*..
gi 23956242   541 LasvfVTVFGVHLNKWQ 557
Cdd:TIGR00367 284 L----FFKTSMKLGRWE 296
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
79-204 1.95e-28

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 115.23  E-value: 1.95e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  79 DFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALS 158
Cdd:COG0530   2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 23956242 159 SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIVIM 204
Cdd:COG0530  80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL 125
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 62-204 6.48e-27

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 106.53  E-value: 6.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    62 HVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNIL 141
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23956242   142 CIIGVCGLFAGQVVALS----SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIVIM 204
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLllklDLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 427-579 6.39e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.45  E-value: 6.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   427 WFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDIL 506
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23956242   507 IGLGLPWALQTLAVDyGSYIRLNSRGLIYSVGLLLASVFVTVFgvhLNKWQLDKKLGCGCLFLYGVFLCFSIM 579
Cdd:pfam01699  81 LVLGLSALIGPVKVD-SLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
38-204 3.49e-23

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 99.82  E-value: 3.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  38 EPALHEFPRDIFSNEDRRQGAVVLHVLCAMymfyALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSV 117
Cdd:COG0530 132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242 118 IGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALSSWCLLRDSIYYTLSVVALIVFIY-DEKVSWWESLVLVLM 196
Cdd:COG0530 208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285


                ....*...
gi 23956242 197 YLIYIVIM 204
Cdd:COG0530 286 YLAYLALL 293
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 57-590 6.77e-15

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 77.88  E-value: 6.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   57 GAVVLHVlCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSvIGVFI--TKGDVGVGTIVG 134
Cdd:PLN03151 139 GYAVLGV-WLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVgkDAGEVGLNSVLG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  135 SAVFNILCIIGVCGL-FAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNAcIHQC 213
Cdd:PLN03151 217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANE-ILRK 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  214 FERRTKgagnmvnglannaeiddssnCDATVVLLKKANFHRKASvimVDELLSAYPHQL-SFSEAGlrimitshfPPKTR 292
Cdd:PLN03151 296 HARRLK--------------------LDVVTPLLPVQGSIFSPS---VEEDESMYSPLLeSDTESD---------VPRLQ 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  293 LSMASRMLinerqrlinsraytngESEVAIKipIKHTVENGTGPSSAPDRGVN--GTRRDDIVAETDNETENENEDNENN 370
Cdd:PLN03151 344 TSLPQWMW----------------ASNVAIY--SNHFAKGSVHDEERPPWGWTdeGAEVESSLFSCSKLFSLLEMPLTIP 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  371 ENDEEEEEDEDDDEGPYTpfdPPSGKLETVKWAFTW-----------------------PLSFVLY-FTVPncNKPHWE- 425
Cdd:PLN03151 406 RRLTIPIVEEDRWSKTYA---VASASLAPVLLAFLWssqddvslqariaayfigvaigsTLGFLAYkYTEP--DRPPRRf 480

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  426 --KWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGmGD---MAVSNSIGS 500
Cdd:PLN03151 481 liPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAG 559

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  501 NVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFSIMT 580
Cdd:PLN03151 560 PMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRVST 639

                        570
                 ....*....|
gi 23956242  581 EFNVFTFVNL 590
Cdd:PLN03151 640 AMGFIPWAGL 649
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 25-264 1.42e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 77.14  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    25 SEDAGLQSSKNCTEPALHE--FPRDIfSNEDRRQGAVVLHVLcAMYMFYALAIVCDDFFV----------------PSLE 86
Cdd:TIGR00845  41 SNTGECTGSYYCKEGVILPiwEPQNP-SVGDKIARATVYFVA-MVYMFLGVSIIADRFMAsievitsqekeitikkPNGE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    87 KICERLHL-SEDVAGATFMAAGSSAPELFTSVIGVF---ITKGDVGVGTIVGSAVFNILCIIGVCGLF--AGQVVAL--- 157
Cdd:TIGR00845 119 TTVTTVRIwNETVSNLTLMALGSSAPEILLSVIEVCghnFEAGDLGPSTIVGSAAFNMFIIIAICVYVipDGETRKIkhl 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   158 ------SSWcllrdSIY-YTLSVVALIVFIYDEkVSWWESLvLVLMYLIYIVIMKYNACIHQCFE-------RRTKGAGN 223
Cdd:TIGR00845 199 rvffvtAAW-----SVFaYVWLYLILAVFSPGV-VEVWEGL-LTFFFFPLCVVFAWVADRRLLFYkyvykryRAGKQRGM 271

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 23956242   224 MVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDEL 264
Cdd:TIGR00845 272 IIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEF 312
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
457-581 5.35e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 69.78  E-value: 5.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242 457 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDygsyirlnSRGLIYS 536
Cdd:COG0530  15 LGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVD--------RRVLRRD 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 23956242 537 VGLLLASVFVTVFGVHLNkwQLDKKLGCGCLFLYGVFLCFSIMTE 581
Cdd:COG0530  87 LPFLLLASLLLLALLLDG--TLSRIDGVILLLLYVLYLYYLIRRA 129
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 52-200 1.02e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 69.27  E-value: 1.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    52 EDRRQGAVVLHVLCAMYMFYALAIVCDdFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGT 131
Cdd:TIGR00367 161 ENNRRPQIFFSLVLLIIGLIGLVVGSR-LLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGN 239

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23956242   132 IVGSAVFNILCIIGVCGLFA-GQVVALSswcLLRD-SIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIY 200
Cdd:TIGR00367 240 VIGSNIFNILVGLGVPSLFMpIPVEPLA---YNLDaPVMVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 445-587 1.11e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 69.29  E-value: 1.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242  445 MMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGS 524
Cdd:PRK10734 192 MVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEINPLA 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23956242  525 YIRlnsrglIYSVgLLLASVFVTVFGvhlnkWQLDKKLG--CGCLFLYGVFLCFSIMTEFNVFTF 587
Cdd:PRK10734 272 FSR------DYWV-MLLVSVIFALLC-----WRRKRRIGrgAGALLLGGFIVWLAMLYWLSPILV 324
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 451-578 5.16e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 66.96  E-value: 5.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   451 TIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYgSYIRLNS 530
Cdd:TIGR00367  26 VRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFSPIIVDK-DWLRRDI 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 23956242   531 RGLIYSVGLLLasvFVTVFGvhlnkwQLDKKLGCGCLFLYGVFLCFSI 578
Cdd:TIGR00367 105 LFYLLVSILLL---FFGLDG------QISRIDGVVLLILYIVYLLFLV 143
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 411-548 5.90e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 65.58  E-value: 5.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   411 VLYFTVPNCNkpHWEKWfmVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMG 490
Cdd:TIGR00845 742 VLFAFVPPTE--YWGGW--ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQY 817

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23956242   491 -DMAVSNSIGSNVFDILIGLGLPWalqTLAVDY----GSYIRLNSRGLIYSVGLLLASVFVTV 548
Cdd:TIGR00845 818 aDASIGNVTGSNAVNVFLGIGVAW---SIAAIYhaanGTQFKVSPGTLAFSVTLFTIFAFICI 877
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 446-520 2.95e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 61.97  E-value: 2.95e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23956242  446 MVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAV 520
Cdd:PRK10734  22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTV 96
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 60-204 3.97e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 52.34  E-value: 3.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   60 VLHVLCAMYMFYALAIVCDDFFVPSLekicerlhlsedVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFN 139
Cdd:PRK10734  13 LLLVYGADRLVFAASILCRTFGIPPL------------IIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 23956242  140 ILCIIGVCGLFAGQVVALSswcLLRDSIYYTLSVVALI-VFIYDEKVSWWESLVLVLMYLIYIVIM 204
Cdd:PRK10734  81 ILLILGLAALIRPFTVHSD---VLRRELPLMLLVSVLAgSVLYDGQLSRSDGIFLLLLAVLWLLFI 143
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 94-171 5.42e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 51.96  E-value: 5.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242   94 LSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGL-----FAGQVVALSSWCLLRDSIY 168
Cdd:PRK10734 206 ISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALispgeINPLAFSRDYWVMLLVSVI 285


                 ...
gi 23956242  169 YTL 171
Cdd:PRK10734 286 FAL 288
caca2 TIGR00846
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ...
 75-200 1.96e-03

calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273297 [Multi-domain]  Cd Length: 363  Bit Score: 40.90  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956242    75 IVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIgvcglfagQV 154
Cdd:TIGR00846 232 ILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSALQIILFVV--------PL 303

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 23956242   155 VALSSWCLLRD---------SIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIY 200
Cdd:TIGR00846 304 VVLVAWMLGIPmdlnfgtfeTIVLALSLFLTTITLQDGRSNYLEGAVLLALYIII 358
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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