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Conserved domains on  [gi|225690500|ref|NP_115828|]
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junctophilin-4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-143 1.82e-24

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 103.50  E-value: 1.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAqGEYSGCWAHG-FESLGVFTGPGGHSYQGHWQQGKREGLGVER-KSRW 81
Cdd:COG4642  116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNG-DVYEGEFKNGkPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTyANGD 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225690500  82 TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGV 143
Cdd:COG4642  195 VYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGT 256
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
281-336 1.12e-09

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 59.58  E-value: 1.12e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 225690500 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNR 336
Cdd:COG4642  149 VYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQ 204
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
369-606 1.58e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 369 RAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGR-RPRQDSEGSDTEPLDEDSPGVY 447
Cdd:PRK07003 378 GAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAtADRGDDAADGDAPVPAKANARA 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 448 ENGLTPSEGSPELPSSPASSRQPW---RPPACRSPLPPGGDQGPFSSPKAwpeewggagAQAEELAGYEAEDEAGMQG-P 523
Cdd:PRK07003 458 SADSRCDERDAQPPADSGSASAPAsdaPPDAAFEPAPRAAAPSAATPAAV---------PDARAPAAASREDAPAAAApP 528

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 524 GPRDGSPllggcSDSSGSLREEEGEDEEPLPPLRApAGtepepiamlvLRGSSSRGPDAGCLTEELGEPAATERPAQPGA 603
Cdd:PRK07003 529 APEARPP-----TPAAAAPAARAGGAAAALDVLRN-AG----------MRVSSDRGARAAAAAKPAAAPAAAPKPAAPRV 592


                 ...
gi 225690500 604 ANP 606
Cdd:PRK07003 593 AVQ 595
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-143 1.82e-24

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 103.50  E-value: 1.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAqGEYSGCWAHG-FESLGVFTGPGGHSYQGHWQQGKREGLGVER-KSRW 81
Cdd:COG4642  116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNG-DVYEGEFKNGkPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTyANGD 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225690500  82 TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGV 143
Cdd:COG4642  195 VYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGT 256
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-143 2.82e-20

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 95.29  E-value: 2.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500   5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGP-GA--QGEYSGCWAHGFeslGVFTGPGGHSYQGHWQQGKREGLGVER---- 77
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPsGAtyEGEFSGGYMHGS---GTYTGTDGTTYKGRWRLNLKHGLGYQRypng 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500  78 ----------------KSRW----TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGK 137
Cdd:PLN03185 101 dvfegswiqglqegpgKYTWangnVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGL 180


                 ....*.
gi 225690500 138 RHGYGV 143
Cdd:PLN03185 181 KDGKGV 186
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
281-336 1.12e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 59.58  E-value: 1.12e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 225690500 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNR 336
Cdd:COG4642  149 VYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQ 204
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
369-606 1.58e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 369 RAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGR-RPRQDSEGSDTEPLDEDSPGVY 447
Cdd:PRK07003 378 GAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAtADRGDDAADGDAPVPAKANARA 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 448 ENGLTPSEGSPELPSSPASSRQPW---RPPACRSPLPPGGDQGPFSSPKAwpeewggagAQAEELAGYEAEDEAGMQG-P 523
Cdd:PRK07003 458 SADSRCDERDAQPPADSGSASAPAsdaPPDAAFEPAPRAAAPSAATPAAV---------PDARAPAAASREDAPAAAApP 528

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 524 GPRDGSPllggcSDSSGSLREEEGEDEEPLPPLRApAGtepepiamlvLRGSSSRGPDAGCLTEELGEPAATERPAQPGA 603
Cdd:PRK07003 529 APEARPP-----TPAAAAPAARAGGAAAALDVLRN-AG----------MRVSSDRGARAAAAAKPAAAPAAAPKPAAPRV 592


                 ...
gi 225690500 604 ANP 606
Cdd:PRK07003 593 AVQ 595
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 281-340 2.44e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.52  E-value: 2.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNrLVHG 340
Cdd:PLN03185  33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN-LKHG 91
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 305-327 1.74e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.85  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|...
gi 225690500  305 YEGEWLGNRRHGYGRTTRPDGSR 327
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
304-324 3.39e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.01  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|.
gi 225690500   304 RYEGEWLGNRRHGYGRTTRPD 324
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
128-143 3.74e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.01  E-value: 3.74e-03
                           10
                   ....*....|....*.
gi 225690500   128 TYQGQWQAGKRHGYGV 143
Cdd:smart00698   2 RYEGEWRNGKRHGRGV 17
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-143 1.82e-24

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 103.50  E-value: 1.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAqGEYSGCWAHG-FESLGVFTGPGGHSYQGHWQQGKREGLGVER-KSRW 81
Cdd:COG4642  116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNG-DVYEGEFKNGkPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTyANGD 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225690500  82 TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGV 143
Cdd:COG4642  195 VYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGT 256
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-143 8.25e-22

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 95.79  E-value: 8.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGV-ERKSRWT 82
Cdd:COG4642   93 GGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTlTYADGDR 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225690500  83 YRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGV 143
Cdd:COG4642  173 YEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGT 233
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-143 2.82e-20

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 95.29  E-value: 2.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500   5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGP-GA--QGEYSGCWAHGFeslGVFTGPGGHSYQGHWQQGKREGLGVER---- 77
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPsGAtyEGEFSGGYMHGS---GTYTGTDGTTYKGRWRLNLKHGLGYQRypng 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500  78 ----------------KSRW----TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGK 137
Cdd:PLN03185 101 dvfegswiqglqegpgKYTWangnVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGL 180


                 ....*.
gi 225690500 138 RHGYGV 143
Cdd:PLN03185 181 KDGKGV 186
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-133 1.96e-19

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 88.47  E-value: 1.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGaQGEYSGCWAHG-FESLGVFTGPGGHSYQGHWQQGKREGLGV-ERKSRW 81
Cdd:COG4642  139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYAD-GDRYEGEFKNGkRHGQGTLTYANGDVYEGEFKNGQRHGQGTyTYADGD 217

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 225690500  82 TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQW 133
Cdd:COG4642  218 RYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEW 269
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
10-333 4.60e-17

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 81.54  E-value: 4.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500  10 DDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERK----------- 78
Cdd:COG4642   41 PGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKggggggggvle 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500  79 --SRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSvpyhqaallr 156
Cdd:COG4642  121 gdDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTY---------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 157 sprrtsldsghsdpptpppplplpgdeggspASGSR--GGFVlagpgdadgassrkrtpaaggffrrslllSGLRAGgrr 234
Cdd:COG4642  191 -------------------------------ANGDVyeGEFK-----------------------------NGQRHG--- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 235 sslgskRGSLRSevssevgstgppgseASGppaaappaliegsatEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRR 314
Cdd:COG4642  208 ------QGTYTY---------------ADG---------------DRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKR 251

                        330
                 ....*....|....*....
gi 225690500 315 HGYGRTTRPDGSREEGKYK 333
Cdd:COG4642  252 HGQGTMTYADGSVYEGEWK 270
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
281-336 1.12e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 59.58  E-value: 1.12e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 225690500 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNR 336
Cdd:COG4642  149 VYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQ 204
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 56-148 1.31e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 57.92  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500  56 PGGHSYQGHWQQGKREGLGverKSRW----TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQG 131
Cdd:PLN03185   6 SNGDFYSGSLLGNVPEGPG---KYLWsdgcMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKG 82

                         90
                 ....*....|....*..
gi 225690500 132 QWQAGKRHGYGvRQSVP 148
Cdd:PLN03185  83 RWRLNLKHGLG-YQRYP 98
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
275-340 1.41e-06

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 50.34  E-value: 1.41e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225690500 275 EGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLvHG 340
Cdd:COG4642  120 EGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKR-HG 184
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
369-606 1.58e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 369 RAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGR-RPRQDSEGSDTEPLDEDSPGVY 447
Cdd:PRK07003 378 GAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAtADRGDDAADGDAPVPAKANARA 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 448 ENGLTPSEGSPELPSSPASSRQPW---RPPACRSPLPPGGDQGPFSSPKAwpeewggagAQAEELAGYEAEDEAGMQG-P 523
Cdd:PRK07003 458 SADSRCDERDAQPPADSGSASAPAsdaPPDAAFEPAPRAAAPSAATPAAV---------PDARAPAAASREDAPAAAApP 528

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 524 GPRDGSPllggcSDSSGSLREEEGEDEEPLPPLRApAGtepepiamlvLRGSSSRGPDAGCLTEELGEPAATERPAQPGA 603
Cdd:PRK07003 529 APEARPP-----TPAAAAPAARAGGAAAALDVLRN-AG----------MRVSSDRGARAAAAAKPAAAPAAAPKPAAPRV 592


                 ...
gi 225690500 604 ANP 606
Cdd:PRK07003 593 AVQ 595
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 281-340 2.44e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.52  E-value: 2.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNrLVHG 340
Cdd:PLN03185  33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN-LKHG 91
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 421-601 4.81e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.52  E-value: 4.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 421 EAPGRRPRQDSEGSDTEPldeDSPGVYENGLTPSegSPELPSSPASSRQPWRPPACRSPLPPGGDQGPF--SSPKAWPEE 498
Cdd:PTZ00449 604 QRPTRPKSPKLPELLDIP---KSPKRPESPKSPK--RPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFdpKFKEKFYDD 678

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 499 WGGAGAQAEELAGYEAEDEAGmqgpgprdGSPLLGGCSDSSGSlreeEGEDEEPLPPLRA------------PAGTEPEP 566
Cdd:PTZ00449 679 YLDAAAKSKETKTTVVLDESF--------ESILKETLPETPGT----PFTTPRPLPPKLPrdeefpfepigdPDAEQPDD 746

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 225690500 567 IAMLV--------LRGSSSRGPDAGCLTEELGEP---AATERPAQP 601
Cdd:PTZ00449 747 IEFFTppeeertfFHETPADTPLPDILAEEFKEEdihAETGEPDEA 792
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 305-327 1.74e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.85  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|...
gi 225690500  305 YEGEWLGNRRHGYGRTTRPDGSR 327
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-67 2.43e-03

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 40.32  E-value: 2.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225690500   5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGpgAQGE-YSGCWAHG-FESLGVFTGPGGHSYQGHWQQ 67
Cdd:COG4642  209 GTYTYADGDRYEGEFKNGKRHGQGTLTY--ADGDrYEGEFKNGkRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 280-332 3.33e-03

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 40.59  E-value: 3.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 225690500 280 EVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKY 332
Cdd:PLN03185   9 DFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEF 61
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
304-324 3.39e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.01  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|.
gi 225690500   304 RYEGEWLGNRRHGYGRTTRPD 324
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
128-143 3.74e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.01  E-value: 3.74e-03
                           10
                   ....*....|....*.
gi 225690500   128 TYQGQWQAGKRHGYGV 143
Cdd:smart00698   2 RYEGEWRNGKRHGRGV 17
PHA03379 PHA03379
EBNA-3A; Provisional
 326-608 5.13e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.04  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 326 SREEGKYKRNRLVHGGRVRSLLplaLRRGKVKEKVDRAVEGARRAVSAArQRQEIAAARAADALLKAVAASSVAEKAVEA 405
Cdd:PHA03379 370 SREGTKRKRPPIFLRRLHRLLL---MRAGKLTERAREALEKASEPTYGT-PRPPVEKPRPEVPQSLETATSHGSAQVPEP 445

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 406 ARMAKLIAQDLQPMLE-APGrrPRQDSEGSdtePLDEDSPGVYENGLtPSEGSPELPSSPASSR---QPWRPPACRSPlp 481
Cdd:PHA03379 446 PPVHDLEPGPLHDQHSmAPC--PVAQLPPG---PLQDLEPGDQLPGV-VQDGRPACAPVPAPAGpivRPWEASLSQVP-- 517

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 482 pgGDQGPFSSPKAWPEEWGGAGAQAEELAGYEAEDEAGMQGPGprdgspllggcsDSSGSLREEEGEDEEPLPPlrapag 561
Cdd:PHA03379 518 --GVAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAMQGPG------------ETSGIVRVRERWRPAPWTP------ 577

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 225690500 562 TEPEPIAMLVLRGSSSRG-PDAGCLTE--ELGEPAATERPAQPGAANPLV 608
Cdd:PHA03379 578 NPPRSPSQMSVRDRLARLrAEAQPYQAsvEVQPPQLTQVSPQQPMEYPLE 627
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 453-606 6.04e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690500 453 PSEGSPELPSSPASSRQPWRPPAcrsPLPPGGDQGPFSSPKAWPEEWGGAGAQAEELAGYEAEDEAGMQGPGPRDGSPLL 532
Cdd:PRK07764 604 ASSGPPEEAARPAAPAAPAAPAA---PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAA 680

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225690500 533 GGCSDSSGSLREEEGEDEE---PLPPLRAPAG--TEPEPIAMLVLRGSSSRGPDAGCLTEELGEPAATERPAQPGAANP 606
Cdd:PRK07764 681 PPPAPAPAAPAAPAGAAPAqpaPAPAATPPAGqaDDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPP 759
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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