F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15812188  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYW 61
Cdd:cd22084   1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49

CO2+/MG2+ efflux protein ApaG; Reviewed

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812188  279 ATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIE-MSKDALpekacQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISP 357
Cdd:PRK05461   4 AVTYGIEVSVQPRYLEEQSDPEEGRYVFAYTITIEnLGRVPV-----QLLSRHWLITDANGRVQEVRGEGVVGEQPVLAP 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 15812188  358 GRVYEYTSCTTFSTTSGYMEGYYTFHflyfkD---KIFNVAIPRFHMACP 404
Cdd:PRK05461  79 GESFEYTSGAVLETPSGTMQGHYQMV-----DedgERFEVPIPPFRLAVP 123

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15812188  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYW 61
Cdd:cd22084   1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812188   121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPG--LLGSMALSNHYRSEDLLDVDtaagGFQQRQGLKYCLpLTF 198
Cdd:pfam09346   1 PATEEEIQEFEKELGVKLPEDYREFLLKTNGGGGLFEGldLLPLEEIEEEYEDLLAEDSL----YFIREWGLPEGL-IPF 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15812188   199 CiHTGLSQYIAVEAAEGRNKNEVFYQCPDqmarnpaAIDMFIIGATFTDWF 249
Cdd:pfam09346  76 A-DDGGGDYLCLDLRDGGEEGQVYFWDED-------DDELKLVADSFEEFL 118

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812188    121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVV---PGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLT 197
Cdd:smart00860   1 PATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGsaeLPLGGLSLLDLLELEAAIEDQEEIDSDIEEEEYALPGWLIF 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 15812188    198 FCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPaaidmFIIGATFTDWF 249
Cdd:smart00860  81 IADGGGGGILIDLDDGPGGEGGEVGVILFGDDDDEK-----YVVADSFEEFL 127

CO2+/MG2+ efflux protein ApaG; Reviewed

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812188  279 ATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIE-MSKDALpekacQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISP 357
Cdd:PRK05461   4 AVTYGIEVSVQPRYLEEQSDPEEGRYVFAYTITIEnLGRVPV-----QLLSRHWLITDANGRVQEVRGEGVVGEQPVLAP 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 15812188  358 GRVYEYTSCTTFSTTSGYMEGYYTFHflyfkD---KIFNVAIPRFHMACP 404
Cdd:PRK05461  79 GESFEYTSGAVLETPSGTMQGHYQMV-----DedgERFEVPIPPFRLAVP 123

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15812188  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYW 61
Cdd:cd22084   1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812188   121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPG--LLGSMALSNHYRSEDLLDVDtaagGFQQRQGLKYCLpLTF 198
Cdd:pfam09346   1 PATEEEIQEFEKELGVKLPEDYREFLLKTNGGGGLFEGldLLPLEEIEEEYEDLLAEDSL----YFIREWGLPEGL-IPF 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15812188   199 CiHTGLSQYIAVEAAEGRNKNEVFYQCPDqmarnpaAIDMFIIGATFTDWF 249
Cdd:pfam09346  76 A-DDGGGDYLCLDLRDGGEEGQVYFWDED-------DDELKLVADSFEEFL 118

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812188    121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVV---PGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLT 197
Cdd:smart00860   1 PATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGsaeLPLGGLSLLDLLELEAAIEDQEEIDSDIEEEEYALPGWLIF 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 15812188    198 FCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPaaidmFIIGATFTDWF 249
Cdd:smart00860  81 IADGGGGGILIDLDDGPGGEGGEVGVILFGDDDDEK-----YVVADSFEEFL 127

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15812188  12 TLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCK 58
Cdd:cd20090   1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRIAR 47

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15812188  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCK 58
Cdd:cd22093   1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLYS 46

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15812188  15 SLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22137   2 QLPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNLC 44

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15812188  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22147   2 LSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46

A Receptor for Ubiquitination Targets;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15812188     16 LPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRH 56
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15812188  15 SLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCK 58
Cdd:cd22102   3 DLPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIWQRRCK 46

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15812188  12 TLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSShDPLWRR 55
Cdd:cd22143   1 AFDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLAL-PELWRS 43

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15812188  15 SLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22134   6 QLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15812188  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRR 55
Cdd:cd22166   1 LTKLPPELFRHILKFLSPEDLTSCATVCRFLRGAASDESLWRR 43

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15812188  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22087   1 LLALPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15812188  15 SLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22151   2 KLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15812188  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQL-SSHDPLWRRHC 57
Cdd:cd22113   1 IELLPPEMSLRIFSQLDVQSLCRASQTCKTWNDLiENSDYLWRPHC 46

F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called FBX2, is a neuron-specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It binds specifically to proteins attached with N-linked high-mannose type oligosaccharides, and subsequently contributes to ubiquitination of glycoproteins. FBXO2 regulates amyloid precursor protein (APP) levels and processing in the brain, and may play a role in modulating Alzheimer disease (AD) pathogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15812188  13 LESLPTDPLLLILSFLDYRDLINCC-YVSRRLSQLSSHDPLWRRHCKKYWLISEEEKTQKNQcWKSLF 79
Cdd:cd22167   1 MESLPEAVLVRILAYLPAEELVLVCrLVCSQWKELVDGAALWILKCQQEGFSPTELEEEPDN-WQTFY 67

F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI family includes FBX5 (EMI1) and FBX43 (EMI2), which are anaphase-promoting complex/cyclosome (APC/C) inhibitors that bind APC/C-CCD20 (Cell division cycle protein 20) and/or APC/C-CDH1 (CDC20 homologue 1) complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15812188  24 ILSFLDYRDLINCCYVSRRlsqlsshdplWRRHCKK 59
Cdd:cd22086  15 ILSYLSPEDLCRVSCVSKT----------WRQICLS 40

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15812188  11 LTLESLPTDPLLLILSFLDYRDLI-NC---CYVSRRLSQLSShdpLWRRHCKKYWLISEEEKT 69
Cdd:cd22168   2 LTISDLPEDVLLEILSLVPARDLIlSCrlvCSRWRDLVDLPT---LWKRKCQREGFILKDWDG 61